Aliases for PPP1R3C Gene
External Ids for PPP1R3C Gene
Previous HGNC Symbols for PPP1R3C Gene
Previous GeneCards Identifiers for PPP1R3C Gene
This gene encodes a regulatory subunit of protein phosphatase-1 (PP1). PP1 catalyzes reversible protein phosphorylation, which is important in a wide range of cellular activities: neuronal, muscular, RNA splicing, protein synthesis, cell death, and glycogen metabolism, to name just a few. By interacting with different regulatory subunits, PP1 is directed to different parts of the cell, to different substrates, or to respond to extracellular signals. [provided by RefSeq, Oct 2011]
GeneCards Summary for PPP1R3C Gene
PPP1R3C (Protein Phosphatase 1 Regulatory Subunit 3C) is a Protein Coding gene. Diseases associated with PPP1R3C include Barre-Lieou Syndrome and Water-Clear Cell Adenoma. Among its related pathways are Glycosaminoglycan metabolism and Diseases of metabolism. GO annotations related to this gene include protein phosphatase binding and protein phosphatase regulator activity. An important paralog of this gene is PPP1R3E.
UniProtKB/Swiss-Prot for PPP1R3C Gene
Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in a variety of cell types.