Aliases for PRKAA1 Gene
Aliases for PRKAA1 Gene
- Protein Kinase AMP-Activated Catalytic Subunit Alpha 1 2 3 5
- Protein Kinase, AMP-Activated, Alpha 1 Catalytic Subunit 2 3
- Hydroxymethylglutaryl-CoA Reductase Kinase 3 4
- Acetyl-CoA Carboxylase Kinase 3 4
- Tau-Protein Kinase PRKAA1 3 4
- AMPK Subunit Alpha-1 3 4
- ACACA Kinase 3 4
- HMGCR Kinase 3 4
- EC 2.7.11.1 4 56
- 5-AMP-Activated Protein Kinase Catalytic Subunit Alpha-1 3
- 5-AMP-Activated Protein Kinase, Catalytic Alpha-1 Chain 3
- AMP-Activated Protein Kinase, Catalytic, Alpha-1 3
External Ids for PRKAA1 Gene
- HGNC: 9376
- Entrez Gene: 5562
- Ensembl: ENSG00000132356
- OMIM: 602739
- UniProtKB: Q13131
Previous GeneCards Identifiers for PRKAA1 Gene
- GC05M041069
- GC05M041854
- GC05M040804
- GC05M040795
- GC05M040711
Summaries for PRKAA1 Gene
-
The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
GeneCards Summary for PRKAA1 Gene
PRKAA1 (Protein Kinase AMP-Activated Catalytic Subunit Alpha 1) is a Protein Coding gene. Diseases associated with PRKAA1 include Myotonia and Body Mass Index Quantitative Trait Locus 11. Among its related pathways are Metformin Pathway, Pharmacodynamics and Gene Expression. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PRKAA2.
UniProtKB/Swiss-Prot for PRKAA1 Gene
-
Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively. Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3. AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160. Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A. Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm. In response to stress, phosphorylates Ser-36 of histone H2B (H2BS36ph), leading to promote transcription. Acts as a key regulator of cell growth and proliferation by phosphorylating TSC2, RPTOR and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2. In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1. AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it. May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it. Also has tau-protein kinase activity: in response to amyloid beta A4 protein (APP) exposure, activated by CAMKK2, leading to phosphorylation of MAPT/TAU; however the relevance of such data remains unclear in vivo. Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1.
-
AMP-activated protein kinase (AMPK) is a heterodimeric protein serine/threonine kinase that is composed of alpha- (catalytic) and beta/gamma- (regulatory) subunits. AMPK acts as a sensor of the energy status of cells and ensures survival during times of cellular metabolic stress.
Additional gene information for PRKAA1 Gene
- Monarch Initiative
- Search for PRKAA1 at DataMed
- Search for PRKAA1 at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRKAA1 Gene
Genomics for PRKAA1 Gene
GeneHancer (GH) Regulatory Elements for PRKAA1 Gene
Regulatory Element Products
Genomic Locations for PRKAA1 Gene
- chr5:40,759,379-40,798,374
- (GRCh38/hg38)
- Size:
- 38,996 bases
- Orientation:
- Minus strand
- chr5:40,759,481-40,798,476
- (GRCh37/hg19)
Genomic View for PRKAA1 Gene
- Cytogenetic band:
-
- 5p13.1 by Ensembl
- 5p13.1 by Entrez Gene
- 5p13.1 by HGNC


RefSeq DNA sequence for PRKAA1 Gene
Proteins for PRKAA1 Gene
-
Protein details for PRKAA1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q13131-AAPK1_HUMAN
- Recommended name:
- 5-AMP-activated protein kinase catalytic subunit alpha-1
- Protein Accession:
- Q13131
- A8MTQ6
- B2R7E1
- O00286
- Q5D0E1
- Q86VS1
- Q9UNQ4
Protein attributes for PRKAA1 Gene
- Size:
- 559 amino acids
- Molecular mass:
- 64009 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Quaternary structure:
-
- AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2.
- SequenceCaution:
-
- Sequence=AAA64850.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAD43027.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH37303.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA36547.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG35788.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for PRKAA1 Gene
Protein Expression for PRKAA1 Gene
Selected DME Specific Peptides for PRKAA1 Gene
- Q13131:
-
- IKDIREHEWFKQDLP
- TMIDDEALK
- VDYCHRHMVVHRDLKPEN
- LAVAYHL
- KHQGVRKAK
- AEKQKHDGRV
- YLFPEDPSY
- LCGTLPFDD
- VSGGELFDY
- HPHIIKL
- KMSLQLY
- DFYLATSPPDSFLDDHHLTR
- KVVNPYYLRVRRK
- KIADFGLSN
- GPEVDIWS
- KRATIKD
- VVHRDLK
- QDPLAVA
- KVAVKILNRQKI
- TSCGSPNYAAPEVISG
- LGDTLGVGTFGK
- LFRHPHI
- TLGVGTFGKVK
- RDLKPEN
- HVPTLFKKI
- SYSSTMI
- VISTPSDIF
- RVPFLVAETPR
- AKWHLGIRSQS
- IIKLYQV
- VHRDLKP
- DELNPQK
Post-translational modifications for PRKAA1 Gene
- Phosphorylated at Thr-183 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Also phosphorylated at Thr-183 by CAMKK2; triggered by a rise in intracellular calcium ions, without detectable changes in the AMP/ATP ratio. CAMKK1 can also phosphorylate Thr-183, but at a much lower level. Dephosphorylated by protein phosphatase 2A and 2C (PP2A and PP2C). Phosphorylated by ULK1 and ULK2; leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1, ULK2 and AMPK. Dephosphorylated by PPM1A and PPM1B.
- Ubiquitinated.
Other Protein References for PRKAA1 Gene
Antibody Products
- R&D Systems Antibodies for PRKAA1 (AMPK alpha 1)
- Cell Signaling Technology (CST) Antibodies for PRKAA1 (AMPKA1)
-
Custom Antibody ServicesOriGene Antibodies for PRKAA1
- Novus Biologicals Antibodies for PRKAA1
-
Abcam antibodies for PRKAA1
-
Cloud-Clone Corp. Antibodies for PRKAA1
- Invitrogen Antibodies for PRKAA1
- antibodies-online: Search results for 326 available PRKAA1 Antibodies ranked by validation data
- Compare Top PRKAA1 Antibodies
-
Recommended
- 261 WB Antibodies (anti-human)
- 13 IHC Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 9 IHC (p) Antibodies (anti-human)
- 3 IP Antibodies (anti-human)
- 2 FACS Antibodies (anti-human)
- 1 IF Antibody (anti-human)
- 141 WB Antibodies (anti-rat)
- 22 IF (p) Antibodies (anti-rat)
- 9 IHC Antibodies (anti-rat)
- 6 IHC (p) Antibodies (anti-rat)
- 3 IP Antibodies (anti-rat)
- 2 FACS Antibodies (anti-rat)
- 150 WB Antibodies (anti-mouse)
- 22 IF (p) Antibodies (anti-mouse)
- 9 IHC Antibodies (anti-mouse)
- 7 IHC (p) Antibodies (anti-mouse)
- 2 FACS Antibodies (anti-mouse)
- 1 IP Antibody (anti-mouse)
- GeneTex PRKAA1 antibody for PRKAA1
-
Santa Cruz Biotechnology (SCBT) Antibodies for PRKAA1
- Sino Biological Antibodies for PRKAA1
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for PRKAA1
- Origene Custom Protein Services for PRKAA1
- Sino Biological Cell Lysates for PRKAA1
- Sino Biological Recombinant Proteins for PRKAA1
- ProSpec Recombinant Proteins for PRKAA1
-
Cloud-Clone Corp. Proteins for PRKAA1
- Search GeneTex for Proteins for PRKAA1
-
Abcam proteins for PRKAA1
Assay Products
- R&D Systems Proteome Profiler Antibody Arrays, ELISAs, and other biochemical assays for PRKAA1 (AMPK alpha 1)
- Cell Signaling Technology (CST) Sandwich ELISA Kits for PRKAA1 (AMPKA1)
-
Cloud-Clone Corp. Assay Kits for PRKAA1
Domains & Families for PRKAA1 Gene
Gene Families for PRKAA1 Gene
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- FDA approved drug targets
- Predicted intracellular proteins
Protein Domains for PRKAA1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for PRKAA1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q13131UniProtKB/Swiss-Prot:
AAPK1_HUMAN :- The AIS (autoinhibitory sequence) region shows some sequence similarity with the ubiquitin-associated domains and represses kinase activity.
- Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
- Domain:
-
- The AIS (autoinhibitory sequence) region shows some sequence similarity with the ubiquitin-associated domains and represses kinase activity.
- Family:
-
- Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
Function for PRKAA1 Gene
Molecular function for PRKAA1 Gene
- GENATLAS Biochemistry:
- protein kinase,cAMP activated,alpha 1 catalytic subunit,involved in fatty acid and cholesterol metabolism
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + [acetyl-CoA carboxylase] = ADP + [acetyl-CoA carboxylase] phosphate.
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + [hydroxymethylglutaryl-CoA reductase (NADPH)] = ADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate.
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + [tau protein] = ADP + [tau protein] phosphate.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Activated by phosphorylation on Thr-183. Binding of AMP to non-catalytic gamma subunit (PRKAG1, PRKAG2 or PRKAG3) results in allosteric activation, inducing phosphorylation on Thr-183. AMP-binding to gamma subunit also sustains activity by preventing dephosphorylation of Thr-183. ADP also stimulates Thr-183 phosphorylation, without stimulating already phosphorylated AMPK. ATP promotes dephosphorylation of Thr-183, rendering the enzyme inactive. Under physiological conditions AMPK mainly exists in its inactive form in complex with ATP, which is much more abundant than AMP. AMPK is activated by antihyperglycemic drug metformin, a drug prescribed to patients with type 2 diabetes: in vivo, metformin seems to mainly inhibit liver gluconeogenesis. However, metformin can be used to activate AMPK in muscle and other cells in culture or ex vivo (PubMed:11602624). Selectively inhibited by compound C (6-[4-(2-Piperidin-1-yl-ethoxy)-phenyl)]-3-pyridin-4-yl-pyyrazolo[1,5-a] pyrimidine. Activated by resveratrol, a natural polyphenol present in red wine, and S17834, a synthetic polyphenol.
- UniProtKB/Swiss-Prot Function:
- Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively. Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3. AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160. Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A. Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm. In response to stress, phosphorylates Ser-36 of histone H2B (H2BS36ph), leading to promote transcription. Acts as a key regulator of cell growth and proliferation by phosphorylating TSC2, RPTOR and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2. In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1. AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it. May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it. Also has tau-protein kinase activity: in response to amyloid beta A4 protein (APP) exposure, activated by CAMKK2, leading to phosphorylation of MAPT/TAU; however the relevance of such data remains unclear in vivo. Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1.
Enzyme Numbers (IUBMB) for PRKAA1 Gene
Phenotypes From GWAS Catalog for PRKAA1 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003682 | chromatin binding | IEA,ISS | -- |
GO:0004672 | protein kinase activity | IEA,IDA | 17028174 |
GO:0004674 | protein serine/threonine kinase activity | IEA | -- |
GO:0004679 | AMP-activated protein kinase activity | IEA,IDA | 18439900 |
GO:0004691 | cAMP-dependent protein kinase activity | NAS | 8557660 |
Phenotypes for PRKAA1 Gene
- MGI mutant phenotypes for PRKAA1:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for PRKAA1:
-
- shRNA abundance <= 50%
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased viability in esophageal squamous lineage
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- Decreased viability after Maraba virus infection
- Increased shRNA abundance (Z-score > 2)
- Decreased viability
- Decreased HIV-LTR-beta-galactosidase protein expression
- Decreased cell migration
- Decreased shRNA abundance (Z-score < -2)
- Decreased human cytomegalovirus (HCMV) strain AD169 replication
- Increased cell viability after pRB stimulation
- Increased cell migration
- Increased senescence-associated beta-galactosidase protein expression after pRB stimulation
Animal Models for PRKAA1 Gene
- MGI Knock Outs for PRKAA1:
-
- Prkaa1 tm1Sbj
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for PRKAA1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PRKAA1 gene
- Search ViGene Biosciences for PRKAA1
CRISPR Products
-
OriGene CRISPR knockouts for PRKAA1
- genomics-online: gRNA clones - Search results for 124 available PRKAA1 gene related products
- Overview of 124 available PRKAA1 gene related products
- Applied Biological Materials CRISPR for PRKAA1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PRKAA1
- GenScript: Design CRISPR guide RNA sequences for PRKAA1
miRNA for PRKAA1 Gene
- miRTarBase miRNAs that target PRKAA1
-
- hsa-mir-19b-3p (MIRT006742)
- hsa-mir-148b-3p (MIRT019393)
- hsa-mir-130b-3p (MIRT020218)
- hsa-mir-128-3p (MIRT021937)
- hsa-mir-30a-5p (MIRT028534)
- hsa-mir-652-3p (MIRT039458)
- hsa-mir-30e-5p (MIRT044135)
- hsa-mir-29b-3p (MIRT048377)
- hsa-mir-26a-5p (MIRT122040)
- hsa-mir-26b-5p (MIRT122041)
- hsa-mir-1-5p (MIRT215707)
- hsa-mir-154-3p (MIRT313559)
- hsa-mir-487a-3p (MIRT313561)
- hsa-mir-3149 (MIRT470268)
- hsa-mir-6833-5p (MIRT470269)
- hsa-mir-297 (MIRT470270)
- hsa-mir-675-3p (MIRT470271)
- hsa-mir-1298-5p (MIRT470272)
- hsa-mir-582-5p (MIRT470273)
- hsa-mir-101-3p (MIRT470274)
- hsa-mir-3613-5p (MIRT470275)
- hsa-mir-3190-3p (MIRT470276)
- hsa-mir-567 (MIRT470277)
- hsa-mir-4781-3p (MIRT470278)
- hsa-mir-299-3p (MIRT470279)
- hsa-mir-4657 (MIRT470280)
- hsa-mir-4491 (MIRT470281)
- hsa-mir-1305 (MIRT521687)
- hsa-mir-607 (MIRT521688)
- hsa-mir-195-3p (MIRT521689)
- hsa-mir-16-2-3p (MIRT521690)
- hsa-mir-8063 (MIRT521691)
- hsa-mir-4698 (MIRT521692)
- hsa-mir-519c-3p (MIRT521693)
- hsa-mir-519b-3p (MIRT521694)
- hsa-mir-519a-3p (MIRT521695)
- hsa-mir-301b-3p (MIRT521696)
- hsa-mir-454-3p (MIRT521697)
- hsa-mir-4295 (MIRT521698)
- hsa-mir-3666 (MIRT521699)
- hsa-mir-301a-3p (MIRT521700)
- hsa-mir-130a-3p (MIRT521701)
- hsa-mir-524-5p (MIRT535040)
- hsa-mir-520d-5p (MIRT535041)
- hsa-mir-561-3p (MIRT535042)
- hsa-mir-4638-3p (MIRT555221)
- hsa-mir-3690 (MIRT555222)
- hsa-mir-6838-5p (MIRT555223)
- hsa-mir-497-5p (MIRT555224)
- hsa-mir-424-5p (MIRT555225)
- hsa-mir-195-5p (MIRT555226)
- hsa-mir-16-5p (MIRT555227)
- hsa-mir-15b-5p (MIRT555228)
- hsa-mir-15a-5p (MIRT555229)
- hsa-mir-451b (MIRT555230)
- hsa-mir-548e-5p (MIRT555231)
- hsa-mir-19a-3p (MIRT726855)
- hsa-mir-33a-5p (MIRT732687)
- hsa-mir-9-5p (MIRT733489)
- hsa-mir-137 (MIRT735470)
miRNA Products
- Search ViGene Biosciences for PRKAA1
Inhibitory RNA Products
- Origene RNAi and shrna products in human, mouse, rat for PRKAA1
- Browse OriGene Inhibitory RNA Products For PRKAA1
- genomics-online: shRNA clones - Search results for 124 available PRKAA1 gene related products
- Overview of 124 available PRKAA1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PRKAA1 gene
Clone Products
- Sino Biological Human cDNA Clone for PRKAA1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for PRKAA1
- Applied Biological Materials Clones for PRKAA1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for PRKAA1 (AMPK alpha 1)
Cell Line Products
-
Horizon Cell Lines for PRKAA1
-
ViGene Biosciences adenoviral particle packaged cDNA for PRKAA1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PRKAA1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PRKAA1 gene
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRKAA1 Gene
Localization for PRKAA1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PRKAA1 Gene
- Cytoplasm. Nucleus. Note=In response to stress, recruited by p53/TP53 to specific promoters.
- Nuclear speckles (3)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005622 | intracellular | IMP | 26103054 |
GO:0005634 | nucleus | IBA,ISS | -- |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005737 | cytoplasm | IBA | -- |
GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for PRKAA1 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | RET signaling | ||
2 | mTOR signalling |
.70
|
.51
|
3 | AMP-activated Protein Kinase (AMPK) Signaling | ||
4 | Regulation of TP53 Activity | ||
5 | Longevity regulating pathway |
Pathways by source for PRKAA1 Gene
2 Sino Biological pathways for PRKAA1 Gene
1 GeneTex pathway for PRKAA1 Gene
1 Cell Signaling Technology pathway for PRKAA1 Gene
12 BioSystems pathways for PRKAA1 Gene
19 Reactome pathways for PRKAA1 Gene
1 PharmGKB pathway for PRKAA1 Gene
18 KEGG pathways for PRKAA1 Gene
3 GeneGo (Thomson Reuters) pathways for PRKAA1 Gene
3 R&D Systems pathways for PRKAA1 Gene
1 Tocris pathway for PRKAA1 Gene
3 Qiagen pathways for PRKAA1 Gene
Interacting Proteins for PRKAA1 Gene
SIGNOR curated interactions for PRKAA1 Gene
- Activates:
- Inactivates:
- Is activated by:
- Is inactivated by:
- Other effect:
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000187 | activation of MAPK activity | NAS | 11546797 |
GO:0001666 | response to hypoxia | NAS | 8557660 |
GO:0006006 | glucose metabolic process | IEA | -- |
GO:0006351 | transcription, DNA-templated | IEA | -- |
GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
Drugs & Compounds for PRKAA1 Gene
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Phenformin | Approved, Investigational, Withdrawn | Pharma | Target, activator | 4 | ||
Metformin | Approved | Pharma | activator, inhibitor | AMP-activated protein kinase (AMPK) activator | 1891 | |
calcium | Approved | Nutra | 0 | |||
Aspirin | Approved, Vet_approved | Pharma | Channel blocker, Target, activator | 1232 | ||
Adenosine monophosphate | Approved, Investigational | Nutra | Target, activator | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
Full agonist, Agonist | 58-64-0 | |||
glucosylceramide |
|
85305-87-9 |
|
|||
Glucosylceramide (d18:1/16:0) |
|
85305-87-9 |
|
|||
Glucosylceramide (d18:1/18:0) |
|
85305-87-9 |
|
|||
Glucosylceramide (d18:1/22:0) |
|
85305-87-9 |
|
(3) Tocris Compounds for PRKAA1 Gene
Compound | Action | Cas Number |
---|---|---|
AICAR | AMPK activator | 2627-69-2 |
Dorsomorphin dihydrochloride | Potent AMPK inhibitor | 1219168-18-9 |
RSVA 405 | AMPK activator; also STAT3 inhibitor | 140405-36-3 |
(16) ApexBio Compounds for PRKAA1 Gene
Compound | Action | Cas Number |
---|---|---|
A-769662 | AMPK activator,potent and reversible | 844499-71-4 |
AICAR | AMPK activator | 2627-69-2 |
AICAR phosphate | AMPK activator | 681006-28-0 |
Dorsomorphin | AMPK inhibitor | 866405-64-3 |
Dorsomorphin 2HCl | AMPK inhibitor | 1219168-18-9 |
GSK621 | AMPK agonist | 1346607-05-3 |
Imeglimin | Antidiabetic agent | 775351-65-0 |
Imeglimin hydrochloride | Antidiabetic agent | 775351-61-6 |
Metformin HCl | Anti-diabetic drug | 1115-70-4 |
Phenformin HCl | 834-28-6 | |
PT 1 | AMPK activator, selective | 331002-70-1 |
RSVA 405 | 140405-36-3 | |
SAMS Peptide | 125911-68-4 | |
YLF-466D | 1273323-67-3 | |
ZLN024 | 723249-01-2 | |
ZLN024 hydrochloride |
Transcripts for PRKAA1 Gene
mRNA/cDNA for PRKAA1 Gene
- (11) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (205) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for PRKAA1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for PRKAA1
- genomics-online: gRNA clones - Search results for 124 available PRKAA1 gene related products
- Overview of 124 available PRKAA1 gene related products
- Applied Biological Materials CRISPR for PRKAA1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PRKAA1
- GenScript: Design CRISPR guide RNA sequences for PRKAA1
miRNA Products
- Search ViGene Biosciences for PRKAA1
Inhibitory RNA Products
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Clone Products
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-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
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ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | · | 9d | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b |
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SP4: | - | - | - | ||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
SP8: | |||||||||||||||||||||||||||||||||||||||
SP9: |
Expression for PRKAA1 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PRKAA1 Gene
NURSA nuclear receptor signaling pathways regulating expression of PRKAA1 Gene:
PRKAA1SOURCE GeneReport for Unigene cluster for PRKAA1 Gene:
Hs.43322Evidence on tissue expression from TISSUES for PRKAA1 Gene
- Nervous system(4.6)
- Liver(4.5)
- Blood(4.4)
- Intestine(4.3)
- Muscle(2)
Primer Products
-
OriGene qPCR primer pairs for PRKAA1
- genomics-online: primer clones - Search results for 124 available PRKAA1 gene related products
- Overview of 124 available PRKAA1 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRKAA1 Gene
Orthologs for PRKAA1 Gene
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | PRKAA1 33 34 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | PRKAA1 34 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | PRKAA1 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | PRKAA1 33 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Prkaa1 33 |
|
||
mouse (Mus musculus) |
Mammalia | Prkaa1 33 16 34 |
|
||
platypus (Ornithorhynchus anatinus) |
Mammalia | PRKAA1 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | PRKAA1 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | PRKAA1 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | prkaa1 33 |
|
||
Str.304 33 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.5251 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | prkaa1 33 33 34 |
|
||
fruit fly (Drosophila melanogaster) |
Insecta | SNF1A 34 |
|
OneToMany | |
worm (Caenorhabditis elegans) |
Secernentea | T01C8.1a 35 |
|
|
|
T01C8.1b 35 |
|
|
|||
aak-2 34 |
|
ManyToMany | |||
aak-1 34 |
|
ManyToMany | |||
R02C2.1 35 |
|
|
|||
Y38H8A.4 35 |
|
|
|||
DC2.7a 35 |
|
|
|||
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SNF1 34 |
|
OneToMany | |
thale cress (Arabidopsis thaliana) |
eudicotyledons | KIN10 33 |
|
||
soybean (Glycine max) |
eudicotyledons | Gma.134 33 |
|
||
rice (Oryza sativa) |
Liliopsida | Os05g0530500 33 |
|
||
Os.3393 33 |
|
||||
wheat (Triticum aestivum) |
Liliopsida | Ta.27319 33 |
|
||
corn (Zea mays) |
Liliopsida | Zm.13240 33 |
|
||
sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany | |
sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.4991 33 |
|
- Species where no ortholog for PRKAA1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Paralogs for PRKAA1 Gene
(179) SIMAP similar genes for PRKAA1 Gene using alignment to 2 proteins:
- PRKAA2
- SIK2
- NUAK1
- MARK4
- SIK1
- BRSK1
- BRSK2
- KIAA0999
- SIK3
- HUNK
- MARK1
- MARK2
- MELK
- DCLK1
- DAPK3
- PNCK
- DAPK1
- SNRK
- Par1b
- CAMK1G
- NIM1K
- CHEK1
- CHEK2
- MARK3
- TSSK3
- PRKCZ
- PDPK1
- CAMK2G
- PHKG1
- STK17B
- STK17A
- PkB-like 1
- PDPK2
- MASTL
- KIN27
- DCLK3
- CAMK1D
- DAPK2
- PHKG2
- STK32A
- PRKCH
- PLK4
- MGC45428
- DKFZp781N0293
- CAMK2D
- CAMK2A
- STK33
- PRKACB
- ULK3
- STK36
- STK32B
- SGKL
- SGK3
- RPS6KA5
- PSKH2
- PSKH1
- PRKD2
- PRKD1
- PRKCI
- PRKCG
- PRKCB
- PRKCA
- PKN2
- NEK5
- MYLK2
- DCLK2
- CDK18
- BMX
- AURKB
- ADRBK2
- STK32C
- CAMK1
- CAMK2B
- RPS6KB1
- MYLK4
- STK11
- ULK2
- TSSK6
- STK38L
- STK25
- STK24
- RPS6KA6
- PRKX
- PRKG1
- PRKCQ
- PRKCE
- PCTK1
- PASK
- NEK8
- NEK2
- MYLK3
- MYLK
- CDKL3
- CDK17
- CDK16
- AKT1
- ADRBK1
- CASK
- SGK2
- PRKACA
- PRKY
- PKN1
- AURKC
- TSSK2
- TRIO
- STK38
- RPS6KB2
- RPS6KA1
- PRKG2
- PAK3
- PAK2
- MYO3A
- MKNK1
- LYN
- CIT
- AURKA
- AKT3
- AKT2
- TSSK1B
- TSSK1
- ULK1
- SGK1
- RPS6KA4
- RPS6KA3
- PRKACG
- OBSCN
- MYO3B
- MST4
- CDK3
- CAMKV
- STK3
- RPS6KA2
- TSSK4
- STK4
- SBK1
- PKN3
- PAK6
- NEK3
- MAK
- ICK
- GRK1
- DKFZp434B079
- CDKL2
- CDK1
- CDC42BPA
- CDC2
- CAMKK1
- TNIK
- ROCK2
- PIM2
- PAK7
- OXSR1
- NEK1
- MKNK2
- MAP4K2
- GRK5
- DMPK
- DKFZp686L20222
- CDK2
- CDC42BPB
- CDKL4
- ROCK1
- MINK1
- CDKL1
- CAMKK2
- MAP4K1
- CDK4
- MAP4K4
- MAST3
- MAST2
- MAST1
- MAPK15
- MAP3K3
- MAP3K2
- GRK6
- PAK4
- PLK1
- MAST4
- MAP3K1
Variants for PRKAA1 Gene
SNP ID | Clin | Chr 05 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs928784854 | A breast cancer sample | 40,798,143(-) | T/C | 5_prime_UTR_variant, coding_sequence_variant, genic_upstream_transcript_variant, missense_variant | |
rs1000040161 | -- | 40,786,294(-) | G/A | genic_upstream_transcript_variant, intron_variant | |
rs1000046191 | -- | 40,778,455(-) | G/A | intron_variant | |
rs1000221103 | -- | 40,759,615(-) | A/C | 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant | |
rs1000442139 | -- | 40,759,824(-) | A/G | 3_prime_UTR_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2671114 | CNV | deletion | 23128226 |
esv2675082 | CNV | deletion | 23128226 |
esv2730120 | CNV | deletion | 23290073 |
esv3351655 | CNV | insertion | 20981092 |
esv3565850 | CNV | deletion | 23714750 |
esv3604824 | CNV | loss | 21293372 |
esv3604825 | CNV | loss | 21293372 |
nsv597877 | CNV | gain | 21841781 |
Additional Variant Information for PRKAA1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PRKAA1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRKAA1 Gene
Disorders for PRKAA1 Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
myotonia |
|
|
body mass index quantitative trait locus 11 |
|
Additional Disease Information for PRKAA1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for PRKAA1 Gene
Publications for PRKAA1 Gene
- AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. (PMID: 15866171) Jones RG … Thompson CB (Molecular cell 2005) 3 4 22 58
- Mammalian AMP-activated protein kinase subfamily. (PMID: 8557660) Stapleton D … Kemp BE (The Journal of biological chemistry 1996) 2 3 4 58
- A genome-wide association study identifies new susceptibility loci for non-cardia gastric cancer at 3q13.31 and 5p13.1. (PMID: 22037551) Shi Y … Shen H (Nature genetics 2011) 3 44 58
- Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PMID: 20602615) Ruaño G … Wu AH (Pharmacogenomics 2010) 3 44 58
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
Products for PRKAA1 Gene
- R&D Systems Antibodies for PRKAA1 (AMPK alpha 1)
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- 1 IF Antibody (anti-human)
- 141 WB Antibodies (anti-rat)
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- 150 WB Antibodies (anti-mouse)
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- genomics-online: shRNA clones - Search results for 124 available PRKAA1 gene related products
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Sources for PRKAA1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10)