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Aliases for SLC47A1 Gene

Aliases for SLC47A1 Gene

  • Solute Carrier Family 47 (Multidrug And Toxin Extrusion), Member 1 2 3
  • MATE1 3 4 6
  • Multidrug And Toxin Extrusion 1 2 3
  • HMATE-1 3 4
  • MATE-1 3 4
  • Multidrug And Toxin Extrusion Protein 1 3
  • Solute Carrier Family 47, Member 1 3
  • Solute Carrier Family 47 Member 1 4
  • FLJ10847 6

External Ids for SLC47A1 Gene

Previous GeneCards Identifiers for SLC47A1 Gene

  • GC17P019378
  • GC17P019437
  • GC17P018816
  • GC17P019398

Summaries for SLC47A1 Gene

Entrez Gene Summary for SLC47A1 Gene

  • This gene is located within the Smith-Magenis syndrome region on chromosome 17. It encodes a protein of unknown function. [provided by RefSeq, Jul 2008]

GeneCards Summary for SLC47A1 Gene

SLC47A1 (Solute Carrier Family 47 (Multidrug And Toxin Extrusion), Member 1) is a Protein Coding gene. Diseases associated with SLC47A1 include smith-magenis syndrome. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include drug transmembrane transporter activity and monovalent cation:proton antiporter activity. An important paralog of this gene is SLC47A2.

UniProtKB/Swiss-Prot for SLC47A1 Gene

  • Solute transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide (NMN), metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, ganciclovir and also the zwitterionic cephalosporin, cephalexin and cephradin. Seems to also play a role in the uptake of oxaliplatin (a new platinum anticancer agent). Able to transport paraquat (PQ or N,N-dimethyl-4-4-bipiridinium); a widely used herbicid. Responsible for the secretion of cationic drugs across the brush border membranes.

Gene Wiki entry for SLC47A1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC47A1 Gene

Genomics for SLC47A1 Gene

Regulatory Elements for SLC47A1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC47A1 Gene

Start:
19,495,385 bp from pter
End:
19,579,034 bp from pter
Size:
83,650 bases
Orientation:
Plus strand

Genomic View for SLC47A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC47A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC47A1 Gene

Proteins for SLC47A1 Gene

  • Protein details for SLC47A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96FL8-S47A1_HUMAN
    Recommended name:
    Multidrug and toxin extrusion protein 1
    Protein Accession:
    Q96FL8
    Secondary Accessions:
    • Q53HF5
    • Q6PD77
    • Q86VL4
    • Q9NVA3

    Protein attributes for SLC47A1 Gene

    Size:
    570 amino acids
    Molecular mass:
    61922 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH50592.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC47A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC47A1 Gene

Proteomics data for SLC47A1 Gene at MOPED

Post-translational modifications for SLC47A1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC47A1 Gene

No data available for DME Specific Peptides for SLC47A1 Gene

Domains for SLC47A1 Gene

Gene Families for SLC47A1 Gene

Protein Domains for SLC47A1 Gene

Suggested Antigen Peptide Sequences for SLC47A1 Gene

Graphical View of Domain Structure for InterPro Entry

Q96FL8

UniProtKB/Swiss-Prot:

S47A1_HUMAN :
  • Q96FL8
Family:
  • Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
genes like me logo Genes that share domains with SLC47A1: view

Function for SLC47A1 Gene

Molecular function for SLC47A1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=0.38 mM for TEA {ECO:0000269 PubMed:16330770, ECO:0000269 PubMed:17509534}; KM=0.10 mM for MPP {ECO:0000269 PubMed:16330770, ECO:0000269 PubMed:17509534}; KM=0.17 mM for cimetidine {ECO:0000269 PubMed:16330770, ECO:0000269 PubMed:17509534}; KM=0.78 mM for metformin {ECO:0000269 PubMed:16330770, ECO:0000269 PubMed:17509534}; KM=2.1 mM for guanidine {ECO:0000269 PubMed:16330770, ECO:0000269 PubMed:17509534}; KM=1.23 mM for procainamide {ECO:0000269 PubMed:16330770, ECO:0000269 PubMed:17509534}; KM=0.07 mM for topotecan {ECO:0000269 PubMed:16330770, ECO:0000269 PubMed:17509534}; KM=0.47 mM for estrone sulfate {ECO:0000269 PubMed:16330770, ECO:0000269 PubMed:17509534}; KM=2.64 mM for acyclovir {ECO:0000269 PubMed:16330770, ECO:0000269 PubMed:17509534}; KM=5.12 mM for ganciclovir {ECO:0000269 PubMed:16330770, ECO:0000269 PubMed:17509534}; Vmax=1.185 nmol/min/mg enzyme toward TEA {ECO:0000269 PubMed:16330770, ECO:0000269 PubMed:17509534}; Vmax=0.735 nmol/min/mg enzyme toward MPP {ECO:0000269 PubMed:16330770, ECO:0000269 PubMed:17509534}; Vmax=0.135 nmol/min/mg enzyme toward cimetidine {ECO:0000269 PubMed:16330770, ECO:0000269 PubMed:17509534}; Vmax=2.23 nmol/min/mg enzyme toward metformin {ECO:0000269 PubMed:16330770, ECO:0000269 PubMed:17509534}; Vmax=0.89 nmol/min/mg enzyme toward guanidine {ECO:0000269 PubMed:16330770, ECO:0000269 PubMed:17509534}; Vmax=3.78 nmol/min/mg enzyme toward procainamide {ECO:0000269 PubMed:16330770, ECO:0000269 PubMed:17509534}; Vmax=0.21 nmol/min/mg enzyme toward topotecan {ECO:0000269 PubMed:16330770, ECO:0000269 PubMed:17509534}; Vmax=0.265 nmol/min/mg enzyme toward estrone sulfate {ECO:0000269 PubMed:16330770, ECO:0000269 PubMed:17509534}; Vmax=0.62 nmol/min/mg enzyme toward acyclovir {ECO:0000269 PubMed:16330770, ECO:0000269 PubMed:17509534}; Vmax=1.08 nmol/min/mg enzyme toward ganciclovir {ECO:0000269 PubMed:16330770, ECO:0000269 PubMed:17509534}; pH dependence: Optimum pH is 8.5. Active from pH 6 to 8.5. {ECO:0000269 PubMed:16330770, ECO:0000269 PubMed:17509534};
UniProtKB/Swiss-Prot Function: Solute transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide (NMN), metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, ganciclovir and also the zwitterionic cephalosporin, cephalexin and cephradin. Seems to also play a role in the uptake of oxaliplatin (a new platinum anticancer agent). Able to transport paraquat (PQ or N,N-dimethyl-4-4-bipiridinium); a widely used herbicid. Responsible for the secretion of cationic drugs across the brush border membranes.

Gene Ontology (GO) - Molecular Function for SLC47A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005451 monovalent cation:proton antiporter activity IEA --
GO:0015238 drug transmembrane transporter activity IEA --
GO:0015297 antiporter activity --
genes like me logo Genes that share ontologies with SLC47A1: view
genes like me logo Genes that share phenotypes with SLC47A1: view

Animal Models for SLC47A1 Gene

MGI Knock Outs for SLC47A1:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC47A1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC47A1 Gene

Localization for SLC47A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC47A1 Gene

Cell membrane; Multi-pass membrane protein. Note=Predominantly localized at the plasma membrane but also found in intracellular organelles.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC47A1 Gene COMPARTMENTS Subcellular localization image for SLC47A1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for SLC47A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
GO:0031988 membrane-bounded vesicle IEA --
genes like me logo Genes that share ontologies with SLC47A1: view

Pathways for SLC47A1 Gene

genes like me logo Genes that share pathways with SLC47A1: view

Interacting Proteins for SLC47A1 Gene

Gene Ontology (GO) - Biological Process for SLC47A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006855 drug transmembrane transport IEA --
GO:0015695 organic cation transport IEA --
GO:0015893 drug transport --
GO:0055085 transmembrane transport TAS --
GO:1902600 hydrogen ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC47A1: view

Compounds for SLC47A1 Gene

(6) Drugbank Compounds for SLC47A1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Acyclovir
  • 9-Hyroxyethoxymethylguanine
59277-89-3 transporter substrate
Bromodiphenhydramine
  • Ambodryl Hydrochloride
1808-12-4 transporter inhibitor
Cephalexin
  • Cefalessina [DCIT]
15686-71-2 transporter substrate
Cimetidine
51481-61-9 transporter inhibitor
Metformin
657-24-9 transporter inhibitor

(3) IUPHAR Ligand for SLC47A1 Gene

Ligand Type Action Affinity Pubmed IDs
pyrimethamine Inhibitor Inhibition 6.8
[14C]TEA None None
[14C]metformin None None
genes like me logo Genes that share compounds with SLC47A1: view

Transcripts for SLC47A1 Gene

Unigene Clusters for SLC47A1 Gene

Solute carrier family 47, member 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC47A1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SLC47A1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC47A1 Gene

No ASD Table

Relevant External Links for SLC47A1 Gene

GeneLoc Exon Structure for
SLC47A1
ECgene alternative splicing isoforms for
SLC47A1

Expression for SLC47A1 Gene

mRNA expression in normal human tissues for SLC47A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC47A1 Gene

This gene is overexpressed in Adrenal Gland (11.7), Liver (8.2), Kidney - Cortex (4.8), and Muscle - Skeletal (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for SLC47A1 Gene

SOURCE GeneReport for Unigene cluster for SLC47A1 Gene Hs.232054

mRNA Expression by UniProt/SwissProt for SLC47A1 Gene

Q96FL8-S47A1_HUMAN
Tissue specificity: Expressed in adrenal gland, and to a lower extent in liver, skeletal muscle and kidney (especially found in luminal membranes of the urinary tubules, bile caniculi and brush border membranes).
genes like me logo Genes that share expressions with SLC47A1: view

In Situ Assay Products

Orthologs for SLC47A1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC47A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC47A1 35
  • 99.3 (n)
  • 99.3 (a)
SLC47A1 36
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC47A1 35
  • 79.52 (n)
  • 77.11 (a)
SLC47A1 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC47A1 35
  • 81.72 (n)
  • 75.75 (a)
SLC47A1 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc47a1 35
  • 80.83 (n)
  • 78.48 (a)
Slc47a1 16
Slc47a1 36
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC47A1 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC47A1 36
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc47a1 35
  • 80.33 (n)
  • 78.98 (a)
chicken
(Gallus gallus)
Aves SLC47A1 36
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC47A1 36
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498310 35
  • 58.79 (n)
  • 55.44 (a)
zebrafish
(Danio rerio)
Actinopterygii BX248108.1 36
  • 45 (a)
OneToMany
slc47a1 36
  • 38 (a)
OneToMany
SLC47A1 (3 of 6) 36
  • 40 (a)
OneToMany
SLC47A1 (4 of 6) 36
  • 48 (a)
OneToMany
SLC47A1 (5 of 6) 36
  • 41 (a)
OneToMany
slc47a2 36
  • 48 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL099W 35
  • 44.71 (n)
  • 31.53 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 19 (a)
ManyToMany
-- 38
ERC1 36
  • 19 (a)
ManyToMany
YDR338C 35
  • 41.14 (n)
  • 29.32 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A06952g 35
  • 41.28 (n)
  • 28.47 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G52450 35
  • 44.52 (n)
  • 36.02 (a)
rice
(Oryza sativa)
Liliopsida Os06g0495500 35
  • 47.17 (n)
  • 36.16 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07720 35
  • 47.05 (n)
  • 35.17 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC4B3.13 35
  • 44.8 (n)
  • 37.07 (a)
Species with no ortholog for SLC47A1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC47A1 Gene

ENSEMBL:
Gene Tree for SLC47A1 (if available)
TreeFam:
Gene Tree for SLC47A1 (if available)

Paralogs for SLC47A1 Gene

Paralogs for SLC47A1 Gene

Selected SIMAP similar genes for SLC47A1 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for SLC47A1 Gene

genes like me logo Genes that share paralogs with SLC47A1: view

Variants for SLC47A1 Gene

Sequence variations from dbSNP and Humsavar for SLC47A1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs10735 -- 19,578,868(-) gggtg(A/C/G/T)tggga utr-variant-3-prime
rs716126 -- 19,570,178(-) TCTGT(G/T)TCTTG intron-variant
rs720252 -- 19,554,285(-) AGTTT(C/T)CAAAG intron-variant
rs735579 -- 19,538,833(-) GCGCC(A/T)GGCAG intron-variant
rs751259 -- 19,536,968(-) ATGGA(C/T)GCATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC47A1 Gene

Variant ID Type Subtype PubMed ID
nsv428337 CNV Loss 18775914

Relevant External Links for SLC47A1 Gene

HapMap Linkage Disequilibrium report
SLC47A1
Human Gene Mutation Database (HGMD)
SLC47A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC47A1 Gene

Disorders for SLC47A1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for SLC47A1 Gene including...

Search for SLC47A1 Gene in MalaCards »

Relevant External Links for SLC47A1

Genetic Association Database (GAD)
SLC47A1
Human Genome Epidemiology (HuGE) Navigator
SLC47A1
genes like me logo Genes that share disorders with SLC47A1: view

No data available for UniProtKB/Swiss-Prot for SLC47A1 Gene

Publications for SLC47A1 Gene

  1. A human transporter protein that mediates the final excretion step for toxic organic cations. (PMID: 16330770) Otsuka M. … Moriyama Y. (Proc. Natl. Acad. Sci. U.S.A. 2005) 2 3 4
  2. The MATE proteins as fundamental transporters of metabolic and xenobiotic organic cations. (PMID: 16996621) Omote H. … Moriyama Y. (Trends Pharmacol. Sci. 2006) 2 3 4
  3. Molecular identification and functional characterization of rat multidrug and toxin extrusion type transporter 1 as an organic cation/H+ antiporter in the kidney. (PMID: 16928787) Ohta K.Y. … Yuasa H. (Drug Metab. Dispos. 2006) 2 3
  4. Transport of paraquat by human organic cation transporters and multidrug and toxic compound extrusion family. (PMID: 17495125) Chen Y. … Giacomini K.M. (J. Pharmacol. Exp. Ther. 2007) 3 4
  5. Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters. (PMID: 17509534) Tanihara Y. … Inui K. (Biochem. Pharmacol. 2007) 3 4

Products for SLC47A1 Gene

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Sources for SLC47A1 Gene

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