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Aliases for KLK15 Gene

Aliases for KLK15 Gene

  • Kallikrein Related Peptidase 15 2 3 5
  • ACO Protease 3 4
  • Kallikrein-Like Serine Protease 3
  • Kallikrein 15 2
  • Kallikrein-15 3
  • Prostinogen 3
  • EC 58
  • EC 3.4.21.- 4
  • EC 3.4.21 58
  • ACO 3

External Ids for KLK15 Gene

Previous GeneCards Identifiers for KLK15 Gene

  • GC19M051957
  • GC19M051689
  • GC19M056004
  • GC19M056020
  • GC19M051328
  • GC19M047663

Summaries for KLK15 Gene

Entrez Gene Summary for KLK15 Gene

  • Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In prostate cancer, this gene has increased expression, which indicates its possible use as a diagnostic or prognostic marker for prostate cancer. The gene contains multiple polyadenylation sites and alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for KLK15 Gene

KLK15 (Kallikrein Related Peptidase 15) is a Protein Coding gene. Diseases associated with KLK15 include Prostate Cancer. Among its related pathways are Collagen chain trimerization and PPAR Alpha Pathway. GO annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is KLK11.

UniProtKB/Swiss-Prot for KLK15 Gene

  • Protease whose physiological substrate is not yet known.

Gene Wiki entry for KLK15 Gene

Additional gene information for KLK15 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLK15 Gene

Genomics for KLK15 Gene

Regulatory Elements for KLK15 Gene

Enhancers for KLK15 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H050896 1.3 Ensembl ENCODE 11.5 -59.9 -59888 1.8 HDGF PKNOX1 ZNF766 ZNF143 FOS SP3 JUNB REST ZNF592 SMARCA4 ZNF175 ZNF577 NUP62 KLK2 LINC01869 KLK15 KLK1 KLK11 POLD1 CTU1
GH19H050720 1.4 FANTOM5 ENCODE 10.3 +113.9 113857 5.7 HDGF SIN3A ZNF2 ZBTB7B CBX5 FOS SP3 REST ZNF592 ZNF610 CLEC11A NUP62 ZNF175 CTU1 C19orf48 GPR32 ENSG00000268047 AKT1S1 SNORD88A SNORD88C
GH19H050727 1.2 Ensembl ENCODE 10.4 +108.7 108732 1.3 HDGF PKNOX1 ATF1 CBX5 FOS ATF7 SP3 ZNF592 SMARCA4 MYNN GPR32 SNORD88C SNORD88B SNORD88A C19orf48 LINC01869 KLK1 KLK15 FUZ CLEC11A
GH19H050890 1 ENCODE dbSUPER 11.3 -53.9 -53940 1 HDGF EBF1 RELA FOSL1 ZNF157 FOS ATF7 RUNX3 IKZF2 CREM KLK4 LINC01869 C19orf48 SNORD88C KLK15 KLK1 KLKP1 KLK2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KLK15 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the KLK15 gene promoter:

Genomic Locations for KLK15 Gene

Genomic Locations for KLK15 Gene
11,925 bases
Minus strand

Genomic View for KLK15 Gene

Genes around KLK15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLK15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLK15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLK15 Gene

Proteins for KLK15 Gene

  • Protein details for KLK15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A0AUY8
    • Q15358
    • Q6ISI0
    • Q9H2R3
    • Q9H2R4
    • Q9H2R6
    • Q9HBG9

    Protein attributes for KLK15 Gene

    256 amino acids
    Molecular mass:
    28087 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KLK15 Gene


neXtProt entry for KLK15 Gene

Selected DME Specific Peptides for KLK15 Gene


Post-translational modifications for KLK15 Gene

  • Glycosylation at isoforms=5171 and posLast=232232
  • Modification sites at PhosphoSitePlus

Domains & Families for KLK15 Gene

Gene Families for KLK15 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for KLK15 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase S1 family. Kallikrein subfamily.
  • Belongs to the peptidase S1 family. Kallikrein subfamily.
genes like me logo Genes that share domains with KLK15: view

Function for KLK15 Gene

Molecular function for KLK15 Gene

UniProtKB/Swiss-Prot Function:
Protease whose physiological substrate is not yet known.

Enzyme Numbers (IUBMB) for KLK15 Gene

Phenotypes From GWAS Catalog for KLK15 Gene

Gene Ontology (GO) - Molecular Function for KLK15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity NAS 11010966
GO:0005515 protein binding IPI 25416956
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity TAS 8018728
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with KLK15: view
genes like me logo Genes that share phenotypes with KLK15: view

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KLK15 Gene

Localization for KLK15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLK15 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLK15 gene
Compartment Confidence
extracellular 5
mitochondrion 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for KLK15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with KLK15: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for KLK15 Gene

Pathways & Interactions for KLK15 Gene

genes like me logo Genes that share pathways with KLK15: view

Pathways by source for KLK15 Gene

1 BioSystems pathway for KLK15 Gene

Gene Ontology (GO) - Biological Process for KLK15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with KLK15: view

No data available for SIGNOR curated interactions for KLK15 Gene

Drugs & Compounds for KLK15 Gene

(3) Drugs for KLK15 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for KLK15 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with KLK15: view

Transcripts for KLK15 Gene

Unigene Clusters for KLK15 Gene

Kallikrein-related peptidase 15:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLK15 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b
SP4: - -

Relevant External Links for KLK15 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KLK15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KLK15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLK15 Gene

This gene is overexpressed in Testis (x17.7), Colon - Transverse (x13.9), Prostate (x5.6), and Adrenal Gland (x4.6).

Protein differential expression in normal tissues from HIPED for KLK15 Gene

This gene is overexpressed in Monocytes (49.8) and Rectum (19.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KLK15 Gene

Protein tissue co-expression partners for KLK15 Gene

NURSA nuclear receptor signaling pathways regulating expression of KLK15 Gene:


SOURCE GeneReport for Unigene cluster for KLK15 Gene:


mRNA Expression by UniProt/SwissProt for KLK15 Gene:

Tissue specificity: Highest expression in the thyroid gland. Also expressed in the prostate, salivary, and adrenal glands and in the colon testis and kidney.

Evidence on tissue expression from TISSUES for KLK15 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with KLK15: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for KLK15 Gene

Orthologs for KLK15 Gene

This gene was present in the common ancestor of animals.

Orthologs for KLK15 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KLK15 33 34
  • 99.48 (n)
(Canis familiaris)
Mammalia KLK15 33
  • 83.46 (n)
(Bos Taurus)
Mammalia KLK15 33 34
  • 81.77 (n)
(Rattus norvegicus)
Mammalia LOC102553035 33
  • 80.38 (n)
(Mus musculus)
Mammalia Klk15 33 16 34
  • 79.61 (n)
(Monodelphis domestica)
Mammalia KLK15 34
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia KLK15 34
  • 65 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17239 35
  • 33 (a)
Species where no ortholog for KLK15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KLK15 Gene

Gene Tree for KLK15 (if available)
Gene Tree for KLK15 (if available)

Paralogs for KLK15 Gene

Variants for KLK15 Gene

Sequence variations from dbSNP and Humsavar for KLK15 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_036298 A breast cancer sample
rs1000290070 -- 50,831,936(+) CCTCC(C/T)GAGTA intron-variant, upstream-variant-2KB
rs1000426976 -- 50,831,595(+) CACAG(A/T)CTTAT intron-variant, upstream-variant-2KB
rs1000549668 -- 50,825,501(+) GGGAT(C/T)GGGGT nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs1000704134 -- 50,831,247(+) AGAGG(-/C)CCCAG intron-variant, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for KLK15 Gene

Variant ID Type Subtype PubMed ID
nsv515608 CNV loss 19592680
nsv2531 CNV deletion 18451855
nsv1140251 OTHER inversion 24896259
esv3644657 CNV gain 21293372
esv3644656 CNV loss 21293372
esv3583464 CNV loss 25503493
esv3583463 CNV loss 25503493
esv3556538 CNV deletion 23714750
esv2763099 CNV loss 21179565
esv2662649 CNV deletion 23128226
esv2422090 CNV deletion 20811451
dgv204n21 CNV loss 19592680
dgv203n21 CNV loss 19592680
dgv1802n106 CNV deletion 24896259
dgv1058e212 CNV loss 25503493

Variation tolerance for KLK15 Gene

Residual Variation Intolerance Score: 82.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.80; 47.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KLK15 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLK15 Gene

Disorders for KLK15 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KLK15 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
prostate cancer
  • prostate cancer, hereditary, 5
- elite association - COSMIC cancer census association via MalaCards
Search KLK15 in MalaCards View complete list of genes associated with diseases

Relevant External Links for KLK15

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with KLK15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KLK15 Gene

Publications for KLK15 Gene

  1. Molecular cloning of the human kallikrein 15 gene (KLK15). Up-regulation in prostate cancer. (PMID: 11010966) Yousef GM … Diamandis EP (The Journal of biological chemistry 2001) 2 3 4 22 60
  2. The androgen-regulated gene human kallikrein 15 (KLK15) is an independent and favourable prognostic marker for breast cancer. (PMID: 12439720) Yousef GM … Diamandis EP (British journal of cancer 2002) 2 3 22 60
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60
  4. Replication of prostate cancer risk loci on 8q24, 11q13, 17q12, 19q33, and Xp11 in African Americans. (PMID: 19902474) Hooker S … Kittles RA (The Prostate 2010) 3 45 60
  5. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P … Inskip PD (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 45 60

Products for KLK15 Gene

Sources for KLK15 Gene

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