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Aliases for PSPC1 Gene

Aliases for PSPC1 Gene

  • Paraspeckle Component 1 2 3
  • PSP1 3 4 6
  • Paraspeckle Protein 1 3 4

External Ids for PSPC1 Gene

Previous GeneCards Identifiers for PSPC1 Gene

  • GC13M019178
  • GC13M018046
  • GC13M018047
  • GC13M019146
  • GC13M020249
  • GC13M001053

Summaries for PSPC1 Gene

Entrez Gene Summary for PSPC1 Gene

  • This gene encodes a nucleolar protein that localizes to punctate subnuclear structures that occur close to splicing speckles, known as paraspeckles. These paraspeckles are composed of RNA-protein structures that include a non-coding RNA, NEAT1/Men epsilon/beta, and the Drosophila Behavior Human Splicing family of proteins, which include the product of this gene and the P54NRB/NONO and PSF/SFPQ proteins. Paraspeckles may function in the control of gene expression via an RNA nuclear retention mechanism. The protein encoded by this gene is found in paraspeckles in transcriptionally active cells, but it localizes to unique cap structures at the nucleolar periphery when RNA polymerase II transcription is inhibited, or during telophase. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene, which is also located on chromosome 13, has been identified. [provided by RefSeq, Aug 2011]

GeneCards Summary for PSPC1 Gene

PSPC1 (Paraspeckle Component 1) is a Protein Coding gene. Diseases associated with PSPC1 include western equine encephalitis. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is NONO.

UniProtKB/Swiss-Prot for PSPC1 Gene

  • Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line (By similarity). Binds to poly(A), poly(G) and poly(U) RNA homopolymers. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). Together with NONO, required for the formation of nuclear paraspeckles.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSPC1 Gene

Genomics for PSPC1 Gene

Regulatory Elements for PSPC1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PSPC1 Gene

Start:
19,674,752 bp from pter
End:
19,783,019 bp from pter
Size:
108,268 bases
Orientation:
Minus strand

Genomic View for PSPC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PSPC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSPC1 Gene

Proteins for PSPC1 Gene

  • Protein details for PSPC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WXF1-PSPC1_HUMAN
    Recommended name:
    Paraspeckle component 1
    Protein Accession:
    Q8WXF1
    Secondary Accessions:
    • Q5JTQ3
    • Q8NCZ9
    • Q8WXE8
    • Q9NV36

    Protein attributes for PSPC1 Gene

    Size:
    523 amino acids
    Molecular mass:
    58744 Da
    Quaternary structure:
    • Forms heterodimers with NONO; this involves formation of a coiled coil domain by helices from both proteins. Found in a RNP complex with CAT2 transcribed nuclear RNA (CTN-RNA). Interaction with NONO is required for its targeting to paraspeckles and perinucleolar caps. Interacts with SFPQ (By similarity).
    SequenceCaution:
    • Sequence=BAA91924.1; Type=Erroneous termination; Positions=14; Note=Translated as Lys.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PSPC1 Gene

    Alternative splice isoforms for PSPC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSPC1 Gene

Proteomics data for PSPC1 Gene at MOPED

Post-translational modifications for PSPC1 Gene

  • Ubiquitination at Lys198
  • Modification sites at PhosphoSitePlus

Other Protein References for PSPC1 Gene

Antibody Products

No data available for DME Specific Peptides for PSPC1 Gene

Domains for PSPC1 Gene

Gene Families for PSPC1 Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Protein Domains for PSPC1 Gene

Suggested Antigen Peptide Sequences for PSPC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WXF1

UniProtKB/Swiss-Prot:

PSPC1_HUMAN :
  • Q8WXF1
Domain:
  • Contains 2 RRM (RNA recognition motif) domains.
Family:
  • Belongs to the PSPC family.
genes like me logo Genes that share domains with PSPC1: view

Function for PSPC1 Gene

Molecular function for PSPC1 Gene

UniProtKB/Swiss-Prot Function:
Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line (By similarity). Binds to poly(A), poly(G) and poly(U) RNA homopolymers. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). Together with NONO, required for the formation of nuclear paraspeckles.

Gene Ontology (GO) - Molecular Function for PSPC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0001047 core promoter binding ISS --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding --
GO:0005515 protein binding IPI 16148043
genes like me logo Genes that share ontologies with PSPC1: view

Phenotypes for PSPC1 Gene

MGI mutant phenotypes for PSPC1:
inferred from 1 alleles
GenomeRNAi human phenotypes for PSPC1:
genes like me logo Genes that share phenotypes with PSPC1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PSPC1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PSPC1 Gene

Localization for PSPC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSPC1 Gene

Nucleus, nucleolus. Nucleus matrix. Cytoplasm. Nucleus speckle. Note=In punctate subnuclear structures often located adjacent to splicing speckles, called paraspeckles. Colocalizes with NONO and SFPQ in paraspeckles and perinucleolar caps in an RNA-dependent manner. May cycles between paraspeckles and nucleolus. In telophase, when daughter nuclei form, localizes to perinucleolar caps.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PSPC1 Gene COMPARTMENTS Subcellular localization image for PSPC1 gene
Compartment Confidence
nucleus 5
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PSPC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
GO:0016363 nuclear matrix IEA --
genes like me logo Genes that share ontologies with PSPC1: view

Pathways for PSPC1 Gene

SuperPathways for PSPC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PSPC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0042752 regulation of circadian rhythm ISS --
GO:0045892 negative regulation of transcription, DNA-templated ISS --
GO:0048511 rhythmic process IEA --
genes like me logo Genes that share ontologies with PSPC1: view

No data available for Pathways by source for PSPC1 Gene

Transcripts for PSPC1 Gene

Unigene Clusters for PSPC1 Gene

Paraspeckle component 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PSPC1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSPC1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13
SP1: - -
SP2: - - - - - - - -
SP3: - - - - - - - - -
SP4: -
SP5: -
SP6:
SP7:

Relevant External Links for PSPC1 Gene

GeneLoc Exon Structure for
PSPC1
ECgene alternative splicing isoforms for
PSPC1

Expression for PSPC1 Gene

mRNA expression in normal human tissues for PSPC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for PSPC1 Gene

This gene is overexpressed in Fetal ovary (9.1) and Fetal Brain (6.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PSPC1 Gene

SOURCE GeneReport for Unigene cluster for PSPC1 Gene Hs.213198

mRNA Expression by UniProt/SwissProt for PSPC1 Gene

Q8WXF1-PSPC1_HUMAN
Tissue specificity: Expressed in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain and heart.
genes like me logo Genes that share expressions with PSPC1: view

Expression partners for PSPC1 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PSPC1 Gene

Orthologs for PSPC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PSPC1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PSPC1 35
  • 90.38 (n)
  • 96.35 (a)
PSPC1 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PSPC1 35
  • 92.51 (n)
  • 96.33 (a)
PSPC1 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pspc1 35
  • 91.83 (n)
  • 97.32 (a)
Pspc1 16
Pspc1 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PSPC1 35
  • 99.68 (n)
  • 100 (a)
PSPC1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pspc1 35
  • 92.08 (n)
  • 97.13 (a)
oppossum
(Monodelphis domestica)
Mammalia PSPC1 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 68 (a)
OneToMany
-- 36
  • 98 (a)
OneToMany
chicken
(Gallus gallus)
Aves PSPC1 35
  • 85.69 (n)
  • 94.85 (a)
PSPC1 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PSPC1 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pspc1 35
  • 75.42 (n)
  • 78.99 (a)
zebrafish
(Danio rerio)
Actinopterygii pspc1 35
  • 69.59 (n)
  • 72.58 (a)
pspc1 36
  • 69 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta nonA 36
  • 21 (a)
ManyToMany
nonA-l 36
  • 24 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea nono-1 36
  • 30 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
OneToMany
Species with no ortholog for PSPC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PSPC1 Gene

ENSEMBL:
Gene Tree for PSPC1 (if available)
TreeFam:
Gene Tree for PSPC1 (if available)

Paralogs for PSPC1 Gene

Paralogs for PSPC1 Gene

Selected SIMAP similar genes for PSPC1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PSPC1: view

Variants for PSPC1 Gene

Sequence variations from dbSNP and Humsavar for PSPC1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs11840 -- 19,703,131(+) GCATA(C/T)CACTG utr-variant-3-prime, intron-variant
rs657656 -- 19,710,027(-) TGTTC(A/G)AATAC intron-variant
rs657676 -- 19,710,014(-) TTCAA(C/T)ATGAA intron-variant
rs1023227 -- 19,686,706(-) AATCA(A/G)CAGCC intron-variant
rs1023228 -- 19,686,660(-) ATTTT(A/T)TGAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PSPC1 Gene

Variant ID Type Subtype PubMed ID
esv2747051 CNV Deletion 23290073
dgv334e199 CNV Deletion 23128226
nsv899855 CNV Gain 21882294
nsv516945 CNV Gain+Loss 19592680
nsv899856 CNV Gain 21882294
nsv899857 CNV Gain 21882294
nsv826574 CNV Loss 20364138
esv2672732 CNV Deletion 23128226
nsv455826 CNV Loss 19166990
dgv1551n71 CNV Loss 21882294
nsv899860 CNV Loss 21882294
dgv1552n71 CNV Loss 21882294
esv2675516 CNV Deletion 23128226

Relevant External Links for PSPC1 Gene

HapMap Linkage Disequilibrium report
PSPC1
Human Gene Mutation Database (HGMD)
PSPC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSPC1 Gene

Disorders for PSPC1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for PSPC1 Gene in MalaCards »

(1) Diseases for PSPC1 Gene including...

(1) University of Copenhagen DISEASES for PSPC1 Gene

genes like me logo Genes that share disorders with PSPC1: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for PSPC1 Gene

Publications for PSPC1 Gene

  1. Paraspeckles: a novel nuclear domain. (PMID: 11790299) Fox A.H. … Lamond A.I. (Curr. Biol. 2002) 2 3 4 23
  2. P54nrb forms a heterodimer with PSP1 that localizes to paraspeckles in an RNA-dependent manner. (PMID: 16148043) Fox A.H. … Lamond A.I. (Mol. Biol. Cell 2005) 3 4 23
  3. MENepsilon/beta noncoding RNAs are essential for structural integrity of nuclear paraspeckles. (PMID: 19188602) Sasaki Y.T. … Hirose T. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 23
  4. An architectural role for a nuclear noncoding RNA: NEAT1 RNA is essential for the structure of paraspeckles. (PMID: 19217333) Clemson C.M. … Lawrence J.B. (Mol. Cell 2009) 3 23
  5. p54nrb acts as a transcriptional coactivator for activation function 1 of the human androgen receptor. (PMID: 12810069) Ishitani K. … Kato S. (Biochem. Biophys. Res. Commun. 2003) 3 23

Products for PSPC1 Gene

  • Addgene plasmids for PSPC1

Sources for PSPC1 Gene

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