Aliases for CHRNA9 Gene
- Cholinergic Receptor Nicotinic Alpha 9 Subunit 2 3
- Cholinergic Receptor, Nicotinic Alpha 9 2 3 5
- Cholinergic Receptor, Nicotinic, Alpha Polypeptide 9 2 3
- Cholinergic Receptor, Nicotinic, Alpha 9 (Neuronal) 2 3
- NACHRA9 3 4
- Acetylcholine Receptor, Neuronal Nicotinic, Alpha-9 Subunit 3
- Neuronal Acetylcholine Receptor Protein, Alpha-9 Subunit 3
- Nicotinic Acetylcholine Receptor Subunit Alpha 9 3
External Ids for CHRNA9 Gene
Previous GeneCards Identifiers for CHRNA9 Gene
This gene is a member of the ligand-gated ionic channel family and nicotinic acetylcholine receptor gene superfamily. It encodes a plasma membrane protein that forms homo- or hetero-oligomeric divalent cation channels. This protein is involved in cochlea hair cell development and is also expressed in the outer hair cells (OHCs) of the adult cochlea. [provided by RefSeq, Feb 2012]
GeneCards Summary for CHRNA9 Gene
CHRNA9 (Cholinergic Receptor Nicotinic Alpha 9 Subunit) is a Protein Coding gene. Diseases associated with CHRNA9 include nicotine dependence, protection against. Among its related pathways are Transmission across Chemical Synapses and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include calcium channel activity and acetylcholine-activated cation-selective channel activity. An important paralog of this gene is HTR3A.
UniProtKB/Swiss-Prot for CHRNA9 Gene
Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding induces a conformation change that leads to the opening of an ion-conducting channel across the plasma membrane (PubMed:11752216, PubMed:25282151). The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane (PubMed:11752216, PubMed:25282151). In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. May also regulate keratinocyte adhesion (PubMed:11021840).