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Aliases for PPP2CB Gene

Aliases for PPP2CB Gene

  • Protein Phosphatase 2 Catalytic Subunit Beta 2 3 5
  • Protein Phosphatase 2 (Formerly 2A), Catalytic Subunit, Beta Isoform 2 3
  • Protein Phosphatase 2A Catalytic Subunit, Beta Isoform 2 3
  • Protein Phosphatase 2, Catalytic Subunit, Beta Isozyme 2 3
  • EC 3.1.3.16 4 61
  • PP2A-Beta 3 4
  • Serine/Threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform 3
  • Serine/Threonine-Protein Phosphatase 2A Catalytic Subunit Beta Isoform 3
  • Protein Phosphatase 2, Catalytic Subunit, Beta Isoform 3
  • Protein Phosphatase Type 2A Catalytic Subunit 3
  • Testicular Tissue Protein Li 146 3
  • PP2Abeta 3
  • PP2CB 3

External Ids for PPP2CB Gene

Previous GeneCards Identifiers for PPP2CB Gene

  • GC08M030548
  • GC08M031095
  • GC08M030499
  • GC08M030700
  • GC08M029189
  • GC08M030631

Summaries for PPP2CB Gene

Entrez Gene Summary for PPP2CB Gene

  • This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes a beta isoform of the catalytic subunit. [provided by RefSeq, Mar 2010]

GeneCards Summary for PPP2CB Gene

PPP2CB (Protein Phosphatase 2 Catalytic Subunit Beta) is a Protein Coding gene. Among its related pathways are Development IGF-1 receptor signaling and mTOR Pathway. GO annotations related to this gene include hydrolase activity and phosphoprotein phosphatase activity. An important paralog of this gene is PPP2CA.

UniProtKB/Swiss-Prot for PPP2CB Gene

  • PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase.

Tocris Summary for PPP2CB Gene

  • Protein Ser/Thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by hydrolysis of phosphoric acid monoesters. They oppose the action of kinases and phosphorylases and are involved in signal transduction.

Gene Wiki entry for PPP2CB Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP2CB Gene

Genomics for PPP2CB Gene

Regulatory Elements for PPP2CB Gene

Enhancers for PPP2CB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G030800 1.6 Ensembl ENCODE dbSUPER 30.8 +11.0 10952 5.3 HDGF PKNOX1 FOXA2 ARNT AGO1 ARID4B SIN3A DMAP1 ZNF2 YY1 PPP2CB GTF2E2 WRN PIR42776
GH08G030911 1.3 Ensembl ENCODE 33 -98.2 -98153 1.8 ATF1 CREB3L1 ARNT ARID4B ZNF2 GLIS2 CBX5 SP3 NCOA1 REST PPP2CB TEX15 LOC105379357
GH08G030811 1.1 ENCODE 31.2 +1.8 1808 2.5 HDGF MLX ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 ZNF766 ZNF143 PPP2CB PIR42776
GH08G030743 1.4 ENCODE dbSUPER 10.8 +70.2 70173 2.5 PKNOX1 FOXA2 CREB3L1 ARNT SIN3A ARID4B DMAP1 ZNF2 YY1 ZNF766 WRN GTF2E2 PPP2CB RNU5A-3P GSR UBXN8 GC08M030742 LOC105379355
GH08G030777 0.7 ENCODE dbSUPER 13.2 +36.3 36292 2.4 SCRT1 ZNF121 NR2F2 PPP2CB PIR42776 ENSG00000271081
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PPP2CB on UCSC Golden Path with GeneCards custom track

Genomic Location for PPP2CB Gene

Chromosome:
8
Start:
30,774,457 bp from pter
End:
30,814,314 bp from pter
Size:
39,858 bases
Orientation:
Minus strand

Genomic View for PPP2CB Gene

Genes around PPP2CB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP2CB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP2CB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP2CB Gene

Proteins for PPP2CB Gene

  • Protein details for PPP2CB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62714-PP2AB_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
    Protein Accession:
    P62714
    Secondary Accessions:
    • D3DSV4
    • P11082
    • Q6FHK5

    Protein attributes for PPP2CB Gene

    Size:
    309 amino acids
    Molecular mass:
    35575 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD. Interacts with TBCD (By similarity). PP2A consists of a common heterodimeric core enzyme (composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65) (subunit A)) that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B/PR72/PR130/PR59 and R5/B/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Binds PPME1. May indirectly interact with SGO1, most probably through regulatory B56 subunits. Interacts with CTTNBP2NL.

neXtProt entry for PPP2CB Gene

Selected DME Specific Peptides for PPP2CB Gene

P62714:
  • FCLHGGLSP
  • LCEKAKEIL
  • DLLWSDP
  • YGFYDEC
  • RAHQLVMEG
  • PAPRRGEP
  • FTKELDQW
  • PDTNYLF
  • SAPNYCYRC
  • LLVALKVRY
  • NYLFMGD
  • TIFSAPNY
  • FLQFDPAPR
  • SVETVTLLV
  • HGQFHDL
  • RGNHESRQ
  • QEVPHEG
  • ELFRIGG
  • GDYVDRG
  • GWGISPRGAG
  • FTDLFDYLPLTAL
  • SPRGAGYTFG
  • CGDVHGQ
  • CPVTVCGD

Post-translational modifications for PPP2CB Gene

  • May be monoubiquitinated by NOSIP.
  • Phosphorylation of either threonine (by autophosphorylation-activated protein kinase) or tyrosine results in inactivation of the phosphatase. Auto-dephosphorylation has been suggested as a mechanism for reactivation.
  • Reversibly methyl esterified on Leu-309 by leucine carboxyl methyltransferase 1 (LCMT1) and protein phosphatase methylesterase 1 (PPME1). Carboxyl methylation influences the affinity of the catalytic subunit for the different regulatory subunits, thereby modulating the PP2A holoenzymes substrate specificity, enzyme activity and cellular localization.
  • Ubiquitination at Lys21
  • Modification sites at PhosphoSitePlus

Other Protein References for PPP2CB Gene

Domains & Families for PPP2CB Gene

Graphical View of Domain Structure for InterPro Entry

P62714

UniProtKB/Swiss-Prot:

PP2AB_HUMAN :
  • Belongs to the PPP phosphatase family. PP-1 subfamily.
Family:
  • Belongs to the PPP phosphatase family. PP-1 subfamily.
genes like me logo Genes that share domains with PPP2CB: view

Function for PPP2CB Gene

Molecular function for PPP2CB Gene

GENATLAS Biochemistry:
protein phosphatase 2A,catalytic subunit,beta isoform
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot Function:
PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase.

Enzyme Numbers (IUBMB) for PPP2CB Gene

Gene Ontology (GO) - Molecular Function for PPP2CB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0004722 contributes_to protein serine/threonine phosphatase activity TAS 8206937
GO:0005515 protein binding IPI 9647778
GO:0008022 protein C-terminus binding IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PPP2CB: view
genes like me logo Genes that share phenotypes with PPP2CB: view

Animal Models for PPP2CB Gene

MGI Knock Outs for PPP2CB:

Animal Model Products

  • Taconic Biosciences Mouse Models for PPP2CB

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PPP2CB Gene

Localization for PPP2CB Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP2CB Gene

Cytoplasm. Nucleus. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle pole. Note=In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP2CB gene
Compartment Confidence
extracellular 5
cytosol 5
nucleus 4
cytoskeleton 3

Gene Ontology (GO) - Cellular Components for PPP2CB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000159 protein phosphatase type 2A complex TAS 8206937
GO:0000775 chromosome, centromeric region IEA --
GO:0000922 spindle pole IEA --
GO:0005634 nucleus IEA --
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with PPP2CB: view

Pathways & Interactions for PPP2CB Gene

SuperPathways for PPP2CB Gene

SuperPathway Contained pathways
1 RET signaling
2 Activated TLR4 signalling
3 S45 mutants of beta-catenin arent phosphorylated
4 Negative regulation of FGFR1 signaling
5 GAB1 signalosome
genes like me logo Genes that share pathways with PPP2CB: view

SIGNOR curated interactions for PPP2CB Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for PPP2CB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation TAS,IEA 2849765
GO:0008637 apoptotic mitochondrial changes IEA --
GO:0010468 regulation of gene expression IEA --
GO:0034976 response to endoplasmic reticulum stress IEA --
GO:0042542 response to hydrogen peroxide IEA --
genes like me logo Genes that share ontologies with PPP2CB: view

Drugs & Compounds for PPP2CB Gene

(12) Drugs for PPP2CB Gene - From: DrugBank, ApexBio, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vitamin E Approved, Vet_approved Nutra Target 414,411
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Manganese Approved Nutra 34
Cyclosporine Approved, Investigational, Vet_approved Pharma Antagonist Immunosuppressant drug, Immunosuppressive agent, Calcineurin inhibitor 922

(3) Additional Compounds for PPP2CB Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
FK 506
104987-11-3

(5) Tocris Compounds for PPP2CB Gene

Compound Action Cas Number
Calyculin A Protein phosphatase 1 and 2A inhibitor 101932-71-2
Cyclosporin A Calcineurin inhibitor 59865-13-3
FK 506 Potent calcineurin inhibitor; immunosuppressant 104987-11-3
Okadaic acid Protein phosphatase 1 and 2A inhibitor 78111-17-8
Tautomycetin Selective PP1 inhibitor 119757-73-2

(3) ApexBio Compounds for PPP2CB Gene

Compound Action Cas Number
DL-AP3 Glutamate receptor antagonist and HPSP inhibitor 20263-06-3
Microcystin-LR Inhibitor of protein phosphatase PP1/PP2A,potent and selective 101043-37-2
Sal 003 Cellular phosphatase complex inhibitor 1164470-53-4
genes like me logo Genes that share compounds with PPP2CB: view

Transcripts for PPP2CB Gene

Unigene Clusters for PPP2CB Gene

Protein phosphatase 2, catalytic subunit, beta isozyme:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP2CB Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c
SP1: - -
SP2: -
SP3: - -
SP4:
SP5: - - - - - - - - - -

Relevant External Links for PPP2CB Gene

GeneLoc Exon Structure for
PPP2CB
ECgene alternative splicing isoforms for
PPP2CB

Expression for PPP2CB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPP2CB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PPP2CB Gene

This gene is overexpressed in Uterus (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PPP2CB Gene



Protein tissue co-expression partners for PPP2CB Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PPP2CB Gene:

PPP2CB

SOURCE GeneReport for Unigene cluster for PPP2CB Gene:

Hs.491440

Evidence on tissue expression from TISSUES for PPP2CB Gene

  • Nervous system(4.5)
  • Kidney(4.4)
  • Liver(4.4)
  • Eye(2)
genes like me logo Genes that share expression patterns with PPP2CB: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP2CB Gene

Orthologs for PPP2CB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP2CB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPP2CB 34
  • 99.89 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 99 (a)
OneToMany
-- 35
  • 68 (a)
OneToMany
dog
(Canis familiaris)
Mammalia PPP2CB 34 35
  • 95.15 (n)
cow
(Bos Taurus)
Mammalia PPP2CB 34 35
  • 93.2 (n)
rat
(Rattus norvegicus)
Mammalia Ppp2cb 34
  • 93.1 (n)
mouse
(Mus musculus)
Mammalia Ppp2cb 34 16 35
  • 92.13 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PPP2CB 35
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPP2CA 35
  • 97 (a)
OneToOne
PPP2CB 34
  • 87.27 (n)
lizard
(Anolis carolinensis)
Reptilia PPP2CB 35
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp2cb 34
  • 84.47 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.6686 34
zebrafish
(Danio rerio)
Actinopterygii ppp2cb 34 35
  • 81.45 (n)
Dr.5120 34
fruit fly
(Drosophila melanogaster)
Insecta mts 36 35
  • 94 (a)
CG11597 36
  • 51 (a)
worm
(Caenorhabditis elegans)
Secernentea F38H4.9 36
  • 89 (a)
let-92 35
  • 86 (a)
OneToMany
pph-4.1 36
  • 63 (a)
pph-4.2 36
  • 61 (a)
C34C12.3 36
  • 52 (a)
C25A6.1 36
  • 44 (a)
C06A1.3 36
  • 40 (a)
W03D8.2 36
  • 40 (a)
Y40H4A.2 36
  • 39 (a)
C23G10.1a 36
  • 38 (a)
C23G10.1b 36
  • 38 (a)
C24H11.1 36
  • 38 (a)
C24H11.2 36
  • 38 (a)
R13A5.11 36
  • 37 (a)
F58G1.3 36
  • 36 (a)
R08A2.2 36
  • 35 (a)
F42G8.8 36
  • 34 (a)
C27B7.6 36
  • 33 (a)
F49E11.7 36
  • 32 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PPH22 34 35 37
  • 66.67 (n)
PPH21 35
  • 62 (a)
ManyToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F05357g 34
  • 66.56 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR099C 34
  • 64.57 (n)
soybean
(Glycine max)
eudicotyledons Gma.10798 34
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.9171 34
rice
(Oryza sativa)
Liliopsida Os10g0410600 34
  • 71.44 (n)
barley
(Hordeum vulgare)
Liliopsida Hv.6175 34
wheat
(Triticum aestivum)
Liliopsida Ta.11307 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11024 35
  • 90 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU06630 34
  • 70 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ppa2 34
  • 68.73 (n)
Species where no ortholog for PPP2CB was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PPP2CB Gene

ENSEMBL:
Gene Tree for PPP2CB (if available)
TreeFam:
Gene Tree for PPP2CB (if available)

Paralogs for PPP2CB Gene

Paralogs for PPP2CB Gene

(11) SIMAP similar genes for PPP2CB Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for PPP2CB Gene

genes like me logo Genes that share paralogs with PPP2CB: view

Variants for PPP2CB Gene

Sequence variations from dbSNP and Humsavar for PPP2CB Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000034624 -- 30,806,210(+) GCCTG(A/G)CTGAT intron-variant
rs1000154240 -- 30,812,288(+) CCCCG(C/T)GCTCC intron-variant
rs1000227299 -- 30,789,005(+) TACTT(A/C)CCCCA intron-variant
rs1000323652 -- 30,806,421(+) ATTTG(A/G/T)TCATT intron-variant
rs1000324121 -- 30,799,860(+) AAAAG(C/T)GTATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPP2CB Gene

Variant ID Type Subtype PubMed ID
esv3386082 CNV insertion 20981092
nsv1077034 CNV deletion 25765185
nsv1144225 CNV deletion 24896259
nsv971635 CNV duplication 23825009

Variation tolerance for PPP2CB Gene

Residual Variation Intolerance Score: 51.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.21; 4.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPP2CB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPP2CB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP2CB Gene

Disorders for PPP2CB Gene

Relevant External Links for PPP2CB

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPP2CB

No disorders were found for PPP2CB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP2CB Gene

Publications for PPP2CB Gene

  1. A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. (PMID: 18782753) Goudreault M. … Gingras A.C. (Mol. Cell. Proteomics 2009) 3 4 22 64
  2. The catalytic subunit of protein phosphatase 2A is carboxyl- methylated in vivo. (PMID: 8206937) Favre B. … Hemmings B.A. (J. Biol. Chem. 1994) 3 4 22 64
  3. Structure and transcriptional regulation of protein phosphatase 2A catalytic subunit genes. (PMID: 1846293) Khew-Goodall Y. … Hemmings B.A. (Biochemistry 1991) 3 4 22 64
  4. Shugoshin collaborates with protein phosphatase 2A to protect cohesin. (PMID: 16541025) Kitajima T.S. … Watanabe Y. (Nature 2006) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for PPP2CB Gene

Sources for PPP2CB Gene

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