Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PPP1R3A Gene

Aliases for PPP1R3A Gene

  • Protein Phosphatase 1, Regulatory Subunit 3A 2 3
  • Glycogen-Associated Regulatory Subunit Of Protein Phosphatase-1 2 3
  • Protein Phosphatase 1 Glycogen-Associated Regulatory Subunit 3 4
  • Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 3A 2 3
  • Protein Phosphatase Type-1 Glycogen Targeting Subunit 3 4
  • Protein Phosphatase 1 Regulatory Subunit GM 2 3
  • PPP1R3 3 6
  • PP1G 3 4
  • RG1 3 4
  • Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 3A (Glycogen And Sarcoplasmic Reticulum Binding Subunit, Skeletal Muscle) 2
  • Type-1 Protein Phosphatase Skeletal Muscle Glycogen Targeting Subunit 3
  • Glycogen And Sarcoplasmic Reticulum Binding Subunit, Skeletal Muscle 3
  • Protein Phosphatase 1 Glycogen- Associated Regulatory Subunit 3
  • Serine /Threonine Specific Protein Phosphatase 3
  • Protein Phosphatase 1 Regulatory Subunit 3A 3
  • GM 3

External Ids for PPP1R3A Gene

Previous HGNC Symbols for PPP1R3A Gene

  • PPP1R3

Previous GeneCards Identifiers for PPP1R3A Gene

  • GC07M111992
  • GC07M113055
  • GC07M113068
  • GC07M113108
  • GC07M113301
  • GC07M113516
  • GC07M107880

Summaries for PPP1R3A Gene

Entrez Gene Summary for PPP1R3A Gene

  • The glycogen-associated form of protein phosphatase-1 (PP1) derived from skeletal muscle is a heterodimer composed of a 37-kD catalytic subunit and a 124-kD targeting and regulatory subunit. This gene encodes the regulatory subunit which binds to muscle glycogen with high affinity, thereby enhancing dephosphorylation of glycogen-bound substrates for PP1 such as glycogen synthase and glycogen phosphorylase kinase. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPP1R3A Gene

PPP1R3A (Protein Phosphatase 1, Regulatory Subunit 3A) is a Protein Coding gene. Diseases associated with PPP1R3A include lipodystrophy, familial partial, type 3 and rippling muscle disease. Among its related pathways are ERK Signaling and GPCR Pathway. An important paralog of this gene is PPP1R3E.

UniProtKB/Swiss-Prot for PPP1R3A Gene

  • Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Plays an important role in glycogen synthesis but is not essential for insulin activation of glycogen synthase (By similarity).

Gene Wiki entry for PPP1R3A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP1R3A Gene

Genomics for PPP1R3A Gene

Regulatory Elements for PPP1R3A Gene

Genomic Location for PPP1R3A Gene

Start:
113,876,777 bp from pter
End:
114,075,920 bp from pter
Size:
199,144 bases
Orientation:
Minus strand

Genomic View for PPP1R3A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPP1R3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1R3A Gene

Proteins for PPP1R3A Gene

  • Protein details for PPP1R3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16821-PPR3A_HUMAN
    Recommended name:
    Protein phosphatase 1 regulatory subunit 3A
    Protein Accession:
    Q16821
    Secondary Accessions:
    • A0AVQ2
    • A4D0T6
    • O43476
    • Q75LN8
    • Q7KYM8
    • Q86UI6

    Protein attributes for PPP1R3A Gene

    Size:
    1122 amino acids
    Molecular mass:
    125767 Da
    Quaternary structure:
    • Interacts with PPP1CC catalytic subunit of PP1, and associates with glycogen.
    SequenceCaution:
    • Sequence=AAS07492.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for PPP1R3A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPP1R3A Gene

Proteomics data for PPP1R3A Gene at MOPED

Post-translational modifications for PPP1R3A Gene

  • Phosphorylation at Ser-46 by ISPK stimulates the dephosphorylation of glycogen synthase and phosphorylase kinase.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPP1R3A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PPP1R3A Gene

Domains for PPP1R3A Gene

Gene Families for PPP1R3A Gene

HGNC:
  • PPP1R :Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits

Protein Domains for PPP1R3A Gene

Suggested Antigen Peptide Sequences for PPP1R3A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16821

UniProtKB/Swiss-Prot:

PPR3A_HUMAN :
  • Q16821
Domain:
  • The CBM21 domain is known to be involved in the localization to glycogen and is characteristic of some regulatory subunit of phosphatase complexes
  • Contains 1 CBM21 (carbohydrate binding type-21) domain.
genes like me logo Genes that share domains with PPP1R3A: view

Function for PPP1R3A Gene

Molecular function for PPP1R3A Gene

UniProtKB/Swiss-Prot Function: Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Plays an important role in glycogen synthesis but is not essential for insulin activation of glycogen synthase (By similarity).

Gene Ontology (GO) - Molecular Function for PPP1R3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with PPP1R3A: view

Phenotypes for PPP1R3A Gene

genes like me logo Genes that share phenotypes with PPP1R3A: view

Animal Models for PPP1R3A Gene

MGI Knock Outs for PPP1R3A:

miRNA for PPP1R3A Gene

miRTarBase miRNAs that target PPP1R3A

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for PPP1R3A Gene

Localization for PPP1R3A Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP1R3A Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPP1R3A Gene COMPARTMENTS Subcellular localization image for PPP1R3A gene
Compartment Confidence
cytosol 2
nucleus 2
endoplasmic reticulum 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PPP1R3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PPP1R3A: view

Pathways for PPP1R3A Gene

genes like me logo Genes that share pathways with PPP1R3A: view

Pathways by source for PPP1R3A Gene

1 GeneGo (Thomson Reuters) pathway for PPP1R3A Gene
1 Tocris pathway for PPP1R3A Gene

Gene Ontology (GO) - Biological Process for PPP1R3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005977 glycogen metabolic process IEA --
genes like me logo Genes that share ontologies with PPP1R3A: view

Compounds for PPP1R3A Gene

(6) Novoseek inferred chemical compound relationships for PPP1R3A Gene

Compound -log(P) Hits PubMed IDs
glycogen 73.6 23
glucose 45.3 4
2-deoxyglucose 35.2 1
glucose 6-phosphate 27.7 1
epinephrine 7.34 1
genes like me logo Genes that share compounds with PPP1R3A: view

Transcripts for PPP1R3A Gene

mRNA/cDNA for PPP1R3A Gene

Unigene Clusters for PPP1R3A Gene

Protein phosphatase 1, regulatory subunit 3A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R3A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP1:
SP2:

Relevant External Links for PPP1R3A Gene

GeneLoc Exon Structure for
PPP1R3A
ECgene alternative splicing isoforms for
PPP1R3A

Expression for PPP1R3A Gene

mRNA expression in normal human tissues for PPP1R3A Gene

mRNA differential expression in normal tissues according to GTEx for PPP1R3A Gene

This gene is overexpressed in Muscle - Skeletal (23.5), Heart - Left Ventricle (19.0), and Heart - Atrial Appendage (9.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PPP1R3A Gene

SOURCE GeneReport for Unigene cluster for PPP1R3A Gene Hs.458309

mRNA Expression by UniProt/SwissProt for PPP1R3A Gene

Q16821-PPR3A_HUMAN
Tissue specificity: Skeletal muscle and heart.
genes like me logo Genes that share expressions with PPP1R3A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for PPP1R3A Gene

Orthologs for PPP1R3A Gene

This gene was present in the common ancestor of animals.

Orthologs for PPP1R3A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPP1R3A 35
  • 99.49 (n)
  • 99.02 (a)
PPP1R3A 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PPP1R3A 35
  • 86.14 (n)
  • 75.25 (a)
PPP1R3A 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPP1R3A 35
  • 87.46 (n)
  • 77.06 (a)
PPP1R3A 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppp1r3a 35
  • 77.31 (n)
  • 64.02 (a)
Ppp1r3a 16
Ppp1r3a 36
  • 63 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPP1R3A 36
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPP1R3A 36
  • 40 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppp1r3a 35
  • 77.74 (n)
  • 65.96 (a)
chicken
(Gallus gallus)
Aves PPP1R3A 35
  • 58.8 (n)
  • 42.04 (a)
PPP1R3A 36
  • 38 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPP1R3A 36
  • 37 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ppp1r3aa 36
  • 19 (a)
OneToMany
ppp1r3ab 36
  • 23 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Gbs-76A 36
  • 12 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea CC8.2 36
  • 24 (a)
OneToMany
Species with no ortholog for PPP1R3A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PPP1R3A Gene

ENSEMBL:
Gene Tree for PPP1R3A (if available)
TreeFam:
Gene Tree for PPP1R3A (if available)

Paralogs for PPP1R3A Gene

Paralogs for PPP1R3A Gene

genes like me logo Genes that share paralogs with PPP1R3A: view

Variants for PPP1R3A Gene

Sequence variations from dbSNP and Humsavar for PPP1R3A Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1133676 -- 113,877,033(-) AATTC(C/T)GAAAA utr-variant-3-prime
rs1799999 other, - 113,878,379(-) ACTCA(G/T)ACACT reference, missense
rs1800000 - 113,878,443(-) CTTAG(G/T)CAGGT reference, missense
rs2968845 -- 113,876,561(-) AATGC(A/G)AAGAT downstream-variant-500B
rs2974938 - 113,878,447(-) AGATC(A/T)TAGGC missense, reference

Structural Variations from Database of Genomic Variants (DGV) for PPP1R3A Gene

Variant ID Type Subtype PubMed ID
nsv7405 OTHER Inversion 18451855
nsv831100 CNV Gain 17160897
nsv824277 CNV Loss 20364138

Relevant External Links for PPP1R3A Gene

HapMap Linkage Disequilibrium report
PPP1R3A
Human Gene Mutation Database (HGMD)
PPP1R3A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP1R3A Gene

Disorders for PPP1R3A Gene

(1) OMIM Diseases for PPP1R3A Gene (600917)

UniProtKB/Swiss-Prot

PPR3A_HUMAN
  • Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM:125853]: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the bodys own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. {ECO:0000269 PubMed:7926294}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

(13) Novoseek inferred disease relationships for PPP1R3A Gene

Disease -log(P) Hits PubMed IDs
insulin resistance 60.3 10
niddm 45.8 7
insulin sensitivity 36.7 2
somatic mutations 30.3 3
impaired glucose tolerance 29.2 1

Relevant External Links for PPP1R3A

Genetic Association Database (GAD)
PPP1R3A
Human Genome Epidemiology (HuGE) Navigator
PPP1R3A
genes like me logo Genes that share disorders with PPP1R3A: view

Publications for PPP1R3A Gene

  1. Sequence of the human glycogen-associated regulatory subunit of type I protein phosphatase and analysis of its coding region and mRNA level in muscle from patients with non-insulin-dependent diabetes. (PMID: 7926294) Chen Y.H. … Pederson O. (Diabetes 1994) 2 3 4 23
  2. A common variant in PPP1R3 associated with insulin resistance and type 2 diabetes. (PMID: 9726244) Xia J. … Prochazka M. (Diabetes 1998) 3 4 23
  3. Genetic variability in the insulin signalling pathway may contribute to the risk of late onset Alzheimer's disease. (PMID: 12185156) Liolitsa D. … Lovestone S. (J. Neurol. Neurosurg. Psychiatr. 2002) 3 23 48
  4. [Study on association of PPP1R3 gene 5 bp deletion/insertion within 3'-untranslated region polymorphism with type 2 diabetes]. (PMID: 14767904) Chen M.W. … Sun H.Y. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2004) 3 23 48
  5. Association of the (AU)AT-rich element polymorphism in PPP1R3 with hormonal and metabolic features of polycystic ovary syndrome. (PMID: 15181086) Alcoser S.Y. … Ehrmann D.A. (J. Clin. Endocrinol. Metab. 2004) 3 23 48

Products for PPP1R3A Gene

Sources for PPP1R3A Gene

Back to Top

Content