Aliases for PLCXD1 Gene
External Ids for PLCXD1 Gene
Previous GeneCards Identifiers for PLCXD1 Gene
This gene is the most terminal protein-coding gene in the pseudoautosomal (PAR) region on chromosomes X and Y. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
GeneCards Summary for PLCXD1 Gene
PLCXD1 (Phosphatidylinositol-Specific Phospholipase C, X Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include phosphoric diester hydrolase activity. An important paralog of this gene is PLCXD2.
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. PLC is subdivided into beta, gamma, delta, epsilon, zeta and eta subtypes, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) to inositol 1,4,5-trisphosphate (IP3) and 1,2-diacylglycerol (DAG). IP3 and DAG both have important second messenger functions. PLC-beta is primarily activated by Gq/11 proteins and PLC-gamma is activated by phosphorylation in response to a variety of growth factor and immune system signals. Phospholipases are ubiquitously expressed and have diverse biological functions including roles in inflammation, cell growth, signaling and death and maintenance of membrane phospholipids.