Aliases for PPP2R3C Gene
External Ids for PPP2R3C Gene
Previous HGNC Symbols for PPP2R3C Gene
Previous GeneCards Identifiers for PPP2R3C Gene
This gene encodes a regulatory subunit of the serine/threonine phosphatase, protein phosphatase 2. This protein is localized to both nuclear and cytoplasmic regions depending on cell cycle phase. Homozygous conditional knockout mice for this gene exhibit reduced numbers and impaired proliferation of immune system B cells. This protein may regulate the expression of the P-glycoprotein ATP-binding cassette transporter through its phosphatase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
GeneCards Summary for PPP2R3C Gene
PPP2R3C (Protein Phosphatase 2, Regulatory Subunit B'', Gamma) is a Protein Coding gene. Diseases associated with PPP2R3C include holoprosencephaly. Among its related pathways are PI3K-Akt signaling pathway and Circadian entrainment. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is PPP2R3B.
UniProtKB/Swiss-Prot for PPP2R3C Gene
May regulate MCM3AP phosphorylation through phosphatase recruitment. May act as a negative regulator of ABCB1 expression and function through the dephosphorylation of ABCB1 by TFPI2/PPP2R3C complex. May play a role in the activation-induced cell death of B-cells.
Protein Ser/Thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by hydrolysis of phosphoric acid monoesters. They oppose the action of kinases and phosphorylases and are involved in signal transduction.