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PRKAA1 Gene(Protein Coding)

Protein Kinase AMP-Activated Catalytic Subunit Alpha 1

GCID:
GC05M040759
GIFtS:
57
Genes Participants
UDN Logo

Aliases for PRKAA1 Gene

Aliases for PRKAA1 Gene

  • Protein Kinase AMP-Activated Catalytic Subunit Alpha 1 2 3 5
  • Protein Kinase, AMP-Activated, Alpha 1 Catalytic Subunit 2 3
  • Hydroxymethylglutaryl-CoA Reductase Kinase 3 4
  • Acetyl-CoA Carboxylase Kinase 3 4
  • Tau-Protein Kinase PRKAA1 3 4
  • AMPK Subunit Alpha-1 3 4
  • ACACA Kinase 3 4
  • HMGCR Kinase 3 4
  • EC 2.7.11.1 4 56
  • 5-AMP-Activated Protein Kinase Catalytic Subunit Alpha-1 3
  • 5-AMP-Activated Protein Kinase, Catalytic Alpha-1 Chain 3
  • AMP-Activated Protein Kinase, Catalytic, Alpha-1 3
  • AMP -Activate Kinase Alpha 1 Subunit 3
  • AMPK, Alpha, 1 2
  • AMPK Alpha 1 3
  • EC 2.7.11.27 4
  • EC 2.7.11.31 4
  • EC 2.7.11.26 4
  • EC 2.7.11 56
  • AMPKa1 3
  • AMPK1 4
  • AMPK 3

External Ids for PRKAA1 Gene

Previous GeneCards Identifiers for PRKAA1 Gene

  • GC05M041069
  • GC05M041854
  • GC05M040804
  • GC05M040795
  • GC05M040711

Summaries for PRKAA1 Gene

Entrez Gene Summary for PRKAA1 Gene

  • The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRKAA1 Gene

PRKAA1 (Protein Kinase AMP-Activated Catalytic Subunit Alpha 1) is a Protein Coding gene. Diseases associated with PRKAA1 include Myotonia and Body Mass Index Quantitative Trait Locus 11. Among its related pathways are Metformin Pathway, Pharmacodynamics and Gene Expression. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PRKAA2.

UniProtKB/Swiss-Prot for PRKAA1 Gene

  • Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively. Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3. AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160. Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A. Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm. In response to stress, phosphorylates Ser-36 of histone H2B (H2BS36ph), leading to promote transcription. Acts as a key regulator of cell growth and proliferation by phosphorylating TSC2, RPTOR and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2. In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1. AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it. May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it. Also has tau-protein kinase activity: in response to amyloid beta A4 protein (APP) exposure, activated by CAMKK2, leading to phosphorylation of MAPT/TAU; however the relevance of such data remains unclear in vivo. Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1.

Tocris Summary for PRKAA1 Gene

  • AMP-activated protein kinase (AMPK) is a heterodimeric protein serine/threonine kinase that is composed of alpha- (catalytic) and beta/gamma- (regulatory) subunits. AMPK acts as a sensor of the energy status of cells and ensures survival during times of cellular metabolic stress.

Gene Wiki entry for PRKAA1 Gene

Additional gene information for PRKAA1 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRKAA1 Gene

Genomics for PRKAA1 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for PRKAA1 Gene

Promoters and enhancers for PRKAA1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH05I040795 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 550.8 +0.5 497 5 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B ZNF766 ZNF213 PRKAA1 CARD6 TTC33 ENSG00000212567 GC05M040791
GH05I040832 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 52.1 -36.1 -36105 4.7 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 GC05M040833 RPL37 SNORD72 PRKAA1 CARD6 TTC33 PLCXD3
GH05I040754 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 24.6 +43.1 43067 2.6 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC TTC33 PRKAA1 CARD6 PTGER4 GC05M040716
GH05I040840 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 11.6 -43.5 -43460 2 PKNOX1 FOXA2 FEZF1 ZNF2 YY1 ZNF766 ZNF213 FOS ATF7 REST CARD6 PRKAA1 PLCXD3 C7
GH05I040825 Enhancer 0.8 ENCODE 21.2 -27.3 -27289 0.3 HDAC1 HDGF HNRNPUL1 ATF1 NFRKB MZF1 NFXL1 ZEB1 POLR2B E2F8 PIR57920 PRKAA1 LOC100506548 GC05P040818 RPL37
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PRKAA1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PRKAA1 gene promoter:

Genomic Locations for PRKAA1 Gene

Genomic Locations for PRKAA1 Gene
chr5:40,759,379-40,798,374
(GRCh38/hg38)
Size:
38,996 bases
Orientation:
Minus strand
chr5:40,759,481-40,798,476
(GRCh37/hg19)

Genomic View for PRKAA1 Gene

Genes around PRKAA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRKAA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRKAA1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for PRKAA1 Gene

Proteins for PRKAA1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for PRKAA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13131-AAPK1_HUMAN
    Recommended name:
    5-AMP-activated protein kinase catalytic subunit alpha-1
    Protein Accession:
    Q13131
    Secondary Accessions:
    • A8MTQ6
    • B2R7E1
    • O00286
    • Q5D0E1
    • Q86VS1
    • Q9UNQ4

    Protein attributes for PRKAA1 Gene

    Size:
    559 amino acids
    Molecular mass:
    64009 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2.
    SequenceCaution:
    • Sequence=AAA64850.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAD43027.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH37303.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA36547.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG35788.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PRKAA1 Gene

    Alternative splice isoforms for PRKAA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRKAA1 Gene

Protein Expression for PRKAA1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for PRKAA1 Gene

Q13131:
  • IKDIREHEWFKQDLP
  • TMIDDEALK
  • VDYCHRHMVVHRDLKPEN
  • LAVAYHL
  • KHQGVRKAK
  • AEKQKHDGRV
  • YLFPEDPSY
  • LCGTLPFDD
  • VSGGELFDY
  • HPHIIKL
  • KMSLQLY
  • DFYLATSPPDSFLDDHHLTR
  • KVVNPYYLRVRRK
  • KIADFGLSN
  • GPEVDIWS
  • KRATIKD
  • VVHRDLK
  • QDPLAVA
  • KVAVKILNRQKI
  • TSCGSPNYAAPEVISG
  • LGDTLGVGTFGK
  • LFRHPHI
  • TLGVGTFGKVK
  • RDLKPEN
  • HVPTLFKKI
  • SYSSTMI
  • VISTPSDIF
  • RVPFLVAETPR
  • AKWHLGIRSQS
  • IIKLYQV
  • VHRDLKP
  • DELNPQK

Post-translational modifications for PRKAA1 Gene

  • Phosphorylated at Thr-183 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Also phosphorylated at Thr-183 by CAMKK2; triggered by a rise in intracellular calcium ions, without detectable changes in the AMP/ATP ratio. CAMKK1 can also phosphorylate Thr-183, but at a much lower level. Dephosphorylated by protein phosphatase 2A and 2C (PP2A and PP2C). Phosphorylated by ULK1 and ULK2; leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1, ULK2 and AMPK. Dephosphorylated by PPM1A and PPM1B.
  • Ubiquitinated.

Other Protein References for PRKAA1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for PRKAA1 (AMPK alpha 1)
  • Cell Signaling Technology (CST) Antibodies for PRKAA1 (AMPKA1)

Domains & Families for PRKAA1 Gene

Gene Families for PRKAA1 Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • FDA approved drug targets
  • Predicted intracellular proteins

Protein Domains for PRKAA1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PRKAA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13131

UniProtKB/Swiss-Prot:

AAPK1_HUMAN :
  • The AIS (autoinhibitory sequence) region shows some sequence similarity with the ubiquitin-associated domains and represses kinase activity.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
Domain:
  • The AIS (autoinhibitory sequence) region shows some sequence similarity with the ubiquitin-associated domains and represses kinase activity.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
genes like me logo Genes that share domains with PRKAA1: view

Function for PRKAA1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for PRKAA1 Gene

GENATLAS Biochemistry:
protein kinase,cAMP activated,alpha 1 catalytic subunit,involved in fatty acid and cholesterol metabolism
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + [acetyl-CoA carboxylase] = ADP + [acetyl-CoA carboxylase] phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + [hydroxymethylglutaryl-CoA reductase (NADPH)] = ADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + [tau protein] = ADP + [tau protein] phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by phosphorylation on Thr-183. Binding of AMP to non-catalytic gamma subunit (PRKAG1, PRKAG2 or PRKAG3) results in allosteric activation, inducing phosphorylation on Thr-183. AMP-binding to gamma subunit also sustains activity by preventing dephosphorylation of Thr-183. ADP also stimulates Thr-183 phosphorylation, without stimulating already phosphorylated AMPK. ATP promotes dephosphorylation of Thr-183, rendering the enzyme inactive. Under physiological conditions AMPK mainly exists in its inactive form in complex with ATP, which is much more abundant than AMP. AMPK is activated by antihyperglycemic drug metformin, a drug prescribed to patients with type 2 diabetes: in vivo, metformin seems to mainly inhibit liver gluconeogenesis. However, metformin can be used to activate AMPK in muscle and other cells in culture or ex vivo (PubMed:11602624). Selectively inhibited by compound C (6-[4-(2-Piperidin-1-yl-ethoxy)-phenyl)]-3-pyridin-4-yl-pyyrazolo[1,5-a] pyrimidine. Activated by resveratrol, a natural polyphenol present in red wine, and S17834, a synthetic polyphenol.
UniProtKB/Swiss-Prot Function:
Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively. Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3. AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160. Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A. Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm. In response to stress, phosphorylates Ser-36 of histone H2B (H2BS36ph), leading to promote transcription. Acts as a key regulator of cell growth and proliferation by phosphorylating TSC2, RPTOR and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2. In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1. AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it. May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it. Also has tau-protein kinase activity: in response to amyloid beta A4 protein (APP) exposure, activated by CAMKK2, leading to phosphorylation of MAPT/TAU; however the relevance of such data remains unclear in vivo. Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1.

Enzyme Numbers (IUBMB) for PRKAA1 Gene

Phenotypes From GWAS Catalog for PRKAA1 Gene

Gene Ontology (GO) - Molecular Function for PRKAA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA,ISS --
GO:0004672 protein kinase activity IEA,IDA 17028174
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004679 AMP-activated protein kinase activity IEA,IDA 18439900
GO:0004691 cAMP-dependent protein kinase activity NAS 8557660
genes like me logo Genes that share ontologies with PRKAA1: view
genes like me logo Genes that share phenotypes with PRKAA1: view

Animal Models for PRKAA1 Gene

MGI Knock Outs for PRKAA1:

miRNA for PRKAA1 Gene

miRTarBase miRNAs that target PRKAA1

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRKAA1 Gene

Localization for PRKAA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRKAA1 Gene

Cytoplasm. Nucleus. Note=In response to stress, recruited by p53/TP53 to specific promoters.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRKAA1 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 2
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PRKAA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IMP 26103054
GO:0005634 nucleus IBA,ISS --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PRKAA1: view

Pathways & Interactions for PRKAA1 Gene

genes like me logo Genes that share pathways with PRKAA1: view

Pathways by source for PRKAA1 Gene

2 Sino Biological pathways for PRKAA1 Gene
1 GeneTex pathway for PRKAA1 Gene
1 Cell Signaling Technology pathway for PRKAA1 Gene
1 PharmGKB pathway for PRKAA1 Gene
1 Tocris pathway for PRKAA1 Gene

SIGNOR curated interactions for PRKAA1 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for PRKAA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity NAS 11546797
GO:0001666 response to hypoxia NAS 8557660
GO:0006006 glucose metabolic process IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with PRKAA1: view

Drugs & Compounds for PRKAA1 Gene

Products:

  1. Drug

(39) Drugs for PRKAA1 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phenformin Approved, Investigational, Withdrawn Pharma Target, activator 4
Metformin Approved Pharma activator, inhibitor AMP-activated protein kinase (AMPK) activator 1891
calcium Approved Nutra 0
Aspirin Approved, Vet_approved Pharma Channel blocker, Target, activator 1232
Adenosine monophosphate Approved, Investigational Nutra Target, activator 0

(19) Additional Compounds for PRKAA1 Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
 Full agonist, Agonist 58-64-0
glucosylceramide
  • 1-O-b-D-Glucopyranosyl-Ceramide
  • 1-O-beta-delta-Glucopyranosyl-Ceramide
  • Ganglioside GL1a
  • Gaucher cerebroside
  • Glc-beta1->1'Cer
 85305-87-9
Glucosylceramide (d18:1/16:0)
  • 1-O-b-D-Glucopyranosyl-Ceramide
  • 1-O-beta-delta-Glucopyranosyl-Ceramide
  • Ganglioside GL1a
  • Gaucher cerebroside
  • Glc-beta1->1'Cer
 85305-87-9
Glucosylceramide (d18:1/18:0)
  • 1-O-b-D-Glucopyranosyl-Ceramide
  • 1-O-beta-delta-Glucopyranosyl-Ceramide
  • Ganglioside GL1a
  • Gaucher cerebroside
  • Glc-beta1->1'Cer
 85305-87-9
Glucosylceramide (d18:1/22:0)
  • 1-O-b-D-Glucopyranosyl-Ceramide
  • 1-O-beta-delta-Glucopyranosyl-Ceramide
  • Ganglioside GL1a
  • Gaucher cerebroside
  • Glc-beta1->1'Cer
 85305-87-9

(3) Tocris Compounds for PRKAA1 Gene

Compound Action Cas Number
AICAR AMPK activator 2627-69-2
Dorsomorphin dihydrochloride Potent AMPK inhibitor 1219168-18-9
RSVA 405 AMPK activator; also STAT3 inhibitor 140405-36-3

(16) ApexBio Compounds for PRKAA1 Gene

Compound Action Cas Number
A-769662 AMPK activator,potent and reversible 844499-71-4
AICAR AMPK activator 2627-69-2
AICAR phosphate AMPK activator 681006-28-0
Dorsomorphin AMPK inhibitor 866405-64-3
Dorsomorphin 2HCl AMPK inhibitor 1219168-18-9
GSK621 AMPK agonist 1346607-05-3
Imeglimin Antidiabetic agent 775351-65-0
Imeglimin hydrochloride Antidiabetic agent 775351-61-6
Metformin HCl Anti-diabetic drug 1115-70-4
Phenformin HCl 834-28-6
PT 1 AMPK activator, selective 331002-70-1
RSVA 405 140405-36-3
SAMS Peptide 125911-68-4
YLF-466D 1273323-67-3
ZLN024 723249-01-2
ZLN024 hydrochloride
genes like me logo Genes that share compounds with PRKAA1: view

Drug Products

Transcripts for PRKAA1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for PRKAA1 Gene

(11) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(205) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRKAA1 Gene

Protein kinase, AMP-activated, alpha 1 catalytic subunit:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRKAA1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12a · 12b
SP1: - - -
SP2: - - - -
SP3: - - - -
SP4: - - -
SP5: - - - - -
SP6: - - - - -
SP7: - - - - -
SP8:
SP9:

Relevant External Links for PRKAA1 Gene

GeneLoc Exon Structure for
PRKAA1
ECgene alternative splicing isoforms for
PRKAA1

Expression for PRKAA1 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRKAA1 Gene

mRNA expression in normal human tissues for PRKAA1 Gene
mRNA expression by GTEx for PRKAA1 GenemRNA expression by BioGPS for PRKAA1 Gene

Protein differential expression in normal tissues from HIPED for PRKAA1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PRKAA1 Gene



Protein tissue co-expression partners for PRKAA1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PRKAA1 Gene:

PRKAA1

SOURCE GeneReport for Unigene cluster for PRKAA1 Gene:

Hs.43322

Evidence on tissue expression from TISSUES for PRKAA1 Gene

  • Nervous system(4.6)
  • Liver(4.5)
  • Blood(4.4)
  • Intestine(4.3)
  • Muscle(2)
genes like me logo Genes that share expression patterns with PRKAA1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRKAA1 Gene

Orthologs for PRKAA1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PRKAA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia PRKAA1 33 34
  • 99.88 (n)
oppossum
(Monodelphis domestica)
 Mammalia PRKAA1 34
  • 97 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia PRKAA1 33 34
  • 96.18 (n)
cow
(Bos Taurus)
 Mammalia PRKAA1 33 34
  • 95.05 (n)
rat
(Rattus norvegicus)
 Mammalia Prkaa1 33
  • 90.7 (n)
mouse
(Mus musculus)
 Mammalia Prkaa1 33 16 34
  • 90.22 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia PRKAA1 34
  • 89 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves PRKAA1 33 34
  • 85.01 (n)
lizard
(Anolis carolinensis)
 Reptilia PRKAA1 34
  • 94 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia prkaa1 33
  • 78.57 (n)
Str.304 33
African clawed frog
(Xenopus laevis)
 Amphibia Xl.5251 33
zebrafish
(Danio rerio)
 Actinopterygii prkaa1 33 33 34
  • 73.89 (n)
fruit fly
(Drosophila melanogaster)
 Insecta SNF1A 34
  • 57 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea T01C8.1a 35
  • 58 (a)
T01C8.1b 35
  • 57 (a)
aak-2 34
  • 53 (a)
 ManyToMany
aak-1 34
  • 42 (a)
 ManyToMany
R02C2.1 35
  • 34 (a)
Y38H8A.4 35
  • 34 (a)
DC2.7a 35
  • 32 (a)
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes SNF1 34
  • 36 (a)
 OneToMany
thale cress
(Arabidopsis thaliana)
 eudicotyledons KIN10 33
  • 58.23 (n)
soybean
(Glycine max)
 eudicotyledons Gma.134 33
rice
(Oryza sativa)
 Liliopsida Os05g0530500 33
  • 56.51 (n)
Os.3393 33
wheat
(Triticum aestivum)
 Liliopsida Ta.27319 33
corn
(Zea mays)
 Liliopsida Zm.13240 33
sea squirt
(Ciona savignyi)
 Ascidiacea -- 34
  • 57 (a)
 OneToMany
sea squirt
(Ciona intestinalis)
 Ascidiacea Cin.4991 33
Species where no ortholog for PRKAA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PRKAA1 Gene

ENSEMBL:
Gene Tree for PRKAA1 (if available)
TreeFam:
Gene Tree for PRKAA1 (if available)

Paralogs for PRKAA1 Gene

Paralogs for PRKAA1 Gene

(179) SIMAP similar genes for PRKAA1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PRKAA1: view

Variants for PRKAA1 Gene

Sequence variations from dbSNP and Humsavar for PRKAA1 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs928784854 A breast cancer sample 40,798,143(-) T/C 5_prime_UTR_variant, coding_sequence_variant, genic_upstream_transcript_variant, missense_variant
rs1000040161 -- 40,786,294(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000046191 -- 40,778,455(-) G/A intron_variant
rs1000221103 -- 40,759,615(-) A/C 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant
rs1000442139 -- 40,759,824(-) A/G 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for PRKAA1 Gene

Variant ID Type Subtype PubMed ID
esv2671114 CNV deletion 23128226
esv2675082 CNV deletion 23128226
esv2730120 CNV deletion 23290073
esv3351655 CNV insertion 20981092
esv3565850 CNV deletion 23714750
esv3604824 CNV loss 21293372
esv3604825 CNV loss 21293372
nsv597877 CNV gain 21841781

Variation tolerance for PRKAA1 Gene

Residual Variation Intolerance Score: 18% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.72; 15.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRKAA1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRKAA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRKAA1 Gene

Disorders for PRKAA1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PRKAA1 Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PRKAA1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PRKAA1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRKAA1 Gene

Publications for PRKAA1 Gene

  1. AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. (PMID: 15866171) Jones RG … Thompson CB (Molecular cell 2005) 3 4 22 58
  2. Mammalian AMP-activated protein kinase subfamily. (PMID: 8557660) Stapleton D … Kemp BE (The Journal of biological chemistry 1996) 2 3 4 58
  3. A genome-wide association study identifies new susceptibility loci for non-cardia gastric cancer at 3q13.31 and 5p13.1. (PMID: 22037551) Shi Y … Shen H (Nature genetics 2011) 3 44 58
  4. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PMID: 20602615) Ruaño G … Wu AH (Pharmacogenomics 2010) 3 44 58
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58

Products for PRKAA1 Gene

Sources for PRKAA1 Gene