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Aliases for H2AFY2 Gene

Aliases for H2AFY2 Gene

  • H2A Histone Family, Member Y2 2 3
  • Histone MacroH2A2 3 4
  • MacroH2A2 3 4
  • MH2A2 3 4
  • Core Histone Macro-H2A.2 3
  • Core Histone MacroH2A2.2 3

External Ids for H2AFY2 Gene

Previous GeneCards Identifiers for H2AFY2 Gene

  • GC10P070623
  • GC10P070899
  • GC10P071704
  • GC10P071157
  • GC10P071482
  • GC10P071812
  • GC10P065804

Summaries for H2AFY2 Gene

GeneCards Summary for H2AFY2 Gene

H2AFY2 (H2A Histone Family, Member Y2) is a Protein Coding gene. Among its related pathways are RNA Polymerase I Promoter Opening and RNA Polymerase I Promoter Opening. GO annotations related to this gene include protein heterodimerization activity. An important paralog of this gene is H2AFB2.

UniProtKB/Swiss-Prot for H2AFY2 Gene

  • Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation.

Gene Wiki entry for H2AFY2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for H2AFY2 Gene

Genomics for H2AFY2 Gene

Regulatory Elements for H2AFY2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for H2AFY2 Gene

Start:
70,052,601 bp from pter
End:
70,112,284 bp from pter
Size:
59,684 bases
Orientation:
Plus strand

Genomic View for H2AFY2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for H2AFY2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for H2AFY2 Gene

Proteins for H2AFY2 Gene

  • Protein details for H2AFY2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P0M6-H2AW_HUMAN
    Recommended name:
    Core histone macro-H2A.2
    Protein Accession:
    Q9P0M6
    Secondary Accessions:
    • Q5SQT2

    Protein attributes for H2AFY2 Gene

    Size:
    372 amino acids
    Molecular mass:
    40058 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers

    Three dimensional structures from OCA and Proteopedia for H2AFY2 Gene

neXtProt entry for H2AFY2 Gene

Proteomics data for H2AFY2 Gene at MOPED

Post-translational modifications for H2AFY2 Gene

  • Ubiquitination at Lys116 and Lys332
  • Modification sites at PhosphoSitePlus

Other Protein References for H2AFY2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for H2AFY2 Gene

Domains for H2AFY2 Gene

Gene Families for H2AFY2 Gene

HGNC:
  • RIH :Histones / Replication-independent

Suggested Antigen Peptide Sequences for H2AFY2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P0M6

UniProtKB/Swiss-Prot:

H2AW_HUMAN :
  • Q9P0M6
Domain:
  • Contains 1 histone H2A domain.
  • Contains 1 Macro domain.
genes like me logo Genes that share domains with H2AFY2: view

Function for H2AFY2 Gene

Molecular function for H2AFY2 Gene

UniProtKB/Swiss-Prot Function: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation.

Gene Ontology (GO) - Molecular Function for H2AFY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 23595991
GO:0003677 DNA binding --
GO:0031490 chromatin DNA binding IDA 19734898
GO:0044212 transcription regulatory region DNA binding IDA 19734898
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with H2AFY2: view

Phenotypes for H2AFY2 Gene

GenomeRNAi human phenotypes for H2AFY2:
genes like me logo Genes that share phenotypes with H2AFY2: view

Animal Model Products

CRISPR Products

miRNA for H2AFY2 Gene

miRTarBase miRNAs that target H2AFY2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for H2AFY2

Clone Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for H2AFY2 Gene

Localization for H2AFY2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for H2AFY2 Gene

Nucleus. Chromosome. Note=Enriched in inactive X chromosome chromatin and in senescence-associated heterochromatin.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for H2AFY2 Gene COMPARTMENTS Subcellular localization image for H2AFY2 gene
Compartment Confidence
nucleus 5
mitochondrion 3
cytosol 2

Gene Ontology (GO) - Cellular Components for H2AFY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000786 nucleosome IEA --
GO:0000790 nuclear chromatin IDA 19734898
GO:0001740 Barr body IDA 11331621
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with H2AFY2: view

Pathways for H2AFY2 Gene

SuperPathways for H2AFY2 Gene

genes like me logo Genes that share pathways with H2AFY2: view

Pathways by source for H2AFY2 Gene

2 KEGG pathways for H2AFY2 Gene

Gene Ontology (GO) - Biological Process for H2AFY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 19734898
GO:0001558 NOT regulation of cell growth IGI 24071584
GO:0006334 nucleosome assembly IEA --
GO:0007420 brain development IMP 19734898
GO:0007549 dosage compensation IDA 11331621
genes like me logo Genes that share ontologies with H2AFY2: view

Transcripts for H2AFY2 Gene

mRNA/cDNA for H2AFY2 Gene

Unigene Clusters for H2AFY2 Gene

H2A histone family, member Y2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for H2AFY2

Clone Products

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for H2AFY2 Gene

No ASD Table

Relevant External Links for H2AFY2 Gene

GeneLoc Exon Structure for
H2AFY2
ECgene alternative splicing isoforms for
H2AFY2

Expression for H2AFY2 Gene

mRNA expression in normal human tissues for H2AFY2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for H2AFY2 Gene

SOURCE GeneReport for Unigene cluster for H2AFY2 Gene Hs.499953

genes like me logo Genes that share expressions with H2AFY2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for H2AFY2 Gene

Orthologs for H2AFY2 Gene

This gene was present in the common ancestor of animals.

Orthologs for H2AFY2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia H2AFY2 35
  • 99.46 (n)
  • 100 (a)
H2AFY2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia H2AFY2 35
  • 93.1 (n)
  • 99.73 (a)
H2AFY2 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia H2AFY2 35
  • 92.83 (n)
  • 99.19 (a)
H2AFY2 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia H2afy2 35
  • 90.23 (n)
  • 98.39 (a)
H2afy2 16
H2afy2 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia H2AFY2 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia H2AFY2 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia H2afy2 35
  • 90.77 (n)
  • 98.39 (a)
chicken
(Gallus gallus)
Aves H2AFY2 35
  • 80.11 (n)
  • 90.32 (a)
H2AFY2 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia H2AFY2 36
  • 87 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia h2afy2-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia h2afy2 35
  • 71.25 (n)
  • 78.98 (a)
Str.12885 35
zebrafish
(Danio rerio)
Actinopterygii h2afy2 35
  • 69.49 (n)
  • 73.77 (a)
h2afy2 36
  • 74 (a)
OneToMany
h2afy2 36
  • 74 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea htas-1 36
  • 39 (a)
OneToMany
Species with no ortholog for H2AFY2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for H2AFY2 Gene

ENSEMBL:
Gene Tree for H2AFY2 (if available)
TreeFam:
Gene Tree for H2AFY2 (if available)

Paralogs for H2AFY2 Gene

Paralogs for H2AFY2 Gene

genes like me logo Genes that share paralogs with H2AFY2: view

Variants for H2AFY2 Gene

Sequence variations from dbSNP and Humsavar for H2AFY2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1016255 -- 70,071,025(-) ataca(A/T)gcacg intron-variant
rs2011654 -- 70,059,709(-) GACCT(C/T)GTAGG intron-variant
rs2078414 -- 70,071,097(-) acacg(C/T)gcaca intron-variant
rs2172075 -- 70,070,282(+) AGCTG(C/T)ATCCC intron-variant
rs2271698 -- 70,109,007(-) TGCCG(C/T)GGGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for H2AFY2 Gene

Variant ID Type Subtype PubMed ID
esv32737 CNV Gain+Loss 17666407
nsv819142 CNV Gain 19587683

Relevant External Links for H2AFY2 Gene

HapMap Linkage Disequilibrium report
H2AFY2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for H2AFY2 Gene

Disorders for H2AFY2 Gene

Relevant External Links for H2AFY2

Genetic Association Database (GAD)
H2AFY2
Human Genome Epidemiology (HuGE) Navigator
H2AFY2
genes like me logo Genes that share disorders with H2AFY2: view

No data available for UniProtKB/Swiss-Prot for H2AFY2 Gene

Publications for H2AFY2 Gene

  1. Histone H2A variants and the inactive X chromosome: identification of a second macroH2A variant. (PMID: 11331621) Chadwick B.P. … Willard H.F. (Hum. Mol. Genet. 2001) 2 3 4 23
  2. MACROH2A2, a new member of the MACROH2A core histone family. (PMID: 11262398) Costanzi C. … Pehrson J.R. (J. Biol. Chem. 2001) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for H2AFY2 Gene

Sources for H2AFY2 Gene

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