Aliases for IMPACT Gene
External Ids for IMPACT Gene
Previous GeneCards Identifiers for IMPACT Gene
GeneCards Summary for IMPACT Gene
IMPACT (Impact RWD Domain Protein) is a Protein Coding gene.
UniProtKB/Swiss-Prot for IMPACT Gene
Translational regulator that ensures constant high levels of translation under amino acid starvation. Acts by interacting with GCN1/GCN1L1, thereby preventing activation of GCN2 protein kinases (EIF2AK1 to 4) and subsequent down-regulation of protein synthesis (By similarity). May be required to regulate translation in specific neuronal cells under amino acid starvation conditions by preventing GCN2 activation and therefore ATF4 synthesis (By similarity). Through its action on GCN2, may also facilitate neuritogenesis (By similarity).