Aliases for PPP1R3C Gene
External Ids for PPP1R3C Gene
Previous HGNC Symbols for PPP1R3C Gene
Previous GeneCards Identifiers for PPP1R3C Gene
This gene encodes a regulatory subunit of protein phosphatase-1 (PP1). PP1 catalyzes reversible protein phosphorylation, which is important in a wide range of cellular activities: neuronal, muscular, RNA splicing, protein synthesis, cell death, and glycogen metabolism, to name just a few. By interacting with different regulatory subunits, PP1 is directed to different parts of the cell, to different substrates, or to respond to extracellular signals. [provided by RefSeq, Oct 2011]
GeneCards Summary for PPP1R3C Gene
PPP1R3C (Protein Phosphatase 1, Regulatory Subunit 3C) is a Protein Coding gene. Among its related pathways are ERK Signaling and GPCR Pathway. GO annotations related to this gene include protein phosphatase binding and protein serine/threonine phosphatase activity. An important paralog of this gene is PPP1R3E.
UniProtKB/Swiss-Prot for PPP1R3C Gene
Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in a variety of cell types.