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Aliases for PLEKHJ1 Gene

Aliases for PLEKHJ1 Gene

  • Pleckstrin Homology Domain Containing, Family J Member 1 2 3
  • Guanine Nucleotide Releasing Protein X 2 3
  • PH Domain-Containing Family J Member 1 3 4
  • GNRPX 3 4
  • Pleckstrin Homology Domain-Containing Family J Member 1 3
  • Guanine Nucleotide-Releasing Protein X 4

External Ids for PLEKHJ1 Gene

Summaries for PLEKHJ1 Gene

GeneCards Summary for PLEKHJ1 Gene

PLEKHJ1 (Pleckstrin Homology Domain Containing, Family J Member 1) is a Protein Coding gene. GO annotations related to this gene include phospholipid binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLEKHJ1 Gene

Genomics for PLEKHJ1 Gene

Genomic Location for PLEKHJ1 Gene

2,230,019 bp from pter
2,237,704 bp from pter
7,686 bases
Minus strand

Genomic View for PLEKHJ1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PLEKHJ1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLEKHJ1 Gene

Regulatory Elements for PLEKHJ1 Gene

Proteins for PLEKHJ1 Gene

  • Protein details for PLEKHJ1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Pleckstrin homology domain-containing family J member 1
    Protein Accession:
    Secondary Accessions:
    • B3KUQ9
    • D6W604

    Protein attributes for PLEKHJ1 Gene

    149 amino acids
    Molecular mass:
    17551 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PLEKHJ1 Gene

Proteomics data for PLEKHJ1 Gene at MOPED

Post-translational modifications for PLEKHJ1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys6

Other Protein References for PLEKHJ1 Gene

No data available for DME Specific Peptides for PLEKHJ1 Gene

Domains for PLEKHJ1 Gene

Gene Families for PLEKHJ1 Gene

  • PLEKH :Pleckstrin homology (PH) domain containing

Protein Domains for PLEKHJ1 Gene



  • Contains 1 PH domain.:
    • Q9NW61
genes like me logo Genes that share domains with PLEKHJ1: view

Function for PLEKHJ1 Gene

Phenotypes for PLEKHJ1 Gene

GenomeRNAi human phenotypes for PLEKHJ1:
genes like me logo Genes that share phenotypes with PLEKHJ1: view

miRNA for PLEKHJ1 Gene

miRTarBase miRNAs that target PLEKHJ1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for PLEKHJ1 Gene

Localization for PLEKHJ1 Gene

Subcellular locations from

Jensen Localization Image for PLEKHJ1 Gene COMPARTMENTS Subcellular localization image for PLEKHJ1 gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for PLEKHJ1 Gene

Pathways for PLEKHJ1 Gene

SuperPathways for PLEKHJ1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PLEKHJ1 Gene


No data available for Pathways by source for PLEKHJ1 Gene

Transcripts for PLEKHJ1 Gene

Unigene Clusters for PLEKHJ1 Gene

Pleckstrin homology domain containing, family J member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLEKHJ1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8
SP1: - - - - - -
SP2: - - -
SP3: - - - - -
SP4: - - -
SP5: - - - -
SP6: - - - -

Relevant External Links for PLEKHJ1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PLEKHJ1 Gene

mRNA expression in normal human tissues for PLEKHJ1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PLEKHJ1 Gene

SOURCE GeneReport for Unigene cluster for PLEKHJ1 Gene Hs.501353

mRNA Expression by UniProt/SwissProt for PLEKHJ1 Gene

Tissue specificity: Expressed in testis and liver.
genes like me logo Genes that share expressions with PLEKHJ1: view

Orthologs for PLEKHJ1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLEKHJ1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PLEKHJ1 36
  • 99.11 (n)
  • 99.33 (a)
  • 99 (a)
(Bos Taurus)
Mammalia PLEKHJ1 36
  • 88.14 (n)
  • 88.59 (a)
  • 89 (a)
(Canis familiaris)
Mammalia PLEKHJ1 37
  • 75 (a)
(Mus musculus)
Mammalia Plekhj1 36
  • 86.17 (n)
  • 87.76 (a)
Plekhj1 16
Plekhj1 37
  • 79 (a)
(Monodelphis domestica)
Mammalia PLEKHJ1 37
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia PLEKHJ1 37
  • 66 (a)
(Rattus norvegicus)
Mammalia Plekhj1 36
  • 86.39 (n)
  • 89.8 (a)
(Gallus gallus)
Aves PLEKHJ1 36
  • 79 (n)
  • 82.88 (a)
  • 81 (a)
(Anolis carolinensis)
Reptilia PLEKHJ1 37
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia plekhj1 36
  • 71.53 (n)
  • 77.78 (a)
(Danio rerio)
Actinopterygii LOC100537951 36
  • 68.49 (n)
  • 69.18 (a)
plekhj1 37
  • 64 (a)
Species with no ortholog for PLEKHJ1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLEKHJ1 Gene

Gene Tree for PLEKHJ1 (if available)
Gene Tree for PLEKHJ1 (if available)

Paralogs for PLEKHJ1 Gene

Selected SIMAP similar genes for PLEKHJ1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with PLEKHJ1: view

No data available for Paralogs for PLEKHJ1 Gene

Variants for PLEKHJ1 Gene

Sequence variations from dbSNP and Humsavar for PLEKHJ1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs3833283 -- 2,233,194(-) GGGCC(-/A)GGGTG intron-variant, utr-variant-3-prime
rs35228862 -- 2,233,351(+) CCAGC(-/C)TGGGG intron-variant, utr-variant-3-prime
rs59123239 -- 2,233,334(+) GCAGG(-/GGGGCCATGCCACCAGCCTGGGGGCTCACCAGG)CCCCT intron-variant, cds-indel
rs62119664 -- 2,233,355(+) CCTGG(A/G)GGCTC intron-variant, utr-variant-3-prime
rs72101460 -- 2,233,330(+) CGGGG(-/CAGGGGGGCCATGCCACCAGCCTGGGGGCTCAC)CAGGC intron-variant, cds-indel

Structural Variations from Database of Genomic Variants (DGV) for PLEKHJ1 Gene

Variant ID Type Subtype PubMed ID
nsv910499 CNV Loss 21882294
dgv3614n71 CNV Loss 21882294
dgv3622n71 CNV Loss 21882294
dgv3626n71 CNV Loss 21882294
nsv910623 CNV Loss 21882294
dgv3629n71 CNV Loss 21882294
dgv3630n71 CNV Loss 21882294
nsv833706 CNV Loss 17160897
dgv3631n71 CNV Loss 21882294
nsv833707 CNV Loss 17160897
nsv2389 CNV Insertion 18451855
nsv910636 CNV Loss 21882294
dgv3632n71 CNV Loss 21882294
dgv3633n71 CNV Loss 21882294

Relevant External Links for PLEKHJ1 Gene

HapMap Linkage Disequilibrium report

Disorders for PLEKHJ1 Gene

No disorders were found for PLEKHJ1 Gene.

No data available for UniProtKB/Swiss-Prot for PLEKHJ1 Gene

Publications for PLEKHJ1 Gene

  1. An expressed GNRP-like gene shares a bi-directional promoter with SF3A2 (SAP62) immediately upstream of AMH. (PMID: 11602354) Dresser D.W. … Guerrier D. (Gene 2001) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. High-throughput mapping of a dynamic signaling network in mammalian cells. (PMID: 15761153) Barrios-Rodiles M. … Wrana J.L. (Science 2005) 3
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  5. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PMID: 17353931) Ewing R.M. … Figeys D. (Mol. Syst. Biol. 2007) 3

Products for PLEKHJ1 Gene

Sources for PLEKHJ1 Gene

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