Aliases for WRAP53 Gene
External Ids for WRAP53 Gene
Previous HGNC Symbols for WRAP53 Gene
Previous GeneCards Identifiers for WRAP53 Gene
This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene. [provided by RefSeq, Mar 2011]
GeneCards Summary for WRAP53 Gene
WRAP53 (WD Repeat Containing, Antisense To TP53) is a Protein Coding gene. Diseases associated with WRAP53 include dyskeratosis congenita, autosomal recessive 3 and wrap53-related dyskeratosis congenita. Among its related pathways are Cell Cycle, Mitotic and Telomere C-strand (Lagging Strand) Synthesis. GO annotations related to this gene include RNA binding.
UniProtKB/Swiss-Prot for WRAP53 Gene
Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes. In the telomerase holoenzyme complex, it controls telomerase localization to Cajal body. Required for delivery of TERC to telomeres during S phase and for telomerase activity. Binds small Cajal body RNAs (scaRNAs). The mRNA encoding this protein plays a critical role in the regulation of p53 expression at the post-transcriptional level; it is involved both in maintaining basal p53 mRNA levels and in p53 induction upon DNA damage.