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Aliases for PPP2CA Gene

Aliases for PPP2CA Gene

  • Protein Phosphatase 2 Catalytic Subunit Alpha 2 3
  • Protein Phosphatase 2, Catalytic Subunit, Alpha Isozyme 2 3 5
  • Protein Phosphatase 2 (Formerly 2A), Catalytic Subunit, Alpha Isoform 2 3
  • Replication Protein C 3 4
  • EC 3.1.3.16 4 63
  • PP2A-Alpha 3 4
  • RP-C 3 4
  • Serine/Threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform 3
  • Protein Phosphatase 2A Catalytic Subunit, Alpha Isoform 3
  • Protein Phosphatase 2A Catalytic Subunit 2
  • Alpha Isoform 2
  • PP2Calpha 3
  • PP2CA 3
  • PP2Ac 3

External Ids for PPP2CA Gene

Previous GeneCards Identifiers for PPP2CA Gene

  • GC05M133180
  • GC05M134046
  • GC05M133563
  • GC05M133608
  • GC05M133560
  • GC05M128717
  • GC05M133530

Summaries for PPP2CA Gene

Entrez Gene Summary for PPP2CA Gene

  • This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPP2CA Gene

PPP2CA (Protein Phosphatase 2 Catalytic Subunit Alpha) is a Protein Coding gene. Among its related pathways are Negative regulation of MAPK pathway and p70S6K Signaling. GO annotations related to this gene include hydrolase activity and protein C-terminus binding. An important paralog of this gene is PPP4C.

UniProtKB/Swiss-Prot for PPP2CA Gene

  • PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at Ser-259.

Tocris Summary for PPP2CA Gene

  • Protein Ser/Thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by hydrolysis of phosphoric acid monoesters. They oppose the action of kinases and phosphorylases and are involved in signal transduction.

Gene Wiki entry for PPP2CA Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP2CA Gene

Genomics for PPP2CA Gene

Regulatory Elements for PPP2CA Gene

Enhancers for PPP2CA Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PPP2CA on UCSC Golden Path with GeneCards custom track

Promoters for PPP2CA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PPP2CA on UCSC Golden Path with GeneCards custom track

Genomic Location for PPP2CA Gene

Chromosome:
5
Start:
134,194,334 bp from pter
End:
134,226,259 bp from pter
Size:
31,926 bases
Orientation:
Minus strand

Genomic View for PPP2CA Gene

Genes around PPP2CA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP2CA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP2CA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP2CA Gene

Proteins for PPP2CA Gene

  • Protein details for PPP2CA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P67775-PP2AA_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
    Protein Accession:
    P67775
    Secondary Accessions:
    • P05323
    • P13197

    Protein attributes for PPP2CA Gene

    Size:
    309 amino acids
    Molecular mass:
    35594 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • PP2A consists of a common heterodimeric core enzyme, composed of PPP2CA a 36 kDa catalytic subunit (subunit C) and PPP2R1A a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B/PR72/PR130/PR59 and R5/B/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with NXN; the interaction is direct (By similarity). Interacts with KCTD20 (By similarity). Interacts with BTBD10 (By similarity). Interacts with TP53, SGOL1 and SGOL2. Interacts with AXIN1; the interaction dephosphorylates AXIN1. Interacts with PIM3; this interaction promotes dephosphorylation, ubiquitination and proteasomal degradation of PIM3. Interacts with RAF1. Interaction with IGBP1 protects unassembled PPP2CA from degradative ubiquitination. Interacts with GSK3B (via C2 domain).

    Three dimensional structures from OCA and Proteopedia for PPP2CA Gene

    Alternative splice isoforms for PPP2CA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPP2CA Gene

Proteomics data for PPP2CA Gene at MOPED

Post-translational modifications for PPP2CA Gene

  • May be monoubiquitinated by NOSIP.
  • Phosphorylation of either threonine (by autophosphorylation-activated protein kinase) or tyrosine results in inactivation of the phosphatase. Auto-dephosphorylation has been suggested as a mechanism for reactivation.
  • Reversibly methyl esterified on Leu-309 by leucine carboxyl methyltransferase 1 (LCMT1) and protein phosphatase methylesterase 1 (PPME1). Carboxyl methylation influences the affinity of the catalytic subunit for the different regulatory subunits, thereby modulating the PP2A holoenzymes substrate specificity, enzyme activity and cellular localization.
  • Ubiquitination at Lys 4, Lys 8, Lys 21, and Lys 29
  • Modification sites at PhosphoSitePlus

Other Protein References for PPP2CA Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PPP2CA Gene

Gene Families for PPP2CA Gene

Graphical View of Domain Structure for InterPro Entry

P67775

UniProtKB/Swiss-Prot:

PP2AA_HUMAN :
  • Belongs to the PPP phosphatase family. PP-1 subfamily.
Family:
  • Belongs to the PPP phosphatase family. PP-1 subfamily.
genes like me logo Genes that share domains with PPP2CA: view

Function for PPP2CA Gene

Molecular function for PPP2CA Gene

GENATLAS Biochemistry:
protein phosphatase 2A,catalytic subunit,alpha isoform,antagonizing cdc2/CCNB1 complex which regulates the G2-M transition in the cell cycle
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot Function:
PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at Ser-259.

Enzyme Numbers (IUBMB) for PPP2CA Gene

Gene Ontology (GO) - Molecular Function for PPP2CA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 1328865
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PPP2CA: view
genes like me logo Genes that share phenotypes with PPP2CA: view

Animal Models for PPP2CA Gene

MGI Knock Outs for PPP2CA:

Animal Model Products

miRNA for PPP2CA Gene

miRTarBase miRNAs that target PPP2CA

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PPP2CA Gene

Localization for PPP2CA Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP2CA Gene

Cytoplasm. Nucleus. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle pole. Note=In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles. Centromeric localization requires the presence of SGOL2 (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPP2CA Gene COMPARTMENTS Subcellular localization image for PPP2CA gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 5
mitochondrion 5
nucleus 5
plasma membrane 3

Gene Ontology (GO) - Cellular Components for PPP2CA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000159 protein phosphatase type 2A complex TAS 11007961
GO:0000775 chromosome, centromeric region IEA --
GO:0005739 mitochondrion NAS 11007961
genes like me logo Genes that share ontologies with PPP2CA: view

Pathways & Interactions for PPP2CA Gene

SuperPathways for PPP2CA Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 MyD88 cascade initiated on plasma membrane
3 S45 mutants of beta-catenin arent phosphorylated
4 PI3K events in ERBB4 signaling
5 DAG and IP3 signaling
genes like me logo Genes that share pathways with PPP2CA: view

SIGNOR curated interactions for PPP2CA Gene

Gene Ontology (GO) - Biological Process for PPP2CA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0000188 inactivation of MAPK activity NAS 11007961
GO:0000278 mitotic cell cycle TAS --
GO:0006275 regulation of DNA replication NAS 11007961
GO:0006355 regulation of transcription, DNA-templated NAS 11007961
genes like me logo Genes that share ontologies with PPP2CA: view

Drugs & Compounds for PPP2CA Gene

(14) Drugs for PPP2CA Gene - From: DrugBank, ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vitamin E Approved Nutra Target 382,385
Okadaic acid Experimental Pharma Protein phosphatase 1 and 2A inhibitor 0
(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid Experimental Pharma Target 0
2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid Experimental Pharma Target 0
Calyculin A Experimental Pharma Protein phosphatase 1 and 2A inhibitor 0

(7) Additional Compounds for PPP2CA Gene - From: HMDB, Tocris, and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
Ceramide
3102-57-6

(5) Tocris Compounds for PPP2CA Gene

Compound Action Cas Number
Calyculin A Protein phosphatase 1 and 2A inhibitor 101932-71-2
Ceramide Ser/Thr protein phosphatase activator 3102-57-6
Cyclosporin A Calcineurin inhibitor 59865-13-3
DL-AP3 Group I mGlu antagonist 20263-06-3
Okadaic acid Protein phosphatase 1 and 2A inhibitor 78111-17-8

(2) ApexBio Compounds for PPP2CA Gene

Compound Action Cas Number
Microcystin-LR Inhibitor of protein phosphatase PP1/PP2A,potent and selective 101043-37-2
Sal 003 Cellular phosphatase complex inhibitor 1164470-53-4
genes like me logo Genes that share compounds with PPP2CA: view

Transcripts for PPP2CA Gene

Unigene Clusters for PPP2CA Gene

Protein phosphatase 2, catalytic subunit, alpha isozyme:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPP2CA Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11
SP1: - - - - -
SP2:
SP3: - - - -
SP4: - - - - -
SP5: - - -
SP6: - - -
SP7: - -
SP8: - -

Relevant External Links for PPP2CA Gene

GeneLoc Exon Structure for
PPP2CA
ECgene alternative splicing isoforms for
PPP2CA

Expression for PPP2CA Gene

mRNA expression in normal human tissues for PPP2CA Gene

Protein differential expression in normal tissues from HIPED for PPP2CA Gene

This gene is overexpressed in Cervix (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPP2CA Gene



SOURCE GeneReport for Unigene cluster for PPP2CA Gene Hs.105818

genes like me logo Genes that share expression patterns with PPP2CA: view

Protein tissue co-expression partners for PPP2CA Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PPP2CA Gene

Orthologs for PPP2CA Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP2CA Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PPP2CA 35
  • 96.87 (n)
  • 100 (a)
PPP2CA 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPP2CA 35
  • 96.44 (n)
  • 99.35 (a)
mouse
(Mus musculus)
Mammalia Ppp2ca 35
  • 94.28 (n)
  • 99.68 (a)
Ppp2ca 16
Ppp2ca 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PPP2CA 35
  • 99.68 (n)
  • 99.35 (a)
PPP2CA 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppp2ca 35
  • 94.39 (n)
  • 99.68 (a)
oppossum
(Monodelphis domestica)
Mammalia PPP2CA 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPP2CA 36
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPP2CA 35
  • 88.67 (n)
  • 99.03 (a)
PPP2CA 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPP2CA 36
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75638 35
ppp2ca 35
  • 85.11 (n)
  • 99.03 (a)
African clawed frog
(Xenopus laevis)
Amphibia ppp2ca-prov 35
zebrafish
(Danio rerio)
Actinopterygii zgc:56064 35
  • 79.94 (n)
  • 97.09 (a)
ppp2ca 36
  • 97 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10181 35
fruit fly
(Drosophila melanogaster)
Insecta CG11597 37
  • 52 (a)
mts 37
  • 93 (a)
mts 35
  • 73.03 (n)
  • 93.85 (a)
mts 36
  • 94 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010172 35
  • 72.71 (n)
  • 93.85 (a)
worm
(Caenorhabditis elegans)
Secernentea C06A1.3 37
  • 41 (a)
C24H11.1 37
  • 38 (a)
C24H11.2 37
  • 38 (a)
C25A6.1 37
  • 43 (a)
C27B7.6 37
  • 32 (a)
C34C12.3 37
  • 52 (a)
F38H4.9 37
  • 89 (a)
F42G8.8 37
  • 34 (a)
F49E11.7 37
  • 32 (a)
F58G1.3 37
  • 36 (a)
pph-4.1 37
  • 62 (a)
pph-4.2 37
  • 62 (a)
R13A5.11 37
  • 36 (a)
W03D8.2 37
  • 40 (a)
Y40H4A.2 37
  • 38 (a)
let-92 35
  • 73.4 (n)
  • 89.25 (a)
let-92 36
  • 86 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PPH21 36
  • 62 (a)
ManyToMany
PPH22 36
  • 61 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons PP2A-1 35
  • 70.65 (n)
  • 80.4 (a)
soybean
(Glycine max)
eudicotyledons Gma.10697 35
rice
(Oryza sativa)
Liliopsida Os06g0574500 35
  • 70.21 (n)
  • 82.39 (a)
corn
(Zea mays)
Liliopsida Zm.9014 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5327 35
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ppa1 35
  • 70.65 (n)
  • 80.07 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11024 36
  • 92 (a)
OneToMany
Species with no ortholog for PPP2CA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP2CA Gene

ENSEMBL:
Gene Tree for PPP2CA (if available)
TreeFam:
Gene Tree for PPP2CA (if available)

Paralogs for PPP2CA Gene

Paralogs for PPP2CA Gene

(11) SIMAP similar genes for PPP2CA Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for PPP2CA Gene

genes like me logo Genes that share paralogs with PPP2CA: view

Variants for PPP2CA Gene

Sequence variations from dbSNP and Humsavar for PPP2CA Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs11552681 - 134,206,079(-) TCCAG(C/T)TACTG reference, missense
rs14548 -- 134,197,166(-) TTTTT(C/T)CCCTT utr-variant-3-prime
rs14549 -- 134,197,173(-) AGAAT(G/T)TTTTT utr-variant-3-prime
rs2868600 -- 134,221,625(+) CAAAG(A/C)GGAAC intron-variant
rs1052469 -- 134,196,763(+) GGGTT(A/C/G/T)TGTTT utr-variant-3-prime

Variation tolerance for PPP2CA Gene

Residual Variation Intolerance Score: 37.9% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for PPP2CA Gene

Disorders for PPP2CA Gene

Relevant External Links for PPP2CA

Genetic Association Database (GAD)
PPP2CA
Human Genome Epidemiology (HuGE) Navigator
PPP2CA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPP2CA

No disorders were found for PPP2CA Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP2CA Gene

Publications for PPP2CA Gene

  1. Methylated C-terminal leucine residue of PP2A catalytic subunit is important for binding of regulatory Balpha subunit. (PMID: 10191253) Bryant J.C. … Wadzinski B.E. (Biochem. J. 1999) 3 4 23 67
  2. Protein phosphatase 6 interacts with the DNA-dependent protein kinase catalytic subunit and dephosphorylates gamma-H2AX. (PMID: 20065038) Douglas P. … Lees-Miller S.P. (Mol. Cell. Biol. 2010) 3 23
  3. A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. (PMID: 18782753) Goudreault M. … Gingras A.C. (Mol. Cell. Proteomics 2009) 3 23
  4. Methylation status of CpG islands flanking a cAMP response element motif on the protein phosphatase 2Ac alpha promoter determines CREB binding and activity. (PMID: 19155497) Sunahori K. … Tsokos G.C. (J. Immunol. 2009) 3 23
  5. Inactivation of mammalian target of rapamycin increases STAT1 nuclear content and transcriptional activity in alpha4- and protein phosphatase 2A-dependent fashion. (PMID: 19553685) Fielhaber J.A. … Kristof A.S. (J. Biol. Chem. 2009) 3 23

Products for PPP2CA Gene

Sources for PPP2CA Gene

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