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Aliases for MIS18BP1 Gene

Aliases for MIS18BP1 Gene

  • MIS18 Binding Protein 1 2 3
  • Kinetochore-Associated Protein KNL-2 Homolog 3 4
  • C14orf106 3 4
  • HsKNL-2 3 4
  • M18BP1 3 4
  • KNL2 3 4
  • P243 3 4
  • Putative Protein P243 Which Interacts With Transcription Factor Sp1 3
  • Kinetochore Null 2 Homolog (C. Elegans) 2
  • Chromosome 14 Open Reading Frame 106 2
  • Kinetochore Null 2 Homolog 3
  • Mis18-Binding Protein 1 3
  • HSA242977 3
  • KIAA1903 4

External Ids for MIS18BP1 Gene

Previous HGNC Symbols for MIS18BP1 Gene

  • C14orf106

Previous GeneCards Identifiers for MIS18BP1 Gene

  • GC14M045673

Summaries for MIS18BP1 Gene

GeneCards Summary for MIS18BP1 Gene

MIS18BP1 (MIS18 Binding Protein 1) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Packaging Of Telomere Ends. GO annotations related to this gene include chromatin binding.

UniProtKB/Swiss-Prot for MIS18BP1 Gene

  • Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.

Gene Wiki entry for MIS18BP1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIS18BP1 Gene

Genomics for MIS18BP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MIS18BP1 Gene

45,203,190 bp from pter
45,253,540 bp from pter
50,351 bases
Minus strand

Genomic View for MIS18BP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIS18BP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIS18BP1 Gene

No data available for Regulatory Elements for MIS18BP1 Gene

Proteins for MIS18BP1 Gene

  • Protein details for MIS18BP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mis18-binding protein 1
    Protein Accession:
    Secondary Accessions:
    • D3DSA7
    • Q86V14
    • Q96PY4
    • Q9NUR5
    • Q9Y4X9

    Protein attributes for MIS18BP1 Gene

    1132 amino acids
    Molecular mass:
    129085 Da
    Quaternary structure:
    • Interacts (via N-terminus) with FLNA (via N-terminus) (By similarity). Interacts with SP1 (Probable). Interacts with MIS18A. Identified in a complex containing MIS18A, MIS18B, MIS18BP1, RBBP7 and RBBP4.
    • Sequence=AK002048; Type=Frameshift; Positions=157; Evidence={ECO:0000305}; Sequence=BAB67796.1; Type=Frameshift; Positions=154; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MIS18BP1 Gene

    Alternative splice isoforms for MIS18BP1 Gene


neXtProt entry for MIS18BP1 Gene

Proteomics data for MIS18BP1 Gene at MOPED

Post-translational modifications for MIS18BP1 Gene

  • Ubiquitination at Lys65, Lys113, Lys458, Lys647, Lys850, Lys1066, and Lys1093
  • Modification sites at PhosphoSitePlus

Other Protein References for MIS18BP1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for MIS18BP1 Gene

Domains for MIS18BP1 Gene

Protein Domains for MIS18BP1 Gene

Suggested Antigen Peptide Sequences for MIS18BP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q6P0N0
  • Contains 1 SANT domain.
genes like me logo Genes that share domains with MIS18BP1: view

No data available for Gene Families for MIS18BP1 Gene

Function for MIS18BP1 Gene

Molecular function for MIS18BP1 Gene

UniProtKB/Swiss-Prot Function: Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.

Gene Ontology (GO) - Molecular Function for MIS18BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IEA --
GO:0005515 protein binding IPI 17199038
genes like me logo Genes that share ontologies with MIS18BP1: view

Animal Model Products

CRISPR Products

miRNA for MIS18BP1 Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MIS18BP1 Gene

Localization for MIS18BP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIS18BP1 Gene

Nucleus. Chromosome. Chromosome, centromere. Note=Associated with centromeres in interphase cells, from late anaphase to the G1 phase. Not detected on centromeres during earlier phases of mitosis. Associated with chromatin.

Gene Ontology (GO) - Cellular Components for MIS18BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IEA --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with MIS18BP1: view

No data available for Subcellular locations from COMPARTMENTS for MIS18BP1 Gene

Pathways for MIS18BP1 Gene

genes like me logo Genes that share pathways with MIS18BP1: view

Pathways by source for MIS18BP1 Gene

Gene Ontology (GO) - Biological Process for MIS18BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006334 nucleosome assembly TAS --
GO:0007067 mitotic nuclear division IEA --
GO:0034080 CENP-A containing nucleosome assembly TAS --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with MIS18BP1: view

Transcripts for MIS18BP1 Gene

Unigene Clusters for MIS18BP1 Gene

MIS18 binding protein 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MIS18BP1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIS18BP1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b ^
SP1: - -
SP2: - - -

ExUns: 19

Relevant External Links for MIS18BP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIS18BP1 Gene

mRNA expression in normal human tissues for MIS18BP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MIS18BP1 Gene

SOURCE GeneReport for Unigene cluster for MIS18BP1 Gene Hs.732769

genes like me logo Genes that share expressions with MIS18BP1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MIS18BP1 Gene

Orthologs for MIS18BP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIS18BP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MIS18BP1 35
  • 99.47 (n)
  • 98.76 (a)
MIS18BP1 36
  • 99 (a)
(Bos Taurus)
Mammalia MIS18BP1 35
  • 83.7 (n)
  • 73.72 (a)
MIS18BP1 36
  • 70 (a)
(Canis familiaris)
Mammalia MIS18BP1 35
  • 85.15 (n)
  • 73.43 (a)
MIS18BP1 36
  • 72 (a)
(Mus musculus)
Mammalia Mis18bp1 35
  • 72.96 (n)
  • 57.03 (a)
Mis18bp1 16
Mis18bp1 36
  • 56 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 34 (a)
-- 36
  • 47 (a)
(Ornithorhynchus anatinus)
Mammalia MIS18BP1 36
  • 33 (a)
(Rattus norvegicus)
Mammalia Mis18bp1 35
  • 74.45 (n)
  • 59.06 (a)
(Gallus gallus)
Aves MIS18BP1 36
  • 30 (a)
(Anolis carolinensis)
Reptilia MIS18BP1 36
  • 30 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15885 35
(Danio rerio)
Actinopterygii MIS18BP1 36
  • 20 (a)
Species with no ortholog for MIS18BP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIS18BP1 Gene

Gene Tree for MIS18BP1 (if available)
Gene Tree for MIS18BP1 (if available)

Paralogs for MIS18BP1 Gene

No data available for Paralogs for MIS18BP1 Gene

Variants for MIS18BP1 Gene

Sequence variations from dbSNP and Humsavar for MIS18BP1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs941878 -- 45,245,331(-) aagat(G/T)gtgag intron-variant
rs1000048 -- 45,235,806(+) GACAG(A/T)CATTT intron-variant
rs1252955 -- 45,255,474(-) gctta(C/T)ttttc upstream-variant-2KB
rs1252956 -- 45,255,332(-) ccaat(C/T)agcac upstream-variant-2KB
rs1252957 -- 45,253,811(-) AGCGA(A/G)ACCCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIS18BP1 Gene

Variant ID Type Subtype PubMed ID
nsv901841 CNV Loss 21882294
nsv901842 CNV Loss 21882294
nsv901843 CNV Gain 21882294
nsv832785 CNV Loss 17160897
nsv901844 CNV Loss 21882294
nsv901845 CNV Loss 21882294
esv2748677 CNV Deletion 23290073
esv2748678 CNV Deletion 23290073
nsv901846 CNV Loss 21882294
dgv631e1 CNV Complex 17122850

Relevant External Links for MIS18BP1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIS18BP1 Gene

Disorders for MIS18BP1 Gene

No disorders were found for MIS18BP1 Gene.

No data available for UniProtKB/Swiss-Prot for MIS18BP1 Gene

Publications for MIS18BP1 Gene

  1. Priming of centromere for CENP-A recruitment by human hMis18alpha, hMis18beta, and M18BP1. (PMID: 17199038) Fujita Y. … Yanagida M. (Dev. Cell 2007) 2 3 4
  2. Functional genomics identifies a Myb domain-containing protein family required for assembly of CENP-A chromatin. (PMID: 17339379) Maddox P.S. … Desai A. (J. Cell Biol. 2007) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening. (PMID: 10976766) Gunther M. … Brison O. (Mol. Cell. Biochem. 2000) 3 4

Products for MIS18BP1 Gene

Sources for MIS18BP1 Gene

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