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Aliases for TRIM68 Gene

Aliases for TRIM68 Gene

  • Tripartite Motif Containing 68 2 3 5
  • RING-Type E3 Ubiquitin Transferase TRIM68 3 4
  • Tripartite Motif-Containing Protein 68 3 4
  • Ring Finger Protein 137 2 3
  • SSA Protein SS-56 3 4
  • RNF137 3 4
  • GC109 3 4
  • SS-56 3 4
  • SS56 3 4
  • E3 Ubiquitin-Protein Ligase TRIM68 3
  • Tripartite Motif-Containing 68 2
  • Ro/SSA1 Related Protein 3
  • RING Finger Protein 137 4
  • EC 2.3.2.27 4

External Ids for TRIM68 Gene

Previous HGNC Symbols for TRIM68 Gene

  • RNF137

Previous GeneCards Identifiers for TRIM68 Gene

  • GC11M004278

Summaries for TRIM68 Gene

Entrez Gene Summary for TRIM68 Gene

  • This gene encodes a member of the tripartite motif-containing protein family, whose members are characterized by a "really interesting new gene" (RING) finger domain, a zinc-binding B-box motif, and a coiled-coil region. Members of this family function as E3 ubiquitin ligases and are involved in a broad range of biological processes. This gene regulates the activation of nuclear receptors, such as androgen receptor, and has been implicated in development of prostate cancer cells, where its expression increases in response to a downregulation of microRNAs. In addition, this gene participates in viral defense regulation as a negative regulator of interferon-beta. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

GeneCards Summary for TRIM68 Gene

TRIM68 (Tripartite Motif Containing 68) is a Protein Coding gene. Diseases associated with TRIM68 include Prostate Cancer. Among its related pathways are Interferon gamma signaling and Innate Immune System. GO annotations related to this gene include ligase activity and androgen receptor binding. An important paralog of this gene is TRIM21.

UniProtKB/Swiss-Prot for TRIM68 Gene

  • Functions as a ubiquitin E3 ligase. Acts as a coactivator of androgen receptor (AR) depending on its ubiquitin ligase activity.

Gene Wiki entry for TRIM68 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM68 Gene

Genomics for TRIM68 Gene

Regulatory Elements for TRIM68 Gene

Enhancers for TRIM68 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G003892 1.4 Ensembl ENCODE dbSUPER 14.4 +714.0 714001 2.7 ATF1 PKNOX1 WRNIP1 YBX1 ELK1 JUNB ZNF491 TBX21 NFIL3 NBN STIM1 TRIM68 LOC105376527 ENSG00000229368 ENSG00000206976 RHOG RRM1 ENSG00000230593 GC11P003897
GH11G003915 1.2 Ensembl ENCODE dbSUPER 14.4 +692.1 692090 0.7 GATAD2A NFIA NFIB ZNF384 ZNF491 RAD21 NFIC PRDM6 KLF16 ZNF580 TRIM68 STIM1 GC11P003920 GC11P003897
GH11G004637 0.7 Ensembl 16.8 -29.0 -29042 0.2 ZBTB10 CTCF ZNF654 TEAD4 TRIM22 MAX REST ZNF2 RAD21 ZNF592 TRIM68 OR52M1 OR51D1 GC11P004628
GH11G003972 0.9 dbSUPER 11.4 +635.6 635637 0.7 HDAC1 ATF1 CBX3 RB1 ARNT INSM2 CHAMP1 ZNF155 ZEB1 CBX5 TRIM68 HNRNPA1P76 ENSG00000255232
GH11G004606 1 ENCODE 8 +0.3 261 2.3 PKNOX1 ATF1 CREB3L1 SIN3A ZNF2 YY1 GLIS2 ZNF143 ZNF207 FOS TRIM68 OR52I1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRIM68 on UCSC Golden Path with GeneCards custom track

Promoters for TRIM68 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000036187 259 1601 PKNOX1 ATF1 CREB3L1 SIN3A ZNF2 YY1 GLIS2 ZNF143 ZNF207 FOS

Genomic Location for TRIM68 Gene

Chromosome:
11
Start:
4,598,672 bp from pter
End:
4,608,259 bp from pter
Size:
9,588 bases
Orientation:
Minus strand

Genomic View for TRIM68 Gene

Genes around TRIM68 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM68 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM68 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM68 Gene

Proteins for TRIM68 Gene

  • Protein details for TRIM68 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6AZZ1-TRI68_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase TRIM68
    Protein Accession:
    Q6AZZ1
    Secondary Accessions:
    • A6NI19
    • A8K551
    • B3KPM5
    • B4DVK4
    • Q8WZ70
    • Q96LE5
    • Q96PF7
    • Q9H9C2
    • Q9NW18

    Protein attributes for TRIM68 Gene

    Size:
    485 amino acids
    Molecular mass:
    56259 Da
    Quaternary structure:
    • Interacts with AR/androgen receptor (via ligand-binding domain). Interacts with KAT5/TIP60.
    Miscellaneous:
    • Antibodies against TRIM68 are found in patients with systemic lupus erythematosus (SLE) and primary Sjoegren syndrome.
    SequenceCaution:
    • Sequence=BAA91569.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14309.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TRIM68 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM68 Gene

Post-translational modifications for TRIM68 Gene

Other Protein References for TRIM68 Gene

No data available for DME Specific Peptides for TRIM68 Gene

Domains & Families for TRIM68 Gene

Gene Families for TRIM68 Gene

Suggested Antigen Peptide Sequences for TRIM68 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6AZZ1

UniProtKB/Swiss-Prot:

TRI68_HUMAN :
  • The RING domain is essential for ubiquitin E3 ligase activity.
  • Belongs to the TRIM/RBCC family.
Domain:
  • The RING domain is essential for ubiquitin E3 ligase activity.
Family:
  • Belongs to the TRIM/RBCC family.
genes like me logo Genes that share domains with TRIM68: view

Function for TRIM68 Gene

Molecular function for TRIM68 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
Functions as a ubiquitin E3 ligase. Acts as a coactivator of androgen receptor (AR) depending on its ubiquitin ligase activity.
UniProtKB/Swiss-Prot Induction:
Up-regulated in prostate cancer.

Enzyme Numbers (IUBMB) for TRIM68 Gene

Gene Ontology (GO) - Molecular Function for TRIM68 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 18451177
GO:0008270 zinc ion binding IEA --
GO:0016740 transferase activity IEA --
GO:0035035 histone acetyltransferase binding IPI 18451177
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TRIM68: view
genes like me logo Genes that share phenotypes with TRIM68: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM68 Gene

Localization for TRIM68 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM68 Gene

Cytoplasm, perinuclear region. Nucleus. Note=Colocalized with AR in nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM68 gene
Compartment Confidence
nucleus 5
cytosol 5
golgi apparatus 5

Gene Ontology (GO) - Cellular Components for TRIM68 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IDA 18451177
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with TRIM68: view

Pathways & Interactions for TRIM68 Gene

genes like me logo Genes that share pathways with TRIM68: view

Pathways by source for TRIM68 Gene

UniProtKB/Swiss-Prot Q6AZZ1-TRI68_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for TRIM68 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0051865 protein autoubiquitination IDA 18451177
GO:0060333 interferon-gamma-mediated signaling pathway TAS --
GO:0060765 regulation of androgen receptor signaling pathway IDA 18451177
genes like me logo Genes that share ontologies with TRIM68: view

No data available for SIGNOR curated interactions for TRIM68 Gene

Transcripts for TRIM68 Gene

Unigene Clusters for TRIM68 Gene

Tripartite motif containing 68:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM68 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7
SP1: -
SP2: -

Relevant External Links for TRIM68 Gene

GeneLoc Exon Structure for
TRIM68
ECgene alternative splicing isoforms for
TRIM68

Expression for TRIM68 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRIM68 Gene

Protein differential expression in normal tissues from HIPED for TRIM68 Gene

This gene is overexpressed in Colon muscle (66.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRIM68 Gene



Protein tissue co-expression partners for TRIM68 Gene

NURSA nuclear receptor signaling pathways regulating expression of TRIM68 Gene:

TRIM68

SOURCE GeneReport for Unigene cluster for TRIM68 Gene:

Hs.523438

mRNA Expression by UniProt/SwissProt for TRIM68 Gene:

Q6AZZ1-TRI68_HUMAN
Tissue specificity: Widely expressed. Expressed at high levels in prostate cancer cell lines. Up-regulation could be restricted to androgen-dependent cells.

Evidence on tissue expression from TISSUES for TRIM68 Gene

  • Spleen(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with TRIM68: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM68 Gene

Orthologs for TRIM68 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TRIM68 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM68 34 35
  • 99.31 (n)
dog
(Canis familiaris)
Mammalia TRIM68 34 35
  • 89.07 (n)
cow
(Bos Taurus)
Mammalia TRIM68 34 35
  • 87.84 (n)
rat
(Rattus norvegicus)
Mammalia Trim68 34
  • 81.32 (n)
mouse
(Mus musculus)
Mammalia Trim68 34 16 35
  • 80.99 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 39 (a)
ManyToMany
-- 35
  • 35 (a)
ManyToMany
-- 35
  • 35 (a)
ManyToMany
-- 35
  • 34 (a)
ManyToMany
-- 35
  • 30 (a)
ManyToMany
Species where no ortholog for TRIM68 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRIM68 Gene

ENSEMBL:
Gene Tree for TRIM68 (if available)
TreeFam:
Gene Tree for TRIM68 (if available)

Paralogs for TRIM68 Gene

Variants for TRIM68 Gene

Sequence variations from dbSNP and Humsavar for TRIM68 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000168651 -- 4,598,237(+) AACCT(C/T)ACGAG downstream-variant-500B
rs1000449222 -- 4,603,710(+) CAGCA(A/T)CCACA intron-variant
rs1000800529 -- 4,603,434(+) GCAAC(C/T)GGCCA intron-variant
rs1000804845 -- 4,605,993(+) TTACA(C/T)TAATA intron-variant
rs1000873734 -- 4,607,776(+) GGTTG(C/G)TTTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM68 Gene

Variant ID Type Subtype PubMed ID
dgv1586n54 CNV loss 21841781
nsv1047344 CNV loss 25217958
nsv1054705 CNV loss 25217958
nsv832055 CNV loss 17160897

Variation tolerance for TRIM68 Gene

Residual Variation Intolerance Score: 52.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.47; 28.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIM68 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIM68

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM68 Gene

Disorders for TRIM68 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TRIM68 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
prostate cancer
  • prostate cancer, hereditary, 5
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TRIM68

Genetic Association Database (GAD)
TRIM68
Human Genome Epidemiology (HuGE) Navigator
TRIM68
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIM68
genes like me logo Genes that share disorders with TRIM68: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRIM68 Gene

Publications for TRIM68 Gene

  1. A novel gene on human chromosome 2p24 is differentially expressed between androgen-dependent and androgen-independent prostate cancer cells. (PMID: 11597395) Chang G.T. … Brinkmann A.O. (Eur. J. Cancer 2001) 2 3 4 64
  2. Genome-wide linkage scans for type 2 diabetes mellitus in four ethnically diverse populations-significant evidence for linkage on chromosome 4q in African Americans: the Family Investigation of Nephropathy and Diabetes Research Group. (PMID: 19795399) Malhotra A. … Hanson R.L. (Diabetes Metab. Res. Rev. 2009) 3 46 64
  3. TRIM68 regulates ligand-dependent transcription of androgen receptor in prostate cancer cells. (PMID: 18451177) Miyajima N. … Hatakeyama S. (Cancer Res. 2008) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for TRIM68 Gene

Sources for TRIM68 Gene

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