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Aliases for CEP55 Gene

Aliases for CEP55 Gene

  • Centrosomal Protein 55kDa 2 3
  • Up-Regulated In Colon Cancer 6 3 4
  • Cancer/Testis Antigen 111 2 3
  • C10orf3 3 4
  • URCC6 3 4
  • Chromosome 10 Open Reading Frame 3 2
  • CT111 3
  • Cep55 4

External Ids for CEP55 Gene

Previous HGNC Symbols for CEP55 Gene

  • C10orf3

Previous GeneCards Identifiers for CEP55 Gene

  • GC10P095247
  • GC10P088884

Summaries for CEP55 Gene

GeneCards Summary for CEP55 Gene

CEP55 (Centrosomal Protein 55kDa) is a Protein Coding gene.

UniProtKB/Swiss-Prot for CEP55 Gene

  • Plays a role in mitotic exit and cytokinesis. Not required for microtubule nucleation. Recruits PDCD6IP and TSG101 to midbody during cytokinesis.

Gene Wiki entry for CEP55 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEP55 Gene

Genomics for CEP55 Gene

Regulatory Elements for CEP55 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CEP55 Gene

Chromosome:
10
Start:
93,496,612 bp from pter
End:
93,529,094 bp from pter
Size:
32,483 bases
Orientation:
Plus strand

Genomic View for CEP55 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CEP55 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEP55 Gene

Proteins for CEP55 Gene

  • Protein details for CEP55 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53EZ4-CEP55_HUMAN
    Recommended name:
    Centrosomal protein of 55 kDa
    Protein Accession:
    Q53EZ4
    Secondary Accessions:
    • B2RDG8
    • Q32WF5
    • Q3MV20
    • Q5VY28
    • Q6N034
    • Q96H32
    • Q9NVS7

    Protein attributes for CEP55 Gene

    Size:
    464 amino acids
    Molecular mass:
    54178 Da
    Quaternary structure:
    • Homodimer. Interacts (phosphorylated on Ser-425 and Ser-428) with PLK1. Interacts with AKAP9; the interaction occurs in interphase and is lost upon mitotic entry. Interacts with PCNT; the interaction occurs in interphase and is lost upon mitotic entry. Interacts with PDCD6IP; the interaction is direct; CEP55 binds PDCD6IP in a 2:1 stoechiometry; PDCD6IP competes with TSG101 for the same binding site. Interacts with TSG101; TSG101 competes with PDCD6IP for the same binding site; interaction is required for cytokinesis but not for viral budding. Interacts with MVB12A, VPS37B, VPS37C and VPS28.
    SequenceCaution:
    • Sequence=BAA91670.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CEP55 Gene

    Alternative splice isoforms for CEP55 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CEP55 Gene

Proteomics data for CEP55 Gene at MOPED

Post-translational modifications for CEP55 Gene

  • There is a hierachy of phosphorylation, where both Ser-425 and Ser-428 are phosphorylated at the onset of mitosis, prior to Ser-436. Phosphorylation at Ser-425 and Ser-428 is required for dissociation from the centrosome at the G2/M boundary. Phosphorylation at the 3 sites, Ser-425, Ser-428 and Ser-436, is required for protein function at the final stages of cell division to complete cytokinesis successfully.
  • Ubiquitination at Lys 129, Lys 145, Lys 180, Lys 196, Lys 222, Lys 233, Lys 341, Lys 367, Lys 398, and Lys 442
  • Modification sites at PhosphoSitePlus

Other Protein References for CEP55 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CEP55 Gene

Domains & Families for CEP55 Gene

Protein Domains for CEP55 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CEP55 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CEP55: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CEP55 Gene

Function for CEP55 Gene

Molecular function for CEP55 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in mitotic exit and cytokinesis. Not required for microtubule nucleation. Recruits PDCD6IP and TSG101 to midbody during cytokinesis.

Gene Ontology (GO) - Molecular Function for CEP55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with CEP55: view
genes like me logo Genes that share phenotypes with CEP55: view

Animal Model Products

miRNA for CEP55 Gene

miRTarBase miRNAs that target CEP55

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for CEP55 Gene

Localization for CEP55 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEP55 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cleavage furrow. Midbody. Note=Present at the centrosomes at interphase. A small portion is associated preferentially with the mother centriole, whereas the majority localizes to the pericentriolar material. During mitosis, loss of affinity for the centrosome at the onset of prophase and diffusion throughout the cell. This dissociation from the centrosome is phosphorylation-dependent. May remain localized at the centrosome during mitosis in certain cell types. Appears at the cleavage furrow in late anaphase and in the midbody in cytokinesis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CEP55 Gene COMPARTMENTS Subcellular localization image for CEP55 gene
Compartment Confidence
cytoskeleton 5
endosome 2
extracellular 2

Gene Ontology (GO) - Cellular Components for CEP55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005813 centrosome IDA 20186884
GO:0005814 centriole IEA --
GO:0016020 membrane IDA 19946888
GO:0030496 midbody IDA 20186884
GO:0032154 cleavage furrow IEA --
genes like me logo Genes that share ontologies with CEP55: view

Pathways & Interactions for CEP55 Gene

SuperPathways for CEP55 Gene

No Data Available

SIGNOR curated interactions for CEP55 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CEP55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000281 mitotic cytokinesis IGI 19638580
GO:0000920 cell separation after cytokinesis IMP 20616062
GO:0006997 NOT nucleus organization IMP 20616062
GO:0007080 NOT mitotic metaphase plate congression IMP 20616062
GO:0045184 establishment of protein localization IMP 23045692
genes like me logo Genes that share ontologies with CEP55: view

No data available for Pathways by source for CEP55 Gene

Drugs & Compounds for CEP55 Gene

No Compound Related Data Available

Transcripts for CEP55 Gene

Unigene Clusters for CEP55 Gene

Centrosomal protein 55kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CEP55 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7
SP1:
SP2: -
SP3: - -
SP4: -

Relevant External Links for CEP55 Gene

GeneLoc Exon Structure for
CEP55
ECgene alternative splicing isoforms for
CEP55

Expression for CEP55 Gene

mRNA expression in normal human tissues for CEP55 Gene

mRNA differential expression in normal tissues according to GTEx for CEP55 Gene

This gene is overexpressed in Testis (x5.7) and Esophagus - Mucosa (x4.4).

Protein differential expression in normal tissues from HIPED for CEP55 Gene

This gene is overexpressed in Plasma (44.7) and Testis (17.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CEP55 Gene



SOURCE GeneReport for Unigene cluster for CEP55 Gene Hs.14559

mRNA Expression by UniProt/SwissProt for CEP55 Gene

Q53EZ4-CEP55_HUMAN
Tissue specificity: Widely expressed, mostly in proliferative tissues. Highly expressed in testis. Intermediate levels in adult and fetal thymus, as well as in various cancer cell lines. Low levels in different parts of the digestive tract, bone marrow, lymph nodes, placenta, fetal heart and fetal spleen. Hardly detected in brain.
genes like me logo Genes that share expression patterns with CEP55: view

Protein tissue co-expression partners for CEP55 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for CEP55 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CEP55 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CEP55 35
  • 88.41 (n)
  • 85.75 (a)
CEP55 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CEP55 35
  • 90.5 (n)
  • 86.58 (a)
CEP55 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cep55 35
  • 80.16 (n)
  • 75.54 (a)
Cep55 16
Cep55 36
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CEP55 35
  • 99.57 (n)
  • 99.57 (a)
CEP55 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cep55 35
  • 81.1 (n)
  • 76.62 (a)
oppossum
(Monodelphis domestica)
Mammalia CEP55 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CEP55 36
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves CEP55 35
  • 62.28 (n)
  • 53.95 (a)
CEP55 36
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CEP55 36
  • 50 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii cep55l 35
  • 53.43 (n)
  • 41.37 (a)
cep55l 36
  • 39 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9181 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4811 36
  • 20 (a)
OneToOne
Species with no ortholog for CEP55:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CEP55 Gene

ENSEMBL:
Gene Tree for CEP55 (if available)
TreeFam:
Gene Tree for CEP55 (if available)

Paralogs for CEP55 Gene

No data available for Paralogs for CEP55 Gene

Variants for CEP55 Gene

Sequence variations from dbSNP and Humsavar for CEP55 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs947599 -- 93,506,926(+) GGTGA(A/G)TGTAA intron-variant
rs953129 -- 93,529,468(+) TTCAC(A/G)CATCT downstream-variant-500B
rs953130 -- 93,529,518(+) GAGTT(A/G)TTTGT downstream-variant-500B
rs953131 -- 93,529,389(+) ACTCA(A/G)TGTAA downstream-variant-500B
rs956070 -- 93,502,740(+) TGACC(C/G)ACTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CEP55 Gene

Variant ID Type Subtype PubMed ID
nsv825521 CNV Loss 20364138

Variation tolerance for CEP55 Gene

Residual Variation Intolerance Score: 94.18% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.64; 89.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CEP55 Gene

HapMap Linkage Disequilibrium report
CEP55

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEP55 Gene

Disorders for CEP55 Gene

Relevant External Links for CEP55

Genetic Association Database (GAD)
CEP55
Human Genome Epidemiology (HuGE) Navigator
CEP55
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CEP55
genes like me logo Genes that share disorders with CEP55: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CEP55 Gene

Publications for CEP55 Gene

  1. The novel centrosomal associated protein CEP55 is present in the spindle midzone and the midbody. (PMID: 16406728) Martinez-Garay I. … Kutsche K. (Genomics 2006) 23 67
  2. Cdk1/Erk2- and Plk1-dependent phosphorylation of a centrosome protein, Cep55, is required for its recruitment to midbody and cytokinesis. (PMID: 16198290) Fabbro M. … Khanna K.K. (Dev. Cell 2005) 2 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. BioID-based Identification of Skp Cullin F-box (SCF)I^-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E. … Raught B. (Mol. Cell Proteomics 2015) 67
  5. Upregulation of FLJ10540, a PI3K-association protein, in rostral ventrolateral medulla impairs brain stem cardiovascular regulation during mevinphos intoxication. (PMID: 25449601) Tsai C.Y. … Chan S.H. (Biochem. Pharmacol. 2015) 67

Products for CEP55 Gene

Sources for CEP55 Gene

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