Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PPP2R1A Gene

Aliases for PPP2R1A Gene

  • Protein Phosphatase 2, Regulatory Subunit A, Alpha 2 3
  • Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit A (PR 65), Alpha Isoform 2 3
  • PP2A Subunit A Isoform PR65-Alpha 3 4
  • PP2A Subunit A Isoform R1-Alpha 3 4
  • Serine/Threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform 3
  • Serine/Threonine-Protein Phosphatase 2A 65 KDa Regulatory Subunit A Alpha Isoform 3
  • Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit A, Alpha Isoform 2
  • Medium Tumor Antigen-Associated 61 KDA Protein 3
  • Medium Tumor Antigen-Associated 61 KDa Protein 4
  • 65kDa Regulatory Subunit A 2
  • Protein Phosphatase 2A 2
  • Protein Phosphatase 2 2
  • Regulatory Subunit A 2
  • Alpha Isoform 2
  • PP2A-Aalpha 3
  • PP2AAALPHA 3
  • PR65A 3

External Ids for PPP2R1A Gene

Summaries for PPP2R1A Gene

Entrez Gene Summary for PPP2R1A Gene

  • This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]

GeneCards Summary for PPP2R1A Gene

PPP2R1A (Protein Phosphatase 2, Regulatory Subunit A, Alpha) is a Protein Coding gene. Diseases associated with PPP2R1A include serous cystadenocarcinoma. Among its related pathways are PI3K-Akt signaling pathway and Signaling by FGFR. GO annotations related to this gene include protein heterodimerization activity and protein serine/threonine phosphatase activity. An important paralog of this gene is PPP2R1B.

UniProtKB/Swiss-Prot for PPP2R1A Gene

  • The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Required for proper chromosome segregation and for centromeric localization of SGOL1 in mitosis.

Tocris Summary for PPP2R1A Gene

  • Protein ser/thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by the hydrolysis of phosphoric acid monoesters. They directly oppose the actions of kinases and phosphorylases and therefore play an integral role in many signal transduction pathways. There are two groups of serine/threonine phosphatases; phosphoprotein phosphatases (e.g. PP1, calcineurin), which are sensitive to okadaic acid and metallo-phosphatases (e.g. PP2C), which require a divalent cation, commonly Mg2+, for catalytic activity. Dephosphorylation, depending on the residue that the phosphate group is removed from, can have a stimulatory or inhibitory effect on the target molecule. This makes protein Ser/Thr phosphatases essential for many signal transduction pathways. Protein Ser/Thr phosphatase are regulated by their subcellular localization and by inhibitor proteins, which are subtype-specific.

Gene Wiki entry for PPP2R1A Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP2R1A Gene

Genomics for PPP2R1A Gene

Genomic Location for PPP2R1A Gene

Start:
52,189,802 bp from pter
End:
52,229,533 bp from pter
Size:
39,732 bases
Orientation:
Plus strand

Genomic View for PPP2R1A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPP2R1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP2R1A Gene

Regulatory Elements for PPP2R1A Gene

Proteins for PPP2R1A Gene

  • Protein details for PPP2R1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30153-2AAA_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
    Protein Accession:
    P30153
    Secondary Accessions:
    • Q13773
    • Q6ICQ3
    • Q96DH3

    Protein attributes for PPP2R1A Gene

    Size:
    589 amino acids
    Molecular mass:
    65309 Da
    Quaternary structure:
    • Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD. Interacts with FOXO1; the interaction dephosphorylates FOXO1 on AKT-mediated phosphoylation sites (By similarity). PP2A consists of a common heterodimeric core enzyme, composed of PPP2CA a 36 kDa catalytic subunit (subunit C) and PPP2R1A a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B/PR72/PR130/PR59 and R5/B/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with IPO9. Interacts with TP53 and SGOL1. Interacts with PLA2G16; this interaction might decrease PP2A activity. Interacts with CTTNBP2NL.

    Three dimensional structures from OCA and Proteopedia for PPP2R1A Gene

neXtProt entry for PPP2R1A Gene

Proteomics data for PPP2R1A Gene at MOPED

Post-translational modifications for PPP2R1A Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys34, Lys133, Lys163, Lys188, Lys194, Lys255, Lys266, Lys272, Lys280, Lys307, Lys416, Lys472, Lys475, Lys485, Lys519, Lys542, Lys546, and Lys561

Other Protein References for PPP2R1A Gene

No data available for DME Specific Peptides for PPP2R1A Gene

Domains for PPP2R1A Gene

Gene Families for PPP2R1A Gene

HGNC:
  • PPP2R :Serine/threonine phosphatases / Protein phosphatase 2, regulatory subunits

Protein Domains for PPP2R1A Gene

UniProtKB/Swiss-Prot:

2AAA_HUMAN
Domain:
  • Each HEAT repeat appears to consist of two alpha helices joined by a hydrophilic region, the intrarepeat loop. The repeat units may be arranged laterally to form a rod-like structure:
    • P30153
Family:
  • Belongs to the phosphatase 2A regulatory subunit A family.:
    • P30153
Similarity:
  • Contains 15 HEAT repeats.:
    • P30153
genes like me logo Genes that share domains with PPP2R1A: view

Function for PPP2R1A Gene

Molecular function for PPP2R1A Gene

UniProtKB/Swiss-Prot Function: The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Required for proper chromosome segregation and for centromeric localization of SGOL1 in mitosis.

Gene Ontology (GO) - Molecular Function for PPP2R1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding IPI 9847399
GO:0004722 protein serine/threonine phosphatase activity IEA --
GO:0005488 binding --
GO:0005515 protein binding IPI 11504734
GO:0008601 protein phosphatase type 2A regulator activity TAS 11007961
genes like me logo Genes that share ontologies with PPP2R1A: view
genes like me logo Genes that share phenotypes with PPP2R1A: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for PPP2R1A Gene

Localization for PPP2R1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP2R1A Gene

Cytoplasm. Chromosome, centromere. Note=Centromeric localization requires the presence of BUB1.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPP2R1A Gene COMPARTMENTS Subcellular localization image for PPP2R1A gene
Compartment Confidence
cytoskeleton 5
cytosol 5
mitochondrion 5
nucleus 5

Gene Ontology (GO) - Cellular Components for PPP2R1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000159 protein phosphatase type 2A complex TAS 11007961
GO:0000775 chromosome, centromeric region IDA 16580887
GO:0005634 nucleus NAS 11007961
GO:0005739 mitochondrion NAS 11007961
GO:0005829 cytosol TAS 11007961
genes like me logo Genes that share ontologies with PPP2R1A: view

Pathways for PPP2R1A Gene

genes like me logo Genes that share pathways with PPP2R1A: view

Gene Ontology (GO) - Biological Process for PPP2R1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0000188 inactivation of MAPK activity NAS 11007961
GO:0000278 mitotic cell cycle TAS --
GO:0006275 regulation of DNA replication NAS 11007961
genes like me logo Genes that share ontologies with PPP2R1A: view

Compounds for PPP2R1A Gene

(5) Tocris Compounds for PPP2R1A Gene

Compound Action Cas Number
Calyculin A Protein phosphatase 1 and 2A inhibitor [101932-71-2]
Cyclosporin A Calcineurin inhibitor [59865-13-3]
FK 506 Potent calcineurin inhibitor; immunosuppressant [104987-11-3]
Okadaic acid Protein phosphatase 1 and 2A inhibitor [78111-17-8]
Salubrinal Selective inhibitor of eIF2alpha dephosphorylation [405060-95-9]

(2) Drugbank Compounds for PPP2R1A Gene

genes like me logo Genes that share compounds with PPP2R1A: view

Transcripts for PPP2R1A Gene

Unigene Clusters for PPP2R1A Gene

Protein phosphatase 2, regulatory subunit A, alpha:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPP2R1A Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12 ^
SP1: - -
SP2: - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - - - - - - - - - -
SP5:
SP6: - - - - - -
SP7: - - - - - - - - -
SP8: - -
SP9: - - - - - -
SP10: - - - - - - -
SP11:
SP12: -
SP13: -

ExUns: 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for PPP2R1A Gene

GeneLoc Exon Structure for
PPP2R1A
ECgene alternative splicing isoforms for
PPP2R1A

Expression for PPP2R1A Gene

mRNA expression in normal human tissues for PPP2R1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPP2R1A Gene

SOURCE GeneReport for Unigene cluster for PPP2R1A Gene Hs.467192

genes like me logo Genes that share expressions with PPP2R1A: view

Orthologs for PPP2R1A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP2R1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPP2R1A 36
  • 99.83 (n)
  • 100 (a)
PPP2R1A 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PPP2R1A 36
  • 92.76 (n)
  • 99.32 (a)
PPP2R1A 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC484335 36
  • 92.08 (n)
  • 99.83 (a)
PPP2R1A 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppp2r1a 36
  • 90.55 (n)
  • 99.83 (a)
Ppp2r1a 16
Ppp2r1a 37
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPP2R1A 37
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPP2R1A 37
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppp2r1a 36
  • 90.78 (n)
  • 99.83 (a)
lizard
(Anolis carolinensis)
Reptilia PPP2R1A 37
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp2r1a 36
  • 80.08 (n)
  • 96.43 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009105 36
  • 71.18 (n)
  • 72.12 (a)
fruit fly
(Drosophila melanogaster)
Insecta Pp2A-29B 36
  • 69.1 (n)
  • 74.7 (a)
Pp2A-29B 37
  • 67 (a)
OneToMany
Pp2A-29B 38
  • 75 (a)
worm
(Caenorhabditis elegans)
Secernentea paa-1 36
  • 58.88 (n)
  • 62.89 (a)
paa-1 37
  • 62 (a)
OneToMany
F48E8.5 38
  • 62 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR279C 36
  • 51.22 (n)
  • 47.39 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TPD3 36
  • 49.22 (n)
  • 45.75 (a)
TPD3 37
  • 41 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F07689g 36
  • 48.38 (n)
  • 45.31 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6713 36
soybean
(Glycine max)
eudicotyledons Gma.6495 36
thale cress
(Arabidopsis thaliana)
eudicotyledons RCN1 36
  • 56.27 (n)
  • 59.76 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.1113 36
rice
(Oryza sativa)
Liliopsida Os.1308 36
wheat
(Triticum aestivum)
Liliopsida Ta.1998 36
bread mold
(Neurospora crassa)
Ascomycetes NCU00488 36
  • 59.53 (n)
  • 56.28 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes paa1 36
  • 52.39 (n)
  • 53.54 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1500 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8422 37
  • 69 (a)
OneToMany
Species with no ortholog for PPP2R1A:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • zebrafish (Danio rerio)

Evolution for PPP2R1A Gene

ENSEMBL:
Gene Tree for PPP2R1A (if available)
TreeFam:
Gene Tree for PPP2R1A (if available)

Paralogs for PPP2R1A Gene

Paralogs for PPP2R1A Gene

genes like me logo Genes that share paralogs with PPP2R1A: view

Variants for PPP2R1A Gene

Sequence variations from dbSNP and Humsavar for PPP2R1A Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs755531 -- 52,215,937(-) CCCCT(C/T)GGATA intron-variant
rs755532 -- 52,215,734(-) GGCAG(C/T)TTACT intron-variant
rs755533 -- 52,215,546(-) CTCAC(A/G)GTGTT intron-variant
rs874421 -- 52,215,758(-) AGGAG(C/G)GGGAG intron-variant
rs1006111 -- 52,213,979(+) GGAGC(C/T)AGGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPP2R1A Gene

Variant ID Type Subtype PubMed ID
esv22131 CNV Loss 19812545
nsv518533 CNV Loss 19592680

Relevant External Links for PPP2R1A Gene

HapMap Linkage Disequilibrium report
PPP2R1A
Human Gene Mutation Database (HGMD)
PPP2R1A

Disorders for PPP2R1A Gene

(1) MalaCards Diseases for PPP2R1A Gene

Search for PPP2R1A Gene in MalaCards »

(1) University of Copenhagen DISEASES for PPP2R1A Gene

Relevant External Links for PPP2R1A

Genetic Association Database (GAD)
PPP2R1A
Human Genome Epidemiology (HuGE) Navigator
PPP2R1A
genes like me logo Genes that share disorders with PPP2R1A: view

No data available for UniProtKB/Swiss-Prot for PPP2R1A Gene

Publications for PPP2R1A Gene

  1. Alpha- and beta-forms of the 65-kDa subunit of protein phosphatase 2A have a similar 39 amino acid repeating structure. (PMID: 2159327) Hemmings B.A. … Stone S.R. (Biochemistry 1990) 3 4
  2. Molecular cloning and sequence of cDNA encoding polyoma medium tumor antigen-associated 61-kDa protein. (PMID: 2554323) Walter G. … Carbone-Wiley A. (Proc. Natl. Acad. Sci. U.S.A. 1989) 3 4
  3. Molecular model of the A subunit of protein phosphatase 2A: interaction with other subunits and tumor antigens. (PMID: 8254721) Ruediger R. … Walter G. (J. Virol. 1994) 3 4
  4. The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs. (PMID: 9989501) Groves M.R. … Barford D. (Cell 1999) 3 4
  5. Interaction between protein phosphatase 2A and members of the importin beta superfamily. (PMID: 12670497) Lubert E.J. … Sarge K.D. (Biochem. Biophys. Res. Commun. 2003) 3 4

Products for PPP2R1A Gene

Sources for PPP2R1A Gene

Back to Top

Content