Aliases for PPP2R1A Gene
- Protein Phosphatase 2, Regulatory Subunit A, Alpha 2 3
- Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit A (PR 65), Alpha Isoform 2 3
- PP2A Subunit A Isoform PR65-Alpha 3 4
- PP2A Subunit A Isoform R1-Alpha 3 4
- Serine/Threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform 3
- Serine/Threonine-Protein Phosphatase 2A 65 KDa Regulatory Subunit A Alpha Isoform 3
- Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit A, Alpha Isoform 2
- Medium Tumor Antigen-Associated 61 KDA Protein 3
- Medium Tumor Antigen-Associated 61 KDa Protein 4
External Ids for PPP2R1A Gene
Previous GeneCards Identifiers for PPP2R1A Gene
This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]
GeneCards Summary for PPP2R1A Gene
PPP2R1A (Protein Phosphatase 2, Regulatory Subunit A, Alpha) is a Protein Coding gene. Diseases associated with PPP2R1A include serous cystadenocarcinoma. Among its related pathways are PI3K-Akt signaling pathway and Signaling by FGFR. GO annotations related to this gene include protein heterodimerization activity and protein serine/threonine phosphatase activity. An important paralog of this gene is PPP2R1B.
UniProtKB/Swiss-Prot for PPP2R1A Gene
The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Required for proper chromosome segregation and for centromeric localization of SGOL1 in mitosis.
Protein ser/thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by the hydrolysis of phosphoric acid monoesters. They directly oppose the actions of kinases and phosphorylases and therefore play an integral role in many signal transduction pathways. There are two groups of serine/threonine phosphatases; phosphoprotein phosphatases (e.g. PP1, calcineurin), which are sensitive to okadaic acid and metallo-phosphatases (e.g. PP2C), which require a divalent cation, commonly Mg2+, for catalytic activity. Dephosphorylation, depending on the residue that the phosphate group is removed from, can have a stimulatory or inhibitory effect on the target molecule. This makes protein Ser/Thr phosphatases essential for many signal transduction pathways. Protein Ser/Thr phosphatase are regulated by their subcellular localization and by inhibitor proteins, which are subtype-specific.