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Aliases for PPP2CB Gene

Aliases for PPP2CB Gene

  • Protein Phosphatase 2, Catalytic Subunit, Beta Isozyme 2 3
  • Protein Phosphatase 2 (Formerly 2A), Catalytic Subunit, Beta Isoform 2 3
  • EC 3.1.3.16 4 63
  • PP2A-Beta 3 4
  • Serine/Threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform 3
  • Serine/Threonine-Protein Phosphatase 2A Catalytic Subunit Beta Isoform 3
  • Protein Phosphatase 2, Catalytic Subunit, Beta Isoform 3
  • Protein Phosphatase 2A Catalytic Subunit, Beta Isoform 3
  • Protein Phosphatase Type 2A Catalytic Subunit 3
  • Protein Phosphatase 2A Catalytic Subunit 2
  • Beta Isoform 2
  • PP2Abeta 3
  • PP2CB 3

External Ids for PPP2CB Gene

Previous GeneCards Identifiers for PPP2CB Gene

  • GC08M030548
  • GC08M031095
  • GC08M030499
  • GC08M030700
  • GC08M029189
  • GC08M030631

Summaries for PPP2CB Gene

Entrez Gene Summary for PPP2CB Gene

  • This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes a beta isoform of the catalytic subunit. [provided by RefSeq, Mar 2010]

GeneCards Summary for PPP2CB Gene

PPP2CB (Protein Phosphatase 2, Catalytic Subunit, Beta Isozyme) is a Protein Coding gene. Among its related pathways are PI3K-Akt signaling pathway and Signaling by FGFR. GO annotations related to this gene include protein C-terminus binding and protein serine/threonine phosphatase activity. An important paralog of this gene is PPP4C.

UniProtKB/Swiss-Prot for PPP2CB Gene

  • PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase.

Tocris Summary for PPP2CB Gene

  • Protein ser/thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by the hydrolysis of phosphoric acid monoesters. They directly oppose the actions of kinases and phosphorylases and therefore play an integral role in many signal transduction pathways. There are two groups of serine/threonine phosphatases; phosphoprotein phosphatases (e.g. PP1, calcineurin), which are sensitive to okadaic acid and metallo-phosphatases (e.g. PP2C), which require a divalent cation, commonly Mg2+, for catalytic activity. Dephosphorylation, depending on the residue that the phosphate group is removed from, can have a stimulatory or inhibitory effect on the target molecule. This makes protein Ser/Thr phosphatases essential for many signal transduction pathways. Protein Ser/Thr phosphatase are regulated by their subcellular localization and by inhibitor proteins, which are subtype-specific.

Gene Wiki entry for PPP2CB Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP2CB Gene

Genomics for PPP2CB Gene

Regulatory Elements for PPP2CB Gene

Genomic Location for PPP2CB Gene

Start:
30,774,457 bp from pter
End:
30,814,314 bp from pter
Size:
39,858 bases
Orientation:
Minus strand

Genomic View for PPP2CB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPP2CB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP2CB Gene

Proteins for PPP2CB Gene

  • Protein details for PPP2CB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62714-PP2AB_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
    Protein Accession:
    P62714
    Secondary Accessions:
    • D3DSV4
    • P11082
    • Q6FHK5

    Protein attributes for PPP2CB Gene

    Size:
    309 amino acids
    Molecular mass:
    35575 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Binds 2 manganese ions per subunit.;
    Quaternary structure:
    • Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD. Interacts with TBCD (By similarity). PP2A consists of a common heterodimeric core enzyme (composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65) (subunit A)) that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B/PR72/PR130/PR59 and R5/B/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Binds PPME1. May indirectly interact with SGOL1, most probably through regulatory B56 subunits. Interacts with CTTNBP2NL.

neXtProt entry for PPP2CB Gene

Proteomics data for PPP2CB Gene at MOPED

Post-translational modifications for PPP2CB Gene

  • Phosphorylation of either threonine (by autophosphorylation-activated protein kinase) or tyrosine results in inactivation of the phosphatase. Auto-dephosphorylation has been suggested as a mechanism for reactivation
  • Reversibly methyl esterified on Leu-309 by leucine carboxyl methyltransferase 1 (LCMT1) and protein phosphatase methylesterase 1 (PPME1). Carboxyl methylation influences the affinity of the catalytic subunit for the different regulatory subunits, thereby modulating the PP2A holoenzymes substrate specificity, enzyme activity and cellular localization.
  • Ubiquitination at Lys21, Lys41, Lys136, and Lys283
  • Modification sites at PhosphoSitePlus

Other Protein References for PPP2CB Gene

Domains for PPP2CB Gene

Gene Families for PPP2CB Gene

HGNC:
  • PPP :Serine/threonine phosphatases / Protein phosphatase, catalytic subunits

Graphical View of Domain Structure for InterPro Entry

P62714

UniProtKB/Swiss-Prot:

PP2AB_HUMAN :
  • P62714
Family:
  • Belongs to the PPP phosphatase family. PP-1 subfamily.
genes like me logo Genes that share domains with PPP2CB: view

Function for PPP2CB Gene

Molecular function for PPP2CB Gene

GENATLAS Biochemistry: protein phosphatase 2A,catalytic subunit,beta isoform
UniProtKB/Swiss-Prot CatalyticActivity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
UniProtKB/Swiss-Prot Function: PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase.

Enzyme Numbers (IUBMB) for PPP2CB Gene

Gene Ontology (GO) - Molecular Function for PPP2CB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity --
GO:0004722 contributes_to protein serine/threonine phosphatase activity TAS 8206937
GO:0005515 protein binding IPI 10698523
GO:0008022 protein C-terminus binding IEA --
GO:0016787 hydrolase activity --
genes like me logo Genes that share ontologies with PPP2CB: view
genes like me logo Genes that share phenotypes with PPP2CB: view

Animal Models for PPP2CB Gene

MGI Knock Outs for PPP2CB:

miRNA for PPP2CB Gene

miRTarBase miRNAs that target PPP2CB

No data available for Transcription Factor Targeting and HOMER Transcription for PPP2CB Gene

Localization for PPP2CB Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP2CB Gene

Cytoplasm. Nucleus. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle pole. Note=In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPP2CB Gene COMPARTMENTS Subcellular localization image for PPP2CB gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 4
endoplasmic reticulum 1
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PPP2CB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000159 protein phosphatase type 2A complex TAS 8206937
GO:0000775 chromosome, centromeric region IEA --
GO:0000922 spindle pole IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm --
genes like me logo Genes that share ontologies with PPP2CB: view

Pathways for PPP2CB Gene

genes like me logo Genes that share pathways with PPP2CB: view

Gene Ontology (GO) - Biological Process for PPP2CB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation TAS 2849765
GO:0008152 metabolic process --
GO:0008543 fibroblast growth factor receptor signaling pathway TAS --
GO:0008637 apoptotic mitochondrial changes IEA --
GO:0010468 regulation of gene expression IEA --
genes like me logo Genes that share ontologies with PPP2CB: view

Compounds for PPP2CB Gene

(5) Tocris Compounds for PPP2CB Gene

Compound Action Cas Number
Calyculin A Protein phosphatase 1 and 2A inhibitor [101932-71-2]
Cyclosporin A Calcineurin inhibitor [59865-13-3]
FK 506 Potent calcineurin inhibitor; immunosuppressant [104987-11-3]
Okadaic acid Protein phosphatase 1 and 2A inhibitor [78111-17-8]
Salubrinal Selective inhibitor of eIF2alpha dephosphorylation [405060-95-9]

(5) HMDB Compounds for PPP2CB Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Iron
  • Armco iron
7439-89-6
Manganese
  • manganese
7439-96-5
Phosphate
  • NFB Orthophosphate
14265-44-2
Water
  • Dihydrogen oxide
7732-18-5

(1) Drugbank Compounds for PPP2CB Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Vitamin E
  • alpha-Tocopherol
59-02-9 target
genes like me logo Genes that share compounds with PPP2CB: view

Transcripts for PPP2CB Gene

Unigene Clusters for PPP2CB Gene

Protein phosphatase 2, catalytic subunit, beta isozyme:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPP2CB Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c
SP1: - -
SP2: -
SP3: - -
SP4:
SP5: - - - - - - - - - -

Relevant External Links for PPP2CB Gene

GeneLoc Exon Structure for
PPP2CB
ECgene alternative splicing isoforms for
PPP2CB

Expression for PPP2CB Gene

mRNA expression in normal human tissues for PPP2CB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPP2CB Gene

SOURCE GeneReport for Unigene cluster for PPP2CB Gene Hs.491440

genes like me logo Genes that share expressions with PPP2CB: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PPP2CB Gene

Orthologs for PPP2CB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP2CB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPP2CB 35
  • 99.89 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia PPP2CB 35
  • 93.2 (n)
  • 99.68 (a)
PPP2CB 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPP2CB 35
  • 95.15 (n)
  • 100 (a)
PPP2CB 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppp2cb 35
  • 92.13 (n)
  • 100 (a)
Ppp2cb 16
Ppp2cb 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 99 (a)
OneToMany
-- 36
  • 68 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia PPP2CB 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppp2cb 35
  • 93.1 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves PPP2CA 36
  • 97 (a)
OneToOne
PPP2CB 35
  • 87.27 (n)
  • 97.09 (a)
lizard
(Anolis carolinensis)
Reptilia PPP2CB 36
  • 98 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.6686 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp2cb 35
  • 84.47 (n)
  • 98.06 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.5120 35
ppp2cb 35
  • 81.45 (n)
  • 99.68 (a)
ppp2cb 36
  • 100 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta mts 36
  • 94 (a)
OneToMany
mts 37
  • 94 (a)
CG11597 37
  • 51 (a)
worm
(Caenorhabditis elegans)
Secernentea let-92 36
  • 86 (a)
OneToMany
F42G8.8 37
  • 34 (a)
C23G10.1a 37
  • 38 (a)
F49E11.7 37
  • 32 (a)
F58G1.3 37
  • 36 (a)
R08A2.2 37
  • 35 (a)
C24H11.2 37
  • 38 (a)
pph-4.1 37
  • 63 (a)
F38H4.9 37
  • 89 (a)
pph-4.2 37
  • 61 (a)
C06A1.3 37
  • 40 (a)
C23G10.1b 37
  • 38 (a)
C27B7.6 37
  • 33 (a)
Y40H4A.2 37
  • 39 (a)
C25A6.1 37
  • 44 (a)
C34C12.3 37
  • 52 (a)
W03D8.2 37
  • 40 (a)
R13A5.11 37
  • 37 (a)
C24H11.1 37
  • 38 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR099C 35
  • 64.57 (n)
  • 75.17 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PPH21 36
  • 62 (a)
ManyToMany
PPH21 38
PPH22 35
  • 66.67 (n)
  • 75.83 (a)
PPH22 36
  • 61 (a)
ManyToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F05357g 35
  • 66.56 (n)
  • 76.41 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.9171 35
soybean
(Glycine max)
eudicotyledons Gma.10798 35
barley
(Hordeum vulgare)
Liliopsida Hv.6175 35
rice
(Oryza sativa)
Liliopsida Os10g0410600 35
  • 71.44 (n)
  • 82.33 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.11307 35
bread mold
(Neurospora crassa)
Ascomycetes NCU06630 35
  • 70 (n)
  • 86.33 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ppa2 35
  • 68.73 (n)
  • 78.5 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11024 36
  • 90 (a)
OneToMany
Species with no ortholog for PPP2CB:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PPP2CB Gene

ENSEMBL:
Gene Tree for PPP2CB (if available)
TreeFam:
Gene Tree for PPP2CB (if available)

Paralogs for PPP2CB Gene

Paralogs for PPP2CB Gene

Selected SIMAP similar genes for PPP2CB Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for PPP2CB Gene

genes like me logo Genes that share paralogs with PPP2CB: view

Variants for PPP2CB Gene

Sequence variations from dbSNP and Humsavar for PPP2CB Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs988 -- 30,786,071(-) AATGA(C/T)GAGCA utr-variant-3-prime
rs1044 -- 30,786,187(-) GGCTT(A/T)TTAAA utr-variant-3-prime
rs1045 -- 30,786,060(-) TTTAG(C/T)ACAAT utr-variant-3-prime
rs1046 -- 30,786,110(-) TTGGC(A/G)TTAAA utr-variant-3-prime
rs1116003 -- 30,797,847(+) ACGGC(A/G)CTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPP2CB Gene

Variant ID Type Subtype PubMed ID
esv273921 CNV Insertion 20981092

Relevant External Links for PPP2CB Gene

HapMap Linkage Disequilibrium report
PPP2CB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP2CB Gene

Disorders for PPP2CB Gene

No disorders were found for PPP2CB Gene.

No data available for UniProtKB/Swiss-Prot for PPP2CB Gene

Publications for PPP2CB Gene

  1. The catalytic subunit of protein phosphatase 2A is carboxyl- methylated in vivo. (PMID: 8206937) Favre B. … Hemmings B.A. (J. Biol. Chem. 1994) 3 4 23
  2. Structure and transcriptional regulation of protein phosphatase 2A catalytic subunit genes. (PMID: 1846293) Khew-Goodall Y. … Hemmings B.A. (Biochemistry 1991) 3 4 23
  3. A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. (PMID: 18782753) Goudreault M. … Gingras A.C. (Mol. Cell. Proteomics 2009) 3 4 23
  4. A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2A. (PMID: 10318862) Ogris E. … Pallas D.C. (J. Biol. Chem. 1999) 3 4
  5. Shugoshin collaborates with protein phosphatase 2A to protect cohesin. (PMID: 16541025) Kitajima T.S. … Watanabe Y. (Nature 2006) 3 4

Products for PPP2CB Gene

Sources for PPP2CB Gene

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