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Aliases for AVPR1A Gene

Aliases for AVPR1A Gene

  • Arginine Vasopressin Receptor 1A 2 3 5
  • Vascular/Hepatic-Type Arginine Vasopressin Receptor 3 4
  • AVPR V1a 3 4
  • AVPR1 3 4
  • V1aR 3 4
  • V1-Vascular Vasopressin Receptor AVPR1A 3
  • SCCL Vasopressin Subtype 1a Receptor 3
  • Antidiuretic Hormone Receptor 1A 3
  • Antidiuretic Hormone Receptor 1a 4
  • V1a Vasopressin Receptor 3

External Ids for AVPR1A Gene

Previous HGNC Symbols for AVPR1A Gene

  • AVPR1

Previous GeneCards Identifiers for AVPR1A Gene

  • GC12P063279
  • GC12P063551
  • GC12M063255
  • GC12M061826
  • GC12M063540
  • GC12M060591

Summaries for AVPR1A Gene

Entrez Gene Summary for AVPR1A Gene

  • The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1B, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor mediates cell contraction and proliferation, platelet aggregation, release of coagulation factor and glycogenolysis. [provided by RefSeq, Jul 2008]

GeneCards Summary for AVPR1A Gene

AVPR1A (Arginine Vasopressin Receptor 1A) is a Protein Coding gene. Diseases associated with AVPR1A include acth-independent macronodular adrenal hyperplasia and syndrome of inappropriate antidiuretic hormone. Among its related pathways are Signaling by GPCR and Infectious disease. GO annotations related to this gene include G-protein coupled receptor activity and protein kinase C binding. An important paralog of this gene is AVPR1B.

UniProtKB/Swiss-Prot for AVPR1A Gene

  • Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. Has been involved in social behaviors, including affiliation and attachment.

Tocris Summary for AVPR1A Gene

  • Vasopressin receptors are a group of G-protein-coupled receptors that mediate vasoconstriction, antidiuresis and ACTH release. They are currently divided into three subtypes, V1A, V1B and V2 and are closely related to oxytocin receptors (OT).

Gene Wiki entry for AVPR1A Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AVPR1A Gene

Genomics for AVPR1A Gene

Regulatory Elements for AVPR1A Gene

Genomic Location for AVPR1A Gene

Chromosome:
12
Start:
63,142,287 bp from pter
End:
63,153,860 bp from pter
Size:
11,574 bases
Orientation:
Minus strand

Genomic View for AVPR1A Gene

Genes around AVPR1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AVPR1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AVPR1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AVPR1A Gene

Proteins for AVPR1A Gene

  • Protein details for AVPR1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P37288-V1AR_HUMAN
    Recommended name:
    Vasopressin V1a receptor
    Protein Accession:
    P37288

    Protein attributes for AVPR1A Gene

    Size:
    418 amino acids
    Molecular mass:
    46800 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Differences in regional receptor expression in the brain as well as differences in social behavior may result from a highly variable repetitive sequence in the 5 flanking region of AVPR1A. One such allelic variant has been linked to autism.

    Three dimensional structures from OCA and Proteopedia for AVPR1A Gene

neXtProt entry for AVPR1A Gene

Proteomics data for AVPR1A Gene at MOPED

Post-translational modifications for AVPR1A Gene

  • Glycosylation at Asn 27 and Asn 196
  • Modification sites at PhosphoSitePlus

Other Protein References for AVPR1A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for AVPR1A Gene

Domains & Families for AVPR1A Gene

Suggested Antigen Peptide Sequences for AVPR1A Gene

Graphical View of Domain Structure for InterPro Entry

P37288

UniProtKB/Swiss-Prot:

V1AR_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
Family:
  • Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
genes like me logo Genes that share domains with AVPR1A: view

Function for AVPR1A Gene

Molecular function for AVPR1A Gene

GENATLAS Biochemistry:
vasopressin,vascular,ViA-type receptor,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. Has been involved in social behaviors, including affiliation and attachment.
genes like me logo Genes that share phenotypes with AVPR1A: view

Animal Models for AVPR1A Gene

MGI Knock Outs for AVPR1A:

Animal Model Products

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for AVPR1A (V1a Vasopressin R/AVPR1A)

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for AVPR1A Gene

Localization for AVPR1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for AVPR1A Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AVPR1A Gene COMPARTMENTS Subcellular localization image for AVPR1A gene
Compartment Confidence
plasma membrane 5
endosome 4
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for AVPR1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with AVPR1A: view

Pathways & Interactions for AVPR1A Gene

genes like me logo Genes that share pathways with AVPR1A: view

Gene Ontology (GO) - Biological Process for AVPR1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002125 maternal aggressive behavior IEA --
GO:0006091 generation of precursor metabolites and energy TAS 8106369
GO:0007202 activation of phospholipase C activity TAS 8106369
GO:0007204 positive regulation of cytosolic calcium ion concentration IEA --
GO:0007621 negative regulation of female receptivity IEA --
genes like me logo Genes that share ontologies with AVPR1A: view

No data available for SIGNOR curated interactions for AVPR1A Gene

Drugs & Compounds for AVPR1A Gene

(66) Drugs for AVPR1A Gene - From: DGIdb, IUPHAR, Novoseek, ApexBio, DrugBank, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Desmopressin Approved Pharma Full agonist, Agonist, stimulator, Target Synthetic vasopressin analog; V1B and V2 agonist 0
Tolvaptan Approved Pharma Antagonist, antagonist, Target AVP V2-receptor antagonist 84
Conivaptan Approved, Investigational Pharma Antagonist, antagonist, Target 20
Vasopressin Approved Pharma Full agonist, Agonist, agonist, Target 0
Terlipressin Approved, Investigational Pharma stimulator, Target 47

(15) Additional Compounds for AVPR1A Gene - From: HMDB, IUPHAR, Tocris, and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[<sup>3</sup>H]AVP
Full agonist, Agonist
[<sup>3</sup>H]SR49059
Antagonist
[Phe<sup>2</sup>]OVT
Full agonist, Agonist
AVT
Full agonist, Agonist
OPC-31260
Antagonist
genes like me logo Genes that share compounds with AVPR1A: view

Transcripts for AVPR1A Gene

mRNA/cDNA for AVPR1A Gene

Unigene Clusters for AVPR1A Gene

Arginine vasopressin receptor 1A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AVPR1A Gene

No ASD Table

Relevant External Links for AVPR1A Gene

GeneLoc Exon Structure for
AVPR1A
ECgene alternative splicing isoforms for
AVPR1A

Expression for AVPR1A Gene

mRNA expression in normal human tissues for AVPR1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AVPR1A Gene

This gene is overexpressed in Artery - Tibial (x10.6), Adrenal Gland (x7.8), Liver (x5.7), and Adipose - Visceral (Omentum) (x5.1).

Protein differential expression in normal tissues from HIPED for AVPR1A Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for AVPR1A Gene



SOURCE GeneReport for Unigene cluster for AVPR1A Gene Hs.2131

genes like me logo Genes that share expression patterns with AVPR1A: view

Protein tissue co-expression partners for AVPR1A Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for AVPR1A Gene

Orthologs for AVPR1A Gene

This gene was present in the common ancestor of animals.

Orthologs for AVPR1A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia AVPR1A 35
  • 84.53 (n)
  • 79.9 (a)
AVPR1A 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AVPR1A 35
  • 85.35 (n)
  • 81.4 (a)
AVPR1A 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Avpr1a 35
  • 83.25 (n)
  • 83.01 (a)
Avpr1a 16
Avpr1a 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia AVPR1A 35
  • 98.96 (n)
  • 99.04 (a)
AVPR1A 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Avpr1a 35
  • 82.93 (n)
  • 83.25 (a)
oppossum
(Monodelphis domestica)
Mammalia AVPR1A 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AVPR1A 36
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves AVPR1A 35
  • 75.59 (n)
  • 71.78 (a)
VT4 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AVPR1A 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia avpr1a 35
  • 69.85 (n)
  • 71.31 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC571591 35
  • 66.67 (n)
  • 63.44 (a)
AVPR1A (2 of 2) 36
  • 63 (a)
OneToMany
avpr1b 36
  • 56 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6111 37
  • 28 (a)
GRHR 37
  • 31 (a)
worm
(Caenorhabditis elegans)
Secernentea T07D10.2 37
  • 29 (a)
F14F4.1 35
  • 43.8 (n)
  • 33.58 (a)
Species with no ortholog for AVPR1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AVPR1A Gene

ENSEMBL:
Gene Tree for AVPR1A (if available)
TreeFam:
Gene Tree for AVPR1A (if available)

Paralogs for AVPR1A Gene

Paralogs for AVPR1A Gene

(5) SIMAP similar genes for AVPR1A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with AVPR1A: view

Variants for AVPR1A Gene

Sequence variations from dbSNP and Humsavar for AVPR1A Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs2228154 - 63,150,821(-) CCGCC(A/G)GTCCC reference, missense
rs1774 -- 63,143,384(+) CATAC(C/T)ACAGG utr-variant-3-prime
rs1042615 -- 63,150,429(-) ATGTT(A/C/T)GCGTC reference, synonymous-codon
rs1057616 -- 63,142,809(-) TTTCC(C/T)CAATT utr-variant-3-prime
rs1495014 -- 63,155,439(-) GAACT(A/C)TCCCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for AVPR1A Gene

Variant ID Type Subtype PubMed ID
nsv469592 CNV Loss 16826518
nsv832436 CNV Gain 17160897
nsv899164 CNV Loss 21882294
dgv1434n71 CNV Loss 21882294

Variation tolerance for AVPR1A Gene

Residual Variation Intolerance Score: 60.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.02; 60.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AVPR1A Gene

HapMap Linkage Disequilibrium report
AVPR1A
Human Gene Mutation Database (HGMD)
AVPR1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AVPR1A Gene

Disorders for AVPR1A Gene

MalaCards: The human disease database

(5) MalaCards diseases for AVPR1A Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
acth-independent macronodular adrenal hyperplasia
  • acth-independent macronodular adrenal hyperplasia 2
syndrome of inappropriate antidiuretic hormone
  • inappropriate adh syndrome
borderline personality disorder
small cell carcinoma
  • intermediate cell small cell carcinoma
autism spectrum disorder
  • pervasive development disorder
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for AVPR1A

Genetic Association Database (GAD)
AVPR1A
Human Genome Epidemiology (HuGE) Navigator
AVPR1A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AVPR1A
genes like me logo Genes that share disorders with AVPR1A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AVPR1A Gene

Publications for AVPR1A Gene

  1. Molecular cloning, sequencing, and functional expression of a cDNA encoding the human V1a vasopressin receptor. (PMID: 8106369) Thibonnier M. … Clauser E. (J. Biol. Chem. 1994) 2 3 4 23 67
  2. Intrauterine pressure, ischemia markers, and experienced pain during administration of a vasopressin V1a receptor antagonist in spontaneous and vasopressin-induced dysmenorrhea. (PMID: 16532916) Liedman R. … Akerlund M. (Acta Obstet Gynecol Scand 2006) 23 25 26
  3. Oxytocin- and vasopressin-induced growth of human small-cell lung cancer is mediated by the mitogen-activated protein kinase pathway. (PMID: 15613460) PAcqueux C. … North W.G. (Endocr. Relat. Cancer 2004) 23 25 26
  4. Vasopressin V1a receptor polymorphism and interval walking training effects in middle-aged and older people. (PMID: 20142561) Masuki S. … Nose H. (Hypertension 2010) 3 23
  5. Association between arginine vasopressin 1a receptor (AVPR1a) promoter region polymorphisms and prepulse inhibition. (PMID: 19195791) Levin R. … Ebstein R.P. (Psychoneuroendocrinology 2009) 3 23

Products for AVPR1A Gene

Sources for AVPR1A Gene

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