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Aliases for HES6 Gene

Aliases for HES6 Gene

  • Hes Family BHLH Transcription Factor 6 2 3 5
  • Class B Basic Helix-Loop-Helix Protein 41 3 4
  • Hairy And Enhancer Of Split 6 3 4
  • C-HAIRY1 3 4
  • BHLHb41 3 4
  • Hairy And Enhancer Of Split 6 (Drosophila) 2
  • BHLHc23 3
  • HES-6 3

External Ids for HES6 Gene

Previous GeneCards Identifiers for HES6 Gene

  • GC02M237195
  • GC02M237828
  • GC02M239163
  • GC02M239433
  • GC02M238928
  • GC02M238812
  • GC02M230937
  • GC02M239166
  • GC02M239172
  • GC02M239187
  • GC02M239205

Summaries for HES6 Gene

Entrez Gene Summary for HES6 Gene

  • This gene encodes a member of a subfamily of basic helix-loop-helix transcription repressors that have homology to the Drosophila enhancer of split genes. Members of this gene family regulate cell differentiation in numerous cell types. The protein encoded by this gene functions as a cofactor, interacting with other transcription factors through a tetrapeptide domain in its C-terminus. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Dec 2008]

GeneCards Summary for HES6 Gene

HES6 (Hes Family BHLH Transcription Factor 6) is a Protein Coding gene. Among its related pathways are Notch signaling pathway (KEGG) and Notch-mediated HES/HEY network. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein dimerization activity. An important paralog of this gene is HES4.

UniProtKB/Swiss-Prot for HES6 Gene

  • Does not bind DNA itself but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell differentiation (By similarity).

Gene Wiki entry for HES6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HES6 Gene

Genomics for HES6 Gene

Regulatory Elements for HES6 Gene

Promoters for HES6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HES6 on UCSC Golden Path with GeneCards custom track

Genomic Location for HES6 Gene

Chromosome:
2
Start:
238,238,267 bp from pter
End:
238,240,662 bp from pter
Size:
2,396 bases
Orientation:
Minus strand

Genomic View for HES6 Gene

Genes around HES6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HES6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HES6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HES6 Gene

Proteins for HES6 Gene

  • Protein details for HES6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96HZ4-HES6_HUMAN
    Recommended name:
    Transcription cofactor HES-6
    Protein Accession:
    Q96HZ4
    Secondary Accessions:
    • A8KAP6
    • B8ZZA9
    • Q53SN9
    • Q8N2J2
    • Q96T93
    • Q9P2S3

    Protein attributes for HES6 Gene

    Size:
    224 amino acids
    Molecular mass:
    24129 Da
    Quaternary structure:
    • Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family. Interacts with HES1 (By similarity).

    Alternative splice isoforms for HES6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HES6 Gene

Proteomics data for HES6 Gene at MOPED

Post-translational modifications for HES6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for HES6 Gene

Domains & Families for HES6 Gene

Gene Families for HES6 Gene

Protein Domains for HES6 Gene

Suggested Antigen Peptide Sequences for HES6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96HZ4

UniProtKB/Swiss-Prot:

HES6_HUMAN :
  • The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.
Domain:
  • The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.
  • Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
  • Contains 1 bHLH (basic helix-loop-helix) domain.
  • Contains 1 Orange domain.
genes like me logo Genes that share domains with HES6: view

Function for HES6 Gene

Molecular function for HES6 Gene

UniProtKB/Swiss-Prot Function:
Does not bind DNA itself but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell differentiation (By similarity).

Gene Ontology (GO) - Molecular Function for HES6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA --
GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding IEA --
GO:0008134 transcription factor binding NAS 17611704
genes like me logo Genes that share ontologies with HES6: view
genes like me logo Genes that share phenotypes with HES6: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HES6 Gene

Localization for HES6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HES6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HES6 Gene COMPARTMENTS Subcellular localization image for HES6 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for HES6 Gene

Pathways & Interactions for HES6 Gene

genes like me logo Genes that share pathways with HES6: view

Pathways by source for HES6 Gene

SIGNOR curated interactions for HES6 Gene

Activates:

Gene Ontology (GO) - Biological Process for HES6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated TAS 10851137
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with HES6: view

Drugs & Compounds for HES6 Gene

No Compound Related Data Available

Transcripts for HES6 Gene

Unigene Clusters for HES6 Gene

Hairy and enhancer of split 6 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HES6 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b
SP1:
SP2:
SP3:

Relevant External Links for HES6 Gene

GeneLoc Exon Structure for
HES6
ECgene alternative splicing isoforms for
HES6

Expression for HES6 Gene

mRNA expression in normal human tissues for HES6 Gene

mRNA differential expression in normal tissues according to GTEx for HES6 Gene

This gene is overexpressed in Pituitary (x4.8).

Protein differential expression in normal tissues from HIPED for HES6 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HES6 Gene



SOURCE GeneReport for Unigene cluster for HES6 Gene Hs.42949

genes like me logo Genes that share expression patterns with HES6: view

Protein tissue co-expression partners for HES6 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for HES6 Gene

Orthologs for HES6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HES6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HES6 36
  • 87 (a)
OneToOne
HES6 35
  • 87.5 (n)
  • 87.05 (a)
dog
(Canis familiaris)
Mammalia HES6 35
  • 87.77 (n)
  • 90.53 (a)
HES6 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hes6 36
  • 86 (a)
OneToOne
Hes6 16
Hes6 35
  • 83.93 (n)
  • 85.71 (a)
oppossum
(Monodelphis domestica)
Mammalia HES6 36
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HES6 36
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hes6 35
  • 84.01 (n)
  • 86.87 (a)
chicken
(Gallus gallus)
Aves HES6 36
  • 26 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HES6 36
  • 58 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.209 35
tropical clawed frog
(Silurana tropicalis)
Amphibia hes6.1 35
  • 62.78 (n)
  • 60 (a)
Str.1144 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6961 35
zebrafish
(Danio rerio)
Actinopterygii her13 35
  • 56.71 (n)
  • 54.5 (a)
hes6 35
her13 36
  • 50 (a)
OneToMany
hes6 36
  • 52 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9097 36
  • 17 (a)
OneToOne
Species with no ortholog for HES6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HES6 Gene

ENSEMBL:
Gene Tree for HES6 (if available)
TreeFam:
Gene Tree for HES6 (if available)

Paralogs for HES6 Gene

Paralogs for HES6 Gene

(3) SIMAP similar genes for HES6 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with HES6: view

Variants for HES6 Gene

Sequence variations from dbSNP and Humsavar for HES6 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs3739061 - 238,238,849(+) CACTC(C/T)GGGCA reference, missense, utr-variant-3-prime
rs7240 -- 238,238,488(+) CCATT(C/T)CTGCC utr-variant-3-prime
rs1047589 -- 238,239,894(+) GCCGC(A/C/G)GGTGG reference, synonymous-codon
rs1047608 -- 238,239,952(+) GGACG(C/G)GGAGC utr-variant-5-prime
rs10469608 -- 238,238,780(+) GGAGA(C/T)CCAGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for HES6 Gene

Variant ID Type Subtype PubMed ID
nsv876067 CNV Loss 21882294
esv21505 CNV Loss 19812545

Variation tolerance for HES6 Gene

Gene Damage Index Score: 2.60; 45.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HES6 Gene

HapMap Linkage Disequilibrium report
HES6
Human Gene Mutation Database (HGMD)
HES6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HES6 Gene

Disorders for HES6 Gene

Relevant External Links for HES6

Genetic Association Database (GAD)
HES6
Human Genome Epidemiology (HuGE) Navigator
HES6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HES6

No disorders were found for HES6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HES6 Gene

Publications for HES6 Gene

  1. The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation. (PMID: 10851137) Bae S.-K. … Kageyama R. (Development 2000) 2 3 4 23 67
  2. Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer. (PMID: 17611704) Katoh M. … Katoh M. (Int. J. Oncol. 2007) 3 23
  3. Hes6 promotes cortical neurogenesis and inhibits Hes1 transcription repression activity by multiple mechanisms. (PMID: 12972610) Gratton M.O. … Stifani S. (Mol. Cell. Biol. 2003) 3 23
  4. Exploring the genetics of irritable bowel syndrome: a GWA study in the general population and replication in multinational case-control cohorts. (PMID: 25248455) Ek W.E. … D'Amato M. (Gut 2015) 3
  5. DOT1L-HES6 fusion drives androgen independent growth in prostate cancer. (PMID: 25006183) Annala M. … Nykter M. (EMBO Mol Med 2014) 3

Products for HES6 Gene

Sources for HES6 Gene

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