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Aliases for PLCXD1 Gene

Aliases for PLCXD1 Gene

  • Phosphatidylinositol-Specific Phospholipase C, X Domain Containing 1 2 3
  • PI-PLC X Domain-Containing Protein 1 3
  • LL0XNC01-136G2.1 3

External Ids for PLCXD1 Gene

Previous GeneCards Identifiers for PLCXD1 Gene

  • GC0YP000133
  • GC0XP000132

Summaries for PLCXD1 Gene

Entrez Gene Summary for PLCXD1 Gene

  • This gene is the most terminal protein-coding gene in the pseudoautosomal (PAR) region on chromosomes X and Y. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

GeneCards Summary for PLCXD1 Gene

PLCXD1 (Phosphatidylinositol-Specific Phospholipase C, X Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include phosphoric diester hydrolase activity. An important paralog of this gene is PLCXD2.

Tocris Summary for PLCXD1 Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. PLC is subdivided into beta, gamma, delta, epsilon, zeta and eta subtypes, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) to inositol 1,4,5-trisphosphate (IP3) and 1,2-diacylglycerol (DAG). IP3 and DAG both have important second messenger functions. PLC-beta is primarily activated by Gq/11 proteins and PLC-gamma is activated by phosphorylation in response to a variety of growth factor and immune system signals. Phospholipases are ubiquitously expressed and have diverse biological functions including roles in inflammation, cell growth, signaling and death and maintenance of membrane phospholipids.

Gene Wiki entry for PLCXD1 Gene

No data available for UniProtKB/Swiss-Prot , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLCXD1 Gene

Genomics for PLCXD1 Gene

Regulatory Elements for PLCXD1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PLCXD1 Gene

276,322 bp from pter
303,356 bp from pter
27,035 bases
Plus strand

Genomic View for PLCXD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PLCXD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLCXD1 Gene

Proteins for PLCXD1 Gene

  • Protein details for PLCXD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    PI-PLC X domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • A2BH51
    • A2BH52

    Protein attributes for PLCXD1 Gene

    323 amino acids
    Molecular mass:
    36668 Da
    Quaternary structure:
    No Data Available
    • The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes
    • Sequence=CAM28359.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAM28360.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for PLCXD1 Gene

Proteomics data for PLCXD1 Gene at MOPED

Post-translational modifications for PLCXD1 Gene

  • Ubiquitination at Lys227
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for PLCXD1 Gene

Domains for PLCXD1 Gene

Gene Families for PLCXD1 Gene

Protein Domains for PLCXD1 Gene

Suggested Antigen Peptide Sequences for PLCXD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 PI-PLC X-box domain.
  • Contains 1 PI-PLC X-box domain.
genes like me logo Genes that share domains with PLCXD1: view

Function for PLCXD1 Gene

Gene Ontology (GO) - Molecular Function for PLCXD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008081 phosphoric diester hydrolase activity IEA --
genes like me logo Genes that share ontologies with PLCXD1: view

Phenotypes for PLCXD1 Gene

GenomeRNAi human phenotypes for PLCXD1:
genes like me logo Genes that share phenotypes with PLCXD1: view

Animal Model Products

miRNA for PLCXD1 Gene

miRTarBase miRNAs that target PLCXD1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PLCXD1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for PLCXD1 Gene

Localization for PLCXD1 Gene

Subcellular locations from

Jensen Localization Image for PLCXD1 Gene COMPARTMENTS Subcellular localization image for PLCXD1 gene
Compartment Confidence
cytosol 2
extracellular 1
mitochondrion 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PLCXD1 Gene

Pathways for PLCXD1 Gene

SuperPathways for PLCXD1 Gene

No Data Available

Interacting Proteins for PLCXD1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000371073 for PLCXD1 Gene via STRING

Gene Ontology (GO) - Biological Process for PLCXD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
genes like me logo Genes that share ontologies with PLCXD1: view

No data available for Pathways by source for PLCXD1 Gene

Drugs for PLCXD1 Gene

(5) Tocris Compounds for PLCXD1 Gene

Compound Action Cas Number
D609 Selective PC-PLC inhibitor [83373-60-8]
m-3M3FBS Phospholipase C activator [200933-14-8]
U 73343 Inactive analog of U 73122 (Cat. No. 1268) [142878-12-4]
VU 0155069 Potent and selective PLD1 inhibitor [1130067-06-9]
VU 0364739 hydrochloride Potent and selective PLD2 inhibitor [1244640-48-9]

(1) ApexBio Compounds for PLCXD1 Gene

Compound Action Cas Number
D609 PC-PLC inhibitor [83373-60-8]

(379) HMDB Compounds for PLCXD1 Gene

Compound Synonyms Cas Number PubMed IDs
  • 1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-bisphosphate)
  • 1,2-Dihexadecanoyl-rac-glycero-3-phospho-(1'-myo-inositol)
  • 1-Hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho-(1'-myo-inositol)
  • 1-Hexadecanoyl-2-(9Z,12Z-hexadecadienoate
  • 1-Hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-myo-inositol)
genes like me logo Genes that share compounds with PLCXD1: view

Transcripts for PLCXD1 Gene

Unigene Clusters for PLCXD1 Gene

Phosphatidylinositol-specific phospholipase C, X domain containing 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PLCXD1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLCXD1 Gene

No ASD Table

Relevant External Links for PLCXD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PLCXD1 Gene

mRNA expression in normal human tissues for PLCXD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for PLCXD1 Gene Hs.522568

genes like me logo Genes that share expressions with PLCXD1: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for PLCXD1 Gene

Orthologs for PLCXD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLCXD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia PLCXD1 35
  • 82.85 (n)
  • 84.31 (a)
  • 84 (a)
(Rattus norvegicus)
Mammalia LOC100909600 35
  • 74.61 (n)
  • 71.85 (a)
(Mus musculus)
Mammalia 403178 16
Plcxd1 36
  • 61 (a)
(Bos Taurus)
Mammalia -- 36
  • 65 (a)
-- 36
  • 67 (a)
  • 80 (a)
(Monodelphis domestica)
Mammalia PLCXD1 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia PLCXD1 36
  • 33 (a)
(Gallus gallus)
Aves PLCXD1 35
  • 61.92 (n)
  • 61.17 (a)
  • 56 (a)
(Anolis carolinensis)
Reptilia PLCXD1 36
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia plcxd1 35
  • 55.52 (n)
  • 50 (a)
(Danio rerio)
Actinopterygii LOC563489 35
  • 55.56 (n)
  • 51 (a)
  • 47 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10747 36
  • 26 (a)
(Caenorhabditis elegans)
Secernentea F38E9.1 36
  • 13 (a)
Species with no ortholog for PLCXD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLCXD1 Gene

Gene Tree for PLCXD1 (if available)
Gene Tree for PLCXD1 (if available)

Paralogs for PLCXD1 Gene

Paralogs for PLCXD1 Gene

(2) SIMAP similar genes for PLCXD1 Gene using alignment to 3 proteins: Pseudogenes for PLCXD1 Gene

genes like me logo Genes that share paralogs with PLCXD1: view

Variants for PLCXD1 Gene

Structural Variations from Database of Genomic Variants (DGV) for PLCXD1 Gene

Variant ID Type Subtype PubMed ID
esv27600 CNV Gain+Loss 19812545
esv2663649 CNV Deletion 23128226
esv2658490 CNV Deletion 23128226
esv1006189 CNV Deletion 20482838

Relevant External Links for PLCXD1 Gene

HapMap Linkage Disequilibrium report
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for PLCXD1 Gene

Disorders for PLCXD1 Gene

No disorders were found for PLCXD1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for PLCXD1 Gene

Publications for PLCXD1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for PLCXD1 Gene

Sources for PLCXD1 Gene

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