Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PHF10 Gene

Aliases for PHF10 Gene

  • PHD Finger Protein 10 2 3
  • BAF45A 3 4 6
  • BRG1-Associated Factor 45a 3 4
  • XAP135 3 4
  • BRG1-Associated Factor, 45-KD, A 3
  • PHD Zinc Finger Protein XAP135 3

External Ids for PHF10 Gene

Previous GeneCards Identifiers for PHF10 Gene

  • GC06M169719
  • GC06M169860
  • GC06M169921
  • GC06M169845
  • GC06M170104
  • GC06M167523

Summaries for PHF10 Gene

Entrez Gene Summary for PHF10 Gene

  • This gene contains a predicted ORF that encodes a protein with two zinc finger domains. The function of the encoded protein is not known. Sequence analysis suggests that multiple alternatively spliced transcript variants are derived from this gene but the full-length nature of only two of them is known. These two splice variants encode different isoforms. A pseudogene for this gene is located on Xq28. [provided by RefSeq, Jul 2008]

GeneCards Summary for PHF10 Gene

PHF10 (PHD Finger Protein 10) is a Protein Coding gene. An important paralog of this gene is DPF2.

UniProtKB/Swiss-Prot for PHF10 Gene

  • Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).

Gene Wiki entry for PHF10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PHF10 Gene

Genomics for PHF10 Gene

Genomic Location for PHF10 Gene

Start:
169,703,905 bp from pter
End:
169,725,566 bp from pter
Size:
21,662 bases
Orientation:
Minus strand

Genomic View for PHF10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PHF10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PHF10 Gene

Proteins for PHF10 Gene

  • Protein details for PHF10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUB8-PHF10_HUMAN
    Recommended name:
    PHD finger protein 10
    Protein Accession:
    Q8WUB8
    Secondary Accessions:
    • Q2YDA3
    • Q53HG8
    • Q9BXD2
    • Q9NV26

    Protein attributes for PHF10 Gene

    Size:
    498 amino acids
    Molecular mass:
    56051 Da
    Quaternary structure:
    • Component of neural progenitors-specific chromatin remodeling complex (npBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A and actin. Interacts with ACTL6A/BAF53A, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A and PBRM1/BAF180 (By similarity).
    SequenceCaution:
    • Sequence=AAH20954.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI10324.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAK27451.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAA91934.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAD96332.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAG33554.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI12316.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for PHF10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PHF10 Gene

Proteomics data for PHF10 Gene at MOPED

Post-translational modifications for PHF10 Gene

  • Ubiquitination at Lys168, Lys249, and Lys267
  • Modification sites at PhosphoSitePlus

Other Protein References for PHF10 Gene

No data available for DME Specific Peptides for PHF10 Gene

Domains for PHF10 Gene

Gene Families for PHF10 Gene

HGNC:
  • PHF :Zinc fingers, PHD-type

Protein Domains for PHF10 Gene

Suggested Antigen Peptide Sequences for PHF10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WUB8

UniProtKB/Swiss-Prot:

PHF10_HUMAN :
  • Q8WUB8
Family:
  • Belongs to the SAYP family.
Similarity:
  • Contains 2 PHD-type zinc fingers.
genes like me logo Genes that share domains with PHF10: view

Function for PHF10 Gene

Molecular function for PHF10 Gene

UniProtKB/Swiss-Prot Function: Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).

Gene Ontology (GO) - Molecular Function for PHF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with PHF10: view

Phenotypes for PHF10 Gene

MGI mutant phenotypes for PHF10:
inferred from 1 alleles
GenomeRNAi human phenotypes for PHF10:
genes like me logo Genes that share phenotypes with PHF10: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PHF10

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for PHF10 Gene

Localization for PHF10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PHF10 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PHF10 Gene COMPARTMENTS Subcellular localization image for PHF10 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PHF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0071564 npBAF complex ISS --
genes like me logo Genes that share ontologies with PHF10: view

Pathways for PHF10 Gene

SuperPathways for PHF10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PHF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007399 nervous system development IEA --
genes like me logo Genes that share ontologies with PHF10: view

No data available for Pathways by source for PHF10 Gene

Transcripts for PHF10 Gene

Unigene Clusters for PHF10 Gene

PHD finger protein 10:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PHF10

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PHF10 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b
SP1: - -
SP2:
SP3:
SP4:
SP5:

Relevant External Links for PHF10 Gene

GeneLoc Exon Structure for
PHF10
ECgene alternative splicing isoforms for
PHF10

Expression for PHF10 Gene

mRNA expression in normal human tissues for PHF10 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PHF10 Gene

SOURCE GeneReport for Unigene cluster for PHF10 Gene Hs.435933

genes like me logo Genes that share expressions with PHF10: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PHF10 Gene

Orthologs for PHF10 Gene

This gene was present in the common ancestor of animals.

Orthologs for PHF10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PHF10 35
  • 99.85 (n)
  • 100 (a)
PHF10 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PHF10 35
  • 90.65 (n)
  • 93.17 (a)
PHF10 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PHF10 35
  • 92.41 (n)
  • 95.62 (a)
PHF10 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Phf10 35
  • 91.73 (n)
  • 96.31 (a)
Phf10 16
Phf10 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PHF10 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PHF10 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Phf10 35
  • 92.11 (n)
  • 97.56 (a)
chicken
(Gallus gallus)
Aves PHF10 35
  • 85.18 (n)
  • 91.86 (a)
PHF10 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PHF10 36
  • 90 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.16782 35
tropical clawed frog
(Silurana tropicalis)
Amphibia phf10 35
  • 77.97 (n)
  • 83.17 (a)
Str.10792 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12707 35
zebrafish
(Danio rerio)
Actinopterygii phf10 35
  • 72.84 (n)
  • 79.58 (a)
phf10 36
  • 78 (a)
OneToOne
zgc66233 35
fruit fly
(Drosophila melanogaster)
Insecta e(y)3 36
  • 6 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea phf-10 35
  • 47.57 (n)
  • 38.29 (a)
phf-10 36
  • 34 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.105 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
OneToOne
Species with no ortholog for PHF10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PHF10 Gene

ENSEMBL:
Gene Tree for PHF10 (if available)
TreeFam:
Gene Tree for PHF10 (if available)

Paralogs for PHF10 Gene

Paralogs for PHF10 Gene

Selected SIMAP similar genes for PHF10 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for PHF10 Gene

genes like me logo Genes that share paralogs with PHF10: view

Variants for PHF10 Gene

Sequence variations from dbSNP and Humsavar for PHF10 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1127489 -- 169,707,606(-) CTCCT(A/G)TGAGG intron-variant
rs3088034 -- 169,708,321(-) TTTAG(C/G)TTACA intron-variant
rs3211062 -- 169,708,703(-) AATCA(A/G)CTATT intron-variant
rs3807063 -- 169,718,998(+) TGAAA(A/G)CTATT intron-variant
rs3807064 -- 169,719,195(+) TTTAA(A/G)GGACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PHF10 Gene

Variant ID Type Subtype PubMed ID
nsv887010 CNV Gain 21882294
nsv830872 CNV Loss 17160897
nsv887011 CNV Loss 21882294
esv24038 CNV Loss 19812545

Relevant External Links for PHF10 Gene

HapMap Linkage Disequilibrium report
PHF10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PHF10 Gene

Disorders for PHF10 Gene

(1) University of Copenhagen DISEASES for PHF10 Gene

genes like me logo Genes that share disorders with PHF10: view

No data available for UniProtKB/Swiss-Prot for PHF10 Gene

Publications for PHF10 Gene

  1. Physical and genetic characterization reveals a pseudogene, an evolutionary junction, and unstable loci in distal Xq28. (PMID: 11827455) Aradhya S. … Nelson D.L. (Genomics 2002) 2 3 4
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. PHF10 is required for cell proliferation in normal and SV40- immortalized human fibroblast cells. (PMID: 20068294) Banga S.S. … Ozer H.L. (Cytogenet. Genome Res. 2009) 3 4

Products for PHF10 Gene

Sources for PHF10 Gene

Back to Top

Content