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Aliases for PPP2R5D Gene

Aliases for PPP2R5D Gene

  • Protein Phosphatase 2, Regulatory Subunit B', Delta 2
  • Protein Phosphatase 2, Regulatory Subunit B (B56), Delta Isoform 2 3
  • Protein Phosphatase 2, Regulatory Subunit B, Delta Isoform 2 3
  • Protein Phosphatase 2, Regulatory Subunit B, Delta 2 3
  • PP2A B Subunit Isoform PR61-Delta 3 4
  • PP2A B Subunit Isoform B56-Delta 3 4
  • PP2A B Subunit Isoform R5-Delta 3 4
  • PP2A B Subunit Isoform B-Delta 3 4
  • Serine/Threonine Protein Phosphatase 2A, 56 KDa Regulatory Subunit, Delta Isoform 3
  • Serine/Threonine-Protein Phosphatase 2A 56 KDa Regulatory Subunit Delta Isoform 3
  • PP2A, B Subunit, PR61 Delta Isoform 3
  • PP2A, B Subunit, B56 Delta Isoform 3
  • PP2A, B Subunit, R5 Delta Isoform 3
  • PP2A, B Subunit, B Delta Isoform 3
  • B56D 3

External Ids for PPP2R5D Gene

Previous GeneCards Identifiers for PPP2R5D Gene

  • GC06P042954
  • GC06P042999
  • GC06P043060
  • GC06P042952
  • GC06P042669

Summaries for PPP2R5D Gene

Entrez Gene Summary for PPP2R5D Gene

  • The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a delta isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPP2R5D Gene

PPP2R5D (Protein Phosphatase 2, Regulatory Subunit B', Delta) is a Protein Coding gene. Among its related pathways are PI3K-Akt signaling pathway and Signaling by FGFR. GO annotations related to this gene include protein serine/threonine phosphatase activity and protein phosphatase type 2A regulator activity. An important paralog of this gene is PPP2R5E.

UniProtKB/Swiss-Prot for PPP2R5D Gene

  • The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment

Gene Wiki entry for PPP2R5D Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP2R5D Gene

Genomics for PPP2R5D Gene

Regulatory Elements for PPP2R5D Gene

Genomic Location for PPP2R5D Gene

Start:
42,984,499 bp from pter
End:
43,012,345 bp from pter
Size:
27,847 bases
Orientation:
Plus strand

Genomic View for PPP2R5D Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPP2R5D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP2R5D Gene

Proteins for PPP2R5D Gene

  • Protein details for PPP2R5D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14738-2A5D_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform
    Protein Accession:
    Q14738
    Secondary Accessions:
    • A8K3I9
    • B5BUA6
    • O00494
    • O00696
    • Q15171
    • Q5TC39

    Protein attributes for PPP2R5D Gene

    Size:
    602 amino acids
    Molecular mass:
    69992 Da
    Quaternary structure:
    • PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B/PR72/PR130/PR59 and R5/B/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with SGOL1.

    Alternative splice isoforms for PPP2R5D Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPP2R5D Gene

Proteomics data for PPP2R5D Gene at MOPED

Post-translational modifications for PPP2R5D Gene

  • Ubiquitination at Lys367, Lys409, Lys508, Lys548, and Lys583
  • Modification sites at PhosphoSitePlus

Other Protein References for PPP2R5D Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PPP2R5D (PPP2R5D)

No data available for DME Specific Peptides for PPP2R5D Gene

Domains for PPP2R5D Gene

Gene Families for PPP2R5D Gene

HGNC:
  • PPP2R :Serine/threonine phosphatases / Protein phosphatase 2, regulatory subunits

Protein Domains for PPP2R5D Gene

Suggested Antigen Peptide Sequences for PPP2R5D Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14738

UniProtKB/Swiss-Prot:

2A5D_HUMAN :
  • Q14738
Family:
  • Belongs to the phosphatase 2A regulatory subunit B56 family.
genes like me logo Genes that share domains with PPP2R5D: view

Function for PPP2R5D Gene

Molecular function for PPP2R5D Gene

GENATLAS Biochemistry: protein phosphatase 2A,regulatory subunit B56 delta isoform,expressed in adult brain,cytosolic subunit of PPPR2A in interphase cells,concentrated in the nucleus of mitotic and recently divided cells
UniProtKB/Swiss-Prot Function: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment
UniProtKB/Swiss-Prot Induction: By retinoic acid; in neuroblastoma cell lines

Gene Ontology (GO) - Molecular Function for PPP2R5D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004722 protein serine/threonine phosphatase activity TAS --
GO:0005488 binding --
GO:0005515 protein binding IPI 16189514
GO:0008601 protein phosphatase type 2A regulator activity IEA --
genes like me logo Genes that share ontologies with PPP2R5D: view
genes like me logo Genes that share phenotypes with PPP2R5D: view

Animal Models for PPP2R5D Gene

MGI Knock Outs for PPP2R5D:

Animal Model Products

CRISPR Products

miRNA for PPP2R5D Gene

miRTarBase miRNAs that target PPP2R5D

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPP2R5D

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for PPP2R5D Gene

Localization for PPP2R5D Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP2R5D Gene

Cytoplasm. Nucleus. Note=Nuclear in interphase, nuclear during mitosis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPP2R5D Gene COMPARTMENTS Subcellular localization image for PPP2R5D gene
Compartment Confidence
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for PPP2R5D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000159 protein phosphatase type 2A complex IEA --
GO:0005634 nucleus TAS 8703017
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PPP2R5D: view

Pathways for PPP2R5D Gene

genes like me logo Genes that share pathways with PPP2R5D: view

Gene Ontology (GO) - Biological Process for PPP2R5D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS --
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS --
GO:0005975 carbohydrate metabolic process TAS --
GO:0006006 glucose metabolic process TAS --
genes like me logo Genes that share ontologies with PPP2R5D: view

Transcripts for PPP2R5D Gene

Unigene Clusters for PPP2R5D Gene

Protein phosphatase 2, regulatory subunit B, delta:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPP2R5D

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP2R5D Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a ·
SP1: - -
SP2: - - - - - - -
SP3: - - -
SP4:
SP5: - -
SP6:
SP7: -

ExUns: 13b ^ 14 ^ 15 ^ 16a · 16b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for PPP2R5D Gene

GeneLoc Exon Structure for
PPP2R5D
ECgene alternative splicing isoforms for
PPP2R5D

Expression for PPP2R5D Gene

mRNA expression in normal human tissues for PPP2R5D Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPP2R5D Gene

SOURCE GeneReport for Unigene cluster for PPP2R5D Gene Hs.533308

mRNA Expression by UniProt/SwissProt for PPP2R5D Gene

Q14738-2A5D_HUMAN
Tissue specificity: Isoform Delta-2 is widely expressed. Isoform Delta-1 is highly expressed in brain
genes like me logo Genes that share expressions with PPP2R5D: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PPP2R5D Gene

Orthologs for PPP2R5D Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP2R5D Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPP2R5D 35
  • 99.21 (n)
  • 98.99 (a)
PPP2R5D 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PPP2R5D 35
  • 92.22 (n)
  • 98.83 (a)
PPP2R5D 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPP2R5D 35
  • 93.49 (n)
  • 98.65 (a)
PPP2R5D 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppp2r5d 35
  • 90.24 (n)
  • 96.63 (a)
Ppp2r5d 16
Ppp2r5d 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPP2R5D 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPP2R5D 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppp2r5d 35
  • 91.07 (n)
  • 98.28 (a)
chicken
(Gallus gallus)
Aves PPP2R5D 35
  • 80.17 (n)
  • 92.65 (a)
PPP2R5D 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPP2R5D 36
  • 90 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ppp2r5d 35
  • 78.88 (n)
  • 89.18 (a)
ppp2r5d 36
  • 86 (a)
OneToOne
wufc41e12 35
fruit fly
(Drosophila melanogaster)
Insecta PP2A-B 35
  • 66.36 (n)
  • 70.19 (a)
PP2A-B 36
  • 39 (a)
OneToMany
PP2A-B 37
  • 75 (a)
BcDNA:LD34343 37
  • 72 (a)
worm
(Caenorhabditis elegans)
Secernentea pptr-2 35
  • 61.55 (n)
  • 68.18 (a)
pptr-2 36
  • 61 (a)
OneToMany
C13G3.3a 37
  • 65 (a)
W08G11.4 37
  • 62 (a)
C13G3.3b 37
  • 65 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RTS1 36
  • 37 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons ATB DELTA 35
  • 55.15 (n)
  • 52.17 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.5451 35
wheat
(Triticum aestivum)
Liliopsida Ta.23058 35
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes par2 35
  • 53.61 (n)
  • 52.65 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2648 36
  • 65 (a)
OneToMany
Species with no ortholog for PPP2R5D:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)

Evolution for PPP2R5D Gene

ENSEMBL:
Gene Tree for PPP2R5D (if available)
TreeFam:
Gene Tree for PPP2R5D (if available)

Paralogs for PPP2R5D Gene

Paralogs for PPP2R5D Gene

Selected SIMAP similar genes for PPP2R5D Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for PPP2R5D Gene

genes like me logo Genes that share paralogs with PPP2R5D: view

Variants for PPP2R5D Gene

Sequence variations from dbSNP and Humsavar for PPP2R5D Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
VAR_069414 -

Structural Variations from Database of Genomic Variants (DGV) for PPP2R5D Gene

Variant ID Type Subtype PubMed ID
nsv830651 CNV Loss 17160897
nsv462927 CNV Loss 19166990
nsv462929 CNV Loss 19166990
nsv462930 CNV Loss 19166990

Relevant External Links for PPP2R5D Gene

HapMap Linkage Disequilibrium report
PPP2R5D
Human Gene Mutation Database (HGMD)
PPP2R5D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP2R5D Gene

Disorders for PPP2R5D Gene

No disorders were found for PPP2R5D Gene.

No data available for UniProtKB/Swiss-Prot for PPP2R5D Gene

Publications for PPP2R5D Gene

  1. Shugoshin collaborates with protein phosphatase 2A to protect cohesin. (PMID: 16541025) Kitajima T.S. … Watanabe Y. (Nature 2006) 3 4
  2. Phosphorylation on the PPP2R5D B regulatory subunit modulates the biochemical properties of protein phosphatase 2A. (PMID: 20423611) Yu U.Y. … Ahn J.H. (BMB Rep 2010) 3 23
  3. Identification of a new family of protein phosphatase 2A regulatory subunits. (PMID: 7592815) McCright B. … Virshup D.M. (J. Biol. Chem. 1995) 2 3
  4. Molecular cloning of a 74-kDa regulatory subunit (B'' or delta) of human protein phosphatase 2A. (PMID: 8566219) Tanabe O. … Takeda M. (FEBS Lett. 1996) 3 4
  5. The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm. (PMID: 8703017) McCright B. … Virshup D.M. (J. Biol. Chem. 1996) 3 4

Products for PPP2R5D Gene

Sources for PPP2R5D Gene

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