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Aliases for PLCXD1 Gene

Aliases for PLCXD1 Gene

  • Phosphatidylinositol Specific Phospholipase C X Domain Containing 1 2 3 5
  • Phosphatidylinositol-Specific Phospholipase C, X Domain Containing 1 2
  • PI-PLC X Domain-Containing Protein 1 3
  • LL0XNC01-136G2.1 3

External Ids for PLCXD1 Gene

Previous GeneCards Identifiers for PLCXD1 Gene

  • GC0YP000133
  • GC0XP000132

Summaries for PLCXD1 Gene

Entrez Gene Summary for PLCXD1 Gene

  • This gene is the most terminal protein-coding gene in the pseudoautosomal (PAR) region on chromosomes X and Y. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

GeneCards Summary for PLCXD1 Gene

PLCXD1 (Phosphatidylinositol Specific Phospholipase C X Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include phosphoric diester hydrolase activity. An important paralog of this gene is PLCXD3.

Tocris Summary for PLCXD1 Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

Gene Wiki entry for PLCXD1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLCXD1 Gene

Genomics for PLCXD1 Gene

Regulatory Elements for PLCXD1 Gene

Enhancers for PLCXD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG000274 1 dbSUPER 0.7 -0.3 -264 2.5 PKNOX1 ATF1 MLX ARID4B GLI4 ZNF48 ETS1 ZNF121 GLIS2 FOS PLCXD1 ENSG00000228572
GH0XG000278 0.9 dbSUPER 0.7 +3.2 3203 1.8 HDAC1 TBP ARID4B DMAP1 TCF12 GATA4 THAP11 SP5 ZBTB2 NCOA1 PLCXD1 GTPBP6
GH0XG000261 1 Ensembl 0.4 -14.3 -14306 1.9 HNRNPUL1 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF48 SLC30A9 SP5 PPARG ENSG00000228572 PLCXD1
GH0XG000282 0.9 dbSUPER 0.4 +6.9 6890 0.7 HDAC1 HDGF TBP PKNOX1 ATF1 RB1 NFRKB E2F7 DEAF1 SIN3A PLCXD1 GTPBP6
GH0XG000281 0.9 dbSUPER 0.4 +5.5 5525 1.4 ARID4B SIN3A ZNF2 ELK1 KLF7 SP5 SSRP1 GLIS1 NBN KDM1A PLCXD1 GTPBP6
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PLCXD1 on UCSC Golden Path with GeneCards custom track

Promoters for PLCXD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000243687 278 1601 PKNOX1 ARID4B GLI4 ZNF48 ZNF121 GLIS2 FOS SP3 SP5 MXD4

Genomic Location for PLCXD1 Gene

Chromosome:
X
Start:
276,322 bp from pter
End:
303,356 bp from pter
Size:
27,035 bases
Orientation:
Plus strand

Genomic View for PLCXD1 Gene

Genes around PLCXD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLCXD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLCXD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLCXD1 Gene

Proteins for PLCXD1 Gene

  • Protein details for PLCXD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NUJ7-PLCX1_HUMAN
    Recommended name:
    PI-PLC X domain-containing protein 1
    Protein Accession:
    Q9NUJ7
    Secondary Accessions:
    • A2BH51
    • A2BH52

    Protein attributes for PLCXD1 Gene

    Size:
    323 amino acids
    Molecular mass:
    36668 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.
    SequenceCaution:
    • Sequence=CAM28359.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAM28360.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for PLCXD1 Gene

Post-translational modifications for PLCXD1 Gene

  • Ubiquitination at Lys227
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PLCXD1 Gene

Domains & Families for PLCXD1 Gene

Gene Families for PLCXD1 Gene

Protein Domains for PLCXD1 Gene

Suggested Antigen Peptide Sequences for PLCXD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PLCXD1: view

No data available for UniProtKB/Swiss-Prot for PLCXD1 Gene

Function for PLCXD1 Gene

Gene Ontology (GO) - Molecular Function for PLCXD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008081 phosphoric diester hydrolase activity IEA --
genes like me logo Genes that share ontologies with PLCXD1: view
genes like me logo Genes that share phenotypes with PLCXD1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PLCXD1

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PLCXD1 Gene

Localization for PLCXD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLCXD1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLCXD1 gene
Compartment Confidence
cytosol 3
extracellular 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for PLCXD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PLCXD1: view

Pathways & Interactions for PLCXD1 Gene

SuperPathways for PLCXD1 Gene

No Data Available

Interacting Proteins for PLCXD1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000371073%0d%0a9606.ENSP00000258960%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: Q9NUJ7-PLCX1_HUMAN ENSP00000371073 for PLCXD1 Gene via IID STRING

Gene Ontology (GO) - Biological Process for PLCXD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
genes like me logo Genes that share ontologies with PLCXD1: view

No data available for Pathways by source and SIGNOR curated interactions for PLCXD1 Gene

Drugs & Compounds for PLCXD1 Gene

(1) Drugs for PLCXD1 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
D609 Pharma PC-PLC inhibitor, Selective PC-PLC inhibitor 0

(381) Additional Compounds for PLCXD1 Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphatidylinositol-3,4,5-trisphosphate
  • 1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-bisphosphate)
  • 1-Phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
  • Phosphatidylinositol-3,4,5-trisphosphate
PI(16:0/16:0)
  • 1,2-Dihexadecanoyl-rac-glycero-3-phospho-(1'-myo-inositol)
  • 1,2-Dipalmitoyl-rac-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/16:0)
  • Phosphatidylinositol(32:0)
  • PI(16:0/16:0)
PI(16:0/16:1(9Z))
  • 1-Hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho-(1'-myo-inositol)
  • 1-Palmitoyl-2-palmitoleoyl-sn-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/16:1)
  • Phosphatidylinositol(16:0/16:1n7)
  • Phosphatidylinositol(16:0/16:1w7)
PI(16:0/16:2(9Z,12Z))
  • 1-Hexadecanoyl-2-(9Z,12Z-hexadecadienoate
  • 1-Hexadecanoyl-2-(9Z,12Z-hexadecadienoate)-sn-glycero-3-phospho-(1'-myo-inositol)
  • 1-Hexadecanoyl-2-(9Z,12Z-hexadecadienoic acid
  • 1-Palmitoyl-2-(9Z,12Z-hexadecadienoate
  • 1-Palmitoyl-2-(9Z,12Z-hexadecadienoate)-sn-glycero-3-phosphoinositol
PI(16:0/18:0)
  • 1-Hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-myo-inositol)
  • 1-Palmitoyl-2-stearoyl-sn-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/18:0)
  • Phosphatidylinositol(34:0)
  • PI(16:0/18:0)

(2) Tocris Compounds for PLCXD1 Gene

Compound Action Cas Number
o-3M3FBS Inactive analog of m-3M3FBS (Cat. No. 1941) 313981-55-4
U 73122 Phospholipase C inhibitor 112648-68-7

(1) ApexBio Compounds for PLCXD1 Gene

Compound Action Cas Number
D609 PC-PLC inhibitor 83373-60-8
genes like me logo Genes that share compounds with PLCXD1: view

Drug Products

Transcripts for PLCXD1 Gene

Unigene Clusters for PLCXD1 Gene

Phosphatidylinositol-specific phospholipase C, X domain containing 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLCXD1 Gene

No ASD Table

Relevant External Links for PLCXD1 Gene

GeneLoc Exon Structure for
PLCXD1
ECgene alternative splicing isoforms for
PLCXD1

Expression for PLCXD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PLCXD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of PLCXD1 Gene:

PLCXD1

SOURCE GeneReport for Unigene cluster for PLCXD1 Gene:

Hs.522568

mRNA Expression by UniProt/SwissProt for PLCXD1 Gene:

Q9NUJ7-PLCX1_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for PLCXD1 Gene

  • Skin(4.2)
genes like me logo Genes that share expression patterns with PLCXD1: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLCXD1 Gene

Orthologs for PLCXD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLCXD1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia PLCXD1 34 35
  • 82.85 (n)
cow
(Bos Taurus)
Mammalia PLCXD1 35
  • 80 (a)
OneToMany
-- 35
  • 67 (a)
OneToMany
-- 35
  • 65 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia PLCXD1 35
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100909600 34
  • 74.61 (n)
mouse
(Mus musculus)
Mammalia Plcxd1 35
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLCXD1 35
  • 33 (a)
OneToOne
chicken
(Gallus gallus)
Aves PLCXD1 34 35
  • 61.92 (n)
lizard
(Anolis carolinensis)
Reptilia PLCXD1 35
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia plcxd1 34
  • 55.52 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC563489 34
  • 55.56 (n)
PLCXD1 35
  • 47 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG10747 35
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F38E9.1 35
  • 13 (a)
OneToMany
Species where no ortholog for PLCXD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLCXD1 Gene

ENSEMBL:
Gene Tree for PLCXD1 (if available)
TreeFam:
Gene Tree for PLCXD1 (if available)

Paralogs for PLCXD1 Gene

Paralogs for PLCXD1 Gene

(2) SIMAP similar genes for PLCXD1 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for PLCXD1 Gene

genes like me logo Genes that share paralogs with PLCXD1: view

Variants for PLCXD1 Gene

Sequence variations from dbSNP and Humsavar for PLCXD1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000189182 -- 286,410(+) TAGAG(C/T)TGACC intron-variant
rs1000317355 -- 289,820(+) CAACC(A/C/G)CTTTC intron-variant
rs1000327520 -- 290,033(+) GCTTC(C/T)TGCAG intron-variant
rs1000481119 -- 300,688(+) TGTGT(A/G)TGTGT intron-variant, utr-variant-3-prime
rs1000568628 -- 303,258(+) CCCTG(A/G)CTTCC nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PLCXD1 Gene

Variant ID Type Subtype PubMed ID
dgv4187n106 CNV deletion 24896259
esv1006189 CNV deletion 20482838
esv2658490 CNV deletion 23128226
esv2663649 CNV deletion 23128226
esv27600 CNV gain+loss 19812545
esv2969346 CNV duplication 24192839
esv3382952 CNV duplication 20981092
nsv1075293 CNV deletion 25765185
nsv1076233 CNV deletion 25765185
nsv1077604 CNV duplication 25765185
nsv1125140 CNV duplication 24896259
nsv1132797 CNV duplication 24896259
nsv1137704 CNV deletion 24896259
nsv1140084 CNV duplication 24896259
nsv1147800 CNV duplication 26484159
nsv1153299 CNV duplication 26484159

Variation tolerance for PLCXD1 Gene

Residual Variation Intolerance Score: 27.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.71; 46.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLCXD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLCXD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLCXD1 Gene

Disorders for PLCXD1 Gene

Relevant External Links for PLCXD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLCXD1

No disorders were found for PLCXD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLCXD1 Gene

Publications for PLCXD1 Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. Cloning, tissue distribution and sub-cellular localisation of phospholipase C X-domain containing protein (PLCXD) isoforms. (PMID: 22732399) Gellatly S.A. … Cramb G. (Biochem. Biophys. Res. Commun. 2012) 4 64
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3 64

Products for PLCXD1 Gene

Sources for PLCXD1 Gene

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