Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PREP Gene

Aliases for PREP Gene

  • Prolyl Endopeptidase 2 3 5
  • Post-Proline Cleaving Enzyme 3 4
  • EC 4 63
  • PEP 3 4
  • PE 3 4
  • DJ355L5.1 (Prolyl Endopeptidase) 3
  • Prolyl Oligopeptidase 3

External Ids for PREP Gene

Previous GeneCards Identifiers for PREP Gene

  • GC06M105561
  • GC06M105748
  • GC06M105771
  • GC06M105832
  • GC06M105725
  • GC06M103168

Summaries for PREP Gene

Entrez Gene Summary for PREP Gene

  • The protein encoded by this gene is a cytosolic prolyl endopeptidase that cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long. Prolyl endopeptidases have been reported to be involved in the maturation and degradation of peptide hormones and neuropeptides. [provided by RefSeq, Jul 2008]

GeneCards Summary for PREP Gene

PREP (Prolyl Endopeptidase) is a Protein Coding gene. Diseases associated with PREP include Diabetes Mellitus, Insulin-Dependent and Systemic Lupus Erythematosus. Among its related pathways are Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. GO annotations related to this gene include serine-type endopeptidase activity and serine-type exopeptidase activity. An important paralog of this gene is PREPL.

UniProtKB/Swiss-Prot for PREP Gene

  • Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long.

Gene Wiki entry for PREP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PREP Gene

Genomics for PREP Gene

Regulatory Elements for PREP Gene

Enhancers for PREP Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PREP on UCSC Golden Path with GeneCards custom track

Promoters for PREP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PREP on UCSC Golden Path with GeneCards custom track

Genomic Location for PREP Gene

105,277,565 bp from pter
105,403,124 bp from pter
125,560 bases
Minus strand

Genomic View for PREP Gene

Genes around PREP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PREP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PREP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PREP Gene

Proteins for PREP Gene

  • Protein details for PREP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Prolyl endopeptidase
    Protein Accession:
    Secondary Accessions:
    • Q8N6D4

    Protein attributes for PREP Gene

    710 amino acids
    Molecular mass:
    80700 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for PREP Gene

neXtProt entry for PREP Gene

Proteomics data for PREP Gene at MOPED

Post-translational modifications for PREP Gene

Other Protein References for PREP Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for PREP (Prolyl Oligopeptidase/PREP)

Domains & Families for PREP Gene

Suggested Antigen Peptide Sequences for PREP Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase S9A family.
  • Belongs to the peptidase S9A family.
genes like me logo Genes that share domains with PREP: view

No data available for Gene Families for PREP Gene

Function for PREP Gene

Molecular function for PREP Gene

GENATLAS Biochemistry:
prolyl oligopeptidase,alpha/beta hydrolase fold family
UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of Pro- -Xaa >> Ala- -Xaa in oligopeptides.
UniProtKB/Swiss-Prot Function:
Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long.

Enzyme Numbers (IUBMB) for PREP Gene

Gene Ontology (GO) - Molecular Function for PREP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008236 serine-type peptidase activity IEA,TAS 7959018
genes like me logo Genes that share ontologies with PREP: view
genes like me logo Genes that share phenotypes with PREP: view

Animal Models for PREP Gene

MGI Knock Outs for PREP:

Animal Model Products

miRNA for PREP Gene

miRTarBase miRNAs that target PREP

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PREP Gene

Localization for PREP Gene

Subcellular locations from UniProtKB/Swiss-Prot for PREP Gene


Subcellular locations from

Jensen Localization Image for PREP Gene COMPARTMENTS Subcellular localization image for PREP gene
Compartment Confidence
cytosol 4
nucleus 4
extracellular 2
lysosome 1
plasma membrane 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for PREP Gene

Pathways & Interactions for PREP Gene

genes like me logo Genes that share pathways with PREP: view

Pathways by source for PREP Gene

1 KEGG pathway for PREP Gene

Gene Ontology (GO) - Biological Process for PREP Gene


No data available for SIGNOR curated interactions for PREP Gene

Drugs & Compounds for PREP Gene

(27) Drugs for PREP Gene - From: DrugBank, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Oxytocin Approved Pharma Full agonist, Agonist, Enzyme, substrate Involved in uterine contraction and lactation 376
z-pro-prolinal Experimental Pharma Target 0
(6S)-1-chloro-3-[(4-fluorobenzyl)oxy]-6-(pyrrolidin-1-ylcarbonyl)pyrrolo[1,2-a]pyrazin-4(6H)-one Experimental Pharma Target 0
1-{3-oxo-3-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]propyl}-3-phenylquinoxalin-2(1H)-one Experimental Pharma Target 0
1-Hydroxy-1-Thio-Glycerol Experimental Pharma Target 0

(15) Additional Compounds for PREP Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PREP: view

Transcripts for PREP Gene

mRNA/cDNA for PREP Gene

Unigene Clusters for PREP Gene

Prolyl endopeptidase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PREP Gene

No ASD Table

Relevant External Links for PREP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PREP Gene

mRNA expression in normal human tissues for PREP Gene

mRNA differential expression in normal tissues according to GTEx for PREP Gene

This gene is overexpressed in Muscle - Skeletal (x4.6).

Protein differential expression in normal tissues from HIPED for PREP Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.6) and Lymph node (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PREP Gene

SOURCE GeneReport for Unigene cluster for PREP Gene Hs.436564

genes like me logo Genes that share expression patterns with PREP: view

Protein tissue co-expression partners for PREP Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for PREP Gene

Orthologs for PREP Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PREP Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PREP 35
  • 90.46 (n)
  • 95.49 (a)
  • 96 (a)
(Canis familiaris)
Mammalia PREP 35
  • 90.59 (n)
  • 96.69 (a)
  • 95 (a)
(Mus musculus)
Mammalia Prep 35
  • 88.29 (n)
  • 95.91 (a)
Prep 16
Prep 36
  • 96 (a)
(Pan troglodytes)
Mammalia PREP 35
  • 99.3 (n)
  • 99.58 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Prep 35
  • 87.12 (n)
  • 95.35 (a)
(Monodelphis domestica)
Mammalia PREP 36
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia PREP 36
  • 89 (a)
(Gallus gallus)
Aves PREP 35
  • 81.1 (n)
  • 90.41 (a)
  • 90 (a)
(Anolis carolinensis)
Reptilia PREP 36
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76255 35
prep 35
  • 76.74 (n)
  • 83.12 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14450 35
(Danio rerio)
Actinopterygii prep 35
  • 70.2 (n)
  • 76.13 (a)
prep 36
  • 76 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2528 37
  • 51 (a)
CG5355 37
  • 53 (a)
CG5355 35
  • 57.18 (n)
  • 55.19 (a)
CG2528 36
  • 50 (a)
CG5355 36
  • 51 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009172 35
  • 56.59 (n)
  • 55.01 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G76140 35
  • 60.17 (n)
  • 57.89 (a)
(Oryza sativa)
Liliopsida Os.15541 35
Os01g0108200 35
  • 57.66 (n)
  • 56.76 (a)
(Triticum aestivum)
Liliopsida Ta.21279 35
(Zea mays)
Liliopsida Zm.9529 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1572 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10320 36
  • 64 (a)
Species with no ortholog for PREP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • worm (Caenorhabditis elegans)

Evolution for PREP Gene

Gene Tree for PREP (if available)
Gene Tree for PREP (if available)

Paralogs for PREP Gene

Paralogs for PREP Gene

genes like me logo Genes that share paralogs with PREP: view

Variants for PREP Gene

Sequence variations from dbSNP and Humsavar for PREP Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_047790 -
VAR_047791 -
rs1028792 -- 105,363,124(-) TATCT(C/G)TTGTG intron-variant
rs1078725 -- 105,364,828(-) TGTCT(A/G)TGATG intron-variant
rs1078726 -- 105,364,765(-) TAGTT(C/T)GGTCt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PREP Gene

Variant ID Type Subtype PubMed ID
nsv886529 CNV Loss 21882294
esv7369 OTHER Inversion 19470904
esv28038 CNV Loss 19812545
nsv886530 CNV Loss 21882294

Variation tolerance for PREP Gene

Residual Variation Intolerance Score: 6.55% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.44; 94.30% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PREP Gene

Disorders for PREP Gene

MalaCards: The human disease database

(5) MalaCards diseases for PREP Gene - From: OMIM, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
diabetes mellitus, insulin-dependent
  • diabetes, type 1
systemic lupus erythematosus
  • lupus nephritis
rheumatoid arthritis
  • rheumatoid arthritis, progression of
celiac disease
  • celiac sprue
hemolytic anemia due to triosephosphate isomerase deficiency
  • triosephosphate isomerase deficiency
- elite association - COSMIC cancer census association via MalaCards
Search PREP in MalaCards View complete list of genes associated with diseases

Relevant External Links for PREP

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PREP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PREP Gene

Publications for PREP Gene

  1. Cloning and sequence analysis of the gene encoding human lymphocyte prolyl endopeptidase. (PMID: 7959018) Vanhoof G. … Scharpe S. (Gene 1994) 2 3 4 23 67
  2. A new side opening on prolyl oligopeptidase revealed by electron microscopy. (PMID: 19782684) TarragA^ T. … Giralt E. (FEBS Lett. 2009) 3 23
  3. No association between the PREP gene and lithium responsive bipolar disorder. (PMID: 17324276) Mamdani F. … Turecki G. (BMC Psychiatry 2007) 3 23
  4. Distribution of immunoreactive prolyl oligopeptidase in human and rat brain. (PMID: 17401647) MyAPhAonen T.T. … MAonnistAP P.T. (Neurochem. Res. 2007) 3 23
  5. Deficient activity of mammalian prolyl oligopeptidase on the immunoactive peptide digestion in coeliac disease. (PMID: 17454876) Garcia-Horsman J.A. … MAonnistAP P.T. (Scand. J. Gastroenterol. 2007) 3 23

Products for PREP Gene

Sources for PREP Gene