Aliases for PPP2R5C Gene
- Protein Phosphatase 2 Regulatory Subunit B', Gamma 2
- Protein Phosphatase 2 Regulatory Subunit B, Gamma 2 3 5
- Protein Phosphatase 2, Regulatory Subunit B (B56), Gamma Isoform 2 3
- Protein Phosphatase 2, Regulatory Subunit B, Gamma Isoform 2 3
- Renal Carcinoma Antigen NY-REN-29 3 4
- PP2A B Subunit Isoform PR61-Gamma 3 4
- PP2A B Subunit Isoform B56-Gamma 3 4
- PP2A B Subunit Isoform R5-Gamma 3 4
External Ids for PPP2R5C Gene
Previous GeneCards Identifiers for PPP2R5C Gene
The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
GeneCards Summary for PPP2R5C Gene
PPP2R5C (Protein Phosphatase 2 Regulatory Subunit B', Gamma) is a Protein Coding gene. Among its related pathways are CTLA4 Signaling and Negative regulation of MAPK pathway. GO annotations related to this gene include binding and protein phosphatase type 2A regulator activity. An important paralog of this gene is PPP2R5E.
UniProtKB/Swiss-Prot for PPP2R5C Gene
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation.