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Aliases for PNRC2 Gene

Aliases for PNRC2 Gene

  • Proline-Rich Nuclear Receptor Coactivator 2 2 3

External Ids for PNRC2 Gene

Summaries for PNRC2 Gene

GeneCards Summary for PNRC2 Gene

PNRC2 (Proline-Rich Nuclear Receptor Coactivator 2) is a Protein Coding gene. An important paralog of this gene is PNRC1.

UniProtKB/Swiss-Prot for PNRC2 Gene

  • Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery. May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs. Required for UPF1/RENT1 localization to the P-body. Also acts as a nuclear receptor coactivator. May play a role in controlling the energy balance between energy storage and energy expenditure.

Gene Wiki entry for PNRC2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PNRC2 Gene

Genomics for PNRC2 Gene

Genomic Location for PNRC2 Gene

Start:
23,959,109 bp from pter
End:
23,963,462 bp from pter
Size:
4,354 bases
Orientation:
Plus strand

Genomic View for PNRC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PNRC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PNRC2 Gene

Regulatory Elements for PNRC2 Gene

Proteins for PNRC2 Gene

  • Protein details for PNRC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPJ4-PNRC2_HUMAN
    Recommended name:
    Proline-rich nuclear receptor coactivator 2
    Protein Accession:
    Q9NPJ4
    Secondary Accessions:
    • B4DU72

    Protein attributes for PNRC2 Gene

    Size:
    139 amino acids
    Molecular mass:
    15591 Da
    Quaternary structure:
    • Interacts with UPF1/RENT1; preferentially interacts with hyperphosphorylated form. Interacts with DCP1A. Interacts with many nuclear receptors including ESR1, ESRRA, ESRRG, NR3C1/GR, NR5A1, PGR, TR, RAR and RXR.

    Three dimensional structures from OCA and Proteopedia for PNRC2 Gene

    Alternative splice isoforms for PNRC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PNRC2 Gene

Proteomics data for PNRC2 Gene at MOPED

Post-translational modifications for PNRC2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys86

Other Protein References for PNRC2 Gene

No data available for DME Specific Peptides for PNRC2 Gene

Domains for PNRC2 Gene

Protein Domains for PNRC2 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

PNRC2_HUMAN
Domain:
  • The interaction between PNRC2 and nuclear receptors is dependent on the SH3 binding motif.:
    • Q9NPJ4
Family:
  • Belongs to the PNRC family. PNRC2 subfamily.:
    • Q9NPJ4
genes like me logo Genes that share domains with PNRC2: view

No data available for Gene Families for PNRC2 Gene

Function for PNRC2 Gene

Molecular function for PNRC2 Gene

UniProtKB/Swiss-Prot Function: Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery. May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs. Required for UPF1/RENT1 localization to the P-body. Also acts as a nuclear receptor coactivator. May play a role in controlling the energy balance between energy storage and energy expenditure.

Gene Ontology (GO) - Molecular Function for PNRC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19150429
genes like me logo Genes that share ontologies with PNRC2: view
genes like me logo Genes that share phenotypes with PNRC2: view

Animal Models for PNRC2 Gene

MGI Knock Outs for PNRC2:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for PNRC2 Gene

Localization for PNRC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PNRC2 Gene

Nucleus. Cytoplasm, P-body.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PNRC2 Gene COMPARTMENTS Subcellular localization image for PNRC2 gene
Compartment Confidence
nucleus 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PNRC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 cytoplasmic mRNA processing body IDA 19150429
GO:0005634 nucleus IDA 19150429
genes like me logo Genes that share ontologies with PNRC2: view

Pathways for PNRC2 Gene

SuperPathways for PNRC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PNRC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IDA 19150429
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA TAS 19150429
genes like me logo Genes that share ontologies with PNRC2: view

No data available for Pathways by source for PNRC2 Gene

Transcripts for PNRC2 Gene

Unigene Clusters for PNRC2 Gene

Proline-rich nuclear receptor coactivator 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PNRC2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e
SP1: -
SP2: - - - -
SP3: -
SP4: -
SP5: -
SP6:

Relevant External Links for PNRC2 Gene

GeneLoc Exon Structure for
PNRC2
ECgene alternative splicing isoforms for
PNRC2

Expression for PNRC2 Gene

mRNA expression in normal human tissues for PNRC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for PNRC2 Gene Hs.7862

mRNA Expression by UniProt/SwissProt for PNRC2 Gene

Q9NPJ4-PNRC2_HUMAN
Tissue specificity: Expressed in heart, lung, muscle and brain.
genes like me logo Genes that share expressions with PNRC2: view

Orthologs for PNRC2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PNRC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PNRC2 36
  • 99.28 (n)
  • 98.56 (a)
PNRC2 37
  • 99 (a)
OneToMany
cow
(Bos Taurus)
Mammalia PNRC2 36
  • 93.29 (n)
  • 93.53 (a)
PNRC2 37
  • 94 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 94 (a)
ManyToMany
-- 37
  • 66 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Pnrc2 36
  • 86.33 (n)
  • 82.73 (a)
Pnrc2 16
Pnrc2 37
  • 81 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 84 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Pnrc2 36
  • 87.81 (n)
  • 85.82 (a)
chicken
(Gallus gallus)
Aves PNRC2 36
  • 79.38 (n)
  • 75.54 (a)
PNRC2 37
  • 73 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 74 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia pnrc2 36
  • 65.43 (n)
  • 58.52 (a)
Str.8015 36
zebrafish
(Danio rerio)
Actinopterygii pnrc2 36
  • 58.59 (n)
  • 54.55 (a)
pnrc2 37
  • 43 (a)
OneToMany
Species with no ortholog for PNRC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PNRC2 Gene

ENSEMBL:
Gene Tree for PNRC2 (if available)
TreeFam:
Gene Tree for PNRC2 (if available)

Paralogs for PNRC2 Gene

Paralogs for PNRC2 Gene

Selected SIMAP similar genes for PNRC2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PNRC2: view

Variants for PNRC2 Gene

Sequence variations from dbSNP and Humsavar for PNRC2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1043880 -- 23,962,567(+) GCTCT(C/G)GCCTC utr-variant-3-prime
rs3211053 -- 23,961,986(+) AAAAA(C/T)AGACC utr-variant-3-prime
rs6697086 -- 23,963,846(+) AAAAA(A/T)TATAA downstream-variant-500B
rs34796864 -- 23,963,597(+) TGATC(-/AT)ATATA downstream-variant-500B
rs35008260 -- 23,963,775(+) AAAAA(A/G)AGGCC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for PNRC2 Gene

Variant ID Type Subtype PubMed ID
nsv6742 CNV Insertion 18451855
esv2676255 CNV Deletion 23128226
esv2662136 CNV Deletion 23128226

Relevant External Links for PNRC2 Gene

HapMap Linkage Disequilibrium report
PNRC2

Disorders for PNRC2 Gene

No disorders were found for PNRC2 Gene.

No data available for UniProtKB/Swiss-Prot for PNRC2 Gene

Publications for PNRC2 Gene

  1. Identification of PNRC2 and TLE1 as activation function-1 cofactors of the orphan nuclear receptor ERRgamma. (PMID: 14651967) Hentschke M. … Borgmeyer U. (Biochem. Biophys. Res. Commun. 2003) 3 4 23
  2. PNRC2 is a 16 kDa coactivator that interacts with nuclear receptors through an SH3-binding motif. (PMID: 11574675) Zhou D. … Chen S. (Nucleic Acids Res. 2001) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4

Products for PNRC2 Gene

Sources for PNRC2 Gene

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