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Aliases for MRPL20 Gene

Aliases for MRPL20 Gene

  • Mitochondrial Ribosomal Protein L20 2 3
  • MRP-L20 3 4
  • L20mt 3 4
  • 39S Ribosomal Protein L20, Mitochondrial 3

External Ids for MRPL20 Gene

Previous GeneCards Identifiers for MRPL20 Gene

  • GC01M000864
  • GC01M001089
  • GC01M001253
  • GC01M001288
  • GC01M001425
  • GC01M001329
  • GC01M000614

Summaries for MRPL20 Gene

Entrez Gene Summary for MRPL20 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. A pseudogene corresponding to this gene is found on chromosome 21q. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL20 Gene

MRPL20 (Mitochondrial Ribosomal Protein L20) is a Protein Coding gene. Among its related pathways are CFTR translational fidelity (class I mutations). GO annotations related to this gene include structural constituent of ribosome and rRNA binding.

Gene Wiki entry for MRPL20 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL20 Gene

Genomics for MRPL20 Gene

Regulatory Elements for MRPL20 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MRPL20 Gene

Start:
1,401,896 bp from pter
End:
1,407,313 bp from pter
Size:
5,418 bases
Orientation:
Minus strand

Genomic View for MRPL20 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRPL20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL20 Gene

Proteins for MRPL20 Gene

  • Protein details for MRPL20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYC9-RM20_HUMAN
    Recommended name:
    39S ribosomal protein L20, mitochondrial
    Protein Accession:
    Q9BYC9
    Secondary Accessions:
    • B2RE41
    • B7Z746

    Protein attributes for MRPL20 Gene

    Size:
    149 amino acids
    Molecular mass:
    17443 Da
    Quaternary structure:
    • Interacts with OXA1L.

    Three dimensional structures from OCA and Proteopedia for MRPL20 Gene

    Alternative splice isoforms for MRPL20 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MRPL20 Gene

Proteomics data for MRPL20 Gene at MOPED

Post-translational modifications for MRPL20 Gene

  • Ubiquitination at Lys82, Lys100, Lys111, and Lys114
  • Modification sites at PhosphoSitePlus

Other Protein References for MRPL20 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRPL20 Gene

Domains for MRPL20 Gene

Gene Families for MRPL20 Gene

HGNC:
  • MRPL :Mitochondrial ribosomal proteins / large subunits

Protein Domains for MRPL20 Gene

Suggested Antigen Peptide Sequences for MRPL20 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BYC9

UniProtKB/Swiss-Prot:

RM20_HUMAN :
  • Q9BYC9
Family:
  • Belongs to the ribosomal protein L20P family.
genes like me logo Genes that share domains with MRPL20: view

Function for MRPL20 Gene

Gene Ontology (GO) - Molecular Function for MRPL20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IEA --
GO:0005515 protein binding IPI 20601428
GO:0019843 rRNA binding IEA --
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with MRPL20: view

Animal Model Products

CRISPR Products

miRNA for MRPL20 Gene

miRTarBase miRNAs that target MRPL20

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPL20

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MRPL20 Gene

Localization for MRPL20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL20 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRPL20 Gene COMPARTMENTS Subcellular localization image for MRPL20 gene
Compartment Confidence
mitochondrion 5
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for MRPL20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005761 mitochondrial ribosome IDA 20601428
GO:0005840 ribosome --
genes like me logo Genes that share ontologies with MRPL20: view

Pathways for MRPL20 Gene

SuperPathways for MRPL20 Gene

Superpath Contained pathways
1 CFTR translational fidelity (class I mutations)
.54
genes like me logo Genes that share pathways with MRPL20: view

Pathways by source for MRPL20 Gene

1 KEGG pathway for MRPL20 Gene

Gene Ontology (GO) - Biological Process for MRPL20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation --
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0070124 mitochondrial translational initiation TAS --
GO:0070125 mitochondrial translational elongation TAS --
genes like me logo Genes that share ontologies with MRPL20: view

Transcripts for MRPL20 Gene

Unigene Clusters for MRPL20 Gene

Mitochondrial ribosomal protein L20:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPL20

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL20 Gene

No ASD Table

Relevant External Links for MRPL20 Gene

GeneLoc Exon Structure for
MRPL20
ECgene alternative splicing isoforms for
MRPL20

Expression for MRPL20 Gene

mRNA expression in normal human tissues for MRPL20 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPL20 Gene

SOURCE GeneReport for Unigene cluster for MRPL20 Gene Hs.182698

genes like me logo Genes that share expressions with MRPL20: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPL20 Gene

Orthologs for MRPL20 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MRPL20 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPL20 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MRPL20 35
  • 83 (n)
  • 85.23 (a)
MRPL20 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MRPL20 35
  • 85.91 (n)
  • 88.59 (a)
MRPL20 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mrpl20 35
  • 82.33 (n)
  • 87.92 (a)
Mrpl20 16
Mrpl20 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MRPL20 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrpl20 35
  • 81.21 (n)
  • 86.58 (a)
chicken
(Gallus gallus)
Aves MRPL20 35
  • 69.8 (n)
  • 74.5 (a)
MRPL20 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MRPL20 36
  • 69 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.34799 35
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl20 35
  • 66.67 (n)
  • 73.15 (a)
Str.20421 35
zebrafish
(Danio rerio)
Actinopterygii mrpl20 35
  • 59.51 (n)
  • 61.74 (a)
mrpl20 36
  • 62 (a)
OneToOne
wufa27e09 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001311 35
  • 49.08 (n)
  • 41.73 (a)
fruit fly
(Drosophila melanogaster)
Insecta mRpL20 35
  • 49.86 (n)
  • 39.02 (a)
mRpL20 36
  • 35 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G16740 35
  • 49.83 (n)
  • 42.42 (a)
rice
(Oryza sativa)
Liliopsida Os01g0734100 35
  • 51.82 (n)
  • 41.82 (a)
Species with no ortholog for MRPL20:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRPL20 Gene

ENSEMBL:
Gene Tree for MRPL20 (if available)
TreeFam:
Gene Tree for MRPL20 (if available)

Paralogs for MRPL20 Gene

Pseudogenes.org Pseudogenes for MRPL20 Gene

genes like me logo Genes that share paralogs with MRPL20: view

No data available for Paralogs for MRPL20 Gene

Variants for MRPL20 Gene

Sequence variations from dbSNP and Humsavar for MRPL20 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs904584 -- 1,405,757(+) cATGA(C/T)GGTTT intron-variant, reference, missense
rs1240710 -- 1,403,176(+) CAAAG(G/T)GGCCT intron-variant
rs1240711 -- 1,405,162(+) ttttt(G/T)tattt intron-variant, utr-variant-3-prime
rs1240712 -- 1,408,687(+) CTCGC(C/T)TCAAA upstream-variant-2KB
rs2275915 -- 1,407,232(+) AGGCC(C/G)GCGTC utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for MRPL20 Gene

Variant ID Type Subtype PubMed ID
nsv10161 CNV Gain+Loss 18304495
dgv2n67 CNV Gain 20364138
dgv10n71 CNV Loss 21882294
dgv12n71 CNV Loss 21882294
dgv19n71 CNV Loss 21882294
dgv20n71 CNV Loss 21882294
dgv25n71 CNV Loss 21882294
dgv30n71 CNV Gain 21882294
dgv31n71 CNV Gain 21882294
dgv32n71 CNV Gain+Loss 21882294
dgv33n71 CNV Loss 21882294
dgv34n71 CNV Loss 21882294
dgv38n71 CNV Loss 21882294
nsv871837 CNV Loss 21882294
nsv871690 CNV Gain 21882294
essv5472 CNV CNV 17122850
dgv9e1 CNV Complex 17122850
dgv40n71 CNV Loss 21882294

Relevant External Links for MRPL20 Gene

HapMap Linkage Disequilibrium report
MRPL20

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL20 Gene

Disorders for MRPL20 Gene

Relevant External Links for MRPL20

Genetic Association Database (GAD)
MRPL20
Human Genome Epidemiology (HuGE) Navigator
MRPL20
genes like me logo Genes that share disorders with MRPL20: view

No data available for UniProtKB/Swiss-Prot for MRPL20 Gene

Publications for MRPL20 Gene

  1. Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria. (PMID: 11279069) Suzuki T. … Watanabe K. (J. Biol. Chem. 2001) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48

Products for MRPL20 Gene

  • antibodies-online proteins for MRPL20
  • antibodies-online antibodies for MRPL20
  • antibodies-online kits for MRPL20

Sources for MRPL20 Gene

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