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Aliases for AP1AR Gene

Aliases for AP1AR Gene

  • Adaptor-Related Protein Complex 1 Associated Regulatory Protein 2 3
  • C4orf16 3 4 6
  • 2C18 3 4 6
  • GBAR 3 4 6
  • Adaptor-Related Protein Complex 1-Associated Regulatory Protein 3 4
  • Gamma-1-Adaptin Brefeldin A Resistance Protein 3 4
  • Gamma-A1-Adaptin And Kinesin Interactor 3 4
  • Gamma-BAR 3 4
  • Gadkin 3 4
  • Adapter-Related Protein Complex 1-Associated Regulatory Protein 3
  • Gamma1-Adaptin Brefeldin A Resistance Protein, Gamma-BAR 3
  • AP-1 Complex-Associated Regulatory Protein 3
  • Gamma1-Adaptin Brefeldin A Resistance 2
  • Chromosome 4 Open Reading Frame 16 2
  • PRO0971 3

External Ids for AP1AR Gene

Previous HGNC Symbols for AP1AR Gene

  • C4orf16

Previous GeneCards Identifiers for AP1AR Gene

  • GC04P113373
  • GC04P113153
  • GC04P108884

Summaries for AP1AR Gene

GeneCards Summary for AP1AR Gene

AP1AR (Adaptor-Related Protein Complex 1 Associated Regulatory Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for AP1AR Gene

  • Necessary for adaptor protein complex 1 (AP-1)-dependent transport between the trans-Golgi network and endosomes. Regulates the membrane association of AP1G1/gamma1-adaptin, one of the subunits of the AP-1 adaptor complex. The direct interaction with AP1G1/gamma1-adaptin attenuates the release of the AP-1 complex from membranes. Regulates endosomal membrane traffic via association with AP-1 and KIF5B thus linking kinesin-based plus-end-directed microtubular transport to AP-1-dependent membrane traffic. May act as effector of AP-1 in calcium-induced endo-lysosome secretion. Inhibits Arp2/3 complex function; negatively regulates cell spreading, size and motility via intracellular sequestration of the Arp2/3 complex.

Gene Wiki entry for AP1AR Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AP1AR Gene

Genomics for AP1AR Gene

Genomic Location for AP1AR Gene

Start:
112,231,737 bp from pter
End:
112,270,055 bp from pter
Size:
38,319 bases
Orientation:
Plus strand

Genomic View for AP1AR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AP1AR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AP1AR Gene

No data available for Regulatory Elements for AP1AR Gene

Proteins for AP1AR Gene

  • Protein details for AP1AR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q63HQ0-AP1AR_HUMAN
    Recommended name:
    AP-1 complex-associated regulatory protein
    Protein Accession:
    Q63HQ0
    Secondary Accessions:
    • B2RCV7
    • Q96GG6
    • Q9H0V0
    • Q9P1L4

    Protein attributes for AP1AR Gene

    Size:
    302 amino acids
    Molecular mass:
    34280 Da
    Quaternary structure:
    • Interacts (via coiled-coil domain) with AP1G1 (via GAE domain). Interacts with KIF5B. Associates with the Arp2/3 complex.
    SequenceCaution:
    • Sequence=AAF71037.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for AP1AR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AP1AR Gene

Proteomics data for AP1AR Gene at MOPED

Post-translational modifications for AP1AR Gene

Other Protein References for AP1AR Gene

No data available for DME Specific Peptides for AP1AR Gene

Domains for AP1AR Gene

Protein Domains for AP1AR Gene

ProtoNet:

Suggested Antigen Peptide Sequences for AP1AR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with AP1AR: view

No data available for Gene Families and UniProtKB/Swiss-Prot for AP1AR Gene

Function for AP1AR Gene

Molecular function for AP1AR Gene

UniProtKB/Swiss-Prot Function: Necessary for adaptor protein complex 1 (AP-1)-dependent transport between the trans-Golgi network and endosomes. Regulates the membrane association of AP1G1/gamma1-adaptin, one of the subunits of the AP-1 adaptor complex. The direct interaction with AP1G1/gamma1-adaptin attenuates the release of the AP-1 complex from membranes. Regulates endosomal membrane traffic via association with AP-1 and KIF5B thus linking kinesin-based plus-end-directed microtubular transport to AP-1-dependent membrane traffic. May act as effector of AP-1 in calcium-induced endo-lysosome secretion. Inhibits Arp2/3 complex function; negatively regulates cell spreading, size and motility via intracellular sequestration of the Arp2/3 complex.

Gene Ontology (GO) - Molecular Function for AP1AR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019894 kinesin binding IDA 19706427
GO:0035650 AP-1 adaptor complex binding IDA 19706427
genes like me logo Genes that share ontologies with AP1AR: view

Phenotypes for AP1AR Gene

MGI mutant phenotypes for AP1AR:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with AP1AR: view

Animal Models for AP1AR Gene

MGI Knock Outs for AP1AR:

miRNA for AP1AR Gene

miRTarBase miRNAs that target AP1AR

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for AP1AR Gene

Localization for AP1AR Gene

Subcellular locations from UniProtKB/Swiss-Prot for AP1AR Gene

Golgi apparatus, trans-Golgi network. Late endosome. Early endosome. Note=Localizes to the juxta-nuclear Golgi region and to tubular structures throughout the cytoplasm, which are highly mobile and cycle between the juxta-nuclear area and the cell periphery.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AP1AR Gene COMPARTMENTS Subcellular localization image for AP1AR gene
Compartment Confidence
endosome 5
golgi apparatus 4
nucleus 4
cytosol 3
mitochondrion 2
chloroplast 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for AP1AR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus --
GO:0005737 cytoplasm --
GO:0005768 endosome --
GO:0005769 early endosome IEA --
GO:0005770 late endosome IEA --
genes like me logo Genes that share ontologies with AP1AR: view

Pathways for AP1AR Gene

SuperPathways for AP1AR Gene

No Data Available

Interacting Proteins for AP1AR Gene

Gene Ontology (GO) - Biological Process for AP1AR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001920 negative regulation of receptor recycling IMP 19706427
GO:0015031 protein transport IEA --
GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation IEA --
GO:0034613 cellular protein localization IEA --
GO:0048203 vesicle targeting, trans-Golgi to endosome IDA 19706427
genes like me logo Genes that share ontologies with AP1AR: view

No data available for Pathways by source for AP1AR Gene

Transcripts for AP1AR Gene

Unigene Clusters for AP1AR Gene

Adaptor-related protein complex 1 associated regulatory protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AP1AR Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: - -
SP2: - - -
SP3: -
SP4:
SP5:

Relevant External Links for AP1AR Gene

GeneLoc Exon Structure for
AP1AR
ECgene alternative splicing isoforms for
AP1AR

Expression for AP1AR Gene

mRNA expression in normal human tissues for AP1AR Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for AP1AR Gene

SOURCE GeneReport for Unigene cluster for AP1AR Gene Hs.435991

genes like me logo Genes that share expressions with AP1AR: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for AP1AR Gene

Orthologs for AP1AR Gene

This gene was present in the common ancestor of chordates.

Orthologs for AP1AR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AP1AR 35
  • 99.67 (n)
  • 99.67 (a)
AP1AR 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AP1AR 35
  • 94.59 (n)
  • 94.04 (a)
MGC155012 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AP1AR 35
  • 94.81 (n)
  • 96.69 (a)
AP1AR 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ap1ar 35
  • 84 (n)
  • 91.28 (a)
Ap1ar 16
Ap1ar 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 88 (a)
OneToMany
-- 36
  • 88 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 66 (a)
OneToMany
-- 36
  • 86 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ap1ar 35
  • 85.89 (n)
  • 91.33 (a)
chicken
(Gallus gallus)
Aves AP1AR 35
  • 81.99 (n)
  • 84.56 (a)
AP1AR 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AP1AR 36
  • 79 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.11377 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ap1ar 35
  • 74.73 (n)
  • 75.81 (a)
Str.1425 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9297 35
zebrafish
(Danio rerio)
Actinopterygii CABZ01003022.1 36
  • 57 (a)
OneToOne
LOC100332265 35
  • 61.17 (n)
  • 58.76 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
OneToOne
Species with no ortholog for AP1AR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AP1AR Gene

ENSEMBL:
Gene Tree for AP1AR (if available)
TreeFam:
Gene Tree for AP1AR (if available)

Paralogs for AP1AR Gene

No data available for Paralogs for AP1AR Gene

Variants for AP1AR Gene

Sequence variations from dbSNP and Humsavar for AP1AR Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs1521476 -- 112,264,393(+) TACAC(A/T)GACAC intron-variant
rs1915698 -- 112,241,091(+) TTTTT(A/C)AACCC intron-variant
rs1980267 -- 112,232,302(-) GTCTG(C/T)TAAGC intron-variant
rs2280498 -- 112,231,399(-) GAGTC(C/G)CAGGC upstream-variant-2KB
rs2280499 -- 112,231,334(-) TAATA(C/T)TGCAC upstream-variant-2KB

Relevant External Links for AP1AR Gene

HapMap Linkage Disequilibrium report
AP1AR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for AP1AR Gene

Disorders for AP1AR Gene

Relevant External Links for AP1AR

Genetic Association Database (GAD)
AP1AR
Human Genome Epidemiology (HuGE) Navigator
AP1AR
genes like me logo Genes that share disorders with AP1AR: view

No data available for UniProtKB/Swiss-Prot for AP1AR Gene

Publications for AP1AR Gene

  1. Gamma-BAR, a novel AP-1-interacting protein involved in post-Golgi trafficking. (PMID: 15775984) Neubrand V.E. … Simpson J.C. (EMBO J. 2005) 2 3 4
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  4. Regulation of endosomal membrane traffic by a Gadkin/AP-1/kinesin KIF5 complex. (PMID: 19706427) Schmidt M.R. … Haucke V. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 4
  5. A novel subtype of AP-1-binding motif within the palmitoylated trans-Golgi network/endosomal accessory protein Gadkin/gamma-BAR. (PMID: 19965873) Maritzen T. … Haucke V. (J. Biol. Chem. 2010) 3 4

Products for AP1AR Gene

Sources for AP1AR Gene

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