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Aliases for CHRNA9 Gene

Aliases for CHRNA9 Gene

  • Cholinergic Receptor Nicotinic Alpha 9 Subunit 2 3
  • Cholinergic Receptor, Nicotinic Alpha 9 2 3 5
  • Cholinergic Receptor, Nicotinic, Alpha Polypeptide 9 2 3
  • Cholinergic Receptor, Nicotinic, Alpha 9 (Neuronal) 2 3
  • NACHRA9 3 4
  • Acetylcholine Receptor, Neuronal Nicotinic, Alpha-9 Subunit 3
  • Neuronal Acetylcholine Receptor Protein, Alpha-9 Subunit 3
  • Nicotinic Acetylcholine Receptor Subunit Alpha 9 3
  • Nicotinic Acetylcholine Receptor Subunit Alpha-9 4
  • Acetylcholine Receptor 2
  • Alpha 9 (Neuronal) 2
  • NACHR Alpha 9 3
  • NACHR Alpha-9 4
  • Nicotinic 2
  • HSA243342 3

External Ids for CHRNA9 Gene

Previous GeneCards Identifiers for CHRNA9 Gene

  • GC04P040401
  • GC04P040620
  • GC04P040187
  • GC04P040253
  • GC04P040178
  • GC04P040032
  • GC04P039659

Summaries for CHRNA9 Gene

Entrez Gene Summary for CHRNA9 Gene

  • This gene is a member of the ligand-gated ionic channel family and nicotinic acetylcholine receptor gene superfamily. It encodes a plasma membrane protein that forms homo- or hetero-oligomeric divalent cation channels. This protein is involved in cochlea hair cell development and is also expressed in the outer hair cells (OHCs) of the adult cochlea. [provided by RefSeq, Feb 2012]

GeneCards Summary for CHRNA9 Gene

CHRNA9 (Cholinergic Receptor Nicotinic Alpha 9 Subunit) is a Protein Coding gene. Diseases associated with CHRNA9 include nicotine dependence, protection against. Among its related pathways are Transmission across Chemical Synapses and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include calcium channel activity and acetylcholine-activated cation-selective channel activity. An important paralog of this gene is HTR3A.

UniProtKB/Swiss-Prot for CHRNA9 Gene

  • Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding induces a conformation change that leads to the opening of an ion-conducting channel across the plasma membrane (PubMed:11752216, PubMed:25282151). The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane (PubMed:11752216, PubMed:25282151). In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. May also regulate keratinocyte adhesion (PubMed:11021840).

Gene Wiki entry for CHRNA9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHRNA9 Gene

Genomics for CHRNA9 Gene

Regulatory Elements for CHRNA9 Gene

Promoters for CHRNA9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CHRNA9 on UCSC Golden Path with GeneCards custom track

Genomic Location for CHRNA9 Gene

Chromosome:
4
Start:
40,335,329 bp from pter
End:
40,355,217 bp from pter
Size:
19,889 bases
Orientation:
Plus strand

Genomic View for CHRNA9 Gene

Genes around CHRNA9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHRNA9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHRNA9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHRNA9 Gene

Proteins for CHRNA9 Gene

  • Protein details for CHRNA9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UGM1-ACHA9_HUMAN
    Recommended name:
    Neuronal acetylcholine receptor subunit alpha-9
    Protein Accession:
    Q9UGM1
    Secondary Accessions:
    • Q14CY7
    • Q4W5A2
    • Q9NYV2

    Protein attributes for CHRNA9 Gene

    Size:
    479 amino acids
    Molecular mass:
    54807 Da
    Quaternary structure:
    • Can form homo- or hetero-oligomeric channels in conjunction with CHRNA10 (PubMed:11752216). The native outer hair cell receptor may be composed of CHRNA9-CHRNA10 hetero-oligomers.
    Miscellaneous:
    • The hetero-oligomeric receptor composed of CHRNA9 and CHRNA10 has an atypical pharmacological profile, binding several non-nicotinic ligands including strychnine (a glycine receptor antagonist) and atropine (a muscarinic acetylcholine receptor antagonist).

    Three dimensional structures from OCA and Proteopedia for CHRNA9 Gene

neXtProt entry for CHRNA9 Gene

Proteomics data for CHRNA9 Gene at MOPED

Post-translational modifications for CHRNA9 Gene

Other Protein References for CHRNA9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CHRNA9 Gene

Domains & Families for CHRNA9 Gene

Gene Families for CHRNA9 Gene

Suggested Antigen Peptide Sequences for CHRNA9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UGM1

UniProtKB/Swiss-Prot:

ACHA9_HUMAN :
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-9/CHRNA9 sub-subfamily.
Family:
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-9/CHRNA9 sub-subfamily.
genes like me logo Genes that share domains with CHRNA9: view

Function for CHRNA9 Gene

Molecular function for CHRNA9 Gene

UniProtKB/Swiss-Prot Function:
Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding induces a conformation change that leads to the opening of an ion-conducting channel across the plasma membrane (PubMed:11752216, PubMed:25282151). The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane (PubMed:11752216, PubMed:25282151). In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. May also regulate keratinocyte adhesion (PubMed:11021840).

Gene Ontology (GO) - Molecular Function for CHRNA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005230 extracellular ligand-gated ion channel activity IEA --
GO:0015464 acetylcholine receptor activity IBA --
GO:0042166 acetylcholine binding IBA --
genes like me logo Genes that share ontologies with CHRNA9: view
genes like me logo Genes that share phenotypes with CHRNA9: view

Animal Models for CHRNA9 Gene

MGI Knock Outs for CHRNA9:

Animal Model Products

miRNA for CHRNA9 Gene

miRTarBase miRNAs that target CHRNA9

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CHRNA9 Gene

Localization for CHRNA9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHRNA9 Gene

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CHRNA9 Gene COMPARTMENTS Subcellular localization image for CHRNA9 gene
Compartment Confidence
plasma membrane 5
cytosol 3

Gene Ontology (GO) - Cellular Components for CHRNA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IGI --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CHRNA9: view

Pathways & Interactions for CHRNA9 Gene

genes like me logo Genes that share pathways with CHRNA9: view

Interacting Proteins for CHRNA9 Gene

Gene Ontology (GO) - Biological Process for CHRNA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0007165 signal transduction IDA 25282151
GO:0007268 synaptic transmission TAS --
GO:0007271 synaptic transmission, cholinergic IBA --
genes like me logo Genes that share ontologies with CHRNA9: view

No data available for SIGNOR curated interactions for CHRNA9 Gene

Drugs & Compounds for CHRNA9 Gene

(15) Drugs for CHRNA9 Gene - From: IUPHAR, DGIdb, DrugBank, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nicotine Approved Pharma Antagonist, antagonist, Target, agonist 973
Ethanol Approved Pharma Target 1839
Galantamine Approved Pharma Target, allosteric modulator 103
tetraethylammonium Experimental Pharma Inhibitor, Target, agonist, inhibitor 1
ATG003 Investigational Pharma Target 0

(4) Additional Compounds for CHRNA9 Gene - From: IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[<sup>125</sup>I]alpha-bungarotoxin
[<sup>3</sup>H]alpha-bungarotoxin
alpha-bungarotoxin
Antagonist
alpha-conotoxin RgIA
Antagonist
genes like me logo Genes that share compounds with CHRNA9: view

Transcripts for CHRNA9 Gene

mRNA/cDNA for CHRNA9 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CHRNA9 Gene

Cholinergic receptor, nicotinic, alpha 9 (neuronal):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHRNA9 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1: - - -
SP2:
SP3:

Relevant External Links for CHRNA9 Gene

GeneLoc Exon Structure for
CHRNA9
ECgene alternative splicing isoforms for
CHRNA9

Expression for CHRNA9 Gene

mRNA expression in normal human tissues for CHRNA9 Gene

mRNA differential expression in normal tissues according to GTEx for CHRNA9 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x10.3) and Skin - Not Sun Exposed (Suprapubic) (x7.0).

Protein differential expression in normal tissues from HIPED for CHRNA9 Gene

This gene is overexpressed in Pancreas (64.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CHRNA9 Gene



SOURCE GeneReport for Unigene cluster for CHRNA9 Gene Hs.272278

mRNA Expression by UniProt/SwissProt for CHRNA9 Gene

Q9UGM1-ACHA9_HUMAN
Tissue specificity: Expressed in cochlea, keratinocytes, pituitary gland, B-cells and T-cells.
genes like me logo Genes that share expression patterns with CHRNA9: view

Protein tissue co-expression partners for CHRNA9 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CHRNA9 Gene

Orthologs for CHRNA9 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHRNA9 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CHRNA9 35
  • 89.63 (n)
  • 94.36 (a)
CHRNA9 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CHRNA9 35
  • 90.26 (n)
  • 95.62 (a)
CHRNA9 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Chrna9 35
  • 85.46 (n)
  • 91.02 (a)
Chrna9 16
Chrna9 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CHRNA9 35
  • 99.3 (n)
  • 99.16 (a)
CHRNA9 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Chrna9 35
  • 86.57 (n)
  • 91.02 (a)
oppossum
(Monodelphis domestica)
Mammalia CHRNA9 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CHRNA9 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves CHRNA9 35
  • 71.09 (n)
  • 75.59 (a)
CHRNA9 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CHRNA9 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia chrna9 35
  • 70.11 (n)
  • 73.28 (a)
zebrafish
(Danio rerio)
Actinopterygii chrna9 35
  • 71.58 (n)
  • 75.18 (a)
chrna10a 36
  • 53 (a)
OneToMany
chrna9 36
  • 55 (a)
OneToMany
CHRNA9 (1 of 3) 36
  • 62 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.90 35
fruit fly
(Drosophila melanogaster)
Insecta nAcRbgr-21C 37
  • 31 (a)
nAcRbeta-21C 36
  • 23 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea acr-17 37
  • 34 (a)
acr-18 37
  • 30 (a)
acr-22 37
  • 34 (a)
C04C3.2 37
  • 28 (a)
deg-3 37
  • 33 (a)
F18G5.4 37
  • 33 (a)
Y44A6E.1 37
  • 28 (a)
Y57G11C.2 37
  • 25 (a)
Y73F8A.30 37
  • 31 (a)
lgc-1 36
  • 19 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
ManyToMany
Species with no ortholog for CHRNA9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CHRNA9 Gene

ENSEMBL:
Gene Tree for CHRNA9 (if available)
TreeFam:
Gene Tree for CHRNA9 (if available)

Paralogs for CHRNA9 Gene

Paralogs for CHRNA9 Gene

(18) SIMAP similar genes for CHRNA9 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CHRNA9: view

Variants for CHRNA9 Gene

Sequence variations from dbSNP and Humsavar for CHRNA9 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10009228 - 40,354,405(+) CACCA(A/G)TTCCA reference, missense
rs10024518 - 40,337,286(+) GGACC(A/G)AGATC reference, missense
rs55633891 - 40,354,024(+) CACTG(A/C/T)GTTGA reference, missense
rs4359945 -- 40,335,291(+) AGGGG(A/T)GGGAG upstream-variant-2KB
rs4547831 -- 40,345,058(+) TGGTG(G/T)AGTGG intron-variant

Variation tolerance for CHRNA9 Gene

Residual Variation Intolerance Score: 94.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.18; 84.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CHRNA9 Gene

HapMap Linkage Disequilibrium report
CHRNA9
Human Gene Mutation Database (HGMD)
CHRNA9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CHRNA9 Gene

Disorders for CHRNA9 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CHRNA9 Gene - From: DISEASES

Disorder Aliases PubMed IDs
nicotine dependence, protection against
  • nicotine dependence
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CHRNA9

Genetic Association Database (GAD)
CHRNA9
Human Genome Epidemiology (HuGE) Navigator
CHRNA9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CHRNA9
genes like me logo Genes that share disorders with CHRNA9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CHRNA9 Gene

Publications for CHRNA9 Gene

  1. Chromosome location and characterization of the human nicotinic acetylcholine receptor subunit alpha (alpha) 9 (CHRNA9) gene. (PMID: 12697997) Lustig L.R. … Peng H. (Cytogenet. Genome Res. 2002) 3 4 23 67
  2. Neuronal nicotinic acetylcholine receptors: common molecular substrates of nicotine and alcohol dependence. (PMID: 23641218) Hendrickson L.M. … Tapper A.R. (Front Psychiatry 2013) 25 26
  3. Role of alpha5 nicotinic acetylcholine receptors in pharmacological and behavioral effects of nicotine in mice. (PMID: 20400469) Jackson K.J. … Damaj M.I. (J. Pharmacol. Exp. Ther. 2010) 25 26
  4. Nicotinic modulation of synaptic transmission and plasticity in cortico-limbic circuits. (PMID: 19560048) Mansvelder H.D. … Role L.W. (Semin. Cell Dev. Biol. 2009) 25 26
  5. Nicotine dependence - human and animal studies, current pharmacotherapies and future perspectives. (PMID: 20081230) Zaniewska M. … Filip M. (Pharmacol Rep 2009) 25 26

Products for CHRNA9 Gene

Sources for CHRNA9 Gene

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