Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PPP1R3C Gene

Aliases for PPP1R3C Gene

  • Protein Phosphatase 1, Regulatory Subunit 3C 2 3
  • Protein Targeting To Glycogen 2 3 4
  • PPP1R5 3 4 6
  • Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 3C 2 3
  • Protein Phosphatase 1 Regulatory Subunit 5 3 4
  • PP1 Subunit R5 3 4
  • PTG 3 4
  • Phosphatase 1, Regulatory Inhibitor Subunit 5 3
  • Protein Phosphatase 1 Regulatory Subunit 3C 3
  • Regulatory Inhibitor Subunit 5 2
  • Phosphatase 1 2

External Ids for PPP1R3C Gene

Previous HGNC Symbols for PPP1R3C Gene

  • PPP1R5

Previous GeneCards Identifiers for PPP1R3C Gene

  • GC10M092269
  • GC10M092609
  • GC10M093519
  • GC10M093052
  • GC10M093036
  • GC10M093378
  • GC10M087016

Summaries for PPP1R3C Gene

Entrez Gene Summary for PPP1R3C Gene

  • This gene encodes a regulatory subunit of protein phosphatase-1 (PP1). PP1 catalyzes reversible protein phosphorylation, which is important in a wide range of cellular activities: neuronal, muscular, RNA splicing, protein synthesis, cell death, and glycogen metabolism, to name just a few. By interacting with different regulatory subunits, PP1 is directed to different parts of the cell, to different substrates, or to respond to extracellular signals. [provided by RefSeq, Oct 2011]

GeneCards Summary for PPP1R3C Gene

PPP1R3C (Protein Phosphatase 1, Regulatory Subunit 3C) is a Protein Coding gene. Among its related pathways are ERK Signaling and GPCR Pathway. GO annotations related to this gene include protein phosphatase binding and protein serine/threonine phosphatase activity. An important paralog of this gene is PPP1R3E.

UniProtKB/Swiss-Prot for PPP1R3C Gene

  • Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in a variety of cell types.

Gene Wiki entry for PPP1R3C Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP1R3C Gene

Genomics for PPP1R3C Gene

Regulatory Elements for PPP1R3C Gene

Genomic Location for PPP1R3C Gene

Start:
91,628,440 bp from pter
End:
91,633,101 bp from pter
Size:
4,662 bases
Orientation:
Minus strand

Genomic View for PPP1R3C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPP1R3C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1R3C Gene

Proteins for PPP1R3C Gene

  • Protein details for PPP1R3C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UQK1-PPR3C_HUMAN
    Recommended name:
    Protein phosphatase 1 regulatory subunit 3C
    Protein Accession:
    Q9UQK1
    Secondary Accessions:
    • B2R7X0
    • O95686

    Protein attributes for PPP1R3C Gene

    Size:
    317 amino acids
    Molecular mass:
    36445 Da
    Quaternary structure:
    • Interacts with PPP1CC catalytic subunit of PP1 and associates with glycogen. Forms complexes with glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity. Also interacts with EPM2A/laforin.
    SequenceCaution:
    • Sequence=AAD33215.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for PPP1R3C Gene

Proteomics data for PPP1R3C Gene at MOPED

Post-translational modifications for PPP1R3C Gene

  • Ubiquitinated by NHLRC1/malin in a EPM2A/laforin-dependent manner.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPP1R3C Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for PPP1R3C Gene

Domains for PPP1R3C Gene

Gene Families for PPP1R3C Gene

HGNC:
  • PPP1R :Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits

Protein Domains for PPP1R3C Gene

Graphical View of Domain Structure for InterPro Entry

Q9UQK1

UniProtKB/Swiss-Prot:

PPR3C_HUMAN :
  • Q9UQK1
Domain:
  • The N-terminal region is required for binding to PP1, the central region is required for binding to glycogen and the C-terminal region is required for binding to glycogen phosphorylase, glycogen synthase and phosphorylase kinase.
  • Contains 1 CBM21 (carbohydrate binding type-21) domain.
genes like me logo Genes that share domains with PPP1R3C: view

Function for PPP1R3C Gene

Molecular function for PPP1R3C Gene

UniProtKB/Swiss-Prot Function: Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in a variety of cell types.

Gene Ontology (GO) - Molecular Function for PPP1R3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004722 protein serine/threonine phosphatase activity TAS 8985175
GO:0005515 protein binding IPI 14532330
GO:0019888 protein phosphatase regulator activity IEA --
GO:0019903 protein phosphatase binding IEA --
genes like me logo Genes that share ontologies with PPP1R3C: view

Phenotypes for PPP1R3C Gene

genes like me logo Genes that share phenotypes with PPP1R3C: view

Animal Models for PPP1R3C Gene

MGI Knock Outs for PPP1R3C:

miRNA for PPP1R3C Gene

miRTarBase miRNAs that target PPP1R3C

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for PPP1R3C Gene

Localization for PPP1R3C Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPP1R3C Gene COMPARTMENTS Subcellular localization image for PPP1R3C gene
Compartment Confidence
extracellular 2
cytosol 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for PPP1R3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PPP1R3C: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PPP1R3C Gene

Pathways for PPP1R3C Gene

genes like me logo Genes that share pathways with PPP1R3C: view

Pathways by source for PPP1R3C Gene

Gene Ontology (GO) - Biological Process for PPP1R3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0005977 glycogen metabolic process --
GO:0005978 glycogen biosynthetic process TAS --
GO:0006006 glucose metabolic process TAS --
GO:0016311 dephosphorylation TAS 8985175
genes like me logo Genes that share ontologies with PPP1R3C: view

Compounds for PPP1R3C Gene

(1) HMDB Compounds for PPP1R3C Gene

Compound Synonyms Cas Number PubMed IDs
Glycogen
  • Animal starch
9005-79-2
genes like me logo Genes that share compounds with PPP1R3C: view

Transcripts for PPP1R3C Gene

mRNA/cDNA for PPP1R3C Gene

(173) Selected AceView cDNA sequences:
(6) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PPP1R3C Gene

Protein phosphatase 1, regulatory subunit 3C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R3C Gene

No ASD Table

Relevant External Links for PPP1R3C Gene

GeneLoc Exon Structure for
PPP1R3C
ECgene alternative splicing isoforms for
PPP1R3C

Expression for PPP1R3C Gene

mRNA expression in normal human tissues for PPP1R3C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PPP1R3C Gene

This gene is overexpressed in Muscle - Skeletal (6.0), Artery - Tibial (4.7), and Heart - Atrial Appendage (4.2).

SOURCE GeneReport for Unigene cluster for PPP1R3C Gene Hs.303090

genes like me logo Genes that share expressions with PPP1R3C: view

No data available for Protein expression and mRNA Expression by UniProt/SwissProt for PPP1R3C Gene

Orthologs for PPP1R3C Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PPP1R3C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPP1R3C 35
  • 99.16 (n)
  • 99.68 (a)
PPP1R3C 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PPP1R3C 35
  • 85.59 (n)
  • 88.96 (a)
PPP1R3C 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPP1R3C 35
  • 89.7 (n)
  • 90.54 (a)
PPP1R3C 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppp1r3c 35
  • 86.12 (n)
  • 86.12 (a)
Ppp1r3c 16
Ppp1r3c 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPP1R3C 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPP1R3C 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100910671 35
  • 84.54 (n)
  • 85.8 (a)
chicken
(Gallus gallus)
Aves PPP1R3C 35
  • 69.46 (n)
  • 65.16 (a)
PPP1R3C 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPP1R3C 36
  • 66 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.14255 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp1r3c.1 35
  • 65.76 (n)
  • 63.82 (a)
Str.11402 35
zebrafish
(Danio rerio)
Actinopterygii ppp1r3ca 36
  • 44 (a)
OneToMany
ppp1r3cb 35
  • 60.68 (n)
  • 56.09 (a)
ppp1r3cb 36
  • 54 (a)
OneToMany
zgc73259 35
fruit fly
(Drosophila melanogaster)
Insecta CG9238 36
  • 25 (a)
OneToMany
CG9238 37
  • 42 (a)
worm
(Caenorhabditis elegans)
Secernentea H18N23.2 36
  • 19 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GIP2 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
OneToMany
Species with no ortholog for PPP1R3C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP1R3C Gene

ENSEMBL:
Gene Tree for PPP1R3C (if available)
TreeFam:
Gene Tree for PPP1R3C (if available)

Paralogs for PPP1R3C Gene

Paralogs for PPP1R3C Gene

Selected SIMAP similar genes for PPP1R3C Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PPP1R3C: view

Variants for PPP1R3C Gene

Sequence variations from dbSNP and Humsavar for PPP1R3C Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1044563 -- 91,630,392(-) TGCTC(A/G)TTGCA synonymous-codon, reference
rs2242121 -- 91,633,223(-) CGTCT(C/G)GCCCC upstream-variant-2KB
rs3781228 -- 91,630,923(+) CCAGT(A/G)CCAAA intron-variant
rs4382814 -- 91,628,094(+) CTCCA(A/G)CCTTT downstream-variant-500B
rs7071663 -- 91,634,994(+) ACCGC(C/T)GCACC upstream-variant-2KB

Relevant External Links for PPP1R3C Gene

HapMap Linkage Disequilibrium report
PPP1R3C
Human Gene Mutation Database (HGMD)
PPP1R3C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PPP1R3C Gene

Disorders for PPP1R3C Gene

(1) University of Copenhagen DISEASES for PPP1R3C Gene

Relevant External Links for PPP1R3C

Genetic Association Database (GAD)
PPP1R3C
Human Genome Epidemiology (HuGE) Navigator
PPP1R3C
genes like me logo Genes that share disorders with PPP1R3C: view

No data available for UniProtKB/Swiss-Prot for PPP1R3C Gene

Publications for PPP1R3C Gene

  1. Amino acid sequence of a novel protein phosphatase 1 binding protein (R5) which is related to the liver- and muscle-specific glycogen binding subunits of protein phosphatase 1. (PMID: 8985175) Doherty M.J. … Cohen P.T.W. (FEBS Lett. 1996) 2 3 4
  2. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 48
  3. Malin decreases glycogen accumulation by promoting the degradation of protein targeting to glycogen (PTG). (PMID: 18070875) Worby C.A. … Dixon J.E. (J. Biol. Chem. 2008) 3 4
  4. Protein targeting to glycogen/PPP1R5: screening of coding and flanking genomic regions for polymorphisms and association analysis with insulin action in Pima Indians. (PMID: 10222257) Permana P.A. … Bogardus C. (Biochem. Biophys. Res. Commun. 1999) 3 4
  5. Laforin, the dual-phosphatase responsible for Lafora disease, interacts with R5 (PTG), a regulatory subunit of protein phosphatase-1 that enhances glycogen accumulation. (PMID: 14532330) Fernandez-Sanchez M.E. … Rodriguez de Cordoba S. (Hum. Mol. Genet. 2003) 3 4

Products for PPP1R3C Gene

Sources for PPP1R3C Gene

Back to Top

Content