Aliases for WDYHV1 Gene
External Ids for WDYHV1 Gene
Previous HGNC Symbols for WDYHV1 Gene
Previous GeneCards Identifiers for WDYHV1 Gene
GeneCards Summary for WDYHV1 Gene
WDYHV1 (WDYHV Motif Containing 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides and protein-N-terminal glutamine amidohydrolase activity.
UniProtKB/Swiss-Prot for WDYHV1 Gene
Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine.