Aliases for PPP2R2A Gene
- Protein Phosphatase 2, Regulatory Subunit B, Alpha 2 3
- PP2A Subunit B Isoform Alpha 2 4
- Serine/Threonine Protein Phosphatase 2A, 55 KDA Regulatory Subunit B, Alpha Isoform 3
- Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit B (PR 52), Alpha Isoform 2
- Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit B (PR52), Alpha Isoform 3
- Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit B, Alpha Isoform 2
- PP2A Subunit B Isoform PR55-Alpha 4
External Ids for PPP2R2A Gene
Previous GeneCards Identifiers for PPP2R2A Gene
The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]
GeneCards Summary for PPP2R2A Gene
PPP2R2A (Protein Phosphatase 2, Regulatory Subunit B, Alpha) is a Protein Coding gene. Among its related pathways are PI3K-Akt signaling pathway and TGF-Beta Pathway. GO annotations related to this gene include protein serine/threonine phosphatase activity and protein phosphatase type 2A regulator activity. An important paralog of this gene is PPP2R2C.
UniProtKB/Swiss-Prot for PPP2R2A Gene
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment
Protein Ser/Thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by hydrolysis of phosphoric acid monoesters. They oppose the action of kinases and phosphorylases and are involved in signal transduction.