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Aliases for PRKAA1 Gene

Aliases for PRKAA1 Gene

  • Protein Kinase, AMP-Activated, Alpha 1 Catalytic Subunit 2 3
  • Hydroxymethylglutaryl-CoA Reductase Kinase 3 4
  • Acetyl-CoA Carboxylase Kinase 3 4
  • Tau-Protein Kinase PRKAA1 3 4
  • AMPK Subunit Alpha-1 3 4
  • ACACA Kinase 3 4
  • HMGCR Kinase 3 4
  • EC 2.7.11.1 4 63
  • AMPK 2 3
  • 5-AMP-Activated Protein Kinase Catalytic Subunit Alpha-1 3
  • 5-AMP-Activated Protein Kinase, Catalytic Alpha-1 Chain 3
  • AMP-Activated Protein Kinase, Catalytic, Alpha-1 3
  • AMP -Activate Kinase Alpha 1 Subunit 3
  • AMPK Alpha 1 3
  • EC 2.7.11.27 4
  • EC 2.7.11.31 4
  • EC 2.7.11.26 4
  • EC 2.7.11 63
  • AMPKa1 3
  • Alpha 2
  • AMPK1 4
  • 1 2

External Ids for PRKAA1 Gene

Previous GeneCards Identifiers for PRKAA1 Gene

  • GC05M041069
  • GC05M041854
  • GC05M040804
  • GC05M040795
  • GC05M040711

Summaries for PRKAA1 Gene

Entrez Gene Summary for PRKAA1 Gene

  • The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRKAA1 Gene

PRKAA1 (Protein Kinase, AMP-Activated, Alpha 1 Catalytic Subunit) is a Protein Coding gene. Diseases associated with PRKAA1 include wolff-parkinson-white syndrome and obesity. Among its related pathways are PI3K-Akt signaling pathway and Signaling by GPCR. GO annotations related to this gene include chromatin binding and protein C-terminus binding. An important paralog of this gene is NUAK1.

UniProtKB/Swiss-Prot for PRKAA1 Gene

  • Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively. Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3. AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160. Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A. Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm. In response to stress, phosphorylates Ser-36 of histone H2B (H2BS36ph), leading to promote transcription. Acts as a key regulator of cell growth and proliferation by phosphorylating TSC2, RPTOR and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2. In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1. AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it. May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it. Also has tau-protein kinase activity: in response to amyloid beta A4 protein (APP) exposure, activated by CAMKK2, leading to phosphorylation of MAPT/TAU; however the relevance of such data remains unclear in vivo. Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1.

Tocris Summary for PRKAA1 Gene

  • AMP-activated protein kinase (AMPK) is a heterodimeric protein serine/threonine kinase that is composed of alpha- (catalytic) and beta/gamma- (regulatory) subunits. AMPK acts as a sensor of the energy status of cells and ensures survival at times of metabolic stress. AMPK phosphorylates many metabolic enzymes to stimulate catabolic pathways, such as ketogenesis, and inhibit anabolic pathways, such as protein synthesis. The long-term activation of AMPK increases the capacity of cells to produce ATP. AMPK is regulated by phosphorylation at the Thr-172 residue of the alpha-subunit by AMPKK and by phosphorylation by calmodulin-dependent protein kinase kinase-beta (CamKKbeta). In addition, the ratio of AMP:ATP mediates allosteric activation of the enzyme. AMPK is found throughout the body with high concentrations in metabolically active tissues such as the skeletal muscles and liver.

Gene Wiki entry for PRKAA1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRKAA1 Gene

Genomics for PRKAA1 Gene

Regulatory Elements for PRKAA1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PRKAA1 Gene

Start:
40,759,379 bp from pter
End:
40,798,374 bp from pter
Size:
38,996 bases
Orientation:
Minus strand

Genomic View for PRKAA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRKAA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRKAA1 Gene

Proteins for PRKAA1 Gene

  • Protein details for PRKAA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13131-AAPK1_HUMAN
    Recommended name:
    5-AMP-activated protein kinase catalytic subunit alpha-1
    Protein Accession:
    Q13131
    Secondary Accessions:
    • A8MTQ6
    • B2R7E1
    • O00286
    • Q5D0E1
    • Q86VS1
    • Q9UNQ4

    Protein attributes for PRKAA1 Gene

    Size:
    559 amino acids
    Molecular mass:
    64009 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2.
    SequenceCaution:
    • Sequence=AAA64850.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAD43027.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH37303.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA36547.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG35788.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PRKAA1 Gene

    Alternative splice isoforms for PRKAA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRKAA1 Gene

Proteomics data for PRKAA1 Gene at MOPED

Post-translational modifications for PRKAA1 Gene

  • Phosphorylated at Thr-183 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Also phosphorylated at Thr-183 by CAMKK2; triggered by a rise in intracellular calcium ions, without detectable changes in the AMP/ATP ratio. CAMKK1 can also phosphorylate Thr-183, but at a much lower level. Dephosphorylated by protein phosphatase 2A and 2C (PP2A and PP2C). Phosphorylated by ULK1 and ULK2; leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1, ULK2 and AMPK. Dephosphorylated by PPM1A and PPM1B.
  • Ubiquitinated.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRKAA1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for PRKAA1 (AMPK alpha 1)
  • Cell Signaling Technology (CST) Antibodies for PRKAA1 (AMPKA1)

Domains for PRKAA1 Gene

Suggested Antigen Peptide Sequences for PRKAA1 Gene

Graphical View of Domain Structure for InterPro Entry

Q13131

UniProtKB/Swiss-Prot:

AAPK1_HUMAN :
  • Q13131
Domain:
  • The AIS (autoinhibitory sequence) region shows some sequence similarity with the ubiquitin-associated domains and represses kinase activity.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
genes like me logo Genes that share domains with PRKAA1: view

Function for PRKAA1 Gene

Molecular function for PRKAA1 Gene

GENATLAS Biochemistry: protein kinase,cAMP activated,alpha 1 catalytic subunit,involved in fatty acid and cholesterol metabolism
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot CatalyticActivity: ATP + [tau protein] = ADP + [tau protein] phosphate
UniProtKB/Swiss-Prot CatalyticActivity: ATP + [hydroxymethylglutaryl-CoA reductase (NADPH)] = ADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate
UniProtKB/Swiss-Prot CatalyticActivity: ATP + [acetyl-CoA carboxylase] = ADP + [acetyl-CoA carboxylase] phosphate
UniProtKB/Swiss-Prot EnzymeRegulation: Activated by phosphorylation on Thr-183. Binding of AMP to non-catalytic gamma subunit (PRKAG1, PRKAG2 or PRKAG3) results in allosteric activation, inducing phosphorylation on Thr-183. AMP-binding to gamma subunit also sustains activity by preventing dephosphorylation of Thr-183. ADP also stimulates Thr-183 phosphorylation, without stimulating already phosphorylated AMPK. ATP promotes dephosphorylation of Thr-183, rendering the enzyme inactive. Under physiological conditions AMPK mainly exists in its inactive form in complex with ATP, which is much more abundant than AMP. AMPK is activated by antihyperglycemic drug metformin, a drug prescribed to patients with type 2 diabetes: in vivo, metformin seems to mainly inhibit liver gluconeogenesis. However, metformin can be used to activate AMPK in muscle and other cells in culture or ex vivo (PubMed:11602624). Selectively inhibited by compound C (6-[4-(2-Piperidin-1-yl-ethoxy)-phenyl)]-3-pyridin-4-yl-pyyrazolo[1,5-a] pyrimidine. Activated by resveratrol, a natural polyphenol present in red wine, and S17834, a synthetic polyphenol.
UniProtKB/Swiss-Prot Function: Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively. Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3. AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160. Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A. Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm. In response to stress, phosphorylates Ser-36 of histone H2B (H2BS36ph), leading to promote transcription. Acts as a key regulator of cell growth and proliferation by phosphorylating TSC2, RPTOR and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2. In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1. AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it. May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it. Also has tau-protein kinase activity: in response to amyloid beta A4 protein (APP) exposure, activated by CAMKK2, leading to phosphorylation of MAPT/TAU; however the relevance of such data remains unclear in vivo. Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1.

Enzyme Numbers (IUBMB) for PRKAA1 Gene

Gene Ontology (GO) - Molecular Function for PRKAA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding ISS --
GO:0004672 protein kinase activity IDA 17028174
GO:0004674 protein serine/threonine kinase activity --
GO:0004679 AMP-activated protein kinase activity IDA 18439900
GO:0004691 cAMP-dependent protein kinase activity NAS 8557660
genes like me logo Genes that share ontologies with PRKAA1: view
genes like me logo Genes that share phenotypes with PRKAA1: view

Animal Model Products

CRISPR Products

miRNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for PRKAA1 Gene

Localization for PRKAA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRKAA1 Gene

Cytoplasm. Nucleus. Note=In response to stress, recruited by p53/TP53 to specific promoters.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRKAA1 Gene COMPARTMENTS Subcellular localization image for PRKAA1 gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 2

Gene Ontology (GO) - Cellular Components for PRKAA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IC 8557660
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PRKAA1: view

Pathways for PRKAA1 Gene

genes like me logo Genes that share pathways with PRKAA1: view

PCR Array Products

Gene Ontology (GO) - Biological Process for PRKAA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity NAS 11546797
GO:0001666 response to hypoxia NAS 8557660
GO:0006006 glucose metabolic process IEA --
GO:0006351 transcription, DNA-templated --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with PRKAA1: view

Compounds for PRKAA1 Gene

(5) Tocris Compounds for PRKAA1 Gene

Compound Action Cas Number
A 769662 Potent AMPK activator [844499-71-4]
Metformin hydrochloride Activator of LKB1/AMPK; antidiabetic agent [1115-70-4]
PT 1 AMPK activator [331002-70-1]
RSVA 405 AMPK activator [140405-36-3]
ZLN 024 hydrochloride Allosteric AMPK activator

(13) HMDB Compounds for PRKAA1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Calcium
  • Ca
7440-70-2
Glucosylceramide (d18:1/12:0)
  • 1-O-b-D-glucopyranosyl-Ceramide
85305-87-9
Glucosylceramide (d18:1/16:0)
  • 1-O-b-D-glucopyranosyl-Ceramide
85305-87-9

(3) Drugbank Compounds for PRKAA1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Adenosine monophosphate
  • 5'-Adenosine monophosphate
61-19-8 target activator
Adenosine triphosphate
  • 5'-ATP
56-65-5 target
Phenformin
  • Beta-Pebg
114-86-3 target activator

(31) Novoseek inferred chemical compound relationships for PRKAA1 Gene

Compound -log(P) Hits PubMed IDs
acadesine 73.5 6
metformin 72.2 49
atp 68 68
fatty acid 62.7 34
phenformin 62.2 5
genes like me logo Genes that share compounds with PRKAA1: view

Transcripts for PRKAA1 Gene

Unigene Clusters for PRKAA1 Gene

Protein kinase, AMP-activated, alpha 1 catalytic subunit:
Representative Sequences:

CRISPR Products

miRNA Products

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for PRKAA1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRKAA1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12a · 12b
SP1: - - -
SP2: - - - -
SP3: - - - -
SP4: - - -
SP5: - - - - -
SP6: - - - - -
SP7: - - - - -
SP8:
SP9:

Relevant External Links for PRKAA1 Gene

GeneLoc Exon Structure for
PRKAA1
ECgene alternative splicing isoforms for
PRKAA1

Expression for PRKAA1 Gene

mRNA expression in normal human tissues for PRKAA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRKAA1 Gene

SOURCE GeneReport for Unigene cluster for PRKAA1 Gene Hs.43322

genes like me logo Genes that share expressions with PRKAA1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PRKAA1 Gene

Orthologs for PRKAA1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PRKAA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRKAA1 35
  • 99.88 (n)
  • 100 (a)
PRKAA1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PRKAA1 35
  • 95.05 (n)
  • 99.13 (a)
PRKAA1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRKAA1 35
  • 96.18 (n)
  • 99.06 (a)
PRKAA1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prkaa1 35
  • 90.22 (n)
  • 98.75 (a)
Prkaa1 16
Prkaa1 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRKAA1 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRKAA1 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prkaa1 35
  • 90.7 (n)
  • 99.11 (a)
chicken
(Gallus gallus)
Aves PRKAA1 35
  • 85.01 (n)
  • 95.52 (a)
PRKAA1 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRKAA1 36
  • 94 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.5251 35
tropical clawed frog
(Silurana tropicalis)
Amphibia prkaa1 35
  • 78.57 (n)
  • 90.16 (a)
Str.304 35
zebrafish
(Danio rerio)
Actinopterygii prkaa1 35
  • 73.89 (n)
  • 88.16 (a)
prkaa1 35
prkaa1 36
  • 84 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta SNF1A 36
  • 57 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea aak-1 36
  • 42 (a)
ManyToMany
aak-2 36
  • 53 (a)
ManyToMany
T01C8.1b 37
  • 57 (a)
R02C2.1 37
  • 34 (a)
DC2.7a 37
  • 32 (a)
Y38H8A.4 37
  • 34 (a)
T01C8.1a 37
  • 58 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SNF1 36
  • 36 (a)
OneToMany
soybean
(Glycine max)
eudicotyledons Gma.134 35
thale cress
(Arabidopsis thaliana)
eudicotyledons KIN10 35
  • 58.23 (n)
  • 56.58 (a)
corn
(Zea mays)
Liliopsida Zm.13240 35
rice
(Oryza sativa)
Liliopsida Os.3393 35
Os05g0530500 35
  • 56.51 (n)
  • 52.37 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.27319 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4991 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 57 (a)
OneToMany
Species with no ortholog for PRKAA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PRKAA1 Gene

ENSEMBL:
Gene Tree for PRKAA1 (if available)
TreeFam:
Gene Tree for PRKAA1 (if available)

Paralogs for PRKAA1 Gene

Paralogs for PRKAA1 Gene

genes like me logo Genes that share paralogs with PRKAA1: view

Variants for PRKAA1 Gene

Sequence variations from dbSNP and Humsavar for PRKAA1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs29737 -- 40,763,655(-) ACTGG(A/G)GTATA intron-variant
rs29740 -- 40,759,025(-) GGCAA(A/C)AGAGT downstream-variant-500B
rs29741 -- 40,758,932(-) TTAAA(C/T)TGTCA downstream-variant-500B
rs152372 -- 40,787,390(-) cctcc(C/T)gggtt intron-variant
rs152373 -- 40,787,479(-) ttatt(A/G)ttatt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRKAA1 Gene

Variant ID Type Subtype PubMed ID
dgv6040n71 CNV Loss 21882294
nsv880438 CNV Loss 21882294
esv2675082 CNV Deletion 23128226
esv2730120 CNV Deletion 23290073
esv2671114 CNV Deletion 23128226

Relevant External Links for PRKAA1 Gene

HapMap Linkage Disequilibrium report
PRKAA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRKAA1 Gene

Disorders for PRKAA1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for PRKAA1 Gene including...

Search for PRKAA1 Gene in MalaCards »

(17) Novoseek inferred disease relationships for PRKAA1 Gene

Disease -log(P) Hits PubMed IDs
obesity 43.2 9
insulin sensitivity 42.5 4
tuberous sclerosis 41.3 1
insulin resistance 37.9 5
insulinoma 30.4 2

Relevant External Links for PRKAA1

Genetic Association Database (GAD)
PRKAA1
Human Genome Epidemiology (HuGE) Navigator
PRKAA1
genes like me logo Genes that share disorders with PRKAA1: view

No data available for UniProtKB/Swiss-Prot for PRKAA1 Gene

Publications for PRKAA1 Gene

  1. AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. (PMID: 15866171) Jones R.G. … Thompson C.B. (Mol. Cell 2005) 3 4 23
  2. Mammalian AMP-activated protein kinase subfamily. (PMID: 8557660) Stapleton D. … Kemp B.E. (J. Biol. Chem. 1996) 2 3 4
  3. Functional domains of the alpha1 catalytic subunit of the AMP- activated protein kinase. (PMID: 9857077) Crute B.E. … Witters L.A. (J. Biol. Chem. 1998) 3 4
  4. TSC2 mediates cellular energy response to control cell growth and survival. (PMID: 14651849) Inoki K. … Guan K.L. (Cell 2003) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

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