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Aliases for PPP2R2A Gene

Aliases for PPP2R2A Gene

  • Protein Phosphatase 2, Regulatory Subunit B, Alpha 2 3
  • PP2A Subunit B Isoform Alpha 2 4
  • Serine/Threonine Protein Phosphatase 2A, 55 KDA Regulatory Subunit B, Alpha Isoform 3
  • Serine/Threonine-Protein Phosphatase 2A 55 KDa Regulatory Subunit B Alpha Isoform 3
  • Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit B (PR 52), Alpha Isoform 2
  • Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit B (PR52), Alpha Isoform 3
  • Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit B, Alpha Isoform 2
  • PP2A Subunit B Isoform PR55-Alpha 4
  • PP2A Subunit B Isoform B55-Alpha 4
  • PP2A Subunit B Isoform R2-Alpha 4
  • B55ALPHA 3
  • PR52A 3
  • PR55A 3
  • B55A 3

External Ids for PPP2R2A Gene

Summaries for PPP2R2A Gene

Entrez Gene Summary for PPP2R2A Gene

  • The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]

GeneCards Summary for PPP2R2A Gene

PPP2R2A (Protein Phosphatase 2, Regulatory Subunit B, Alpha) is a Protein Coding gene. Among its related pathways are PI3K-Akt signaling pathway and TGF-Beta Pathway. GO annotations related to this gene include protein serine/threonine phosphatase activity and protein phosphatase type 2A regulator activity. An important paralog of this gene is PPP2R2C.

UniProtKB/Swiss-Prot for PPP2R2A Gene

  • The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment

Tocris Summary for PPP2R2A Gene

  • Protein ser/thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by the hydrolysis of phosphoric acid monoesters. They directly oppose the actions of kinases and phosphorylases and therefore play an integral role in many signal transduction pathways. There are two groups of serine/threonine phosphatases; phosphoprotein phosphatases (e.g. PP1, calcineurin), which are sensitive to okadaic acid and metallo-phosphatases (e.g. PP2C), which require a divalent cation, commonly Mg2+, for catalytic activity. Dephosphorylation, depending on the residue that the phosphate group is removed from, can have a stimulatory or inhibitory effect on the target molecule. This makes protein Ser/Thr phosphatases essential for many signal transduction pathways. Protein Ser/Thr phosphatase are regulated by their subcellular localization and by inhibitor proteins, which are subtype-specific.

Gene Wiki entry for PPP2R2A Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP2R2A Gene

Genomics for PPP2R2A Gene

Genomic Location for PPP2R2A Gene

Start:
26,291,491 bp from pter
End:
26,372,680 bp from pter
Size:
81,190 bases
Orientation:
Plus strand

Genomic View for PPP2R2A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPP2R2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP2R2A Gene

Regulatory Elements for PPP2R2A Gene

Proteins for PPP2R2A Gene

  • Protein details for PPP2R2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P63151-2ABA_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
    Protein Accession:
    P63151
    Secondary Accessions:
    • B2RBU8
    • B4E1T7
    • P50409
    • Q00007

    Protein attributes for PPP2R2A Gene

    Size:
    447 amino acids
    Molecular mass:
    51692 Da
    Quaternary structure:
    • Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD (By similarity). PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B/PR72/PR130/PR59 and R5/B/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with TP53.

    Three dimensional structures from OCA and Proteopedia for PPP2R2A Gene

    Alternative splice isoforms for PPP2R2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPP2R2A Gene

Proteomics data for PPP2R2A Gene at MOPED

Post-translational modifications for PPP2R2A Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys62 and Lys105

Other Protein References for PPP2R2A Gene

No data available for DME Specific Peptides for PPP2R2A Gene

Domains for PPP2R2A Gene

Gene Families for PPP2R2A Gene

HGNC:
  • WDR :WD repeat domain containing
  • PPP2R :Serine/threonine phosphatases / Protein phosphatase 2, regulatory subunits

Protein Domains for PPP2R2A Gene

Graphical View of Domain Structure for InterPro Entry

P63151

UniProtKB/Swiss-Prot:

2ABA_HUMAN
Family:
  • Belongs to the phosphatase 2A regulatory subunit B family.:
    • P63151
Similarity:
  • Contains 7 WD repeats.:
    • P63151
genes like me logo Genes that share domains with PPP2R2A: view

Function for PPP2R2A Gene

Molecular function for PPP2R2A Gene

GENATLAS Biochemistry: protein phosphatase 2 (formerly 2A),regulatory subunit B (PR52),alpha isoform
UniProtKB/Swiss-Prot Function: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment

Gene Ontology (GO) - Molecular Function for PPP2R2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004722 protein serine/threonine phosphatase activity TAS --
GO:0005515 protein binding IPI 15761952
GO:0008601 protein phosphatase type 2A regulator activity TAS 1849734
genes like me logo Genes that share ontologies with PPP2R2A: view
genes like me logo Genes that share phenotypes with PPP2R2A: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for PPP2R2A Gene

Localization for PPP2R2A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPP2R2A Gene COMPARTMENTS Subcellular localization image for PPP2R2A gene
Compartment Confidence
cytosol 4
nucleus 2
extracellular 1
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PPP2R2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000159 protein phosphatase type 2A complex IDA 17245430
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PPP2R2A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PPP2R2A Gene

Pathways for PPP2R2A Gene

genes like me logo Genes that share pathways with PPP2R2A: view

Gene Ontology (GO) - Biological Process for PPP2R2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0006470 protein dephosphorylation IDA 1849734
GO:0007084 mitotic nuclear envelope reassembly TAS --
genes like me logo Genes that share ontologies with PPP2R2A: view

Compounds for PPP2R2A Gene

(5) Tocris Compounds for PPP2R2A Gene

Compound Action Cas Number
Calyculin A Protein phosphatase 1 and 2A inhibitor [101932-71-2]
Cyclosporin A Calcineurin inhibitor [59865-13-3]
FK 506 Potent calcineurin inhibitor; immunosuppressant [104987-11-3]
Okadaic acid Protein phosphatase 1 and 2A inhibitor [78111-17-8]
Salubrinal Selective inhibitor of eIF2alpha dephosphorylation [405060-95-9]

(1) Drugbank Compounds for PPP2R2A Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid
target
genes like me logo Genes that share compounds with PPP2R2A: view

Transcripts for PPP2R2A Gene

Unigene Clusters for PPP2R2A Gene

Protein phosphatase 2, regulatory subunit B, alpha:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPP2R2A Gene

No ASD Table

Relevant External Links for PPP2R2A Gene

GeneLoc Exon Structure for
PPP2R2A
ECgene alternative splicing isoforms for
PPP2R2A

Expression for PPP2R2A Gene

mRNA expression in normal human tissues for PPP2R2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPP2R2A Gene

SOURCE GeneReport for Unigene cluster for PPP2R2A Gene Hs.146339

mRNA Expression by UniProt/SwissProt for PPP2R2A Gene

P63151-2ABA_HUMAN
Tissue specificity: Expressed in all tissues examined.
genes like me logo Genes that share expressions with PPP2R2A: view

No data available for mRNA differential expression in normal tissues for PPP2R2A Gene

Orthologs for PPP2R2A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP2R2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPP2R2A 35
  • 99.93 (n)
  • 100 (a)
PPP2R2A 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PPP2R2A 35
  • 96.5 (n)
  • 99.34 (a)
PPP2R2A 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPP2R2A 35
  • 96.57 (n)
  • 99.56 (a)
PPP2R2A 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppp2r2a 35
  • 93.93 (n)
  • 100 (a)
Ppp2r2a 16
Ppp2r2a 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPP2R2A 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPP2R2A 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppp2r2a 35
  • 93.03 (n)
  • 99.78 (a)
chicken
(Gallus gallus)
Aves PPP2R2A 35
  • 89.14 (n)
  • 99.33 (a)
PPP2R2A 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPP2R2A 36
  • 99 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.734 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp2r2a 35
  • 78.43 (n)
  • 94.8 (a)
Str.6179 35
zebrafish
(Danio rerio)
Actinopterygii PPP2R2A (2 of 2) 36
  • 80 (a)
OneToMany
ppp2r2ab 36
  • 92 (a)
OneToMany
ppp2r2d 35
  • 76.93 (n)
  • 91.52 (a)
wufd19g04 35
fruit fly
(Drosophila melanogaster)
Insecta tws 36
  • 70 (a)
OneToMany
tws 37
  • 79 (a)
worm
(Caenorhabditis elegans)
Secernentea sur-6 36
  • 60 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC55 36
  • 46 (a)
OneToMany
soybean
(Glycine max)
eudicotyledons Gma.7239 35
barley
(Hordeum vulgare)
Liliopsida Hv.3832 35
wheat
(Triticum aestivum)
Liliopsida Ta.21357 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6047 36
  • 69 (a)
OneToMany
Species with no ortholog for PPP2R2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PPP2R2A Gene

ENSEMBL:
Gene Tree for PPP2R2A (if available)
TreeFam:
Gene Tree for PPP2R2A (if available)

Paralogs for PPP2R2A Gene

Paralogs for PPP2R2A Gene

Selected SIMAP similar genes for PPP2R2A Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for PPP2R2A Gene

genes like me logo Genes that share paralogs with PPP2R2A: view

Variants for PPP2R2A Gene

Sequence variations from dbSNP and Humsavar for PPP2R2A Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs878910 -- 26,326,435(-) ATATT(C/T)AGAGA intron-variant
rs1010406 -- 26,296,772(+) AAATG(A/G)TAAAA intron-variant
rs1025537 -- 26,363,482(-) ATTTA(G/T)AACCA intron-variant
rs1048527 -- 26,372,177(+) CAAAT(G/T)TGTAT utr-variant-3-prime
rs1059235 -- 26,354,578(+) ATCAA(C/T)AAAAT reference, synonymous-codon, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for PPP2R2A Gene

Variant ID Type Subtype PubMed ID
esv2495705 CNV Insertion 19546169
esv269537 CNV Insertion 20981092
esv273393 CNV Insertion 20981092
nsv831273 CNV Loss 17160897

Relevant External Links for PPP2R2A Gene

HapMap Linkage Disequilibrium report
PPP2R2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP2R2A Gene

Disorders for PPP2R2A Gene

Relevant External Links for PPP2R2A

Genetic Association Database (GAD)
PPP2R2A
Human Genome Epidemiology (HuGE) Navigator
PPP2R2A
genes like me logo Genes that share disorders with PPP2R2A: view

No data available for UniProtKB/Swiss-Prot for PPP2R2A Gene

Publications for PPP2R2A Gene

  1. Structure of the 55-kDa regulatory subunit of protein phosphatase 2A: evidence for a neuronal-specific isoform. (PMID: 1849734) Mayer R.E. … Hemmings B.A. (Biochemistry 1991) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Protein phosphatase 2A subunit gene haplotypes and proliferative breast disease modify breast cancer risk. (PMID: 19890961) Dupont W.D. … Smith J.R. (Cancer 2010) 3 48
  4. A specific PP2A regulatory subunit, B56gamma, mediates DNA damage- induced dephosphorylation of p53 at Thr55. (PMID: 17245430) Li H.H. … Liu X. (EMBO J. 2007) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for PPP2R2A Gene

Sources for PPP2R2A Gene

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