Aliases for PPP2R2A Gene
- Protein Phosphatase 2, Regulatory Subunit B, Alpha 2 3
- PP2A Subunit B Isoform Alpha 2 4
- Serine/Threonine Protein Phosphatase 2A, 55 KDA Regulatory Subunit B, Alpha Isoform 3
- Serine/Threonine-Protein Phosphatase 2A 55 KDa Regulatory Subunit B Alpha Isoform 3
- Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit B (PR 52), Alpha Isoform 2
- Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit B (PR52), Alpha Isoform 3
- Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit B, Alpha Isoform 2
- PP2A Subunit B Isoform PR55-Alpha 4
External Ids for PPP2R2A Gene
The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]
GeneCards Summary for PPP2R2A Gene
PPP2R2A (Protein Phosphatase 2, Regulatory Subunit B, Alpha) is a Protein Coding gene. Among its related pathways are PI3K-Akt signaling pathway and TGF-Beta Pathway. GO annotations related to this gene include protein serine/threonine phosphatase activity and protein phosphatase type 2A regulator activity. An important paralog of this gene is PPP2R2C.
UniProtKB/Swiss-Prot for PPP2R2A Gene
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment
Protein ser/thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by the hydrolysis of phosphoric acid monoesters. They directly oppose the actions of kinases and phosphorylases and therefore play an integral role in many signal transduction pathways. There are two groups of serine/threonine phosphatases; phosphoprotein phosphatases (e.g. PP1, calcineurin), which are sensitive to okadaic acid and metallo-phosphatases (e.g. PP2C), which require a divalent cation, commonly Mg2+, for catalytic activity. Dephosphorylation, depending on the residue that the phosphate group is removed from, can have a stimulatory or inhibitory effect on the target molecule. This makes protein Ser/Thr phosphatases essential for many signal transduction pathways. Protein Ser/Thr phosphatase are regulated by their subcellular localization and by inhibitor proteins, which are subtype-specific.