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Aliases for PPP2R5C Gene

Aliases for PPP2R5C Gene

  • Protein Phosphatase 2, Regulatory Subunit B', Gamma 2
  • Protein Phosphatase 2, Regulatory Subunit B (B56), Gamma Isoform 2 3
  • Protein Phosphatase 2, Regulatory Subunit B, Gamma Isoform 2 3
  • Protein Phosphatase 2, Regulatory Subunit B, Gamma 2 3
  • Renal Carcinoma Antigen NY-REN-29 3 4
  • PP2A B Subunit Isoform PR61-Gamma 3 4
  • PP2A B Subunit Isoform B56-Gamma 3 4
  • PP2A B Subunit Isoform R5-Gamma 3 4
  • PP2A B Subunit Isoform B-Gamma 3 4
  • Serine/Threonine-Protein Phosphatase 2A 56 KDa Regulatory Subunit Gamma Isoform 3
  • B Alpha Regulatory Subunit 3
  • KIAA0044 4
  • PR61G 3
  • B56G 3

External Ids for PPP2R5C Gene

Previous GeneCards Identifiers for PPP2R5C Gene

  • GC14P099667
  • GC14P096091
  • GC14P100219
  • GC14P100266
  • GC14P101345
  • GC14P101298
  • GC14P102228
  • GC14P082408

Summaries for PPP2R5C Gene

Entrez Gene Summary for PPP2R5C Gene

  • The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPP2R5C Gene

PPP2R5C (Protein Phosphatase 2, Regulatory Subunit B', Gamma) is a Protein Coding gene. Among its related pathways are PI3K-Akt signaling pathway and Signaling by GPCR. GO annotations related to this gene include protein phosphatase type 2A regulator activity. An important paralog of this gene is PPP2R5E.

UniProtKB/Swiss-Prot for PPP2R5C Gene

  • The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation.

Gene Wiki entry for PPP2R5C Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP2R5C Gene

Genomics for PPP2R5C Gene

Regulatory Elements for PPP2R5C Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PPP2R5C Gene

Start:
101,760,573 bp from pter
End:
101,927,992 bp from pter
Size:
167,420 bases
Orientation:
Plus strand

Genomic View for PPP2R5C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPP2R5C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP2R5C Gene

Proteins for PPP2R5C Gene

  • Protein details for PPP2R5C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13362-2A5G_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
    Protein Accession:
    Q13362
    Secondary Accessions:
    • B4DYJ8
    • B5BUA5
    • F5GWP3
    • Q14391
    • Q15060
    • Q15174
    • Q6ZN33

    Protein attributes for PPP2R5C Gene

    Size:
    524 amino acids
    Molecular mass:
    61061 Da
    Quaternary structure:
    • PP2A consists of a common heterodimeric core enzyme, composed of PPP2CA a 36 kDa catalytic subunit (subunit C) and PPP2R1A a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B/PR72/PR130/PR59 and R5/B/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with PPP2CA AND PPP2R1A; the interaction is direct. Interacts with SGOL1; the interaction is direct. Isoform 1 and isoform 2 interact with TP53 (phosphorylated at Ser-15 by ATM); increased upon DNA damage it drives PP2A-mediated dephosphorylation of TP53 at Thr-55. Interacts with IER3 and/or ERK kinases; regulates ERK dephosphorylation.
    SequenceCaution:
    • Sequence=AAC50387.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG63760.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PPP2R5C Gene

    Alternative splice isoforms for PPP2R5C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPP2R5C Gene

Proteomics data for PPP2R5C Gene at MOPED

Post-translational modifications for PPP2R5C Gene

  • Isoform Gamma-3 is phosphorylated on serine residues. Isoform Gamma-1 phosphorylation by ERK2 is IER3-dependent and inhibits ERK dephosphorylation by PP2A-PPP2R5C.
  • Ubiquitination at Lys333
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for PPP2R5C Gene

Domains for PPP2R5C Gene

Gene Families for PPP2R5C Gene

HGNC:
  • PPP2R :Serine/threonine phosphatases / Protein phosphatase 2, regulatory subunits

Protein Domains for PPP2R5C Gene

Graphical View of Domain Structure for InterPro Entry

Q13362

UniProtKB/Swiss-Prot:

2A5G_HUMAN :
  • Q13362
Family:
  • Belongs to the phosphatase 2A regulatory subunit B56 family.
genes like me logo Genes that share domains with PPP2R5C: view

Function for PPP2R5C Gene

Molecular function for PPP2R5C Gene

GENATLAS Biochemistry:
protein phosphatase 2A,regulatory subunit B56 gamma isoform,expressed in cardiac and skeletal muscle
UniProtKB/Swiss-Prot Function:
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation.
UniProtKB/Swiss-Prot Induction:
Up-regulated upon DNA damage.

Gene Ontology (GO) - Molecular Function for PPP2R5C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding IPI 1328865
GO:0008233 peptidase activity --
GO:0008601 protein phosphatase type 2A regulator activity NAS 8703017
genes like me logo Genes that share ontologies with PPP2R5C: view

Phenotypes for PPP2R5C Gene

genes like me logo Genes that share phenotypes with PPP2R5C: view

Animal Model Products

miRNA for PPP2R5C Gene

miRTarBase miRNAs that target PPP2R5C

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPP2R5C

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for PPP2R5C Gene

Localization for PPP2R5C Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP2R5C Gene

Nucleus. Chromosome, centromere.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPP2R5C Gene COMPARTMENTS Subcellular localization image for PPP2R5C gene
Compartment Confidence
nucleus 5
cytosol 2
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PPP2R5C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000159 protein phosphatase type 2A complex NAS 8703017
GO:0000775 chromosome, centromeric region IDA 16580887
GO:0005634 nucleus IDA 8703017
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with PPP2R5C: view

Pathways for PPP2R5C Gene

genes like me logo Genes that share pathways with PPP2R5C: view

Gene Ontology (GO) - Biological Process for PPP2R5C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis --
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest IDA 17245430
GO:0007165 signal transduction NAS 8703017
GO:0008285 negative regulation of cell proliferation IDA 17245430
GO:0016485 protein processing --
genes like me logo Genes that share ontologies with PPP2R5C: view

Transcripts for PPP2R5C Gene

Unigene Clusters for PPP2R5C Gene

Protein phosphatase 2, regulatory subunit B, gamma:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPP2R5C

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP2R5C Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^
SP1: - - - - - - - - - -
SP2:
SP3: - - - - - - - - - -
SP4: -
SP5: - - -
SP6: -
SP7: - - - - -
SP8: - - - - - - -
SP9:
SP10: - - - - -
SP11: - - -
SP12: - - - - - - - -
SP13:

ExUns: 18a · 18b ^ 19a · 19b · 19c
SP1:
SP2: -
SP3:
SP4: -
SP5:
SP6: - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for PPP2R5C Gene

GeneLoc Exon Structure for
PPP2R5C
ECgene alternative splicing isoforms for
PPP2R5C

Expression for PPP2R5C Gene

mRNA expression in normal human tissues for PPP2R5C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for PPP2R5C Gene

This gene is overexpressed in Breast (14.1), Peripheral blood mononuclear cells (11.7), Brain (8.7), and Bone (6.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPP2R5C Gene

SOURCE GeneReport for Unigene cluster for PPP2R5C Gene Hs.368264

mRNA Expression by UniProt/SwissProt for PPP2R5C Gene

Q13362-2A5G_HUMAN
Tissue specificity: Highest levels in heart, skeletal muscle and brain. Lower levels in pancreas, kidney, lung and placenta. Very low levels in liver
genes like me logo Genes that share expressions with PPP2R5C: view

Expression partners for PPP2R5C Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PPP2R5C Gene

Orthologs for PPP2R5C Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP2R5C Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Ppp2r5c 16
Ppp2r5c 36
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PPP2R5C 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPP2R5C 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPP2R5C 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPP2R5C 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PPP2R5C 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPP2R5C 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPP2R5C 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76127 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.11152 35
zebrafish
(Danio rerio)
Actinopterygii ppp2r5cb 36
  • 80 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta BcDNA:LD34343 37
  • 73 (a)
PP2A-B 37
  • 79 (a)
PP2A-B 36
  • 37 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C13G3.3a 37
  • 64 (a)
C13G3.3b 37
  • 64 (a)
W08G11.4 37
  • 66 (a)
pptr-2 36
  • 55 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RTS1 36
  • 35 (a)
OneToMany
RTS1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G25510 35
  • 54.87 (n)
  • 49.89 (a)
rice
(Oryza sativa)
Liliopsida Os.27452 35
Os05g0555100 35
  • 57.1 (n)
  • 54.38 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3438 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2648 36
  • 61 (a)
OneToMany
Species with no ortholog for PPP2R5C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP2R5C Gene

ENSEMBL:
Gene Tree for PPP2R5C (if available)
TreeFam:
Gene Tree for PPP2R5C (if available)

Paralogs for PPP2R5C Gene

Paralogs for PPP2R5C Gene

Pseudogenes.org Pseudogenes for PPP2R5C Gene

genes like me logo Genes that share paralogs with PPP2R5C: view

Variants for PPP2R5C Gene

Sequence variations from dbSNP and Humsavar for PPP2R5C Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs2623 -- 101,927,270(-) AAACC(A/T)AGACA utr-variant-3-prime
rs3405 -- 101,845,043(-) TCCCA(C/T)ATAGG intron-variant
rs718941 -- 101,857,339(-) CATGA(A/T)CTATT intron-variant
rs730572 -- 101,921,562(+) AAAAA(C/T)GTGCA intron-variant
rs730573 -- 101,921,262(+) TTTTA(A/C)CATGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPP2R5C Gene

Variant ID Type Subtype PubMed ID
nsv902251 CNV Loss 21882294
nsv512375 CNV Loss 21212237
nsv518045 CNV Loss 19592680
nsv902254 CNV Loss 21882294
esv2565595 CNV Insertion 19546169
esv2749146 CNV Deletion 23290073
esv2749147 CNV Deletion 23290073
esv2656703 CNV Deletion 23128226
nsv84885 CNV Loss 16902084

Relevant External Links for PPP2R5C Gene

HapMap Linkage Disequilibrium report
PPP2R5C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP2R5C Gene

Disorders for PPP2R5C Gene

Relevant External Links for PPP2R5C

Genetic Association Database (GAD)
PPP2R5C
Human Genome Epidemiology (HuGE) Navigator
PPP2R5C

No disorders were found for PPP2R5C Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for PPP2R5C Gene

Publications for PPP2R5C Gene

  1. Identification of a new family of protein phosphatase 2A regulatory subunits. (PMID: 7592815) McCright B. … Virshup D.M. (J. Biol. Chem. 1995) 2 3 4
  2. B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK. (PMID: 16456541) Letourneux C. … Porteu F. (EMBO J. 2006) 3 4
  3. Structure of the protein phosphatase 2A holoenzyme. (PMID: 17174897) Xu Y. … Shi Y. (Cell 2006) 3 4
  4. A specific PP2A regulatory subunit, B56gamma, mediates DNA damage- induced dephosphorylation of p53 at Thr55. (PMID: 17245430) Li H.H. … Liu X. (EMBO J. 2007) 3 4
  5. Serine 15 phosphorylation of p53 directs its interaction with B56gamma and the tumor suppressor activity of B56gamma-specific protein phosphatase 2A. (PMID: 17967874) Shouse G.P. … Liu X. (Mol. Cell. Biol. 2008) 3 4

Products for PPP2R5C Gene

Sources for PPP2R5C Gene

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