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Aliases for PLXNA3 Gene

Aliases for PLXNA3 Gene

  • Plexin A3 2 3
  • Semaphorin Receptor SEX 3 4
  • Plexin-4 3 4
  • PLXN4 3 4
  • SEX 4 6
  • Sex Chromosome X Transmembrane Protein Of HGF Receptor Family 3 3
  • HSSEXGENE 3
  • Plexin-A3 3
  • PLXN3 3
  • XAP-6 3
  • 6.3 3

External Ids for PLXNA3 Gene

Previous Symbols for PLXNA3 Gene

  • PLXN4

Summaries for PLXNA3 Gene

Entrez Gene Summary for PLXNA3 Gene

  • This gene encodes a member of the plexin class of proteins. The encoded protein is a class 3 semaphorin receptor, and may be involved in cytoskeletal remodeling and as well as apoptosis. Studies of a similar gene in zebrafish suggest that it is important for axon pathfinding in the developing nervous system. This gene may be associated with tumor progression. [provided by RefSeq, Aug 2013]

GeneCards Summary for PLXNA3 Gene

PLXNA3 (Plexin A3) is a Protein Coding gene. Among its related pathways are L1CAM interactions and L1CAM interactions. GO annotations related to this gene include transmembrane signaling receptor activity and semaphorin receptor activity. An important paralog of this gene is PLXNB2.

UniProtKB/Swiss-Prot for PLXNA3 Gene

  • Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm

Gene Wiki entry for PLXNA3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLXNA3 Gene

Genomics for PLXNA3 Gene

Genomic Location for PLXNA3 Gene

Start:
154,458,281 bp from pter
End:
154,473,646 bp from pter
Size:
15,366 bases
Orientation:
Plus strand

Genomic View for PLXNA3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PLXNA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLXNA3 Gene

Regulatory Elements for PLXNA3 Gene

Proteins for PLXNA3 Gene

  • Protein details for PLXNA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51805-PLXA3_HUMAN
    Recommended name:
    Plexin-A3
    Protein Accession:
    P51805
    Secondary Accessions:
    • Q5HY36

    Protein attributes for PLXNA3 Gene

    Size:
    1871 amino acids
    Molecular mass:
    207703 Da
    Quaternary structure:
    • Interacts with CBFA2T3/MTG16.

neXtProt entry for PLXNA3 Gene

Proteomics data for PLXNA3 Gene at MOPED

Post-translational modifications for PLXNA3 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn59, Asn548, Asn637, Asn738, Asn746, Asn1009, Asn1036, Asn1073, Asn1115, and Asn1162

Other Protein References for PLXNA3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for PLXNA3 Gene

Domains for PLXNA3 Gene

Gene Families for PLXNA3 Gene

HGNC:

UniProtKB/Swiss-Prot:

PLXA3_HUMAN
Domain:
  • Contains 4 IPT/TIG domains.:
    • P51805
  • Contains 1 Sema domain.:
    • P51805
Family:
  • Belongs to the plexin family.:
    • P51805
genes like me logo Genes that share domains with PLXNA3: view

Function for PLXNA3 Gene

Molecular function for PLXNA3 Gene

GENATLAS Biochemistry: plexin A3,calcium-dependent cell adhesion molecule at the neuronal cell surface,homologous to the hepatocyte growth factor receptor family, expressed in fetal brain,putatively involved in signal transduction
UniProtKB/Swiss-Prot Function: Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm

Gene Ontology (GO) - Molecular Function for PLXNA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity --
GO:0004888 transmembrane signaling receptor activity NAS 8570614
GO:0005515 protein binding IPI 20138877
GO:0017154 semaphorin receptor activity IEA --
genes like me logo Genes that share ontologies with PLXNA3: view
genes like me logo Genes that share phenotypes with PLXNA3: view

miRNA for PLXNA3 Gene

miRTarBase miRNAs that target PLXNA3

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for PLXNA3 Gene

Localization for PLXNA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLXNA3 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLXNA3 Gene COMPARTMENTS Subcellular localization image for PLXNA3 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PLXNA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002116 semaphorin receptor complex TAS 19909241
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane TAS 8570614
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PLXNA3: view

Pathways for PLXNA3 Gene

genes like me logo Genes that share pathways with PLXNA3: view

Pathways by source for PLXNA3 Gene

1 KEGG pathway for PLXNA3 Gene

Gene Ontology (GO) - Biological Process for PLXNA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction --
GO:0007275 multicellular organismal development TAS 8570614
GO:0007411 axon guidance TAS --
GO:0021612 facial nerve structural organization IEA --
GO:0021637 trigeminal nerve structural organization IEA --
genes like me logo Genes that share ontologies with PLXNA3: view

Transcripts for PLXNA3 Gene

Unigene Clusters for PLXNA3 Gene

Plexin A3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLXNA3 Gene

No ASD Table

Relevant External Links for PLXNA3 Gene

GeneLoc Exon Structure for
PLXNA3
ECgene alternative splicing isoforms for
PLXNA3

Expression for PLXNA3 Gene

mRNA expression in normal human tissues for PLXNA3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PLXNA3 Gene

SOURCE GeneReport for Unigene cluster for PLXNA3 Gene Hs.632839

genes like me logo Genes that share expressions with PLXNA3: view

Orthologs for PLXNA3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLXNA3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLXNA3 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PLXNA3 37
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GDI1 37
  • 95 (a)
OneToOne
PLXNA3 36
  • 90.22 (n)
  • 95.36 (a)
mouse
(Mus musculus)
Mammalia Plxna3 36
  • 86.55 (n)
  • 94.6 (a)
Plxna3 16
Plxna3 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PLXNA3 37
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLXNA3 37
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Plxna3 36
  • 86.44 (n)
  • 94.55 (a)
lizard
(Anolis carolinensis)
Reptilia PLXNA3 37
  • 72 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC397805 36
zebrafish
(Danio rerio)
Actinopterygii plxna3 36
  • 70.71 (n)
  • 74.43 (a)
plxna3 37
  • 73 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2624 36
Species with no ortholog for PLXNA3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLXNA3 Gene

ENSEMBL:
Gene Tree for PLXNA3 (if available)
TreeFam:
Gene Tree for PLXNA3 (if available)

Paralogs for PLXNA3 Gene

Paralogs for PLXNA3 Gene

Selected SIMAP similar genes for PLXNA3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PLXNA3: view

Variants for PLXNA3 Gene

Sequence variations from dbSNP and Humsavar for PLXNA3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs2097212 -- 154,460,862(+) GGACT(G/T)TCGGC intron-variant
rs2097213 -- 154,460,865(+) CTTTC(G/T)GCTCC intron-variant
rs2298858 -- 154,470,893(+) AGAGC(A/G)GTGAC intron-variant, utr-variant-3-prime
rs2298859 -- 154,472,961(+) TCCCA(C/T)CCTCC utr-variant-3-prime
rs3838186 -- 154,459,166(-) GGGGG(-/G)AGCGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLXNA3 Gene

Variant ID Type Subtype PubMed ID
esv33199 CNV Gain+Loss 17666407
esv33784 CNV Gain+Loss 17666407
nsv519042 CNV Gain 19592680

Relevant External Links for PLXNA3 Gene

HapMap Linkage Disequilibrium report
PLXNA3
Human Gene Mutation Database (HGMD)
PLXNA3
Locus Specific Mutation Databases (LSDB)
PLXNA3

Disorders for PLXNA3 Gene

No disorders were found for PLXNA3 Gene.

No data available for UniProtKB/Swiss-Prot for PLXNA3 Gene

Publications for PLXNA3 Gene

  1. A family of transmembrane proteins with homology to the MET- hepatocyte growth factor receptor. (PMID: 8570614) Maestrini E. … Comoglio P.M. (Proc. Natl. Acad. Sci. U.S.A. 1996) 3 4 23
  2. Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci. (PMID: 8733135) Chen E.Y. … D'Urso M. (Hum. Mol. Genet. 1996) 2 3
  3. Expression and function of semaphorin 3A and its receptors in human monocyte-derived macrophages. (PMID: 19480842) Ji J.D. … Ivashkiv L.B. (Hum. Immunol. 2009) 3 23
  4. Transcriptional organization of a 450-kb region of the human X chromosome in Xq28. (PMID: 8248200) Bione S. … Toniolo D. (Proc. Natl. Acad. Sci. U.S.A. 1993) 2 3
  5. Myeloid translocation gene 16b is a dual A-kinase anchoring protein that interacts selectively with plexins in a phospho-regulated manner. (PMID: 20138877) Fiedler S.E. … Carr D.W. (FEBS Lett. 2010) 3 4

Products for PLXNA3 Gene

Sources for PLXNA3 Gene

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