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Aliases for PPP2R5E Gene

Aliases for PPP2R5E Gene

  • Protein Phosphatase 2 Regulatory Subunit B', Epsilon 2
  • Protein Phosphatase 2 Regulatory Subunit B, Epsilon 2 3 5
  • Protein Phosphatase 2, Regulatory Subunit B (B56), Epsilon Isoform 2
  • PP2A B Subunit Isoform PR61-Epsilon 4
  • PP2A B Subunit Isoform B56-Epsilon 4
  • PP2A B Subunit Isoform R5-Epsilon 4
  • PP2A B Subunit Isoform B-Epsilon 4

External Ids for PPP2R5E Gene

Previous GeneCards Identifiers for PPP2R5E Gene

  • GC14M061168
  • GC14M057635
  • GC14M061831
  • GC14M062911
  • GC14M063838
  • GC14M044007

Summaries for PPP2R5E Gene

Entrez Gene Summary for PPP2R5E Gene

  • The protein encoded by this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an epsilon isoform of the regulatory subunit B56 subfamily. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]

GeneCards Summary for PPP2R5E Gene

PPP2R5E (Protein Phosphatase 2 Regulatory Subunit B', Epsilon) is a Protein Coding gene. Diseases associated with PPP2R5E include breast disease. Among its related pathways are Platelet activation, signaling and aggregation and Signaling by GPCR. GO annotations related to this gene include binding and protein phosphatase type 2A regulator activity. An important paralog of this gene is PPP2R5A.

UniProtKB/Swiss-Prot for PPP2R5E Gene

  • The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

Gene Wiki entry for PPP2R5E Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP2R5E Gene

Genomics for PPP2R5E Gene

Regulatory Elements for PPP2R5E Gene

Promoters for PPP2R5E Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PPP2R5E on UCSC Golden Path with GeneCards custom track

Genomic Location for PPP2R5E Gene

Chromosome:
14
Start:
63,371,357 bp from pter
End:
63,543,374 bp from pter
Size:
172,018 bases
Orientation:
Minus strand

Genomic View for PPP2R5E Gene

Genes around PPP2R5E on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP2R5E Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP2R5E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP2R5E Gene

Proteins for PPP2R5E Gene

  • Protein details for PPP2R5E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16537-2A5E_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform
    Protein Accession:
    Q16537
    Secondary Accessions:
    • A4FU37
    • B7ZAW5
    • B7ZKK8
    • B7ZKK9
    • J3KQN6
    • Q52LW4

    Protein attributes for PPP2R5E Gene

    Size:
    467 amino acids
    Molecular mass:
    54699 Da
    Quaternary structure:
    • Found in a complex with at least ARL2, PPP2CB; PPP2R1A, PPP2R2A, PPP2R5E and TBCD (By similarity). PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B/PR72/PR130/PR59 and R5/B/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with SGOL1.

    Alternative splice isoforms for PPP2R5E Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPP2R5E Gene

Proteomics data for PPP2R5E Gene at MOPED

Post-translational modifications for PPP2R5E Gene

Other Protein References for PPP2R5E Gene

Antibody Products

No data available for DME Specific Peptides for PPP2R5E Gene

Domains & Families for PPP2R5E Gene

Gene Families for PPP2R5E Gene

Protein Domains for PPP2R5E Gene

Graphical View of Domain Structure for InterPro Entry

Q16537

UniProtKB/Swiss-Prot:

2A5E_HUMAN :
  • Belongs to the phosphatase 2A regulatory subunit B56 family.
Family:
  • Belongs to the phosphatase 2A regulatory subunit B56 family.
genes like me logo Genes that share domains with PPP2R5E: view

Function for PPP2R5E Gene

Molecular function for PPP2R5E Gene

GENATLAS Biochemistry:
protein phosphatase 2A,regulatory subunit B56 epsilon isoform,expressed in brain
UniProtKB/Swiss-Prot Function:
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

Gene Ontology (GO) - Molecular Function for PPP2R5E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding IEA --
genes like me logo Genes that share ontologies with PPP2R5E: view
genes like me logo Genes that share phenotypes with PPP2R5E: view

Animal Model Products

CRISPR Products

miRNA for PPP2R5E Gene

miRTarBase miRNAs that target PPP2R5E

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP2R5E Gene

Localization for PPP2R5E Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP2R5E Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPP2R5E Gene COMPARTMENTS Subcellular localization image for PPP2R5E gene
Compartment Confidence
cytosol 4
nucleus 2
endoplasmic reticulum 1

No data available for Gene Ontology (GO) - Cellular Components for PPP2R5E Gene

Pathways & Interactions for PPP2R5E Gene

SuperPathways for PPP2R5E Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 S45 mutants of beta-catenin arent phosphorylated
3 PI3K events in ERBB4 signaling
4 Immune System
5 Cell Cycle, Mitotic
.61
genes like me logo Genes that share pathways with PPP2R5E: view

Gene Ontology (GO) - Biological Process for PPP2R5E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034047 regulation of protein phosphatase type 2A activity TAS 8703017
genes like me logo Genes that share ontologies with PPP2R5E: view

No data available for SIGNOR curated interactions for PPP2R5E Gene

Drugs & Compounds for PPP2R5E Gene

No Compound Related Data Available

Transcripts for PPP2R5E Gene

Unigene Clusters for PPP2R5E Gene

Protein phosphatase 2, regulatory subunit B, epsilon isoform:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP2R5E Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b
SP1: - - - -
SP2: - - - -
SP3: - - - - -
SP4: - -
SP5: -
SP6: -
SP7: - - -

Relevant External Links for PPP2R5E Gene

GeneLoc Exon Structure for
PPP2R5E
ECgene alternative splicing isoforms for
PPP2R5E

Expression for PPP2R5E Gene

mRNA expression in normal human tissues for PPP2R5E Gene

Protein differential expression in normal tissues from HIPED for PPP2R5E Gene

This gene is overexpressed in Fetal Brain (11.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPP2R5E Gene



SOURCE GeneReport for Unigene cluster for PPP2R5E Gene Hs.334868

genes like me logo Genes that share expression patterns with PPP2R5E: view

Protein tissue co-expression partners for PPP2R5E Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PPP2R5E Gene

Orthologs for PPP2R5E Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP2R5E Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPP2R5E 36
  • 100 (a)
OneToOne
PPP2R5E 35
  • 99.93 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia PPP2R5E 36
  • 100 (a)
OneToOne
PPP2R5E 35
  • 98.07 (n)
  • 100 (a)
dog
(Canis familiaris)
Mammalia PPP2R5E 35
  • 97.64 (n)
  • 100 (a)
PPP2R5E 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppp2r5e 36
  • 100 (a)
OneToOne
Ppp2r5e 16
Ppp2r5e 35
  • 95.86 (n)
  • 99.79 (a)
oppossum
(Monodelphis domestica)
Mammalia PPP2R5E 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPP2R5E 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppp2r5e 35
  • 95.57 (n)
  • 99.77 (a)
chicken
(Gallus gallus)
Aves PPP2R5E 36
  • 100 (a)
OneToOne
PPP2R5E 35
  • 92.36 (n)
  • 100 (a)
lizard
(Anolis carolinensis)
Reptilia PPP2R5E 36
  • 100 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.6938 35
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76234 35
ppp2r5e 35
  • 86.58 (n)
  • 97.4 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12118 35
zebrafish
(Danio rerio)
Actinopterygii efnb3 35
ppp2r5eb 35
  • 79.87 (n)
  • 94.65 (a)
ppp2r5ea 36
  • 90 (a)
OneToMany
ppp2r5eb 36
  • 95 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004096 35
  • 64.85 (n)
  • 76.83 (a)
fruit fly
(Drosophila melanogaster)
Insecta wdb 36
  • 66 (a)
OneToMany
BcDNA:LD34343 37
  • 77 (a)
PP2A-B 37
  • 67 (a)
wdb 35
  • 64.14 (n)
  • 76.17 (a)
worm
(Caenorhabditis elegans)
Secernentea W08G11.4 37
  • 67 (a)
pptr-1 36
  • 57 (a)
OneToMany
pptr-1 35
  • 61.32 (n)
  • 67.25 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RTS1 36
  • 33 (a)
OneToMany
soybean
(Glycine max)
eudicotyledons Gma.7938 35
thale cress
(Arabidopsis thaliana)
eudicotyledons ATB BETA 35
  • 57.41 (n)
  • 56.3 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 51 (a)
ManyToMany
Species with no ortholog for PPP2R5E:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP2R5E Gene

ENSEMBL:
Gene Tree for PPP2R5E (if available)
TreeFam:
Gene Tree for PPP2R5E (if available)

Paralogs for PPP2R5E Gene

Paralogs for PPP2R5E Gene

(4) SIMAP similar genes for PPP2R5E Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with PPP2R5E: view

Variants for PPP2R5E Gene

Sequence variations from dbSNP and Humsavar for PPP2R5E Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs974700 -- 63,405,696(+) TAATC(A/G)AAGTA intron-variant
rs1012145 -- 63,473,364(-) TTTCC(A/C)CTTAC intron-variant
rs1033741 -- 63,430,377(+) TGCAT(A/G)CATAC intron-variant
rs1033742 -- 63,467,419(+) TAATA(C/T)TGTAA intron-variant
rs1033744 -- 63,467,493(+) AATGA(C/T)TTTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPP2R5E Gene

Variant ID Type Subtype PubMed ID
dgv137n21 CNV Gain 19592680
nsv832815 CNV Gain 17160897
dgv87e55 CNV Gain 17911159
nsv519574 CNV Gain 19592680
dgv257n27 CNV Gain 19166990
dgv88e55 CNV Gain 17911159
nsv902018 CNV Loss 21882294
esv2748775 CNV Deletion 23290073
esv2533003 CNV Deletion 19546169
esv2120827 CNV Deletion 18987734
esv3298 CNV Deletion 18987735
esv2748776 CNV Deletion 23290073
esv2657638 CNV Deletion 23128226
esv2748777 CNV Deletion 23290073
esv2670321 CNV Deletion 23128226
esv2673552 CNV Deletion 23128226
esv2659005 CNV Deletion 23128226

Variation tolerance for PPP2R5E Gene

Residual Variation Intolerance Score: 20.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.30; 6.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPP2R5E Gene

HapMap Linkage Disequilibrium report
PPP2R5E

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP2R5E Gene

Disorders for PPP2R5E Gene

MalaCards: The human disease database

(1) MalaCards diseases for PPP2R5E Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
breast disease
  • breast diseases
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PPP2R5E

Genetic Association Database (GAD)
PPP2R5E
Human Genome Epidemiology (HuGE) Navigator
PPP2R5E
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPP2R5E
genes like me logo Genes that share disorders with PPP2R5E: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPP2R5E Gene

Publications for PPP2R5E Gene

  1. Association between single nucleotide polymorphism-genotype and outcome of patients with chronic lymphocytic leukemia in a randomized chemotherapy trial. (PMID: 21659360) Wade R. … Houlston R.S. (Haematologica 2011) 3 48 67
  2. Identification of a new family of protein phosphatase 2A regulatory subunits. (PMID: 7592815) McCright B. … Virshup D.M. (J. Biol. Chem. 1995) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. PP2A-B56I/ complex is involved in dephosphorylation of I^-H2AX in the repair process of CPT-induced DNA double-strand breaks. (PMID: 25772433) Li X. … Lai Y. (Toxicology 2015) 3

Products for PPP2R5E Gene

Sources for PPP2R5E Gene

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