Aliases for SLC47A1 Gene
External Ids for SLC47A1 Gene
Previous GeneCards Identifiers for SLC47A1 Gene
This gene is located within the Smith-Magenis syndrome region on chromosome 17. It encodes a protein of unknown function. [provided by RefSeq, Jul 2008]
GeneCards Summary for SLC47A1 Gene
SLC47A1 (Solute Carrier Family 47 (Multidrug And Toxin Extrusion), Member 1) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Glucose / Energy Metabolism. GO annotations related to this gene include antiporter activity and monovalent cation:proton antiporter activity. An important paralog of this gene is SLC47A2.
UniProtKB/Swiss-Prot for SLC47A1 Gene
Solute transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide (NMN), metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, ganciclovir and also the zwitterionic cephalosporin, cephalexin and cephradin. Seems to also play a role in the uptake of oxaliplatin (a new platinum anticancer agent). Able to transport paraquat (PQ or N,N-dimethyl-4-4-bipiridinium); a widely used herbicid. Responsible for the secretion of cationic drugs across the brush border membranes.