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Aliases for PTPA Gene

Aliases for PTPA Gene

  • Protein Phosphatase 2 Phosphatase Activator 2 3 5
  • Phosphotyrosyl Phosphatase Activator 2 3 4
  • Serine/Threonine-Protein Phosphatase 2A Regulatory Subunit B 3 4
  • Protein Phosphatase 2A Activator, Regulatory Subunit 4 2 3
  • Protein Phosphatase 2A, Regulatory Subunit B (PR 53) 2 3
  • Protein Phosphatase 2 Regulatory Subunit 4 2 3
  • PP2A Phosphatase Activator 2 3
  • PPP2R4 3 4
  • Serine/Threonine-Protein Phosphatase 2A Regulatory Subunit 4 4
  • Serine/Threonine-Protein Phosphatase 2A Activator 3
  • Protein Phosphatase 2A Regulatory Subunit 4 3
  • PP2A, Subunit B, PR53 Isoform 4
  • PP2A Subunit B Isoform PR53 3
  • EC 5.2.1.8 4
  • PP2A 3
  • PR53 3

External Ids for PTPA Gene

Previous HGNC Symbols for PTPA Gene

  • PPP2R4

Summaries for PTPA Gene

Entrez Gene Summary for PTPA Gene

  • Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family. This gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for PTPA Gene

PTPA (Protein Phosphatase 2 Phosphatase Activator) is a Protein Coding gene. Diseases associated with PTPA include Acute Leukemia Of Ambiguous Lineage and Apical Myocardial Infarction. Among its related pathways are CTLA4 Signaling and Validated targets of C-MYC transcriptional repression.

UniProtKB/Swiss-Prot for PTPA Gene

  • PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine-protein phosphatase 2A (PP2A) modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+) (By similarity). Reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A(D) in presence of ATP and Mg(2+) (in vitro). The phosphotyrosyl phosphatase activity is dependent of an ATPase activity of the PP2A(D):PPP2R4 complex. Is involved in apoptosis; the function appears to be independent from PP2A.

Gene Wiki entry for PTPA Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPA Gene

Genomics for PTPA Gene

Regulatory Elements for PTPA Gene

Enhancers for PTPA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G129172 1.8 FANTOM5 ENCODE dbSUPER 5.3 +64.8 64815 7.5 CREB3L1 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 PPARGC1A CRAT LOC101929314 SPOUT1 ENSG00000272696 USP20 PTPA ENDOG NTMT1 IER5L PHYHD1
GH09G129594 2 FANTOM5 Ensembl ENCODE dbSUPER 4.4 +486.0 485960 3.8 HDGF HNRNPUL1 PKNOX1 MLX ARNT ZFP64 ARID4B DMAP1 SLC30A9 ZNF766 SPOUT1 LOC101929314 DOLK WDR34 PKN3 ENSG00000234055 PTPA IER5L CRAT NTMT1
GH09G129084 0.5 ENCODE 12.9 -26.7 -26669 0.1 ESRRA RCOR2 HNF4G HNF4A TEAD3 PTPA CRAT DOLPP1 ENSG00000234055
GH09G129242 0.7 ENCODE 5.5 +132.1 132145 1.0 ZNF263 L3MBTL2 ZBTB21 BHLHE40 KLF17 ZEB2 ATF2 ZSCAN21 ZFP69B NFIC PTPA SLC27A4 LOC105376290 GC09M129195
GH09G129566 2 FANTOM5 Ensembl ENCODE dbSUPER 1.6 +458.4 458353 5.8 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A ZBTB7B YY1 ZNF766 ZNF143 C9orf50 NTMT1 LOC105376292 NCS1 IER5L CRAT PTPA LINC00963
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PTPA on UCSC Golden Path with GeneCards custom track

Promoters for PTPA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000337912 355 2201 HDGF PKNOX1 MLX CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for PTPA Gene

Chromosome:
9
Start:
129,110,945 bp from pter
End:
129,148,946 bp from pter
Size:
38,002 bases
Orientation:
Plus strand

Genomic View for PTPA Gene

Genes around PTPA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTPA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTPA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPA Gene

Proteins for PTPA Gene

  • Protein details for PTPA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15257-PTPA_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase 2A activator
    Protein Accession:
    Q15257
    Secondary Accessions:
    • A2A347
    • A9IZU4
    • B4DXM4
    • Q15258
    • Q53GZ3
    • Q5TZQ2
    • Q9BUK1
    • Q9NNZ7
    • Q9NNZ8
    • Q9NNZ9

    Protein attributes for PTPA Gene

    Size:
    358 amino acids
    Molecular mass:
    40668 Da
    Quaternary structure:
    • Associates with PP2A heterodimeric core enzyme PP2A(D), composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A). Interacts with PPP2CB (By similarity).

    Three dimensional structures from OCA and Proteopedia for PTPA Gene

    Alternative splice isoforms for PTPA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTPA Gene

Post-translational modifications for PTPA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for PTPA

No data available for DME Specific Peptides for PTPA Gene

Domains & Families for PTPA Gene

Protein Domains for PTPA Gene

Graphical View of Domain Structure for InterPro Entry

Q15257

UniProtKB/Swiss-Prot:

PTPA_HUMAN :
  • Belongs to the PTPA-type PPIase family.
Family:
  • Belongs to the PTPA-type PPIase family.
genes like me logo Genes that share domains with PTPA: view

Function for PTPA Gene

Molecular function for PTPA Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Peptidylproline (omega=180) = peptidylproline (omega=0).
UniProtKB/Swiss-Prot Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine-protein phosphatase 2A (PP2A) modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+) (By similarity). Reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A(D) in presence of ATP and Mg(2+) (in vitro). The phosphotyrosyl phosphatase activity is dependent of an ATPase activity of the PP2A(D):PPP2R4 complex. Is involved in apoptosis; the function appears to be independent from PP2A.

Enzyme Numbers (IUBMB) for PTPA Gene

Gene Ontology (GO) - Molecular Function for PTPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IBA --
GO:0005102 receptor binding IPI 10830164
GO:0005515 protein binding IPI 25416956
GO:0005524 ATP binding IDA 16916641
genes like me logo Genes that share ontologies with PTPA: view
genes like me logo Genes that share phenotypes with PTPA: view

Animal Models for PTPA Gene

MGI Knock Outs for PTPA:
  • Ptpa tm1.1(KOMP)Vlcg

miRNA for PTPA Gene

miRTarBase miRNAs that target PTPA

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTPA Gene

Localization for PTPA Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPA Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PTPA gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 4
cytoskeleton 3
plasma membrane 2
mitochondrion 2
endoplasmic reticulum 2
peroxisome 1
golgi apparatus 1
endosome 1

Gene Ontology (GO) - Cellular Components for PTPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000159 protein phosphatase type 2A complex IDA 10318862
GO:0005634 nucleus IEA,IDA 17333320
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA,IEA 17333320
GO:0034704 calcium channel complex IDA 10830164
genes like me logo Genes that share ontologies with PTPA: view

Pathways & Interactions for PTPA Gene

genes like me logo Genes that share pathways with PTPA: view

SIGNOR curated interactions for PTPA Gene

Inactivates:

Gene Ontology (GO) - Biological Process for PTPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IEA --
GO:0030472 mitotic spindle organization in nucleus IBA --
GO:0032515 negative regulation of phosphoprotein phosphatase activity IDA 16916641
GO:0032516 positive regulation of phosphoprotein phosphatase activity IDA 16916641
GO:0035307 positive regulation of protein dephosphorylation IDA 16916641
genes like me logo Genes that share ontologies with PTPA: view

Drugs & Compounds for PTPA Gene

(58) Drugs for PTPA Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calyculin A Experimental Pharma Protein phosphatase inhibitor, Protein phosphatase 1 and 2A inhibitor 0
Okadaic acid Experimental Pharma Protein phosphatase 1 inhibitor, Protein phosphatase 1 and 2A inhibitor 0
Cantharidin Pharma Inhibitor of protein phosphatases 1/2A 9
Ceramide Pharma Protein phosphatase and CAPP modulator 0
microcystin-lr Pharma Inhibitor of protein phosphatase PP1/PP2A,potent and selective 0

(43) Additional Compounds for PTPA Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(8) ApexBio Compounds for PTPA Gene

Compound Action Cas Number
Calyculin A Protein phosphatase inhibitor 101932-71-2
Cantharidin Inhibitor of protein phosphatases 1/2A 56-25-7
Ceramide Protein phosphatase and CAPP modulator 3102-57-6
Fostriecin sodium salt Antitumor antibiotic 87860-39-7
Fumonisin B1 PP5/PP2Cα/PP2A/PP1γ2/PP2B inhibitor 116355-83-0
Microcystin-LR Inhibitor of protein phosphatase PP1/PP2A,potent and selective 101043-37-2
Okadaic acid Protein phosphatase 1 inhibitor 78111-17-8
Tautomycetin 119757-73-2
genes like me logo Genes that share compounds with PTPA: view

Transcripts for PTPA Gene

Alternative Splicing Database (ASD) splice patterns (SP) for PTPA Gene

No ASD Table

Relevant External Links for PTPA Gene

GeneLoc Exon Structure for
PTPA
ECgene alternative splicing isoforms for
PTPA

Expression for PTPA Gene

NURSA nuclear receptor signaling pathways regulating expression of PTPA Gene:

PTPA

mRNA Expression by UniProt/SwissProt for PTPA Gene:

Q15257-PTPA_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for PTPA Gene

  • Nervous system(4.9)
  • Heart(4.6)
  • Blood(4.5)
  • Liver(4.5)
  • Lung(4.2)
  • Kidney(3.5)
  • Intestine(3.4)
  • Skin(3.2)
  • Muscle(3.1)
  • Adrenal gland(2.4)
  • Pancreas(2.3)
  • Stomach(2)

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PTPA Gene

Orthologs for PTPA Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PTPA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPP2R4 35 34
  • 99.59 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPP2R4 35
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PPP2R4 34 35
  • 92.88 (n)
dog
(Canis familiaris)
Mammalia PPP2R4 34 35
  • 92.75 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PPP2R4 35
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppp2r4 34 35
  • 89.89 (n)
Ptpa 16
rat
(Rattus norvegicus)
Mammalia Ppp2r4 34
  • 89.47 (n)
chicken
(Gallus gallus)
Aves PPP2R4 34 35
  • 80.89 (n)
lizard
(Anolis carolinensis)
Reptilia PPP2R4 35
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp2r4 34
  • 76.29 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8828 34
zebrafish
(Danio rerio)
Actinopterygii ppp2r4 34 35
  • 73.65 (n)
wufc23d07 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8890 34
fruit fly
(Drosophila melanogaster)
Insecta Ptpa 34 35
  • 56.76 (n)
CG2104 35
  • 23 (a)
OneToMany
CG8509 35
  • 22 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008652 34
  • 56.44 (n)
worm
(Caenorhabditis elegans)
Secernentea Y71H2AM.20 34 35
  • 51.63 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR139C 34
  • 53.79 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RRD2 34 37
  • 48.46 (n)
RRD1 35
  • 33 (a)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F11187g 34
  • 47.09 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G08960 34
  • 51.36 (n)
soybean
(Glycine max)
eudicotyledons Gma.5058 34
rice
(Oryza sativa)
Liliopsida Os06g0219800 34
  • 54.96 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU03269 34
  • 51.28 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC1782.05 34
  • 45.5 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6463 34
Species where no ortholog for PTPA was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PTPA Gene

ENSEMBL:
Gene Tree for PTPA (if available)
TreeFam:
Gene Tree for PTPA (if available)

Paralogs for PTPA Gene

No data available for Paralogs for PTPA Gene

Variants for PTPA Gene

Sequence variations from dbSNP and Humsavar for PTPA Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000015998 -- 129,110,231(+) CTAAC(-/T)GAAGC intron-variant, upstream-variant-2KB
rs1000067347 -- 129,121,371(+) GGGCC(A/G)TCTAA intron-variant
rs1000087902 -- 129,121,262(+) AGAGT(A/G)TTGCT intron-variant
rs1000177380 -- 129,126,280(+) CCTCC(A/G)CCTCC intron-variant
rs1000294266 -- 129,132,789(+) CACTG(C/G)GCCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PTPA Gene

Variant ID Type Subtype PubMed ID
esv3351712 CNV insertion 20981092
nsv509323 CNV insertion 20534489
nsv615417 CNV loss 21841781
nsv818725 CNV gain 17921354
nsv831729 CNV loss 17160897

Variation tolerance for PTPA Gene

Residual Variation Intolerance Score: 42% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.32; 26.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PTPA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PTPA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPA Gene

Disorders for PTPA Gene

MalaCards: The human disease database

(5) MalaCards diseases for PTPA Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
acute leukemia of ambiguous lineage
  • acute biphenotypic leukemia
apical myocardial infarction
spinocerebellar ataxia 12
  • spinocerebellar ataxia type 12
hereditary wilms' tumor
  • hereditary wilms tumor
alzheimer disease
  • alzheimer disease, late-onset
- elite association - COSMIC cancer census association via MalaCards
Search PTPA in MalaCards View complete list of genes associated with diseases

Relevant External Links for PTPA

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PTPA
genes like me logo Genes that share disorders with PTPA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTPA Gene

Publications for PTPA Gene

  1. Structure and chromosomal localization of the human gene of the phosphotyrosyl phosphatase activator (PTPA) of protein phosphatase 2A. (PMID: 8530035) Van Hoof C. … Goris J. (Genomics 1995) 2 3 4 22 64
  2. The protein phosphatase 2A phosphatase activator is a novel peptidyl-prolyl cis/trans-isomerase. (PMID: 16380387) Jordens J. … Van Hoof C. (J. Biol. Chem. 2006) 2 3 22 64
  3. The crystal structure of a human PP2A phosphatase activator reveals a novel fold and highly conserved cleft implicated in protein-protein interactions. (PMID: 16782712) Magnusdottir A. … Nordlund P. (J. Biol. Chem. 2006) 3 4 22 64
  4. Structure and mechanism of the phosphotyrosyl phosphatase activator. (PMID: 16916641) Chao Y. … Shi Y. (Mol. Cell 2006) 3 4 22 64
  5. Identification and characterization of alternative splice products encoded by the human phosphotyrosyl phosphatase activator gene. (PMID: 10880964) Janssens V. … Goris J. (Eur. J. Biochem. 2000) 3 4 22 64

Products for PTPA Gene

Sources for PTPA Gene

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