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Aliases for CEP55 Gene

Aliases for CEP55 Gene

  • Centrosomal Protein 55 2 3 5
  • Up-Regulated In Colon Cancer 6 3 4
  • Cancer/Testis Antigen 111 2 3
  • Centrosomal Protein 55kDa 2 3
  • C10orf3 3 4
  • URCC6 3 4
  • Chromosome 10 Open Reading Frame 3 2
  • Centrosomal Protein Of 55 KDa 3
  • CT111 3
  • Cep55 4

External Ids for CEP55 Gene

Previous HGNC Symbols for CEP55 Gene

  • C10orf3

Previous GeneCards Identifiers for CEP55 Gene

  • GC10P095247
  • GC10P088884

Summaries for CEP55 Gene

GeneCards Summary for CEP55 Gene

CEP55 (Centrosomal Protein 55) is a Protein Coding gene. Among its related pathways are DNA Damage and Cytoskeletal Signaling.

UniProtKB/Swiss-Prot for CEP55 Gene

  • Plays a role in mitotic exit and cytokinesis. Recruits PDCD6IP and TSG101 to midbody during cytokinesis. Required for successful completion of cytokinesis. Not required for microtubule nucleation.

Gene Wiki entry for CEP55 Gene

Additional gene information for CEP55 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEP55 Gene

Genomics for CEP55 Gene

Regulatory Elements for CEP55 Gene

Enhancers for CEP55 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H093455 2 FANTOM5 Ensembl ENCODE dbSUPER 15.1 -26.8 -26755 28.4 PKNOX1 FOXA2 SIN3A FEZF1 ZNF2 YY1 ZNF143 FOS SP3 JUNB MYOF CEP55 ENSG00000273450 RPL17P34 PDE6C NOC3L IDE GC10M093419 GC10M093427
GH10H093494 1.3 ENCODE dbSUPER 13.2 -0.5 -477 3.1 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF143 ZNF207 SP3 CEP55 MYOF
GH10H093514 0.8 Ensembl ENCODE dbSUPER 19.2 +19.1 19090 2.2 CEP55 FFAR4 CYP26A1 RNA5SP323 GC10M093511 GC10M093549
GH10H093412 0.9 Ensembl ENCODE dbSUPER 11.4 -83.3 -83314 2.2 SP7 MYOF CEP55 GC10M093427 GC10P093383
GH10H093498 0.8 ENCODE dbSUPER 11.7 +1.9 1852 0.9 ZNF202 TCF12 NCOR1 ZNF658 ZNF366 RPL17P34 PDE6C NOC3L CEP55 RNA5SP323 GC10M093511
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CEP55 on UCSC Golden Path with GeneCards custom track

Promoters for CEP55 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000031775 -12 2001 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 SLC30A9 SP3 SP5

Genomic Locations for CEP55 Gene

Genomic Locations for CEP55 Gene
32,483 bases
Plus strand

Genomic View for CEP55 Gene

Genes around CEP55 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CEP55 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CEP55 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEP55 Gene

Proteins for CEP55 Gene

  • Protein details for CEP55 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Centrosomal protein of 55 kDa
    Protein Accession:
    Secondary Accessions:
    • B2RDG8
    • D3DR37
    • Q32WF5
    • Q3MV20
    • Q5VY28
    • Q6N034
    • Q96H32
    • Q9NVS7

    Protein attributes for CEP55 Gene

    464 amino acids
    Molecular mass:
    54178 Da
    Quaternary structure:
    • Homodimer (PubMed:16406728). Interacts (phosphorylated on Ser-425 and Ser-428) with PLK1 (PubMed:16198290). Interacts with AKAP9/CG-NAP; the interaction occurs in interphase and is lost upon mitotic entry (PubMed:16198290). Interacts with PCNT/Kendrin; the interaction occurs in interphase and is lost upon mitotic entry (PubMed:16198290). Directly interacts with PDCD6IP; this interaction is required for PDCD6IP targeting to the midbody; CEP55 binds PDCD6IP in a 2:1 stoichiometry; PDCD6IP competes with TSG101 for the same binding site (PubMed:17853893, PubMed:17556548, PubMed:18641129, PubMed:18948538). Interacts with TSG101; TSG101 competes with PDCD6IP for the same binding site; interaction is required for cytokinesis but not for viral budding (PubMed:17853893, PubMed:17556548, PubMed:18948538). Interacts with MVB12A, VPS37B, VPS37C and VPS28 (PubMed:17853893).
    • Sequence=BAA91670.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CEP55 Gene

    Alternative splice isoforms for CEP55 Gene


neXtProt entry for CEP55 Gene

Post-translational modifications for CEP55 Gene

  • There is a hierachy of phosphorylation, where both Ser-425 and Ser-428 are phosphorylated at the onset of mitosis, prior to Ser-436. Phosphorylation at Ser-425 and Ser-428 is required for dissociation from the centrosome at the G2/M boundary. Phosphorylation at the 3 sites, Ser-425, Ser-428 and Ser-436, is required for protein function at the final stages of cell division to complete cytokinesis successfully.
  • Ubiquitination at posLast=129129, Lys145, Lys180, Lys196, posLast=222222, Lys233, posLast=341341, Lys367, posLast=398398, and Lys442
  • Modification sites at PhosphoSitePlus

Other Protein References for CEP55 Gene

No data available for DME Specific Peptides for CEP55 Gene

Domains & Families for CEP55 Gene

Gene Families for CEP55 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CEP55 Gene


Suggested Antigen Peptide Sequences for CEP55 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CEP55: view

No data available for UniProtKB/Swiss-Prot for CEP55 Gene

Function for CEP55 Gene

Molecular function for CEP55 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in mitotic exit and cytokinesis. Recruits PDCD6IP and TSG101 to midbody during cytokinesis. Required for successful completion of cytokinesis. Not required for microtubule nucleation.

Phenotypes From GWAS Catalog for CEP55 Gene

Gene Ontology (GO) - Molecular Function for CEP55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with CEP55: view
genes like me logo Genes that share phenotypes with CEP55: view

miRNA for CEP55 Gene

miRTarBase miRNAs that target CEP55

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CEP55 Gene

Localization for CEP55 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEP55 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cleavage furrow. Midbody, Midbody ring. Note=Present at the centrosomes at interphase. A small portion is associated preferentially with the mother centriole, whereas the majority localizes to the pericentriolar material. During mitosis, loses affinity for the centrosome at the onset of prophase and diffuses throughout the cell. This dissociation from the centrosome is phosphorylation-dependent. May remain localized at the centrosome during mitosis in certain cell types. Appears at the cleavage furrow in late anaphase and in the midbody in cytokinesis. {ECO:0000269 PubMed:16198290}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CEP55 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
nucleus 3
extracellular 2
cytosol 2
endosome 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Microtubule organizing center (3)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CEP55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 20186884
GO:0005814 centriole IEA --
GO:0005815 microtubule organizing center IDA,IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with CEP55: view

Pathways & Interactions for CEP55 Gene

SuperPathways for CEP55 Gene

SuperPathway Contained pathways
1 Cytoskeletal Signaling
2 DNA Damage
genes like me logo Genes that share pathways with CEP55: view

Pathways by source for CEP55 Gene

2 Cell Signaling Technology pathways for CEP55 Gene

SIGNOR curated interactions for CEP55 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CEP55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000281 mitotic cytokinesis IGI 19638580
GO:0000920 cell separation after cytokinesis IMP 20616062
GO:0006997 NOT nucleus organization IMP 20616062
GO:0007049 cell cycle IEA --
GO:0007080 NOT mitotic metaphase plate congression IMP 20616062
genes like me logo Genes that share ontologies with CEP55: view

Drugs & Compounds for CEP55 Gene

No Compound Related Data Available

Transcripts for CEP55 Gene

Unigene Clusters for CEP55 Gene

Centrosomal protein 55kDa:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CEP55 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7
SP2: -
SP3: - -
SP4: -

Relevant External Links for CEP55 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CEP55 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CEP55 Gene

mRNA differential expression in normal tissues according to GTEx for CEP55 Gene

This gene is overexpressed in Testis (x5.7) and Esophagus - Mucosa (x4.4).

Protein differential expression in normal tissues from HIPED for CEP55 Gene

This gene is overexpressed in Plasma (44.7) and Testis (17.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CEP55 Gene

Protein tissue co-expression partners for CEP55 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CEP55 Gene:


SOURCE GeneReport for Unigene cluster for CEP55 Gene:


mRNA Expression by UniProt/SwissProt for CEP55 Gene:

Tissue specificity: Widely expressed, mostly in proliferative tissues. Highly expressed in testis. Intermediate levels in adult and fetal thymus, as well as in various cancer cell lines. Low levels in different parts of the digestive tract, bone marrow, lymph nodes, placenta, fetal heart and fetal spleen. Hardly detected in brain.

Evidence on tissue expression from TISSUES for CEP55 Gene

  • Muscle(4.1)
genes like me logo Genes that share expression patterns with CEP55: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CEP55 Gene

Orthologs for CEP55 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CEP55 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CEP55 33 34
  • 99.57 (n)
(Canis familiaris)
Mammalia CEP55 33 34
  • 90.5 (n)
(Bos Taurus)
Mammalia CEP55 33 34
  • 88.41 (n)
(Rattus norvegicus)
Mammalia Cep55 33
  • 81.1 (n)
(Mus musculus)
Mammalia Cep55 33 16 34
  • 80.16 (n)
(Monodelphis domestica)
Mammalia CEP55 34
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia CEP55 34
  • 54 (a)
(Gallus gallus)
Aves CEP55 33 34
  • 62.28 (n)
(Anolis carolinensis)
Reptilia CEP55 34
  • 50 (a)
(Danio rerio)
Actinopterygii cep55l 33 34
  • 53.43 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9181 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4811 34
  • 20 (a)
Species where no ortholog for CEP55 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CEP55 Gene

Gene Tree for CEP55 (if available)
Gene Tree for CEP55 (if available)

Paralogs for CEP55 Gene

No data available for Paralogs for CEP55 Gene

Variants for CEP55 Gene

Sequence variations from dbSNP and Humsavar for CEP55 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000086958 -- 93,508,634(+) CCACA(A/G)TGGCT intron-variant
rs1000112075 -- 93,496,760(+) GCCGG(G/T)CCGGA utr-variant-5-prime
rs1000348341 -- 93,514,778(+) TTTTG(C/T)TTGTT intron-variant
rs1000367265 -- 93,521,305(+) CCCAC(G/T)CCTGG intron-variant
rs1000410282 -- 93,502,231(+) AATAG(G/T)AGTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CEP55 Gene

Variant ID Type Subtype PubMed ID
nsv825521 CNV loss 20364138

Variation tolerance for CEP55 Gene

Residual Variation Intolerance Score: 94.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.64; 89.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CEP55 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEP55 Gene

Disorders for CEP55 Gene

Relevant External Links for CEP55

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CEP55 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CEP55 Gene

Publications for CEP55 Gene

  1. The novel centrosomal associated protein CEP55 is present in the spindle midzone and the midbody. (PMID: 16406728) Martinez-Garay I … Kutsche K (Genomics 2006) 3 4 22 60
  2. Cdk1/Erk2- and Plk1-dependent phosphorylation of a centrosome protein, Cep55, is required for its recruitment to midbody and cytokinesis. (PMID: 16198290) Fabbro M … Khanna KK (Developmental cell 2005) 2 3 4 60
  3. Cortical constriction during abscission involves helices of ESCRT-III-dependent filaments. (PMID: 21310966) Guizetti J … Gerlich DW (Science (New York, N.Y.) 2011) 3 4 60
  4. Differential requirements for Alix and ESCRT-III in cytokinesis and HIV-1 release. (PMID: 18641129) Carlton JG … Martin-Serrano J (Proceedings of the National Academy of Sciences of the United States of America 2008) 3 4 60
  5. Midbody targeting of the ESCRT machinery by a noncanonical coiled coil in CEP55. (PMID: 18948538) Lee HH … Hurley JH (Science (New York, N.Y.) 2008) 3 4 60

Products for CEP55 Gene

Sources for CEP55 Gene

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