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Aliases for PLXNA3 Gene

Aliases for PLXNA3 Gene

  • Plexin A3 2 3 5
  • Semaphorin Receptor SEX 3 4
  • Plexin-4 3 4
  • PLXN4 3 4
  • Sex Chromosome X Transmembrane Protein Of HGF Receptor Family 3 3
  • HSSEXGENE 3
  • PLXN3 3
  • XAP-6 3
  • 6.3 3
  • SEX 4

External Ids for PLXNA3 Gene

Previous HGNC Symbols for PLXNA3 Gene

  • PLXN4

Previous GeneCards Identifiers for PLXNA3 Gene

  • GC0XU990185
  • GC0XM150067
  • GC0XP151274
  • GC0XP152154
  • GC0XP152118
  • GC0XP153250
  • GC0XP153339
  • GC0XP153686
  • GC0XP142263

Summaries for PLXNA3 Gene

Entrez Gene Summary for PLXNA3 Gene

  • This gene encodes a member of the plexin class of proteins. The encoded protein is a class 3 semaphorin receptor, and may be involved in cytoskeletal remodeling and as well as apoptosis. Studies of a similar gene in zebrafish suggest that it is important for axon pathfinding in the developing nervous system. This gene may be associated with tumor progression. [provided by RefSeq, Aug 2013]

GeneCards Summary for PLXNA3 Gene

PLXNA3 (Plexin A3) is a Protein Coding gene. Diseases associated with PLXNA3 include rett syndrome. Among its related pathways are Axon guidance and Neuroscience. GO annotations related to this gene include receptor activity and semaphorin receptor activity. An important paralog of this gene is PLXNB2.

UniProtKB/Swiss-Prot for PLXNA3 Gene

  • Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.

Gene Wiki entry for PLXNA3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLXNA3 Gene

Genomics for PLXNA3 Gene

Regulatory Elements for PLXNA3 Gene

Enhancers for PLXNA3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PLXNA3 on UCSC Golden Path with GeneCards custom track

Promoters for PLXNA3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PLXNA3 on UCSC Golden Path with GeneCards custom track

Genomic Location for PLXNA3 Gene

Chromosome:
X
Start:
154,458,281 bp from pter
End:
154,477,779 bp from pter
Size:
19,499 bases
Orientation:
Plus strand

Genomic View for PLXNA3 Gene

Genes around PLXNA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLXNA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLXNA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLXNA3 Gene

Proteins for PLXNA3 Gene

  • Protein details for PLXNA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51805-PLXA3_HUMAN
    Recommended name:
    Plexin-A3
    Protein Accession:
    P51805
    Secondary Accessions:
    • Q5HY36

    Protein attributes for PLXNA3 Gene

    Size:
    1871 amino acids
    Molecular mass:
    207703 Da
    Quaternary structure:
    • Interacts with CBFA2T3/MTG16.

neXtProt entry for PLXNA3 Gene

Proteomics data for PLXNA3 Gene at MOPED

Post-translational modifications for PLXNA3 Gene

  • Glycosylation at Asn 59, Asn 548, Asn 637, Asn 738, Asn 746, Asn 1009, Asn 1036, Asn 1073, Asn 1115, and Asn 1162
  • Modification sites at PhosphoSitePlus

Other Protein References for PLXNA3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PLXNA3 (PLXNA3)

No data available for DME Specific Peptides for PLXNA3 Gene

Domains & Families for PLXNA3 Gene

Gene Families for PLXNA3 Gene

Suggested Antigen Peptide Sequences for PLXNA3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P51805

UniProtKB/Swiss-Prot:

PLXA3_HUMAN :
  • Contains 4 IPT/TIG domains.
  • Belongs to the plexin family.
Domain:
  • Contains 4 IPT/TIG domains.
  • Contains 1 Sema domain.
Family:
  • Belongs to the plexin family.
genes like me logo Genes that share domains with PLXNA3: view

Function for PLXNA3 Gene

Molecular function for PLXNA3 Gene

GENATLAS Biochemistry:
plexin A3,calcium-dependent cell adhesion molecule at the neuronal cell surface,homologous to the hepatocyte growth factor receptor family, expressed in fetal brain,putatively involved in signal transduction
UniProtKB/Swiss-Prot Function:
Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.
genes like me logo Genes that share phenotypes with PLXNA3: view

Animal Models for PLXNA3 Gene

MGI Knock Outs for PLXNA3:

Animal Model Products

miRNA for PLXNA3 Gene

miRTarBase miRNAs that target PLXNA3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLXNA3 Gene

Localization for PLXNA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLXNA3 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLXNA3 Gene COMPARTMENTS Subcellular localization image for PLXNA3 gene
Compartment Confidence
plasma membrane 5
nucleus 4
endoplasmic reticulum 1
extracellular 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for PLXNA3 Gene

Pathways & Interactions for PLXNA3 Gene

genes like me logo Genes that share pathways with PLXNA3: view

Pathways by source for PLXNA3 Gene

1 KEGG pathway for PLXNA3 Gene

Gene Ontology (GO) - Biological Process for PLXNA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007411 axon guidance IEA --
GO:0021612 facial nerve structural organization IEA --
GO:0030334 regulation of cell migration IBA --
GO:0048841 regulation of axon extension involved in axon guidance IBA --
genes like me logo Genes that share ontologies with PLXNA3: view

No data available for SIGNOR curated interactions for PLXNA3 Gene

Drugs & Compounds for PLXNA3 Gene

No Compound Related Data Available

Transcripts for PLXNA3 Gene

Unigene Clusters for PLXNA3 Gene

Plexin A3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLXNA3 Gene

No ASD Table

Relevant External Links for PLXNA3 Gene

GeneLoc Exon Structure for
PLXNA3
ECgene alternative splicing isoforms for
PLXNA3

Expression for PLXNA3 Gene

mRNA expression in normal human tissues for PLXNA3 Gene

Protein differential expression in normal tissues from HIPED for PLXNA3 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (66.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PLXNA3 Gene



SOURCE GeneReport for Unigene cluster for PLXNA3 Gene Hs.632839

genes like me logo Genes that share expression patterns with PLXNA3: view

Protein tissue co-expression partners for PLXNA3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PLXNA3 Gene

Orthologs for PLXNA3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLXNA3 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia PLXNA3 35
  • 90.22 (n)
  • 95.36 (a)
GDI1 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Plxna3 35
  • 86.55 (n)
  • 94.6 (a)
Plxna3 16
Plxna3 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Plxna3 35
  • 86.44 (n)
  • 94.55 (a)
cow
(Bos Taurus)
Mammalia PLXNA3 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PLXNA3 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLXNA3 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PLXNA3 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLXNA3 36
  • 72 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC397805 35
zebrafish
(Danio rerio)
Actinopterygii plxna3 35
  • 70.71 (n)
  • 74.43 (a)
plxna3 36
  • 73 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2624 35
Species with no ortholog for PLXNA3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLXNA3 Gene

ENSEMBL:
Gene Tree for PLXNA3 (if available)
TreeFam:
Gene Tree for PLXNA3 (if available)

Paralogs for PLXNA3 Gene

Paralogs for PLXNA3 Gene

(10) SIMAP similar genes for PLXNA3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PLXNA3: view

Variants for PLXNA3 Gene

Sequence variations from dbSNP and Humsavar for PLXNA3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs34585333 - 154,462,143(-) GTTGC(C/T)GTTGA nc-transcript-variant, reference, missense
rs36115591 - 154,462,230(-) CATGC(A/C/T)GTCGG nc-transcript-variant, reference, missense
rs5945430 - 154,465,991(+) GGTGA(C/G)AACCT nc-transcript-variant, reference, missense
rs2097212 -- 154,460,862(+) GGACT(G/T)TCGGC intron-variant
rs2097213 -- 154,460,865(+) CTTTC(G/T)GCTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLXNA3 Gene

Variant ID Type Subtype PubMed ID
esv33199 CNV Gain+Loss 17666407
esv33784 CNV Gain+Loss 17666407
nsv519042 CNV Gain 19592680

Variation tolerance for PLXNA3 Gene

Residual Variation Intolerance Score: 1.92% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.37; 85.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLXNA3 Gene

HapMap Linkage Disequilibrium report
PLXNA3
Human Gene Mutation Database (HGMD)
PLXNA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLXNA3 Gene

Disorders for PLXNA3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PLXNA3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
rett syndrome
  • rett syndrome, preserved speech variant
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PLXNA3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLXNA3
genes like me logo Genes that share disorders with PLXNA3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLXNA3 Gene

Publications for PLXNA3 Gene

  1. A family of transmembrane proteins with homology to the MET- hepatocyte growth factor receptor. (PMID: 8570614) Maestrini E. … Comoglio P.M. (Proc. Natl. Acad. Sci. U.S.A. 1996) 3 4 23 67
  2. Expression and function of semaphorin 3A and its receptors in human monocyte-derived macrophages. (PMID: 19480842) Ji J.D. … Ivashkiv L.B. (Hum. Immunol. 2009) 3 23
  3. Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci. (PMID: 8733135) Chen E.Y. … D'Urso M. (Hum. Mol. Genet. 1996) 2 3
  4. Transcriptional organization of a 450-kb region of the human X chromosome in Xq28. (PMID: 8248200) Bione S. … Toniolo D. (Proc. Natl. Acad. Sci. U.S.A. 1993) 2 3
  5. PlexinA polymorphisms mediate the developmental trajectory of human corpus callosum microstructure. (PMID: 25518740) Belyk M. … Brown S. (J. Hum. Genet. 2015) 3

Products for PLXNA3 Gene

Sources for PLXNA3 Gene

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