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Aliases for AVPR1A Gene

Aliases for AVPR1A Gene

  • Arginine Vasopressin Receptor 1A 2 3
  • Vascular/Hepatic-Type Arginine Vasopressin Receptor 3 4
  • AVPR V1a 3 4
  • AVPR1 3 4
  • V1aR 3 4
  • V1-Vascular Vasopressin Receptor AVPR1A 3
  • SCCL Vasopressin Subtype 1a Receptor 3
  • Antidiuretic Hormone Receptor 1A 3
  • Antidiuretic Hormone Receptor 1a 4
  • V1a Vasopressin Receptor 3
  • Vasopressin V1a Receptor 3

External Ids for AVPR1A Gene

Previous HGNC Symbols for AVPR1A Gene

  • AVPR1

Previous GeneCards Identifiers for AVPR1A Gene

  • GC12P063279
  • GC12P063551
  • GC12M063255
  • GC12M061826
  • GC12M063540
  • GC12M060591

Summaries for AVPR1A Gene

Entrez Gene Summary for AVPR1A Gene

  • The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1B, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor mediates cell contraction and proliferation, platelet aggregation, release of coagulation factor and glycogenolysis. [provided by RefSeq, Jul 2008]

GeneCards Summary for AVPR1A Gene

AVPR1A (Arginine Vasopressin Receptor 1A) is a Protein Coding gene. Diseases associated with AVPR1A include atypical autism and adenomyosis. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include protein kinase C binding and vasopressin receptor activity. An important paralog of this gene is AVPR1B.

UniProtKB/Swiss-Prot for AVPR1A Gene

  • Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. Has been involved in social behaviors, including affiliation and attachment.

Tocris Summary for AVPR1A Gene

  • Vasopressin receptors are a group of G-protein-coupled receptors that mediate vasoconstriction, antidiuresis and ACTH release. They are currently divided into three subtypes, V1A, V1B and V2 and are closely related to oxytocin receptors (OT). V1A is coupled to Gq/11 proteins and is found at high density on smooth muscle cells. It is involved in regulation of blood pressure through arterial vasoconstriction and has been found to stimulate VEGF secretion. V1B is located in the hypothalamus, where it controls ACTH secretion, and in the pancreas, where it is involved in insulin release. V2 is coupled to Gs proteins and is found exclusively on the basolateral membrane of collecting duct cells in the kidney, where it regulates water excretion.

Gene Wiki entry for AVPR1A Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AVPR1A Gene

Genomics for AVPR1A Gene

Regulatory Elements for AVPR1A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for AVPR1A Gene

Start:
63,142,287 bp from pter
End:
63,154,191 bp from pter
Size:
11,905 bases
Orientation:
Minus strand

Genomic View for AVPR1A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AVPR1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AVPR1A Gene

Proteins for AVPR1A Gene

  • Protein details for AVPR1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P37288-V1AR_HUMAN
    Recommended name:
    Vasopressin V1a receptor
    Protein Accession:
    P37288
    Secondary Accessions:

    Protein attributes for AVPR1A Gene

    Size:
    418 amino acids
    Molecular mass:
    46800 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Differences in regional receptor expression in the brain as well as differences in social behavior may result from a highly variable repetitive sequence in the 5 flanking region of AVPR1A. One such allelic variant has been linked to autism

    Three dimensional structures from OCA and Proteopedia for AVPR1A Gene

neXtProt entry for AVPR1A Gene

Proteomics data for AVPR1A Gene at MOPED

Post-translational modifications for AVPR1A Gene

  • Glycosylation at Asn27 and Asn196
  • Modification sites at PhosphoSitePlus

Other Protein References for AVPR1A Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for AVPR1A Gene

Domains for AVPR1A Gene

Gene Families for AVPR1A Gene

HGNC:
  • AVPR :GPCR / Class A : Vasopressin and oxytocin receptors
IUPHAR :

Suggested Antigen Peptide Sequences for AVPR1A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P37288

UniProtKB/Swiss-Prot:

V1AR_HUMAN :
  • P37288
Family:
  • Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
genes like me logo Genes that share domains with AVPR1A: view

Function for AVPR1A Gene

Molecular function for AVPR1A Gene

GENATLAS Biochemistry: vasopressin,vascular,ViA-type receptor,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. Has been involved in social behaviors, including affiliation and attachment.

Gene Ontology (GO) - Molecular Function for AVPR1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0005000 vasopressin receptor activity IEA --
GO:0005080 protein kinase C binding TAS 10858434
GO:0005515 protein binding IPI 18402937
GO:0017046 peptide hormone binding IEA --
genes like me logo Genes that share ontologies with AVPR1A: view
genes like me logo Genes that share phenotypes with AVPR1A: view

Animal Models for AVPR1A Gene

MGI Knock Outs for AVPR1A:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for AVPR1A Gene

Localization for AVPR1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for AVPR1A Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AVPR1A Gene COMPARTMENTS Subcellular localization image for AVPR1A gene
Compartment Confidence
plasma membrane 5
endosome 4
nucleus 1

Gene Ontology (GO) - Cellular Components for AVPR1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome TAS 10858434
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8838314
GO:0016021 integral component of membrane --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with AVPR1A: view

Pathways for AVPR1A Gene

genes like me logo Genes that share pathways with AVPR1A: view

PCR Array Products

Gene Ontology (GO) - Biological Process for AVPR1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001992 regulation of systemic arterial blood pressure by vasopressin IBA --
GO:0002125 maternal aggressive behavior IEA --
GO:0003084 positive regulation of systemic arterial blood pressure IEA --
GO:0006091 generation of precursor metabolites and energy TAS 8106369
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with AVPR1A: view

Compounds for AVPR1A Gene

(5) Tocris Compounds for AVPR1A Gene

Compound Action Cas Number
d[Leu4,Lys8]-VP Selective V1B agonist [42061-33-6]
[Arg8]-Vasopressin Antidiuretic hormone [113-79-1]
Desmopressin Synthetic vasopressin analog; V1B and V2 agonist [16679-58-6]
SR 49059 Selective, orally active vasopressin V1A receptor antagonist [150375-75-0]
Tolvaptan Potent and selective vasopressin V2 receptor antagonist; renoprotective and orally active [150683-30-0]

(2) HMDB Compounds for AVPR1A Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Vasopressin
  • 3-(Phenylalanine)-8-lysine oxytocin
11000-17-2

(6) Drugbank Compounds for AVPR1A Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Conivaptan
  • Conivaptan hydrochloride
210101-16-9 target antagonist
Desmopressin
  • 1-Desamino-8-D-arginine vasopressin
16679-58-6 target
Felypressin
56-59-7 target agonist
Terlipressin
  • N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin
14636-12-5 target stimulator
Tolvaptan
150683-30-0 target antagonist

(55) IUPHAR Ligand for AVPR1A Gene

Ligand Type Action Affinity Pubmed IDs
[125I]OH-LVA Antagonist Antagonist 10.4
d(CH2)5[Tyr(Me)2,Thr4,Tyr(3125I)-NH29]OVT Antagonist Antagonist 10
d(CH2)5[Tyr(Me)2,Thr4,Tyr-NH29]OVT Antagonist Antagonist 10
[125I]3-N3-Phpa-LVA Antagonist Antagonist 9.9
3-N3-Phpa-LVA Antagonist Antagonist 9.6
d(CH2)5[Tyr(Me)2,Thr4,Phe(3125I,4N3)-NH29]OVT Antagonist Antagonist 9.6
oxytocin Agonist Full agonist 9.6
[3H]OT (human, mouse, rat) Agonist Full agonist 9.5
AVT Agonist Full agonist 9.4
tolvaptan Antagonist Antagonist 9.4
vasopressin Agonist Partial agonist 9.3
SR 121463A Antagonist Antagonist 9.3
conivaptan Antagonist Antagonist 9.2
L023103 Antagonist Antagonist 9.2
d(CH2)5[D-Tyr(Et)2,Val4,Tyr-NH29]AVP Antagonist Antagonist 9.1
dVDAVP Agonist Full agonist 9.1
SSR126768A Antagonist Antagonist 9.05
[3H]d(CH2)5[Tyr(Me)2]AVP Antagonist Antagonist 9
d(CH2)5[Tyr(Me)2,Arg8]VP Antagonist Antagonist 9
d(CH2)5[Tyr(Me)2,Thr4,Phe(3I,4N3)-NH29]OVT Antagonist Antagonist 9
RWJ-351647 Antagonist Antagonist 9
[3H]AVP Agonist Partial agonist 8.9
YM 471 Antagonist Antagonist 8.9
SSR149415 Antagonist Antagonist 8.8
LVP Agonist Full agonist 8.5
[Val4]AVP Agonist Full agonist 8.4
[Thr4,Gly7]OT Agonist Full agonist 8.4
d(CH2)5[Tyr(Me)2]AVP Antagonist Antagonist 8.3
d(CH2)5[Tyr(Et)2,Val4,des-Gly9]AVP Antagonist Antagonist 8.3
dAVP Agonist Full agonist 8.3
[Phe2]OVT Agonist Full agonist 8.3
F180 Agonist Full agonist 8.3
LS-192629 Antagonist Antagonist 7.8
d(CH2)5[D-Ile2,Ile4,Ala-NH29]AVP Antagonist Antagonist 7.7
d[Cha4]AVP Agonist Full agonist 7.7
atosiban Antagonist Antagonist 7.6
desmopressin Agonist Full agonist 7.6
OPC-31260 Antagonist Inverse antagonist 7.6
[tBaa1,D-Tyr(Et)2,Val4,Lys6,Arg-NH28,des-Gly9]AVP Antagonist Antagonist 7.3
d(CH2)5[D-Ile2,Ile4,Ala-NH2]AVP Antagonist Antagonist 7.1
SR 49059 Antagonist Antagonist 7
OPC-51803 Agonist Full agonist 7
OPC-21268 Antagonist Antagonist 6.8
d[Pen1,Tyr(Me)2]AVP Antagonist Antagonist 6.7
d[Leu4]AVP Agonist Full agonist 6.7
[Phaa1,D-Tyr2,Val4,Arg6,Arg-NH29]AVP Antagonist Antagonist 6.6
d[D-Phe2]AVP Agonist Full agonist 6.6
[Phaa1,D-Tyr(Et)2,Lys6,des-Gly9]AVP Antagonist Antagonist 6.6
[Phaa1,D-Tyr(Me)2,Arg6,Tyr-NH29]AVP Antagonist Antagonist 6.5
YM 218 Antagonist Antagonist 6.4
OH-LVA Antagonist Antagonist 6.4
[Phaa1,D-Tyr(Et)2,Val4,Lys6,Tyr-NH28,des-Gly9]AVP Antagonist Antagonist 5.7
d[D-Pal2]AVP Antagonist Antagonist 5.2
d(CH2)5[Tyr(Me)2,Thr4]OVT Antagonist Antagonist 5.2
[3H]SR49059 Antagonist Antagonist

(10) Novoseek inferred chemical compound relationships for AVPR1A Gene

Compound -log(P) Hits PubMed IDs
ovta 90.3 1
sr49059 89.9 9
atosiban 79.3 2
arginine 68.7 24
acth 42.2 3
genes like me logo Genes that share compounds with AVPR1A: view

Transcripts for AVPR1A Gene

mRNA/cDNA for AVPR1A Gene

Unigene Clusters for AVPR1A Gene

Arginine vasopressin receptor 1A:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AVPR1A

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AVPR1A Gene

No ASD Table

Relevant External Links for AVPR1A Gene

GeneLoc Exon Structure for
AVPR1A
ECgene alternative splicing isoforms for
AVPR1A

Expression for AVPR1A Gene

mRNA expression in normal human tissues for AVPR1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AVPR1A Gene

This gene is overexpressed in Artery - Tibial (10.6), Adrenal Gland (7.8), Liver (5.7), and Adipose - Visceral (Omentum) (5.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for AVPR1A Gene

SOURCE GeneReport for Unigene cluster for AVPR1A Gene Hs.2131

genes like me logo Genes that share expressions with AVPR1A: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for AVPR1A Gene

Orthologs for AVPR1A Gene

This gene was present in the common ancestor of animals.

Orthologs for AVPR1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AVPR1A 35
  • 98.96 (n)
  • 99.04 (a)
AVPR1A 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AVPR1A 35
  • 84.53 (n)
  • 79.9 (a)
AVPR1A 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AVPR1A 35
  • 85.35 (n)
  • 81.4 (a)
AVPR1A 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Avpr1a 35
  • 83.25 (n)
  • 83.01 (a)
Avpr1a 16
Avpr1a 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AVPR1A 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AVPR1A 36
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Avpr1a 35
  • 82.93 (n)
  • 83.25 (a)
chicken
(Gallus gallus)
Aves AVPR1A 35
  • 75.59 (n)
  • 71.78 (a)
VT4 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AVPR1A 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia avpr1a 35
  • 69.85 (n)
  • 71.31 (a)
zebrafish
(Danio rerio)
Actinopterygii AVPR1A (2 of 2) 36
  • 63 (a)
OneToMany
avpr1b 36
  • 56 (a)
OneToMany
LOC571591 35
  • 66.67 (n)
  • 63.44 (a)
fruit fly
(Drosophila melanogaster)
Insecta GRHR 37
  • 31 (a)
CG6111 37
  • 28 (a)
worm
(Caenorhabditis elegans)
Secernentea F14F4.1 35
  • 43.8 (n)
  • 33.58 (a)
T07D10.2 37
  • 29 (a)
Species with no ortholog for AVPR1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AVPR1A Gene

ENSEMBL:
Gene Tree for AVPR1A (if available)
TreeFam:
Gene Tree for AVPR1A (if available)

Paralogs for AVPR1A Gene

Paralogs for AVPR1A Gene

Selected SIMAP similar genes for AVPR1A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with AVPR1A: view

Variants for AVPR1A Gene

Sequence variations from dbSNP and Humsavar for AVPR1A Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1774 -- 63,143,384(+) CATAC(C/T)ACAGG utr-variant-3-prime
rs1042615 -- 63,150,429(-) ATGTT(C/T)GCGTC synonymous-codon, reference
rs1057616 -- 63,142,809(-) TTTCC(C/T)CAATT utr-variant-3-prime
rs1495014 -- 63,155,439(-) GAACT(A/C)TCCCT upstream-variant-2KB
rs1803185 -- 63,150,003(-) AGCAG(C/T)GTGAA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for AVPR1A Gene

Variant ID Type Subtype PubMed ID
nsv469592 CNV Loss 16826518
nsv832436 CNV Gain 17160897
nsv899164 CNV Loss 21882294
dgv1434n71 CNV Loss 21882294

Relevant External Links for AVPR1A Gene

HapMap Linkage Disequilibrium report
AVPR1A
Human Gene Mutation Database (HGMD)
AVPR1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AVPR1A Gene

Disorders for AVPR1A Gene

(2) University of Copenhagen DISEASES for AVPR1A Gene

(7) Novoseek inferred disease relationships for AVPR1A Gene

Disease -log(P) Hits PubMed IDs
adrenal hyperplasia 69.3 1
dysmenorrhea 63.6 5
tumors 1.95 1
ischemia 0 1
cancer lung 0 1

Relevant External Links for AVPR1A

Genetic Association Database (GAD)
AVPR1A
Human Genome Epidemiology (HuGE) Navigator
AVPR1A
genes like me logo Genes that share disorders with AVPR1A: view

No data available for UniProtKB/Swiss-Prot for AVPR1A Gene

Publications for AVPR1A Gene

  1. Molecular cloning, sequencing, and functional expression of a cDNA encoding the human V1a vasopressin receptor. (PMID: 8106369) Thibonnier M. … Clauser E. (J. Biol. Chem. 1994) 2 3 4 23
  2. Functional vasopressin V1 type receptors are present in variant as well as classical forms of small-cell carcinoma. (PMID: 9357056) North W.G. … Du J. (Peptides 1997) 3 4 23
  3. Expression of all known vasopressin receptor subtypes by small cell tumors implies a multifaceted role for this neuropeptide. (PMID: 9581826) North W.G. … Du J. (Cancer Res. 1998) 3 4 23
  4. AVPR1a and SLC6A4 gene polymorphisms are associated with creative dance performance. (PMID: 16205790) Bachner-Melman R. … Ebstein R.P. (PLoS Genet. 2005) 3 23 48
  5. Association between the arginine vasopressin 1a receptor (AVPR1a) gene and autism in a family-based study: mediation by socialization skills. (PMID: 16520824) Yirmiya N. … Ebstein R.P. (Mol. Psychiatry 2006) 3 23 48

Products for AVPR1A Gene

Sources for AVPR1A Gene

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