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Aliases for AP1AR Gene

Aliases for AP1AR Gene

  • Adaptor Related Protein Complex 1 Associated Regulatory Protein 2 3 5
  • Adaptor-Related Protein Complex 1 Associated Regulatory Protein 2 3
  • Adaptor-Related Protein Complex 1-Associated Regulatory Protein 3 4
  • Gamma-1-Adaptin Brefeldin A Resistance Protein 3 4
  • Gamma-A1-Adaptin And Kinesin Interactor 3 4
  • Gamma-BAR 3 4
  • C4orf16 3 4
  • Gadkin 3 4
  • 2C18 3 4
  • GBAR 3 4
  • Adapter-Related Protein Complex 1-Associated Regulatory Protein 3
  • Gamma1-Adaptin Brefeldin A Resistance Protein, Gamma-BAR 3
  • Gamma1-Adaptin Brefeldin A Resistance 2
  • Chromosome 4 Open Reading Frame 16 2
  • PRO0971 3

External Ids for AP1AR Gene

Previous HGNC Symbols for AP1AR Gene

  • C4orf16

Previous GeneCards Identifiers for AP1AR Gene

  • GC04P113373
  • GC04P113153
  • GC04P108884

Summaries for AP1AR Gene

GeneCards Summary for AP1AR Gene

AP1AR (Adaptor Related Protein Complex 1 Associated Regulatory Protein) is a Protein Coding gene. Diseases associated with AP1AR include gliosarcoma. GO annotations related to this gene include kinesin binding and AP-1 adaptor complex binding.

UniProtKB/Swiss-Prot for AP1AR Gene

  • Necessary for adaptor protein complex 1 (AP-1)-dependent transport between the trans-Golgi network and endosomes. Regulates the membrane association of AP1G1/gamma1-adaptin, one of the subunits of the AP-1 adaptor complex. The direct interaction with AP1G1/gamma1-adaptin attenuates the release of the AP-1 complex from membranes. Regulates endosomal membrane traffic via association with AP-1 and KIF5B thus linking kinesin-based plus-end-directed microtubular transport to AP-1-dependent membrane traffic. May act as effector of AP-1 in calcium-induced endo-lysosome secretion. Inhibits Arp2/3 complex function; negatively regulates cell spreading, size and motility via intracellular sequestration of the Arp2/3 complex.

Gene Wiki entry for AP1AR Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AP1AR Gene

Genomics for AP1AR Gene

Regulatory Elements for AP1AR Gene

Promoters for AP1AR Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around AP1AR on UCSC Golden Path with GeneCards custom track

Genomic Location for AP1AR Gene

Chromosome:
4
Start:
112,231,737 bp from pter
End:
112,272,715 bp from pter
Size:
40,979 bases
Orientation:
Plus strand

Genomic View for AP1AR Gene

Genes around AP1AR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AP1AR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AP1AR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AP1AR Gene

Proteins for AP1AR Gene

  • Protein details for AP1AR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q63HQ0-AP1AR_HUMAN
    Recommended name:
    AP-1 complex-associated regulatory protein
    Protein Accession:
    Q63HQ0
    Secondary Accessions:
    • B2RCV7
    • Q96GG6
    • Q9H0V0
    • Q9P1L4

    Protein attributes for AP1AR Gene

    Size:
    302 amino acids
    Molecular mass:
    34280 Da
    Quaternary structure:
    • Interacts (via coiled-coil domain) with AP1G1 (via GAE domain). Interacts with KIF5B. Associates with the Arp2/3 complex.
    SequenceCaution:
    • Sequence=AAF71037.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for AP1AR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AP1AR Gene

Proteomics data for AP1AR Gene at MOPED

Post-translational modifications for AP1AR Gene

Other Protein References for AP1AR Gene

Antibody Products

No data available for DME Specific Peptides for AP1AR Gene

Domains & Families for AP1AR Gene

Protein Domains for AP1AR Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for AP1AR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with AP1AR: view

No data available for Gene Families and UniProtKB/Swiss-Prot for AP1AR Gene

Function for AP1AR Gene

Molecular function for AP1AR Gene

UniProtKB/Swiss-Prot Function:
Necessary for adaptor protein complex 1 (AP-1)-dependent transport between the trans-Golgi network and endosomes. Regulates the membrane association of AP1G1/gamma1-adaptin, one of the subunits of the AP-1 adaptor complex. The direct interaction with AP1G1/gamma1-adaptin attenuates the release of the AP-1 complex from membranes. Regulates endosomal membrane traffic via association with AP-1 and KIF5B thus linking kinesin-based plus-end-directed microtubular transport to AP-1-dependent membrane traffic. May act as effector of AP-1 in calcium-induced endo-lysosome secretion. Inhibits Arp2/3 complex function; negatively regulates cell spreading, size and motility via intracellular sequestration of the Arp2/3 complex.

Phenotypes for AP1AR Gene

genes like me logo Genes that share phenotypes with AP1AR: view

Animal Models for AP1AR Gene

MGI Knock Outs for AP1AR:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for AP1AR Gene

Localization for AP1AR Gene

Subcellular locations from UniProtKB/Swiss-Prot for AP1AR Gene

Golgi apparatus, trans-Golgi network. Late endosome. Early endosome. Note=Localizes to the juxta-nuclear Golgi region and to tubular structures throughout the cytoplasm, which are highly mobile and cycle between the juxta-nuclear area and the cell periphery.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AP1AR Gene COMPARTMENTS Subcellular localization image for AP1AR gene
Compartment Confidence
endosome 5
golgi apparatus 5
mitochondrion 2
nucleus 2
peroxisome 2
chloroplast 1
cytosol 1
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for AP1AR Gene

Pathways & Interactions for AP1AR Gene

SuperPathways for AP1AR Gene

No Data Available

Interacting Proteins for AP1AR Gene

Gene Ontology (GO) - Biological Process for AP1AR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:2000146 negative regulation of cell motility IEA --
genes like me logo Genes that share ontologies with AP1AR: view

No data available for Pathways by source and SIGNOR curated interactions for AP1AR Gene

Drugs & Compounds for AP1AR Gene

No Compound Related Data Available

Transcripts for AP1AR Gene

Unigene Clusters for AP1AR Gene

Adaptor-related protein complex 1 associated regulatory protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AP1AR Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: - -
SP2: - - -
SP3: -
SP4:
SP5:

Relevant External Links for AP1AR Gene

GeneLoc Exon Structure for
AP1AR
ECgene alternative splicing isoforms for
AP1AR

Expression for AP1AR Gene

mRNA expression in normal human tissues for AP1AR Gene

Protein differential expression in normal tissues from HIPED for AP1AR Gene

This gene is overexpressed in Testis (50.4) and Blymphocyte (18.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for AP1AR Gene



SOURCE GeneReport for Unigene cluster for AP1AR Gene Hs.435991

genes like me logo Genes that share expression patterns with AP1AR: view

Protein tissue co-expression partners for AP1AR Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for AP1AR Gene

Orthologs for AP1AR Gene

This gene was present in the common ancestor of chordates.

Orthologs for AP1AR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AP1AR 35
  • 99.67 (n)
  • 99.67 (a)
AP1AR 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MGC155012 36
  • 94 (a)
OneToOne
AP1AR 35
  • 94.59 (n)
  • 94.04 (a)
dog
(Canis familiaris)
Mammalia AP1AR 35
  • 94.81 (n)
  • 96.69 (a)
AP1AR 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ap1ar 36
  • 91 (a)
OneToOne
Ap1ar 16
Ap1ar 35
  • 84 (n)
  • 91.28 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 88 (a)
OneToMany
-- 36
  • 88 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 66 (a)
OneToMany
-- 36
  • 86 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ap1ar 35
  • 85.89 (n)
  • 91.33 (a)
chicken
(Gallus gallus)
Aves AP1AR 36
  • 84 (a)
OneToOne
AP1AR 35
  • 81.99 (n)
  • 84.56 (a)
lizard
(Anolis carolinensis)
Reptilia AP1AR 36
  • 79 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.11377 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ap1ar 35
  • 74.73 (n)
  • 75.81 (a)
Str.1425 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9297 35
zebrafish
(Danio rerio)
Actinopterygii CABZ01003022.1 36
  • 57 (a)
OneToOne
LOC100332265 35
  • 61.17 (n)
  • 58.76 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
OneToOne
Species with no ortholog for AP1AR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AP1AR Gene

ENSEMBL:
Gene Tree for AP1AR (if available)
TreeFam:
Gene Tree for AP1AR (if available)

Paralogs for AP1AR Gene

No data available for Paralogs for AP1AR Gene

Variants for AP1AR Gene

Sequence variations from dbSNP and Humsavar for AP1AR Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs34900583 - 112,268,390(+) TGACA(C/T)AGATC reference, missense
rs1521476 -- 112,264,393(+) TACAC(A/T)GACAC intron-variant
rs2293110 -- 112,267,101(+) ATATT(A/G)GTATC intron-variant, downstream-variant-500B
rs1879611 -- 112,271,910(+) TTGAC(A/G)TTTAG utr-variant-3-prime
rs4833401 -- 112,273,008(+) TAATT(A/G)TCTGA downstream-variant-500B

Variation tolerance for AP1AR Gene

Residual Variation Intolerance Score: 49.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.63; 31.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AP1AR Gene

HapMap Linkage Disequilibrium report
AP1AR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for AP1AR Gene

Disorders for AP1AR Gene

MalaCards: The human disease database

(1) MalaCards diseases for AP1AR Gene - From: DISEASES

Disorder Aliases PubMed IDs
gliosarcoma
  • glioblastoma with sarcomatous component
- elite association - COSMIC cancer census association via MalaCards
Search AP1AR in MalaCards View complete list of genes associated with diseases

Relevant External Links for AP1AR

Genetic Association Database (GAD)
AP1AR
Human Genome Epidemiology (HuGE) Navigator
AP1AR
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AP1AR
genes like me logo Genes that share disorders with AP1AR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AP1AR Gene

Publications for AP1AR Gene

  1. Gamma-BAR, a novel AP-1-interacting protein involved in post-Golgi trafficking. (PMID: 15775984) Neubrand V.E. … Simpson J.C. (EMBO J. 2005) 2 3 4 67
  2. Gadkin negatively regulates cell spreading and motility via sequestration of the actin-nucleating ARP2/3 complex. (PMID: 22689987) Maritzen T. … Haucke V. (Proc. Natl. Acad. Sci. U.S.A. 2012) 3
  3. Role of AP1 and Gadkin in the traffic of secretory endo-lysosomes. (PMID: 21525240) Laulagnier K. … Gruenberg J. (Mol. Biol. Cell 2011) 3
  4. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PMID: 20332099) Kalsi G. … Riley B.P. (Hum. Mol. Genet. 2010) 3
  5. A novel subtype of AP-1-binding motif within the palmitoylated trans-Golgi network/endosomal accessory protein Gadkin/gamma-BAR. (PMID: 19965873) Maritzen T. … Haucke V. (J. Biol. Chem. 2010) 3

Products for AP1AR Gene

Sources for AP1AR Gene

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