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Aliases for KLK15 Gene

Aliases for KLK15 Gene

  • Kallikrein Related Peptidase 15 2 3 5
  • ACO Protease 3 4
  • Kallikrein-Like Serine Protease 3
  • Kallikrein-Related Peptidase 15 3
  • Kallikrein 15 2
  • Prostinogen 3
  • EC 3.4.21.4 63
  • EC 3.4.21.- 4
  • EC 3.4.21 63
  • HSRNASPH 3
  • ACO 3

External Ids for KLK15 Gene

Previous GeneCards Identifiers for KLK15 Gene

  • GC19M051957
  • GC19M051689
  • GC19M056004
  • GC19M056020
  • GC19M051328
  • GC19M047663

Summaries for KLK15 Gene

Entrez Gene Summary for KLK15 Gene

  • Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In prostate cancer, this gene has increased expression, which indicates its possible use as a diagnostic or prognostic marker for prostate cancer. The gene contains multiple polyadenylation sites and alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for KLK15 Gene

KLK15 (Kallikrein Related Peptidase 15) is a Protein Coding gene. Diseases associated with KLK15 include prostate cancer. Among its related pathways are MSP-RON Signaling and Collagen biosynthesis and modifying enzymes. GO annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is KLK12.

UniProtKB/Swiss-Prot for KLK15 Gene

  • Protease whose physiological substrate is not yet known.

Gene Wiki entry for KLK15 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLK15 Gene

Genomics for KLK15 Gene

Regulatory Elements for KLK15 Gene

Transcription factor binding sites by QIAGEN in the KLK15 gene promoter:

Genomic Location for KLK15 Gene

Chromosome:
19
Start:
50,825,289 bp from pter
End:
50,837,213 bp from pter
Size:
11,925 bases
Orientation:
Minus strand

Genomic View for KLK15 Gene

Genes around KLK15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLK15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLK15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLK15 Gene

Proteins for KLK15 Gene

  • Protein details for KLK15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2R5-KLK15_HUMAN
    Recommended name:
    Kallikrein-15
    Protein Accession:
    Q9H2R5
    Secondary Accessions:
    • A0AUY8
    • Q15358
    • Q6ISI0
    • Q9H2R3
    • Q9H2R4
    • Q9H2R6
    • Q9HBG9

    Protein attributes for KLK15 Gene

    Size:
    256 amino acids
    Molecular mass:
    28087 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KLK15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLK15 Gene

Proteomics data for KLK15 Gene at MOPED

Selected DME Specific Peptides for KLK15 Gene

Post-translational modifications for KLK15 Gene

  • Glycosylation at Asn 171 and Asn 232
  • Modification sites at PhosphoSitePlus

Other Protein References for KLK15 Gene

Antibody Products

  • R&D Systems Antibodies for KLK15 (Kallikrein 15)

Domains & Families for KLK15 Gene

Gene Families for KLK15 Gene

Suggested Antigen Peptide Sequences for KLK15 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H2R5

UniProtKB/Swiss-Prot:

KLK15_HUMAN :
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family. Kallikrein subfamily.
Domain:
  • Contains 1 peptidase S1 domain.
Family:
  • Belongs to the peptidase S1 family. Kallikrein subfamily.
genes like me logo Genes that share domains with KLK15: view

Function for KLK15 Gene

Molecular function for KLK15 Gene

UniProtKB/Swiss-Prot Function:
Protease whose physiological substrate is not yet known.

Enzyme Numbers (IUBMB) for KLK15 Gene

genes like me logo Genes that share phenotypes with KLK15: view

Animal Model Products

  • Taconic Biosciences Mouse Models for KLK15

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KLK15 Gene

Localization for KLK15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLK15 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLK15 Gene COMPARTMENTS Subcellular localization image for KLK15 gene
Compartment Confidence
extracellular 5
cytosol 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for KLK15 Gene

Pathways & Interactions for KLK15 Gene

genes like me logo Genes that share pathways with KLK15: view

Pathways by source for KLK15 Gene

Gene Ontology (GO) - Biological Process for KLK15 Gene

None

No data available for SIGNOR curated interactions for KLK15 Gene

Drugs & Compounds for KLK15 Gene

(3) Drugs for KLK15 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for KLK15 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with KLK15: view

Transcripts for KLK15 Gene

Unigene Clusters for KLK15 Gene

Kallikrein-related peptidase 15:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KLK15 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b
SP1:
SP2:
SP3:
SP4: - -

Relevant External Links for KLK15 Gene

GeneLoc Exon Structure for
KLK15
ECgene alternative splicing isoforms for
KLK15

Expression for KLK15 Gene

mRNA expression in normal human tissues for KLK15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLK15 Gene

This gene is overexpressed in Testis (x17.7), Colon - Transverse (x13.9), Prostate (x5.6), and Adrenal Gland (x4.6).

Protein differential expression in normal tissues from HIPED for KLK15 Gene

This gene is overexpressed in Monocytes (49.8) and Rectum (19.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KLK15 Gene



SOURCE GeneReport for Unigene cluster for KLK15 Gene Hs.567535

mRNA Expression by UniProt/SwissProt for KLK15 Gene

Q9H2R5-KLK15_HUMAN
Tissue specificity: Highest expression in the thyroid gland. Also expressed in the prostate, salivary, and adrenal glands and in the colon testis and kidney.
genes like me logo Genes that share expression patterns with KLK15: view

Protein tissue co-expression partners for KLK15 Gene

Primer Products

In Situ Assay Products

Orthologs for KLK15 Gene

This gene was present in the common ancestor of animals.

Orthologs for KLK15 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KLK15 35
  • 81.77 (n)
  • 76.17 (a)
KLK15 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KLK15 35
  • 83.46 (n)
  • 79.69 (a)
mouse
(Mus musculus)
Mammalia Klk15 35
  • 79.61 (n)
  • 77.69 (a)
Klk15 16
Klk15 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KLK15 35
  • 99.48 (n)
  • 99.22 (a)
KLK15 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC102553035 35
  • 80.38 (n)
  • 79.42 (a)
oppossum
(Monodelphis domestica)
Mammalia KLK15 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KLK15 36
  • 65 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG17239 37
  • 33 (a)
Species with no ortholog for KLK15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KLK15 Gene

ENSEMBL:
Gene Tree for KLK15 (if available)
TreeFam:
Gene Tree for KLK15 (if available)

Paralogs for KLK15 Gene

genes like me logo Genes that share paralogs with KLK15: view

Variants for KLK15 Gene

Sequence variations from dbSNP and Humsavar for KLK15 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs3212805 - 50,826,958(-) CCACC(C/G/T)GGGGG intron-variant, reference, missense
VAR_036298 A breast cancer sample
rs266112 -- 50,828,333(+) GAGAG(C/G)AAGGG intron-variant
rs2739411 -- 50,826,177(+) aatct(C/T)acccc intron-variant
rs2739415 -- 50,827,574(+) GAGTT(C/G)TGGCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KLK15 Gene

Variant ID Type Subtype PubMed ID
dgv3977n71 CNV Loss 21882294
dgv203n21 CNV Loss 19592680
dgv204n21 CNV Loss 19592680
esv2662649 CNV Deletion 23128226
esv2422090 CNV Deletion 20811451
nsv515608 CNV Loss 19592680
nsv2531 CNV Loss 18451855

Variation tolerance for KLK15 Gene

Residual Variation Intolerance Score: 82.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.80; 47.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KLK15 Gene

HapMap Linkage Disequilibrium report
KLK15
Human Gene Mutation Database (HGMD)
KLK15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLK15 Gene

Disorders for KLK15 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KLK15 Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
prostate cancer
  • prostate cancer, hereditary, 5
- elite association - COSMIC cancer census association via MalaCards
Search KLK15 in MalaCards View complete list of genes associated with diseases

Relevant External Links for KLK15

Genetic Association Database (GAD)
KLK15
Human Genome Epidemiology (HuGE) Navigator
KLK15
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KLK15
genes like me logo Genes that share disorders with KLK15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KLK15 Gene

Publications for KLK15 Gene

  1. Molecular cloning of the human kallikrein 15 gene (KLK15). Up- regulation in prostate cancer. (PMID: 11010966) Yousef G.M. … Diamandis E.P. (J. Biol. Chem. 2001) 2 3 4 23 67
  2. The androgen-regulated gene human kallikrein 15 (KLK15) is an independent and favourable prognostic marker for breast cancer. (PMID: 12439720) Yousef G.M. … Diamandis E.P. (Br. J. Cancer 2002) 2 3 23
  3. Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005. (PMID: 16800723) (Biol. Chem. 2006) 2 3
  4. A comprehensive nomenclature for serine proteases with homology to tissue kallikreins. (PMID: 16800724) Lundwall A. … Yousef G.M. (Biol. Chem. 2006) 2 3
  5. Prognostic value of the human kallikrein gene 15 expression in ovarian cancer. (PMID: 12915603) Yousef G.M. … Diamandis E.P. (J. Clin. Oncol. 2003) 3 23

Products for KLK15 Gene

Sources for KLK15 Gene

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