Aliases for PPP2R4 Gene
- Protein Phosphatase 2A Regulatory Subunit 4 2 3 5
- Phosphotyrosyl Phosphatase Activator 2 3 4
- Serine/Threonine-Protein Phosphatase 2A Regulatory Subunit B 3 4
- Protein Phosphatase 2A Activator, Regulatory Subunit 4 2 3
- Protein Phosphatase 2A, Regulatory Subunit B (PR 53) 2 3
- PP2A Phosphatase Activator 2 3
- PTPA 3 4
External Ids for PPP2R4 Gene
Previous GeneCards Identifiers for PPP2R4 Gene
Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family. This gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
GeneCards Summary for PPP2R4 Gene
PPP2R4 (Protein Phosphatase 2A Regulatory Subunit 4) is a Protein Coding gene. Diseases associated with PPP2R4 include spinocerebellar ataxia 12 and fragile x syndrome. Among its related pathways are Beta-Adrenergic Signaling and p53 pathway (Pathway Interaction Database). GO annotations related to this gene include protein homodimerization activity and receptor binding.
UniProtKB/Swiss-Prot for PPP2R4 Gene
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine-protein phosphatase 2A (PP2A) modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+) (By similarity). Reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A(D) in presence of ATP and Mg(2+) (in vitro). The phosphotyrosyl phosphatase activity is dependent of an ATPase activity of the PP2A(D):PPP2R4 complex. Is involved in apoptosis; the function appears to be independent from PP2A.