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Aliases for PPP2CA Gene

Aliases for PPP2CA Gene

  • Protein Phosphatase 2, Catalytic Subunit, Alpha Isozyme 2 3
  • Protein Phosphatase 2 (Formerly 2A), Catalytic Subunit, Alpha Isoform 2 3
  • Replication Protein C 3 4
  • EC 3.1.3.16 4 64
  • PP2A-Alpha 3 4
  • RP-C 3 4
  • Serine/Threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform 3
  • Serine/Threonine-Protein Phosphatase 2A Catalytic Subunit Alpha Isoform 3
  • Protein Phosphatase 2A Catalytic Subunit, Alpha Isoform 3
  • Protein Phosphatase 2A Catalytic Subunit 2
  • Alpha Isoform 2
  • PP2Calpha 3
  • PP2CA 3
  • PP2Ac 3

External Ids for PPP2CA Gene

Summaries for PPP2CA Gene

Entrez Gene Summary for PPP2CA Gene

  • This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPP2CA Gene

PPP2CA (Protein Phosphatase 2, Catalytic Subunit, Alpha Isozyme) is a Protein Coding gene. Among its related pathways are PI3K-Akt signaling pathway and Signaling by FGFR. GO annotations related to this gene include protein C-terminus binding and protein serine/threonine phosphatase activity. An important paralog of this gene is PPP4C.

UniProtKB/Swiss-Prot for PPP2CA Gene

  • PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at Ser-259.

Tocris Summary for PPP2CA Gene

  • Protein ser/thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by the hydrolysis of phosphoric acid monoesters. They directly oppose the actions of kinases and phosphorylases and therefore play an integral role in many signal transduction pathways. There are two groups of serine/threonine phosphatases; phosphoprotein phosphatases (e.g. PP1, calcineurin), which are sensitive to okadaic acid and metallo-phosphatases (e.g. PP2C), which require a divalent cation, commonly Mg2+, for catalytic activity. Dephosphorylation, depending on the residue that the phosphate group is removed from, can have a stimulatory or inhibitory effect on the target molecule. This makes protein Ser/Thr phosphatases essential for many signal transduction pathways. Protein Ser/Thr phosphatase are regulated by their subcellular localization and by inhibitor proteins, which are subtype-specific.

Gene Wiki entry for PPP2CA Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP2CA Gene

Genomics for PPP2CA Gene

Genomic Location for PPP2CA Gene

Start:
134,194,334 bp from pter
End:
134,226,259 bp from pter
Size:
31,926 bases
Orientation:
Minus strand

Genomic View for PPP2CA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPP2CA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP2CA Gene

Regulatory Elements for PPP2CA Gene

Proteins for PPP2CA Gene

  • Protein details for PPP2CA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P67775-PP2AA_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
    Protein Accession:
    P67775
    Secondary Accessions:
    • P05323
    • P13197

    Protein attributes for PPP2CA Gene

    Size:
    309 amino acids
    Molecular mass:
    35594 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Binds 2 manganese ions per subunit.;
    Quaternary structure:
    • PP2A consists of a common heterodimeric core enzyme, composed of PPP2CA a 36 kDa catalytic subunit (subunit C) and PPP2R1A a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B/PR72/PR130/PR59 and R5/B/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with NXN; the interaction is direct (By similarity). Interacts with KCTD20 (By similarity). Interacts with BTBD10 (By similarity). Interacts with TP53, SGOL1 and SGOL2. Interacts with AXIN1; the interaction dephosphorylates AXIN1. Interacts with PIM3; this interaction promotes dephosphorylation, ubiquitination and proteasomal degradation of PIM3. Interacts with RAF1. Interaction with IGBP1 protects unassembled PPP2CA from degradative ubiquitination. Interacts with GSK3B (via C2 domain).

    Three dimensional structures from OCA and Proteopedia for PPP2CA Gene

    Alternative splice isoforms for PPP2CA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPP2CA Gene

Proteomics data for PPP2CA Gene at MOPED

Post-translational modifications for PPP2CA Gene

  • Phosphorylation of either threonine (by autophosphorylation-activated protein kinase) or tyrosine results in inactivation of the phosphatase. Auto-dephosphorylation has been suggested as a mechanism for reactivation
  • Reversibly methyl esterified on Leu-309 by leucine carboxyl methyltransferase 1 (LCMT1) and protein phosphatase methylesterase 1 (PPME1). Carboxyl methylation influences the affinity of the catalytic subunit for the different regulatory subunits, thereby modulating the PP2A holoenzymes substrate specificity, enzyme activity and cellular localization.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys8, Lys21, Lys29, Lys41, Lys136, and Lys283

Other Protein References for PPP2CA Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for PPP2CA Gene

Gene Families for PPP2CA Gene

HGNC:
  • PPP :Serine/threonine phosphatases / Protein phosphatase, catalytic subunits

UniProtKB/Swiss-Prot:

PP2AA_HUMAN
Family:
  • Belongs to the PPP phosphatase family. PP-1 subfamily.:
    • P67775
genes like me logo Genes that share domains with PPP2CA: view

Function for PPP2CA Gene

Molecular function for PPP2CA Gene

GENATLAS Biochemistry: protein phosphatase 2A,catalytic subunit,alpha isoform,antagonizing cdc2/CCNB1 complex which regulates the G2-M transition in the cell cycle
UniProtKB/Swiss-Prot CatalyticActivity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
UniProtKB/Swiss-Prot Function: PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at Ser-259.

Enzyme Numbers (IUBMB) for PPP2CA Gene

Gene Ontology (GO) - Molecular Function for PPP2CA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity --
GO:0004722 protein serine/threonine phosphatase activity IEA --
GO:0005515 protein binding IPI 11591705
GO:0008022 protein C-terminus binding IEA --
GO:0016787 hydrolase activity --
genes like me logo Genes that share ontologies with PPP2CA: view
genes like me logo Genes that share phenotypes with PPP2CA: view

Animal Models for PPP2CA Gene

MGI Knock Outs for PPP2CA:

miRNA for PPP2CA Gene

miRTarBase miRNAs that target PPP2CA

No data available for Transcription Factor Targeting and HOMER Transcription for PPP2CA Gene

Localization for PPP2CA Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP2CA Gene

Cytoplasm. Nucleus. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle pole. Note=In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles. Centromeric localization requires the presence of SGOL2 (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPP2CA Gene COMPARTMENTS Subcellular localization image for PPP2CA gene
Compartment Confidence
cytoskeleton 5
cytosol 5
mitochondrion 5
nucleus 5
plasma membrane 2
endoplasmic reticulum 1
extracellular 1

Gene Ontology (GO) - Cellular Components for PPP2CA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000159 protein phosphatase type 2A complex TAS 11007961
GO:0000775 chromosome, centromeric region IEA --
GO:0000922 spindle pole IEA --
GO:0005634 nucleus NAS 11007961
GO:0005737 cytoplasm --
genes like me logo Genes that share ontologies with PPP2CA: view

Pathways for PPP2CA Gene

genes like me logo Genes that share pathways with PPP2CA: view

Gene Ontology (GO) - Biological Process for PPP2CA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0000188 inactivation of MAPK activity NAS 11007961
GO:0000278 mitotic cell cycle TAS --
GO:0001932 regulation of protein phosphorylation --
GO:0006275 regulation of DNA replication NAS 11007961
genes like me logo Genes that share ontologies with PPP2CA: view

Compounds for PPP2CA Gene

(5) Tocris Compounds for PPP2CA Gene

Compound Action Cas Number
Calyculin A Protein phosphatase 1 and 2A inhibitor [101932-71-2]
Cyclosporin A Calcineurin inhibitor [59865-13-3]
FK 506 Potent calcineurin inhibitor; immunosuppressant [104987-11-3]
Okadaic acid Protein phosphatase 1 and 2A inhibitor [78111-17-8]
Salubrinal Selective inhibitor of eIF2alpha dephosphorylation [405060-95-9]

(6) HMDB Compounds for PPP2CA Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Iron
  • Armco iron
7439-89-6
Magnesium
  • Magnesium
7439-95-4
Manganese
  • manganese
7439-96-5
Phosphate
  • NFB Orthophosphate
14265-44-2

(3) Drugbank Compounds for PPP2CA Gene

(5) Novoseek inferred chemical compound relationships for PPP2CA Gene

Compound -log(P) Hits PubMed IDs
threonine 70 2
okadaic acid 60 1
serine 59.7 2
leucine 48.7 6
glucose 0 6
genes like me logo Genes that share compounds with PPP2CA: view

Transcripts for PPP2CA Gene

mRNA/cDNA for PPP2CA Gene

Unigene Clusters for PPP2CA Gene

Protein phosphatase 2, catalytic subunit, alpha isozyme:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPP2CA Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11
SP1: - - - - -
SP2:
SP3: - - - -
SP4: - - - - -
SP5: - - -
SP6: - - -
SP7: - -
SP8: - -

Relevant External Links for PPP2CA Gene

GeneLoc Exon Structure for
PPP2CA
ECgene alternative splicing isoforms for
PPP2CA

Expression for PPP2CA Gene

mRNA expression in normal human tissues for PPP2CA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPP2CA Gene

SOURCE GeneReport for Unigene cluster for PPP2CA Gene Hs.105818

genes like me logo Genes that share expressions with PPP2CA: view

Orthologs for PPP2CA Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP2CA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPP2CA 36
  • 99.68 (n)
  • 99.35 (a)
PPP2CA 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PPP2CA 36
  • 96.87 (n)
  • 100 (a)
PPP2CA 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPP2CA 36
  • 96.44 (n)
  • 99.35 (a)
mouse
(Mus musculus)
Mammalia Ppp2ca 36
  • 94.28 (n)
  • 99.68 (a)
Ppp2ca 16
Ppp2ca 37
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPP2CA 37
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPP2CA 37
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppp2ca 36
  • 94.39 (n)
  • 99.68 (a)
chicken
(Gallus gallus)
Aves PPP2CA 36
  • 88.67 (n)
  • 99.03 (a)
PPP2CA 37
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPP2CA 37
  • 99 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia ppp2ca-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75638 36
ppp2ca 36
  • 85.11 (n)
  • 99.03 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10181 36
zebrafish
(Danio rerio)
Actinopterygii ppp2ca 37
  • 97 (a)
OneToOne
zgc:56064 36
  • 79.94 (n)
  • 97.09 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010172 36
  • 72.71 (n)
  • 93.85 (a)
fruit fly
(Drosophila melanogaster)
Insecta mts 36
  • 73.03 (n)
  • 93.85 (a)
mts 37
  • 94 (a)
OneToMany
mts 38
  • 93 (a)
CG11597 38
  • 52 (a)
worm
(Caenorhabditis elegans)
Secernentea let-92 36
  • 73.4 (n)
  • 89.25 (a)
let-92 37
  • 86 (a)
OneToMany
F42G8.8 38
  • 34 (a)
F49E11.7 38
  • 32 (a)
F58G1.3 38
  • 36 (a)
C24H11.2 38
  • 38 (a)
pph-4.1 38
  • 62 (a)
F38H4.9 38
  • 89 (a)
pph-4.2 38
  • 62 (a)
C06A1.3 38
  • 41 (a)
C27B7.6 38
  • 32 (a)
Y40H4A.2 38
  • 38 (a)
C25A6.1 38
  • 43 (a)
C34C12.3 38
  • 52 (a)
W03D8.2 38
  • 40 (a)
R13A5.11 38
  • 36 (a)
C24H11.1 38
  • 38 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PPH21 37
  • 62 (a)
ManyToMany
PPH22 37
  • 61 (a)
ManyToMany
soybean
(Glycine max)
eudicotyledons Gma.10697 36
thale cress
(Arabidopsis thaliana)
eudicotyledons PP2A-1 36
  • 70.65 (n)
  • 80.4 (a)
corn
(Zea mays)
Liliopsida Zm.9014 36
rice
(Oryza sativa)
Liliopsida Os06g0574500 36
  • 70.21 (n)
  • 82.39 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ppa1 36
  • 70.65 (n)
  • 80.07 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5327 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11024 37
  • 92 (a)
OneToMany
Species with no ortholog for PPP2CA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP2CA Gene

ENSEMBL:
Gene Tree for PPP2CA (if available)
TreeFam:
Gene Tree for PPP2CA (if available)

Paralogs for PPP2CA Gene

Paralogs for PPP2CA Gene

Selected SIMAP similar genes for PPP2CA Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for PPP2CA Gene

genes like me logo Genes that share paralogs with PPP2CA: view

Variants for PPP2CA Gene

Sequence variations from dbSNP and Humsavar for PPP2CA Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs14548 -- 134,197,166(-) TTTTT(C/T)CCCTT utr-variant-3-prime
rs14549 -- 134,197,173(-) AGAAT(G/T)TTTTT utr-variant-3-prime
rs254046 -- 134,210,746(+) GGGCA(C/T)CACTT intron-variant
rs254047 -- 134,213,867(+) gctca(C/T)gcctg intron-variant
rs254048 -- 134,214,224(+) CAGAA(C/T)TCTTC intron-variant

Relevant External Links for PPP2CA Gene

HapMap Linkage Disequilibrium report
PPP2CA

No data available for Structural Variations from Database of Genomic Variants (DGV) for PPP2CA Gene

Disorders for PPP2CA Gene

Relevant External Links for PPP2CA

Genetic Association Database (GAD)
PPP2CA
Human Genome Epidemiology (HuGE) Navigator
PPP2CA
genes like me logo Genes that share disorders with PPP2CA: view

No data available for UniProtKB/Swiss-Prot for PPP2CA Gene

Publications for PPP2CA Gene

  1. The catalytic subunit of protein phosphatase 2A is carboxyl- methylated in vivo. (PMID: 8206937) Favre B. … Hemmings B.A. (J. Biol. Chem. 1994) 3 4 23
  2. Methylated C-terminal leucine residue of PP2A catalytic subunit is important for binding of regulatory Balpha subunit. (PMID: 10191253) Bryant J.C. … Wadzinski B.E. (Biochem. J. 1999) 3 4 23
  3. Structure and transcriptional regulation of protein phosphatase 2A catalytic subunit genes. (PMID: 1846293) Khew-Goodall Y. … Hemmings B.A. (Biochemistry 1991) 3 4
  4. PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4. (PMID: 18715871) Chen G.I. … Gingras A.-C. (J. Biol. Chem. 2008) 3 23
  5. A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. (PMID: 18782753) Goudreault M. … Gingras A.C. (Mol. Cell. Proteomics 2009) 3 23

Products for PPP2CA Gene

  • antibodies-online proteins for PPP2CA
  • antibodies-online antibodies for PPP2CA
  • antibodies-online kits for PPP2CA

Sources for PPP2CA Gene

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