Free for academic non-profit institutions. Other users need a Commercial license

Aliases for H2AFY2 Gene

Aliases for H2AFY2 Gene

  • H2A Histone Family Member Y2 2 3 5
  • Histone MacroH2A2 3 4
  • MacroH2A2 3 4
  • MH2A2 3 4
  • H2A Histone Family, Member Y2 2
  • Core Histone Macro-H2A.2 3
  • Core Histone MacroH2A2.2 3

External Ids for H2AFY2 Gene

Previous GeneCards Identifiers for H2AFY2 Gene

  • GC10P070623
  • GC10P070899
  • GC10P071704
  • GC10P071157
  • GC10P071482
  • GC10P071812
  • GC10P065804

Summaries for H2AFY2 Gene

Entrez Gene Summary for H2AFY2 Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and may participate in stable X chromosome inactivation. [provided by RefSeq, Oct 2015]

GeneCards Summary for H2AFY2 Gene

H2AFY2 (H2A Histone Family Member Y2) is a Protein Coding gene. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Preimplantation Embryo. GO annotations related to this gene include protein heterodimerization activity and RNA polymerase II regulatory region sequence-specific DNA binding. An important paralog of this gene is H2AFY.

UniProtKB/Swiss-Prot for H2AFY2 Gene

  • Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation.

Gene Wiki entry for H2AFY2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for H2AFY2 Gene

Genomics for H2AFY2 Gene

Regulatory Elements for H2AFY2 Gene

Enhancers for H2AFY2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G069956 0.6 Ensembl 20.2 -96.2 -96201 0.8 EGR1 USF2 CREB1 ZBTB33 CREM ATF2 EGR2 H2AFY2 LOC102723350 LOC105378347
GH10G069960 0.9 Ensembl ENCODE 10.2 -91.4 -91400 1.1 BCOR CTCF ZSCAN4 ZNF223 ZMYM3 ZIC2 CBX1 NFIC ZSCAN5C ZNF600 H2AFY2 LOC102723350 LOC105378347
GH10G070081 0.7 FANTOM5 11.6 +28.7 28666 0.4 ZNF263 ESRRA ZNF362 RARA GATA3 SMARCA4 CREB1 BCL6 KDM1A H2AFY2 TYSND1 CALM2P2 SAR1A PIR45222
GH10G070052 1 ENCODE 7.2 +0.8 755 2.3 HDGF PKNOX1 ARID4B SIN3A GLI4 ZNF2 ZNF48 YY1 GLIS2 ZNF143 H2AFY2 PIR45222
GH10G070009 0.9 FANTOM5 5.5 -43.1 -43121 0.3 ATF1 IRF2 PKNOX1 CREB3L1 GTF2E2 DDX20 YBX1 RBBP5 GATA3 GATA2 H2AFY2 SUPV3L1 LOC102723350 LOC105378347
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around H2AFY2 on UCSC Golden Path with GeneCards custom track

Promoters for H2AFY2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000029338 799 2001 HDGF PKNOX1 ARID4B SIN3A FEZF1 GLI4 ZNF2 ZNF48 YY1 SLC30A9

Genomic Location for H2AFY2 Gene

Chromosome:
10
Start:
70,052,601 bp from pter
End:
70,112,284 bp from pter
Size:
59,684 bases
Orientation:
Plus strand

Genomic View for H2AFY2 Gene

Genes around H2AFY2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
H2AFY2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for H2AFY2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for H2AFY2 Gene

Proteins for H2AFY2 Gene

  • Protein details for H2AFY2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P0M6-H2AW_HUMAN
    Recommended name:
    Core histone macro-H2A.2
    Protein Accession:
    Q9P0M6
    Secondary Accessions:
    • Q5SQT2

    Protein attributes for H2AFY2 Gene

    Size:
    372 amino acids
    Molecular mass:
    40058 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers.

    Three dimensional structures from OCA and Proteopedia for H2AFY2 Gene

neXtProt entry for H2AFY2 Gene

Post-translational modifications for H2AFY2 Gene

  • Ubiquitination at posLast=332332
  • Modification sites at PhosphoSitePlus

Other Protein References for H2AFY2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for H2AFY2 Gene

Domains & Families for H2AFY2 Gene

Gene Families for H2AFY2 Gene

Suggested Antigen Peptide Sequences for H2AFY2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with H2AFY2: view

No data available for UniProtKB/Swiss-Prot for H2AFY2 Gene

Function for H2AFY2 Gene

Molecular function for H2AFY2 Gene

UniProtKB/Swiss-Prot Function:
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation.

Gene Ontology (GO) - Molecular Function for H2AFY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 23595991
GO:0003677 DNA binding IEA --
GO:0031490 chromatin DNA binding IDA 19734898
GO:0044212 transcription regulatory region DNA binding IDA 19734898
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with H2AFY2: view
genes like me logo Genes that share phenotypes with H2AFY2: view

Animal Models for H2AFY2 Gene

MGI Knock Outs for H2AFY2:

Animal Model Products

miRNA for H2AFY2 Gene

miRTarBase miRNAs that target H2AFY2

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for H2AFY2 Gene

Localization for H2AFY2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for H2AFY2 Gene

Nucleus. Chromosome. Note=Enriched in inactive X chromosome chromatin (PubMed:11331621, PubMed:11262398) and in senescence-associated heterochromatin (PubMed:15621527). {ECO:0000269 PubMed:11262398, ECO:0000269 PubMed:11331621, ECO:0000269 PubMed:15621527}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for H2AFY2 gene
Compartment Confidence
extracellular 5
nucleus 5
mitochondrion 3
cytosol 2

Gene Ontology (GO) - Cellular Components for H2AFY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000784 nuclear chromosome, telomeric region IDA 19135898
GO:0000785 chromatin IEA --
GO:0000786 nucleosome IEA --
GO:0000790 nuclear chromatin IDA 19734898
GO:0001740 Barr body IDA 11331621
genes like me logo Genes that share ontologies with H2AFY2: view

Pathways & Interactions for H2AFY2 Gene

genes like me logo Genes that share pathways with H2AFY2: view

Pathways by source for H2AFY2 Gene

1 BioSystems pathway for H2AFY2 Gene
2 KEGG pathways for H2AFY2 Gene

Gene Ontology (GO) - Biological Process for H2AFY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 19734898
GO:0001558 NOT regulation of cell growth IGI 24071584
GO:0006334 nucleosome assembly IEA --
GO:0006342 chromatin silencing IBA --
GO:0007420 brain development IMP 19734898
genes like me logo Genes that share ontologies with H2AFY2: view

No data available for SIGNOR curated interactions for H2AFY2 Gene

Drugs & Compounds for H2AFY2 Gene

No Compound Related Data Available

Transcripts for H2AFY2 Gene

mRNA/cDNA for H2AFY2 Gene

Unigene Clusters for H2AFY2 Gene

H2A histone family, member Y2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for H2AFY2 Gene

No ASD Table

Relevant External Links for H2AFY2 Gene

GeneLoc Exon Structure for
H2AFY2
ECgene alternative splicing isoforms for
H2AFY2

Expression for H2AFY2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for H2AFY2 Gene

Protein differential expression in normal tissues from HIPED for H2AFY2 Gene

This gene is overexpressed in Fetal Brain (10.3), Testis (9.7), Fetal testis (7.7), and Ovary (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for H2AFY2 Gene



Protein tissue co-expression partners for H2AFY2 Gene

NURSA nuclear receptor signaling pathways regulating expression of H2AFY2 Gene:

H2AFY2

SOURCE GeneReport for Unigene cluster for H2AFY2 Gene:

Hs.499953

Evidence on tissue expression from TISSUES for H2AFY2 Gene

  • Nervous system(3.6)
genes like me logo Genes that share expression patterns with H2AFY2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for H2AFY2 Gene

Orthologs for H2AFY2 Gene

This gene was present in the common ancestor of animals.

Orthologs for H2AFY2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia H2AFY2 34 35
  • 99.46 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia H2AFY2 35
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia H2AFY2 34 35
  • 93.1 (n)
dog
(Canis familiaris)
Mammalia H2AFY2 34 35
  • 92.83 (n)
rat
(Rattus norvegicus)
Mammalia H2afy2 34
  • 90.77 (n)
mouse
(Mus musculus)
Mammalia H2afy2 34 16 35
  • 90.23 (n)
oppossum
(Monodelphis domestica)
Mammalia H2AFY2 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves H2AFY2 34 35
  • 80.11 (n)
lizard
(Anolis carolinensis)
Reptilia H2AFY2 35
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia h2afy2 34
  • 71.25 (n)
Str.12885 34
African clawed frog
(Xenopus laevis)
Amphibia h2afy2-prov 34
zebrafish
(Danio rerio)
Actinopterygii h2afy2 34 35 35
  • 69.49 (n)
worm
(Caenorhabditis elegans)
Secernentea htas-1 35
  • 39 (a)
OneToMany
Species where no ortholog for H2AFY2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for H2AFY2 Gene

ENSEMBL:
Gene Tree for H2AFY2 (if available)
TreeFam:
Gene Tree for H2AFY2 (if available)

Paralogs for H2AFY2 Gene

Variants for H2AFY2 Gene

Sequence variations from dbSNP and Humsavar for H2AFY2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000001984 -- 70,090,534(+) CTGAC(G/T)GTTTA intron-variant
rs1000027150 -- 70,059,285(+) AAAGG(C/T)GGCGA intron-variant
rs1000056718 -- 70,058,923(+) ACCCT(A/G)TCACG intron-variant
rs1000089565 -- 70,063,074(+) AGAGG(G/T)TTTGT intron-variant
rs1000092612 -- 70,052,674(+) CACCA(C/T)TAATA utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for H2AFY2 Gene

Variant ID Type Subtype PubMed ID
esv32737 CNV gain+loss 17666407
nsv551479 CNV loss 21841781
nsv819142 CNV gain 19587683

Variation tolerance for H2AFY2 Gene

Residual Variation Intolerance Score: 32.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.86; 17.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for H2AFY2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
H2AFY2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for H2AFY2 Gene

Disorders for H2AFY2 Gene

Relevant External Links for H2AFY2

Genetic Association Database (GAD)
H2AFY2
Human Genome Epidemiology (HuGE) Navigator
H2AFY2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
H2AFY2

No disorders were found for H2AFY2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for H2AFY2 Gene

Publications for H2AFY2 Gene

  1. Histone H2A variants and the inactive X chromosome: identification of a second macroH2A variant. (PMID: 11331621) Chadwick B.P. … Willard H.F. (Hum. Mol. Genet. 2001) 2 3 4 22 64
  2. MACROH2A2, a new member of the MACROH2A core histone family. (PMID: 11262398) Costanzi C. … Pehrson J.R. (J. Biol. Chem. 2001) 2 3 4 64
  3. Inherited genetic variant predisposes to aggressive but not indolent prostate cancer. (PMID: 20080650) Xu J. … Isaacs W.B. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 46 64
  4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 46 64
  5. Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA. (PMID: 15621527) Zhang R. … Adams P.D. (Dev. Cell 2005) 3 4 64

Products for H2AFY2 Gene

Sources for H2AFY2 Gene

Content
Loading form....