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Aliases for SLC6A15 Gene

Aliases for SLC6A15 Gene

  • Solute Carrier Family 6 Member 15 2 3 4
  • Solute Carrier Family 6 (Neutral Amino Acid Transporter), Member 15 2 3 5
  • Sodium/Chloride Dependent Neurotransmitter Transporter Homo Sapiens Orphan Neurotransmitter Transporter NTT7 2 3
  • Solute Carrier Family 6 (Neurotransmitter Transporter), Member 15 2 3
  • Sodium- And Chloride-Dependent Neurotransmitter Transporter NTT73 3 4
  • Sodium-Coupled Branched-Chain Amino-Acid Transporter 1 3 4
  • Homolog Of Rat Orphan Transporter V7-3 2 3
  • Transporter V7-3 3 4
  • NTT73 3 4
  • SBAT1 3 4
  • Orphan Sodium- And Chloride-Dependent Neurotransmitter Transporter NTT73 3
  • Solute Carrier Family 6, Member 15 3
  • Orphan Transporter V7-3 3
  • Hv7-3 3
  • B0AT2 4
  • V7-3 3

External Ids for SLC6A15 Gene

Previous GeneCards Identifiers for SLC6A15 Gene

  • GC00U990834
  • GC12M083757
  • GC12M083756
  • GC12M085253
  • GC12M082310

Summaries for SLC6A15 Gene

Entrez Gene Summary for SLC6A15 Gene

  • This gene encodes a member of the solute carrier family 6 protein family which transports neutral amino acids. The encoded protein is thought to play a role in neuronal amino acid transport (PMID: 16185194) and may be associated with major depression (PMID: 21521612). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

GeneCards Summary for SLC6A15 Gene

SLC6A15 (Solute Carrier Family 6 Member 15) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include neurotransmitter:sodium symporter activity and proline:sodium symporter activity. An important paralog of this gene is SLC6A18.

UniProtKB/Swiss-Prot for SLC6A15 Gene

  • Functions as a sodium-dependent neutral amino acid transporter. Exhibits preference for the branched-chain amino acids, particularly leucine, valine and isoleucine and methionine. Mediates the saturable, pH-sensitive and electrogenic cotransport of proline and sodium ions with a stoichiometry of 1:1. May have a role as transporter for neurotransmitter precursors into neurons. In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent.

Gene Wiki entry for SLC6A15 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC6A15 Gene

Genomics for SLC6A15 Gene

Regulatory Elements for SLC6A15 Gene

Enhancers for SLC6A15 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLC6A15 on UCSC Golden Path with GeneCards custom track

Promoters for SLC6A15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC6A15 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC6A15 Gene

Chromosome:
12
Start:
84,859,488 bp from pter
End:
84,913,615 bp from pter
Size:
54,128 bases
Orientation:
Minus strand

Genomic View for SLC6A15 Gene

Genes around SLC6A15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC6A15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC6A15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC6A15 Gene

Proteins for SLC6A15 Gene

  • Protein details for SLC6A15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2J7-S6A15_HUMAN
    Recommended name:
    Sodium-dependent neutral amino acid transporter B(0)AT2
    Protein Accession:
    Q9H2J7
    Secondary Accessions:
    • A8K592
    • B7Z2P7
    • E7ESJ5
    • Q9H9F5

    Protein attributes for SLC6A15 Gene

    Size:
    730 amino acids
    Molecular mass:
    81836 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC6A15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC6A15 Gene

Proteomics data for SLC6A15 Gene at MOPED

Post-translational modifications for SLC6A15 Gene

  • Ubiquitination at Lys 658
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for SLC6A15

No data available for DME Specific Peptides for SLC6A15 Gene

Domains & Families for SLC6A15 Gene

Gene Families for SLC6A15 Gene

Protein Domains for SLC6A15 Gene

Suggested Antigen Peptide Sequences for SLC6A15 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H2J7

UniProtKB/Swiss-Prot:

S6A15_HUMAN :
  • Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A15 subfamily.
Family:
  • Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A15 subfamily.
genes like me logo Genes that share domains with SLC6A15: view

Function for SLC6A15 Gene

Molecular function for SLC6A15 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.16 mM for L-leucine (at pH 7.5, 100 mM NaCL, -70 mV) {ECO:0000269 PubMed:16226721}; KM=0.16 mM for L-valine (at pH 7.5, 100 mM NaCL, -70 mV)) {ECO:0000269 PubMed:16226721}; KM=0.08 mM for L-isoleucine (at pH 7.5, 100 mM NaCL, -70 mV) {ECO:0000269 PubMed:16226721}; KM=0.11 mM for L-methionine (at pH 7.5, 100 mM NaCL, -70 mV) {ECO:0000269 PubMed:16226721}; KM=0.38 mM for L-proline (at pH 7.5, 100 mM NaCL, -70 mV) {ECO:0000269 PubMed:16226721}; pH dependence: Optimum pH is 7.5-8.5. Strongly inhibited at acidic PH. {ECO:0000269 PubMed:16226721};
UniProtKB/Swiss-Prot Function:
Functions as a sodium-dependent neutral amino acid transporter. Exhibits preference for the branched-chain amino acids, particularly leucine, valine and isoleucine and methionine. Mediates the saturable, pH-sensitive and electrogenic cotransport of proline and sodium ions with a stoichiometry of 1:1. May have a role as transporter for neurotransmitter precursors into neurons. In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent.

Gene Ontology (GO) - Molecular Function for SLC6A15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005298 proline:sodium symporter activity IBA --
GO:0005326 neurotransmitter transporter activity NAS 11112352
GO:0015171 amino acid transmembrane transporter activity TAS --
genes like me logo Genes that share ontologies with SLC6A15: view
genes like me logo Genes that share phenotypes with SLC6A15: view

Animal Models for SLC6A15 Gene

MGI Knock Outs for SLC6A15:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC6A15

CRISPR Products

miRNA for SLC6A15 Gene

miRTarBase miRNAs that target SLC6A15

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC6A15 Gene

Localization for SLC6A15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC6A15 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC6A15 Gene COMPARTMENTS Subcellular localization image for SLC6A15 gene
Compartment Confidence
plasma membrane 5
nucleus 2
cytosol 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for SLC6A15 Gene

Pathways & Interactions for SLC6A15 Gene

genes like me logo Genes that share pathways with SLC6A15: view

Interacting Proteins for SLC6A15 Gene

Gene Ontology (GO) - Biological Process for SLC6A15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport TAS --
GO:0015820 leucine transport ISS --
GO:0015824 proline transport ISS --
GO:0035524 proline transmembrane transport IEA --
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with SLC6A15: view

No data available for SIGNOR curated interactions for SLC6A15 Gene

Drugs & Compounds for SLC6A15 Gene

(1) Additional Compounds for SLC6A15 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Sodium
  • Sodium ion
7440-23-5
genes like me logo Genes that share compounds with SLC6A15: view

Transcripts for SLC6A15 Gene

Unigene Clusters for SLC6A15 Gene

Solute carrier family 6 (neutral amino acid transporter), member 15:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC6A15 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16
SP1: -
SP2: - - - -
SP3:
SP4: - - -
SP5: - - - - - - - - -
SP6: - - - - - - - - - -
SP7: - -
SP8: -
SP9:

Relevant External Links for SLC6A15 Gene

GeneLoc Exon Structure for
SLC6A15
ECgene alternative splicing isoforms for
SLC6A15

Expression for SLC6A15 Gene

mRNA expression in normal human tissues for SLC6A15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC6A15 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x5.4), Brain - Hypothalamus (x5.3), Brain - Cerebellar Hemisphere (x4.6), and Brain - Frontal Cortex (BA9) (x4.6).

Protein differential expression in normal tissues from HIPED for SLC6A15 Gene

This gene is overexpressed in Plasma (68.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC6A15 Gene



SOURCE GeneReport for Unigene cluster for SLC6A15 Gene Hs.44424

mRNA Expression by UniProt/SwissProt for SLC6A15 Gene

Q9H2J7-S6A15_HUMAN
Tissue specificity: Almost exclusively expressed in the brain.
genes like me logo Genes that share expression patterns with SLC6A15: view

Protein tissue co-expression partners for SLC6A15 Gene

- Elite partner

Primer Products

Orthologs for SLC6A15 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC6A15 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC6A15 35
  • 91.13 (n)
  • 92.46 (a)
SLC6A15 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC6A15 35
  • 90.31 (n)
  • 90.12 (a)
SLC6A15 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc6a15 35
  • 86.83 (n)
  • 91.63 (a)
Slc6a15 16
Slc6a15 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc6a15 35
  • 86.97 (n)
  • 90.95 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC6A15 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 56 (a)
OneToMany
-- 36
  • 88 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia SLC6A15 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC6A15 35
  • 82.49 (n)
  • 89.16 (a)
SLC6A15 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC6A15 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc6a15 35
  • 76.28 (n)
  • 83.24 (a)
zebrafish
(Danio rerio)
Actinopterygii slc6a15 35
  • 69.1 (n)
  • 76.89 (a)
slc6a15 36
  • 75 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG10804 36
  • 38 (a)
ManyToMany
CG43066 36
  • 40 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
ManyToMany
CSA.3644 36
  • 45 (a)
ManyToMany
Species with no ortholog for SLC6A15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC6A15 Gene

ENSEMBL:
Gene Tree for SLC6A15 (if available)
TreeFam:
Gene Tree for SLC6A15 (if available)

Paralogs for SLC6A15 Gene

Paralogs for SLC6A15 Gene

Pseudogenes.org Pseudogenes for SLC6A15 Gene

genes like me logo Genes that share paralogs with SLC6A15: view

Variants for SLC6A15 Gene

Sequence variations from dbSNP and Humsavar for SLC6A15 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs12424429 - 84,872,705(+) CTTCT(A/G/T)CAGTA reference, missense
rs3782369 - 84,863,448(+) TCTTC(A/C)ATCCA reference, missense
rs7298505 -- 84,881,357(+) accca(A/C)tattt intron-variant, utr-variant-3-prime
rs7304260 -- 84,884,208(+) GCAAC(A/C)AACAG intron-variant
rs10862944 -- 84,869,326(+) GCGTG(G/T)TGGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC6A15 Gene

Variant ID Type Subtype PubMed ID
nsv899376 CNV Loss 21882294
nsv899377 CNV Loss 21882294
nsv899378 CNV Loss 21882294
nsv470309 CNV Loss 18288195
nsv899379 CNV Gain 21882294
dgv1471n71 CNV Loss 21882294
nsv899383 CNV Gain+Loss 21882294
dgv208n27 CNV Loss 19166990
esv2678261 CNV Deletion 23128226

Variation tolerance for SLC6A15 Gene

Residual Variation Intolerance Score: 24.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.75; 33.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC6A15 Gene

Human Gene Mutation Database (HGMD)
SLC6A15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC6A15 Gene

Disorders for SLC6A15 Gene

Relevant External Links for SLC6A15

Human Genome Epidemiology (HuGE) Navigator
SLC6A15
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC6A15

No disorders were found for SLC6A15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC6A15 Gene

Publications for SLC6A15 Gene

  1. Cloning and characterization of human NTT5 and v7-3: two orphan transporters of the Na(+)/Cl(-)-dependent neurotransmitter transporter gene family. (PMID: 11112352) Farmer M.K. … Pangalos M.N. (Genomics 2000) 2 3 4 67
  2. The orphan transporter v7-3 (slc6a15) is a Na+-dependent neutral amino acid transporter (B0AT2). (PMID: 16185194) BrAPer A. … BrAPer S. (Biochem. J. 2006) 2 3
  3. Characterization of a branched-chain amino-acid transporter SBAT1 (SLC6A15) that is expressed in human brain. (PMID: 16226721) Takanaga H. … Hediger M.A. (Biochem. Biophys. Res. Commun. 2005) 3 23
  4. Neurotransmitter transporters in the central nervous system. (PMID: 10471414) Masson J. … El Mestikawy S. (Pharmacol. Rev. 1999) 2 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for SLC6A15 Gene

Sources for SLC6A15 Gene

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