Aliases for MOCOS Gene
External Ids for MOCOS Gene
Previous GeneCards Identifiers for MOCOS Gene
MOCOS sulfurates the molybdenum cofactor of xanthine dehydrogenase (XDH; MIM 607633) and aldehyde oxidase (AOX1; MIM 602841), which is required for their enzymatic activities (Ichida et al., 2001 [PubMed 11302742]).[supplied by OMIM, Feb 2010]
GeneCards Summary for MOCOS Gene
MOCOS (Molybdenum Cofactor Sulfurase) is a Protein Coding gene. Diseases associated with MOCOS include xanthinuria type 2 and xanthinuria. Among its related pathways are MAPK signaling pathway and Regulation of actin cytoskeleton. GO annotations related to this gene include pyridoxal phosphate binding and molybdenum ion binding. An important paralog of this gene is MARC1.
UniProtKB/Swiss-Prot for MOCOS Gene
Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form. In vitro, the C-terminal domain is able to reduce N-hydroxylated prodrugs, such as benzamidoxime.