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Aliases for NUDT11 Gene

Aliases for NUDT11 Gene

  • Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 11 2 3
  • DIPP3b 3 4 6
  • APS1 3 4 6
  • Diadenosine 5,5-P1,P6-Hexaphosphate Hydrolase 3-Beta 3 4
  • Diadenosine Hexaphosphate Hydrolase (AMP-Forming) 3 4
  • Nucleoside Diphosphate-Linked Moiety X Motif 11 3 4
  • Nudix Motif 11 3 4
  • DIPP-3-Beta 3 4
  • DIPP3-Beta 3 4
  • HDIPP3beta 3 4
  • HAps1 3 4
  • Diphosphoinositol Polyphosphate Phosphohydrolase 3, Beta 3
  • Diphosphoinositol Polyphosphate Phosphohydrolase 3-Beta 3
  • EC 3.6.1.52 4
  • EC 3.6.1.60 4
  • DIPP3beta 3
  • ASP1 3

External Ids for NUDT11 Gene

Previous GeneCards Identifiers for NUDT11 Gene

  • GC0XP049645
  • GC0XM049277
  • GC0XM049917
  • GC0XM050149
  • GC0XM051065
  • GC0XM051249
  • GC0XM051232
  • GC0XM048674

Summaries for NUDT11 Gene

Entrez Gene Summary for NUDT11 Gene

  • NUDT11 belongs to a subgroup of phosphohydrolases that preferentially attack diphosphoinositol polyphosphates (Hidaka et al., 2002 [PubMed 12105228]).[supplied by OMIM, Mar 2008]

GeneCards Summary for NUDT11 Gene

NUDT11 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 11) is a Protein Coding gene. Among its related pathways are Metabolism and Inositol phosphate metabolism (REACTOME). GO annotations related to this gene include diphosphoinositol-polyphosphate diphosphatase activity and inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity. An important paralog of this gene is NUDT3.

UniProtKB/Swiss-Prot for NUDT11 Gene

  • Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate

Gene Wiki entry for NUDT11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUDT11 Gene

Genomics for NUDT11 Gene

Regulatory Elements for NUDT11 Gene

Genomic Location for NUDT11 Gene

Start:
51,490,011 bp from pter
End:
51,496,607 bp from pter
Size:
6,597 bases
Orientation:
Minus strand

Genomic View for NUDT11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NUDT11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUDT11 Gene

Proteins for NUDT11 Gene

  • Protein details for NUDT11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96G61-NUD11_HUMAN
    Recommended name:
    Diphosphoinositol polyphosphate phosphohydrolase 3-beta
    Protein Accession:
    Q96G61
    Secondary Accessions:
    • Q9NVN0

    Protein attributes for NUDT11 Gene

    Size:
    164 amino acids
    Molecular mass:
    18559 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Binds 3 Mg(2+) or Mn(2+) ions per subunit. Mn(2+) may be the true cofactor in vivo.;
    Quaternary structure:
    No Data Available

neXtProt entry for NUDT11 Gene

Proteomics data for NUDT11 Gene at MOPED

Post-translational modifications for NUDT11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NUDT11 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for NUDT11 Gene

Domains for NUDT11 Gene

Gene Families for NUDT11 Gene

HGNC:
  • NUDT :Nudix motif containing

Protein Domains for NUDT11 Gene

Suggested Antigen Peptide Sequences for NUDT11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96G61

UniProtKB/Swiss-Prot:

NUD11_HUMAN :
  • Q96G61
Domain:
  • Contains 1 nudix hydrolase domain.
Family:
  • Belongs to the Nudix hydrolase family. DIPP subfamily.
genes like me logo Genes that share domains with NUDT11: view

Function for NUDT11 Gene

Molecular function for NUDT11 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=0.053 uM for PP-InsP5 {ECO:0000269 PubMed:12105228, ECO:0000269 PubMed:12121577}; KM=13 uM for Ap6A {ECO:0000269 PubMed:12105228, ECO:0000269 PubMed:12121577}; KM=37 uM for Ap5A {ECO:0000269 PubMed:12105228, ECO:0000269 PubMed:12121577}; pH dependence: Optimum pH is 8.5. {ECO:0000269 PubMed:12105228, ECO:0000269 PubMed:12121577};
UniProtKB/Swiss-Prot CatalyticActivity: Diphospho-myo-inositol polyphosphate + H(2)O = myo-inositol polyphosphate + phosphate
UniProtKB/Swiss-Prot CatalyticActivity: P(1),P(6)-bis(5-adenosyl)hexaphosphate + H(2)O = adenosine 5-pentaphosphate + AMP
UniProtKB/Swiss-Prot CatalyticActivity: P(1),P(5)-bis(5-adenosyl)pentaphosphate + H(2)O = adenosine 5-tetraphosphate + AMP
UniProtKB/Swiss-Prot Function: Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate

Enzyme Numbers (IUBMB) for NUDT11 Gene

Gene Ontology (GO) - Molecular Function for NUDT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008486 diphosphoinositol-polyphosphate diphosphatase activity ISS --
GO:0016787 hydrolase activity --
GO:0046872 metal ion binding IEA --
GO:0052840 inositol diphosphate tetrakisphosphate diphosphatase activity IEA --
GO:0052843 inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity IEA --
genes like me logo Genes that share ontologies with NUDT11: view

Phenotypes for NUDT11 Gene

GenomeRNAi human phenotypes for NUDT11:
genes like me logo Genes that share phenotypes with NUDT11: view

miRNA for NUDT11 Gene

miRTarBase miRNAs that target NUDT11

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for NUDT11 Gene

Localization for NUDT11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUDT11 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NUDT11 Gene COMPARTMENTS Subcellular localization image for NUDT11 gene
Compartment Confidence
cytosol 4
nucleus 3

Gene Ontology (GO) - Cellular Components for NUDT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NUDT11: view

Pathways for NUDT11 Gene

genes like me logo Genes that share pathways with NUDT11: view

Pathways by source for NUDT11 Gene

Interacting Proteins for NUDT11 Gene

Gene Ontology (GO) - Biological Process for NUDT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043647 inositol phosphate metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with NUDT11: view

Compounds for NUDT11 Gene

(7) HMDB Compounds for NUDT11 Gene

Compound Synonyms Cas Number PubMed IDs
5-Diphosphoinositol pentakisphosphate
  • 5-diphospho-1D-myo-inositol pentakisphosphate
Not Available
Diadenosine hexaphosphate
  • Adenosine 5'-(heptahydrogen hexaphosphate) P->5'-ester with adenosine
56983-23-4
Magnesium
  • Magnesium
7439-95-4
Manganese
  • manganese
7439-96-5
Myo-inositol hexakisphosphate
  • 1D-myo-Inositol 1,2,3,4,5,6-hexakisphosphate
83-86-3
genes like me logo Genes that share compounds with NUDT11: view

Transcripts for NUDT11 Gene

mRNA/cDNA for NUDT11 Gene

(68) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NUDT11 Gene

Nudix (nucleoside diphosphate linked moiety X)-type motif 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NUDT11 Gene

No ASD Table

Relevant External Links for NUDT11 Gene

GeneLoc Exon Structure for
NUDT11
ECgene alternative splicing isoforms for
NUDT11

Expression for NUDT11 Gene

mRNA expression in normal human tissues for NUDT11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NUDT11 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (5.0), Brain - Anterior cingulate cortex (BA24) (4.8), Brain - Hypothalamus (4.7), Testis (4.5), and Brain - Frontal Cortex (BA9) (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NUDT11 Gene

SOURCE GeneReport for Unigene cluster for NUDT11 Gene Hs.200016

mRNA Expression by UniProt/SwissProt for NUDT11 Gene

Q96G61-NUD11_HUMAN
Tissue specificity: Mainly expressed in testis and, at lower level in brain. According to PubMed:12121577, it is also expressed in pancreas and weakly expressed in thymus, prostate, ovary, lung, small intestine and heart.
genes like me logo Genes that share expressions with NUDT11: view

Orthologs for NUDT11 Gene

This gene was present in the common ancestor of animals.

Orthologs for NUDT11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUDT11 35
  • 99.59 (n)
  • 99.39 (a)
NUDT11 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NUDT11 35
  • 94.51 (n)
  • 95.12 (a)
NUDT11 36
  • 95 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 96 (a)
ManyToMany
-- 36
  • 96 (a)
ManyToMany
LOC491890 35
  • 93.29 (n)
  • 95.73 (a)
mouse
(Mus musculus)
Mammalia Nudt10 36
  • 96 (a)
ManyToMany
Nudt11 35
  • 88.01 (n)
  • 95.73 (a)
Nudt11 16
Nudt11 36
  • 96 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 53 (a)
ManyToMany
-- 36
  • 72 (a)
ManyToMany
-- 36
  • 70 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 82 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Nudt11 35
  • 87.8 (n)
  • 95.73 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 75 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 82 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii nudt4a 36
  • 58 (a)
ManyToMany
nudt4b 36
  • 73 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Aps 36
  • 52 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y92H12BL.5 36
  • 38 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8787 36
  • 40 (a)
OneToMany
Species with no ortholog for NUDT11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NUDT11 Gene

ENSEMBL:
Gene Tree for NUDT11 (if available)
TreeFam:
Gene Tree for NUDT11 (if available)

Paralogs for NUDT11 Gene

Paralogs for NUDT11 Gene

Selected SIMAP similar genes for NUDT11 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NUDT11: view

Variants for NUDT11 Gene

Sequence variations from dbSNP and Humsavar for NUDT11 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs2768103 -- 51,496,641(-) CCGCC(C/T)GCGCC upstream-variant-2KB
rs2768104 -- 51,496,574(-) TCTCT(C/T)TCCCC utr-variant-5-prime
rs7059759 -- 51,495,305(+) TGCAG(A/G)AAGAG intron-variant
rs7066127 -- 51,493,627(+) AAAAG(A/T)ATCTC intron-variant
rs11091729 -- 51,492,673(+) CCCAG(C/T)CCATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUDT11 Gene

Variant ID Type Subtype PubMed ID
nsv471604 CNV Gain 15918152
nsv524351 CNV Gain 19592680

Relevant External Links for NUDT11 Gene

HapMap Linkage Disequilibrium report
NUDT11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUDT11 Gene

Disorders for NUDT11 Gene

Relevant External Links for NUDT11

Genetic Association Database (GAD)
NUDT11
Human Genome Epidemiology (HuGE) Navigator
NUDT11
genes like me logo Genes that share disorders with NUDT11: view

No data available for UniProtKB/Swiss-Prot for NUDT11 Gene

Publications for NUDT11 Gene

  1. An adjacent pair of human NUDT genes on chromosome X are preferentially expressed in testis and encode two new isoforms of diphosphoinositol polyphosphate phosphohydrolase. (PMID: 12105228) Hidaka K. … Shears S.B. (J. Biol. Chem. 2002) 2 3 4 23
  2. Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases. (PMID: 12121577) Leslie N.R. … Safrany S.T. (BMC Biochem. 2002) 3 4 23
  3. Nudix hydrolases that degrade dinucleoside and diphosphoinositol polyphosphates also have 5-phosphoribosyl 1-pyrophosphate (PRPP) pyrophosphatase activity that generates the glycolytic activator ribose 1,5-bisphosphate. (PMID: 12370170) Fisher D.I. … Cartwright J.L. (J. Biol. Chem. 2002) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for NUDT11 Gene

Sources for NUDT11 Gene

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