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Aliases for RNLS Gene

Aliases for RNLS Gene

  • Renalase, FAD-Dependent Amine Oxidase 2 3
  • C10orf59 3 4 6
  • Alpha-NAD(P)H Oxidase/Anomerase 3 4
  • Monoamine Oxidase-C 3 4
  • MAO-C 3 4
  • Chromosome 10 Open Reading Frame 59 2
  • EC 1.6.3.5 4
  • RENALASE 3

External Ids for RNLS Gene

Previous HGNC Symbols for RNLS Gene

  • C10orf59

Previous GeneCards Identifiers for RNLS Gene

  • GC10M090024
  • GC10M083668

Summaries for RNLS Gene

Entrez Gene Summary for RNLS Gene

  • Renalase is a flavin adenine dinucleotide-dependent amine oxidase that is secreted into the blood from the kidney (Xu et al., 2005 [PubMed 15841207]).[supplied by OMIM, Mar 2008]

GeneCards Summary for RNLS Gene

RNLS (Renalase, FAD-Dependent Amine Oxidase) is a Protein Coding gene. Among its related pathways are Phenylalanine metabolism. GO annotations related to this gene include oxidoreductase activity.

UniProtKB/Swiss-Prot for RNLS Gene

  • Catalyzes the oxidation of the less abundant alpha-NAD(P)H isoform to form beta-NAD(P)(+). The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis.

Gene Wiki entry for RNLS Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNLS Gene

Genomics for RNLS Gene

Regulatory Elements for RNLS Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RNLS Gene

Start:
88,273,864 bp from pter
End:
88,584,530 bp from pter
Size:
310,667 bases
Orientation:
Minus strand

Genomic View for RNLS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNLS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNLS Gene

Proteins for RNLS Gene

  • Protein details for RNLS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VYX0-RNLS_HUMAN
    Recommended name:
    Renalase
    Protein Accession:
    Q5VYX0
    Secondary Accessions:
    • Q9BS33
    • Q9NUP8

    Protein attributes for RNLS Gene

    Size:
    342 amino acids
    Molecular mass:
    37847 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RNLS Gene

    Alternative splice isoforms for RNLS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNLS Gene

Proteomics data for RNLS Gene at MOPED

Post-translational modifications for RNLS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RNLS Gene

Antibody Products

No data available for DME Specific Peptides for RNLS Gene

Domains for RNLS Gene

Protein Domains for RNLS Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for RNLS Gene

Graphical View of Domain Structure for InterPro Entry

Q5VYX0

UniProtKB/Swiss-Prot:

RNLS_HUMAN :
  • Q5VYX0
Family:
  • Belongs to the renalase family.
genes like me logo Genes that share domains with RNLS: view

No data available for Gene Families for RNLS Gene

Function for RNLS Gene

Molecular function for RNLS Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Alpha-NAD(P)H + O(2) = beta-NAD(P)(+) + H(2)O(2)
UniProtKB/Swiss-Prot Function:
Catalyzes the oxidation of the less abundant alpha-NAD(P)H isoform to form beta-NAD(P)(+). The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis.

Enzyme Numbers (IUBMB) for RNLS Gene

Gene Ontology (GO) - Molecular Function for RNLS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with RNLS: view
genes like me logo Genes that share phenotypes with RNLS: view

Animal Models for RNLS Gene

MGI Knock Outs for RNLS:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNLS

In Situ Assay Products

Flow Cytometry Products

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for RNLS Gene

Localization for RNLS Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNLS Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNLS Gene COMPARTMENTS Subcellular localization image for RNLS gene
Compartment Confidence
extracellular 5
peroxisome 2
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RNLS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with RNLS: view

Pathways for RNLS Gene

genes like me logo Genes that share pathways with RNLS: view

Pathways by source for RNLS Gene

1 BioSystems pathway for RNLS Gene

Interacting Proteins for RNLS Gene

Selected Interacting proteins: Q5VYX0-RNLS_HUMAN for RNLS Gene via I2D

Symbol External ID(s) Details
MAST1

Gene Ontology (GO) - Biological Process for RNLS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002931 response to ischemia IEA --
GO:0003073 regulation of systemic arterial blood pressure IEA --
GO:0003214 cardiac left ventricle morphogenesis IEA --
GO:0042414 epinephrine metabolic process IEA --
GO:0042415 norepinephrine metabolic process IEA --
genes like me logo Genes that share ontologies with RNLS: view

Compounds for RNLS Gene

(1) HMDB Compounds for RNLS Gene

Compound Synonyms Cas Number PubMed IDs
FAD
  • 1H-Purin-6-amine flavin dinucleotide
146-14-5

(1) Novoseek inferred chemical compound relationships for RNLS Gene

Compound -log(P) Hits PubMed IDs
amine 75.3 13
genes like me logo Genes that share compounds with RNLS: view

Transcripts for RNLS Gene

Unigene Clusters for RNLS Gene

Renalase, FAD-dependent amine oxidase:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNLS

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNLS Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10
SP1: - - - -
SP2: - -
SP3:

Relevant External Links for RNLS Gene

GeneLoc Exon Structure for
RNLS
ECgene alternative splicing isoforms for
RNLS

Expression for RNLS Gene

mRNA expression in normal human tissues for RNLS Gene

Protein differential expression in normal tissues for RNLS Gene

This gene is overexpressed in Ovary (29.6), Skin (21.2), and Adrenal (6.8).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for RNLS Gene

SOURCE GeneReport for Unigene cluster for RNLS Gene Hs.149849

mRNA Expression by UniProt/SwissProt for RNLS Gene

Q5VYX0-RNLS_HUMAN
Tissue specificity: Secreted into the blood by the kidney. Highly expressed in the kidney, expressed at lower level in heart, skeletal muscle and small intestine. Its plasma concentration is markedly reduced in patients with end-stage renal disease, as compared with healthy subjects.
genes like me logo Genes that share expressions with RNLS: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Expression partners for RNLS Gene

Orthologs for RNLS Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNLS Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RNLS 35
  • 89.67 (n)
  • 84.8 (a)
dog
(Canis familiaris)
Mammalia RNLS 35
  • 80.13 (n)
  • 78.48 (a)
RNLS 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnls 35
  • 82.11 (n)
  • 72.33 (a)
Rnls 16
Rnls 36
  • 72 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RNLS 35
  • 99.32 (n)
  • 98.54 (a)
RNLS 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnls 35
  • 82.59 (n)
  • 78.53 (a)
oppossum
(Monodelphis domestica)
Mammalia RNLS 36
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RNLS 36
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves RNLS 35
  • 65.57 (n)
  • 59.58 (a)
RNLS 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RNLS 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rnls 35
  • 66.27 (n)
  • 63.2 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14218 35
zebrafish
(Danio rerio)
Actinopterygii rnls 35
  • 64.52 (n)
  • 60.53 (a)
rnls 36
  • 59 (a)
OneToOne
Species with no ortholog for RNLS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNLS Gene

ENSEMBL:
Gene Tree for RNLS (if available)
TreeFam:
Gene Tree for RNLS (if available)

Paralogs for RNLS Gene

No data available for Paralogs for RNLS Gene

Variants for RNLS Gene

Sequence variations from dbSNP and Humsavar for RNLS Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs701893 -- 88,385,193(+) TAAAA(A/G)CAAAA intron-variant
rs725683 -- 88,499,119(+) agtgc(C/T)gaagt intron-variant
rs725684 -- 88,499,369(+) CAAAA(C/T)TTAGT intron-variant
rs745354 -- 88,523,287(+) TGCAT(C/T)CCACT intron-variant
rs792201 -- 88,405,083(+) TCTGG(A/G)GATCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNLS Gene

Variant ID Type Subtype PubMed ID
nsv467414 CNV Loss 19166990
nsv895879 CNV Gain 21882294
esv2662982 CNV Deletion 23128226
esv2739317 CNV Deletion 23290073
esv2075872 CNV Deletion 18987734
esv2739328 CNV Deletion 23290073
nsv825500 CNV Loss 20364138
esv271051 CNV Insertion 20981092
nsv825501 CNV Loss 20364138
nsv24973 CNV Loss 16902084

Relevant External Links for RNLS Gene

HapMap Linkage Disequilibrium report
RNLS
Human Gene Mutation Database (HGMD)
RNLS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNLS Gene

Disorders for RNLS Gene

(3) Novoseek inferred disease relationships for RNLS Gene

Disease -log(P) Hits PubMed IDs
renal failure chronic 55.9 2
renal disease 47.6 8
cardiovascular diseases 30.9 1

Relevant External Links for RNLS

Genetic Association Database (GAD)
RNLS
Human Genome Epidemiology (HuGE) Navigator
RNLS
genes like me logo Genes that share disorders with RNLS: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for RNLS Gene

Publications for RNLS Gene

  1. Renalase is a novel, soluble monoamine oxidase that regulates cardiac function and blood pressure. (PMID: 15841207) Xu J. … Desir G.V. (J. Clin. Invest. 2005) 2 3 4 23
  2. Renalase, a new renal hormone: its role in health and disease. (PMID: 17565281) Xu J. … Desir G.V. (Curr. Opin. Nephrol. Hypertens. 2007) 2 3 23
  3. Renalase gene is a novel susceptibility gene for essential hypertension: a two-stage association study in northern Han Chinese population. (PMID: 17216203) Zhao Q. … Gu D. (J. Mol. Med. 2007) 3 23
  4. Renalase, a catecholamine-metabolising enzyme? (PMID: 17385068) Boomsma F. … Tipton K.F. (J. Neural Transm. 2007) 4 23
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for RNLS Gene

Sources for RNLS Gene

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