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Aliases for PREP Gene

Aliases for PREP Gene

  • Prolyl Endopeptidase 2 3
  • Post-Proline Cleaving Enzyme 3 4
  • EC 4 63
  • PEP 3 4
  • PE 3 4
  • DJ355L5.1 (Prolyl Endopeptidase) 3
  • Prolyl Oligopeptidase 3

External Ids for PREP Gene

Previous GeneCards Identifiers for PREP Gene

  • GC06M105561
  • GC06M105748
  • GC06M105771
  • GC06M105832
  • GC06M105725
  • GC06M103168

Summaries for PREP Gene

Entrez Gene Summary for PREP Gene

  • The protein encoded by this gene is a cytosolic prolyl endopeptidase that cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long. Prolyl endopeptidases have been reported to be involved in the maturation and degradation of peptide hormones and neuropeptides. [provided by RefSeq, Jul 2008]

GeneCards Summary for PREP Gene

PREP (Prolyl Endopeptidase) is a Protein Coding gene. Diseases associated with PREP include amnestic disorder and trypanosomiasis. GO annotations related to this gene include serine-type endopeptidase activity and serine-type exopeptidase activity. An important paralog of this gene is PREPL.

UniProtKB/Swiss-Prot for PREP Gene

  • Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long

Gene Wiki entry for PREP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PREP Gene

Genomics for PREP Gene

Regulatory Elements for PREP Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PREP Gene

105,277,565 bp from pter
105,403,124 bp from pter
125,560 bases
Minus strand

Genomic View for PREP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PREP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PREP Gene

Proteins for PREP Gene

  • Protein details for PREP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Prolyl endopeptidase
    Protein Accession:
    Secondary Accessions:
    • Q8N6D4

    Protein attributes for PREP Gene

    710 amino acids
    Molecular mass:
    80700 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for PREP Gene

neXtProt entry for PREP Gene

Proteomics data for PREP Gene at MOPED

Post-translational modifications for PREP Gene

Other Protein References for PREP Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for PREP (Prolyl Oligopeptidase/PREP)

Protein Products

Domains for PREP Gene

Suggested Antigen Peptide Sequences for PREP Gene

Graphical View of Domain Structure for InterPro Entry



  • P48147
  • Belongs to the peptidase S9A family.
genes like me logo Genes that share domains with PREP: view

No data available for Gene Families for PREP Gene

Function for PREP Gene

Molecular function for PREP Gene

GENATLAS Biochemistry: prolyl oligopeptidase,alpha/beta hydrolase fold family
UniProtKB/Swiss-Prot CatalyticActivity: Hydrolysis of Pro- -Xaa >> Ala- -Xaa in oligopeptides
UniProtKB/Swiss-Prot Function: Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long

Enzyme Numbers (IUBMB) for PREP Gene

Gene Ontology (GO) - Molecular Function for PREP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IEA --
GO:0005515 protein binding IPI 23348613
GO:0008236 serine-type peptidase activity TAS 7959018
GO:0070008 serine-type exopeptidase activity IEA --
genes like me logo Genes that share ontologies with PREP: view
genes like me logo Genes that share phenotypes with PREP: view

Animal Model Products

CRISPR Products

miRNA for PREP Gene

miRTarBase miRNAs that target PREP

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for PREP Gene

Localization for PREP Gene

Subcellular locations from UniProtKB/Swiss-Prot for PREP Gene


Subcellular locations from

Jensen Localization Image for PREP Gene COMPARTMENTS Subcellular localization image for PREP gene
Compartment Confidence
cytosol 2
extracellular 2
nucleus 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PREP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with PREP: view

Pathways for PREP Gene

SuperPathways for PREP Gene

No Data Available

Gene Ontology (GO) - Biological Process for PREP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with PREP: view

No data available for Pathways by source for PREP Gene

Compounds for PREP Gene

(3) HMDB Compounds for PREP Gene

Compound Synonyms Cas Number PubMed IDs
Arginine vasopressin 1-8
  • Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg
  • (Arg8)-Vasopressin
Oxytocin 1-8
  • Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu
Not Available

(33) Novoseek inferred chemical compound relationships for PREP Gene

Compound -log(P) Hits PubMed IDs
poststatin 92.2 12
z-pro-prolinal 91.1 7
proline 75 31
serine 72.2 65
gluten 66.8 9
genes like me logo Genes that share compounds with PREP: view

Transcripts for PREP Gene

mRNA/cDNA for PREP Gene

Unigene Clusters for PREP Gene

Prolyl endopeptidase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PREP

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PREP Gene

No ASD Table

Relevant External Links for PREP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PREP Gene

mRNA expression in normal human tissues for PREP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PREP Gene

This gene is overexpressed in Muscle - Skeletal (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PREP Gene

SOURCE GeneReport for Unigene cluster for PREP Gene Hs.436564

genes like me logo Genes that share expressions with PREP: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for PREP Gene

Orthologs for PREP Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PREP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PREP 35
  • 99.3 (n)
  • 99.58 (a)
  • 100 (a)
(Bos Taurus)
Mammalia PREP 35
  • 90.46 (n)
  • 95.49 (a)
  • 96 (a)
(Canis familiaris)
Mammalia PREP 35
  • 90.59 (n)
  • 96.69 (a)
  • 95 (a)
(Mus musculus)
Mammalia Prep 35
  • 88.29 (n)
  • 95.91 (a)
Prep 16
Prep 36
  • 96 (a)
(Monodelphis domestica)
Mammalia PREP 36
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia PREP 36
  • 89 (a)
(Rattus norvegicus)
Mammalia Prep 35
  • 87.12 (n)
  • 95.35 (a)
(Gallus gallus)
Aves PREP 35
  • 81.1 (n)
  • 90.41 (a)
  • 90 (a)
(Anolis carolinensis)
Reptilia PREP 36
  • 87 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14450 35
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76255 35
prep 35
  • 76.74 (n)
  • 83.12 (a)
(Danio rerio)
Actinopterygii prep 35
  • 70.2 (n)
  • 76.13 (a)
prep 36
  • 76 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009172 35
  • 56.59 (n)
  • 55.01 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2528 36
  • 50 (a)
CG5355 35
  • 57.18 (n)
  • 55.19 (a)
CG5355 36
  • 51 (a)
CG2528 37
  • 51 (a)
CG5355 37
  • 53 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G76140 35
  • 60.17 (n)
  • 57.89 (a)
(Zea mays)
Liliopsida Zm.9529 35
(Oryza sativa)
Liliopsida Os.15541 35
Os01g0108200 35
  • 57.66 (n)
  • 56.76 (a)
(Triticum aestivum)
Liliopsida Ta.21279 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1572 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10320 36
  • 64 (a)
Species with no ortholog for PREP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • worm (Caenorhabditis elegans)

Evolution for PREP Gene

Gene Tree for PREP (if available)
Gene Tree for PREP (if available)

Paralogs for PREP Gene

Paralogs for PREP Gene

genes like me logo Genes that share paralogs with PREP: view

Variants for PREP Gene

Sequence variations from dbSNP and Humsavar for PREP Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs11883 -- 105,322,311(-) ATAAT(C/G)TATTT intron-variant, utr-variant-3-prime
rs14289 -- 105,322,299(-) TTTCA(A/T)TCAAC intron-variant, utr-variant-3-prime
rs716490 -- 105,369,603(+) acaac(A/G)gacaa intron-variant
rs717324 -- 105,369,503(+) GCCAA(C/T)ACAAT intron-variant
rs720225 -- 105,394,455(-) CTCAC(A/T)GATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PREP Gene

Variant ID Type Subtype PubMed ID
nsv886529 CNV Loss 21882294
esv7369 OTHER Inversion 19470904
esv28038 CNV Loss 19812545
nsv886530 CNV Loss 21882294

Relevant External Links for PREP Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PREP Gene

Disorders for PREP Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for PREP Gene including...

Search for PREP Gene in MalaCards »

(2) University of Copenhagen DISEASES for PREP Gene

(15) Novoseek inferred disease relationships for PREP Gene

Disease -log(P) Hits PubMed IDs
celiac disease 65.9 10
memory disorders 50.8 3
amnesia 43.5 2
trypanosomiasis 40.8 1
alzheimers disease 34.3 5

Relevant External Links for PREP

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with PREP: view

No data available for UniProtKB/Swiss-Prot for PREP Gene

Publications for PREP Gene

  1. Cloning and sequence analysis of the gene encoding human lymphocyte prolyl endopeptidase. (PMID: 7959018) Vanhoof G. … Scharpe S. (Gene 1994) 2 3 4 23
  2. Molecular cloning and characterization of prolyl endopeptidase from human T cells. (PMID: 8089089) Shirasawa Y. … Hirashima A. (J. Biochem. 1994) 3 4 23
  3. The purification, characterization and analysis of primary and secondary-structure of prolyl oligopeptidase from human lymphocytes. Evidence that the enzyme belongs to the alpha/beta hydrolase fold family. (PMID: 7588785) Goossens F. … Scharpe S. (Eur. J. Biochem. 1995) 3 4 23
  4. No association between the PREP gene and lithium responsive bipolar disorder. (PMID: 17324276) Mamdani F. … Turecki G. (BMC Psychiatry 2007) 3 23 48
  5. Distribution of immunoreactive prolyl oligopeptidase in human and rat brain. (PMID: 17401647) MyAPhAonen T.T. … MAonnistAP P.T. (Neurochem. Res. 2007) 3 23

Products for PREP Gene

Sources for PREP Gene

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