Aliases for PPP2R3C Gene
- Protein Phosphatase 2, Regulatory Subunit B'', Gamma 2
- Protein Phosphatase 2, Regulatory Subunit B, Gamma 2 3
- Protein Phosphatase Subunit G5PR 3 4
- C14orf10 3 4
- G5pr 3 4
- Serine/Threonine-Protein Phosphatase 2A Regulatory Subunit B Subunit Gamma 3
- Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit B, Gamma 2
External Ids for PPP2R3C Gene
Previous HGNC Symbols for PPP2R3C Gene
Previous GeneCards Identifiers for PPP2R3C Gene
This gene encodes a regulatory subunit of the serine/threonine phosphatase, protein phosphatase 2. This protein is localized to both nuclear and cytoplasmic regions depending on cell cycle phase. Homozygous conditional knockout mice for this gene exhibit reduced numbers and impaired proliferation of immune system B cells. This protein may regulate the expression of the P-glycoprotein ATP-binding cassette transporter through its phosphatase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
GeneCards Summary for PPP2R3C Gene
PPP2R3C (Protein Phosphatase 2, Regulatory Subunit B'', Gamma) is a Protein Coding gene. Diseases associated with PPP2R3C include rhabdomyosarcoma. Among its related pathways are PI3K-Akt signaling pathway and Circadian entrainment. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is PPP2R3B.
UniProtKB/Swiss-Prot for PPP2R3C Gene
May regulate MCM3AP phosphorylation through phosphatase recruitment. May act as a negative regulator of ABCB1 expression and function through the dephosphorylation of ABCB1 by TFPI2/PPP2R3C complex. May play a role in the activation-induced cell death of B-cells.
Protein ser/thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by the hydrolysis of phosphoric acid monoesters. They directly oppose the actions of kinases and phosphorylases and therefore play an integral role in many signal transduction pathways. There are two groups of serine/threonine phosphatases; phosphoprotein phosphatases (e.g. PP1, calcineurin), which are sensitive to okadaic acid and metallo-phosphatases (e.g. PP2C), which require a divalent cation, commonly Mg2+, for catalytic activity. Dephosphorylation, depending on the residue that the phosphate group is removed from, can have a stimulatory or inhibitory effect on the target molecule. This makes protein Ser/Thr phosphatases essential for many signal transduction pathways. Protein Ser/Thr phosphatase are regulated by their subcellular localization and by inhibitor proteins, which are subtype-specific.