Aliases for RNLS Gene
External Ids for RNLS Gene
Previous HGNC Symbols for RNLS Gene
Previous GeneCards Identifiers for RNLS Gene
Renalase is a flavin adenine dinucleotide-dependent amine oxidase that is secreted into the blood from the kidney (Xu et al., 2005 [PubMed 15841207]).[supplied by OMIM, Mar 2008]
GeneCards Summary for RNLS Gene
RNLS (Renalase, FAD-Dependent Amine Oxidase) is a Protein Coding gene. Diseases associated with RNLS include cerebral atherosclerosis. GO annotations related to this gene include oxidoreductase activity.
UniProtKB/Swiss-Prot for RNLS Gene
Catalyzes the oxidation of the less abundant 1,2-dihydro-beta-NAD(P) and 1,6-dihydro-beta-NAD(P) to form beta-NAD(P)(+). The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis.