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Aliases for PPP2R3C Gene

Aliases for PPP2R3C Gene

  • Protein Phosphatase 2, Regulatory Subunit B'', Gamma 2
  • Protein Phosphatase 2, Regulatory Subunit B, Gamma 2 3
  • Protein Phosphatase Subunit G5PR 3 4
  • C14orf10 3 4
  • G5pr 3 4
  • Serine/Threonine-Protein Phosphatase 2A Regulatory Subunit B Subunit Gamma 3
  • Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit B, Gamma 2
  • Rhabdomyosarcoma Antigen MU-RMS-40.6A/6C 4
  • Rhabdomyosarcoma Antigen MU-RMS-40.6A 3
  • Rhabdomyosarcoma Antigen Mu-RMS-40.6C 3
  • Chromosome 14 Open Reading Frame 10 2
  • G4-1 3

External Ids for PPP2R3C Gene

Previous HGNC Symbols for PPP2R3C Gene

  • C14orf10

Previous GeneCards Identifiers for PPP2R3C Gene

  • GC14M034625
  • GC14M035554
  • GC14M015667

Summaries for PPP2R3C Gene

Entrez Gene Summary for PPP2R3C Gene

  • This gene encodes a regulatory subunit of the serine/threonine phosphatase, protein phosphatase 2. This protein is localized to both nuclear and cytoplasmic regions depending on cell cycle phase. Homozygous conditional knockout mice for this gene exhibit reduced numbers and impaired proliferation of immune system B cells. This protein may regulate the expression of the P-glycoprotein ATP-binding cassette transporter through its phosphatase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

GeneCards Summary for PPP2R3C Gene

PPP2R3C (Protein Phosphatase 2, Regulatory Subunit B'', Gamma) is a Protein Coding gene. Diseases associated with PPP2R3C include rhabdomyosarcoma. Among its related pathways are PI3K-Akt signaling pathway and Circadian entrainment. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is PPP2R3B.

UniProtKB/Swiss-Prot for PPP2R3C Gene

  • May regulate MCM3AP phosphorylation through phosphatase recruitment. May act as a negative regulator of ABCB1 expression and function through the dephosphorylation of ABCB1 by TFPI2/PPP2R3C complex. May play a role in the activation-induced cell death of B-cells.

Tocris Summary for PPP2R3C Gene

  • Protein ser/thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by the hydrolysis of phosphoric acid monoesters. They directly oppose the actions of kinases and phosphorylases and therefore play an integral role in many signal transduction pathways. There are two groups of serine/threonine phosphatases; phosphoprotein phosphatases (e.g. PP1, calcineurin), which are sensitive to okadaic acid and metallo-phosphatases (e.g. PP2C), which require a divalent cation, commonly Mg2+, for catalytic activity. Dephosphorylation, depending on the residue that the phosphate group is removed from, can have a stimulatory or inhibitory effect on the target molecule. This makes protein Ser/Thr phosphatases essential for many signal transduction pathways. Protein Ser/Thr phosphatase are regulated by their subcellular localization and by inhibitor proteins, which are subtype-specific.

Gene Wiki entry for PPP2R3C Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP2R3C Gene

Genomics for PPP2R3C Gene

Regulatory Elements for PPP2R3C Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PPP2R3C Gene

35,085,467 bp from pter
35,122,662 bp from pter
37,196 bases
Minus strand

Genomic View for PPP2R3C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPP2R3C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP2R3C Gene

Proteins for PPP2R3C Gene

  • Protein details for PPP2R3C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine/threonine-protein phosphatase 2A regulatory subunit B subunit gamma
    Protein Accession:
    Secondary Accessions:
    • B4DEN7
    • D3DS97
    • D3DS98
    • Q5GJ55
    • Q5GJ56
    • Q6P4G2
    • Q86TZ3
    • Q9NWR9

    Protein attributes for PPP2R3C Gene

    453 amino acids
    Molecular mass:
    53316 Da
    Quaternary structure:
    • Interacts with MCM3AP/GANP. Interacts with PPP5C, and the phosphatase 2A core enzyme composed of the PPP2CA catalytic subunit and the constant regulatory subunit PPP2R1A. Finds in a complex with ABCB1, TFPI2 and PPP2R3C; leading to the dephosphorylation of ABCB1.
    • Sequence=AAT44532.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAT44533.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PPP2R3C Gene


neXtProt entry for PPP2R3C Gene

Proteomics data for PPP2R3C Gene at MOPED

Post-translational modifications for PPP2R3C Gene

  • Ubiquitination at Lys341
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for PPP2R3C

No data available for DME Specific Peptides for PPP2R3C Gene

Domains for PPP2R3C Gene

Gene Families for PPP2R3C Gene

Protein Domains for PPP2R3C Gene

Suggested Antigen Peptide Sequences for PPP2R3C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 EF-hand domains.
  • Contains 2 EF-hand domains.
genes like me logo Genes that share domains with PPP2R3C: view

Function for PPP2R3C Gene

Molecular function for PPP2R3C Gene

UniProtKB/Swiss-Prot Function:
May regulate MCM3AP phosphorylation through phosphatase recruitment. May act as a negative regulator of ABCB1 expression and function through the dephosphorylation of ABCB1 by TFPI2/PPP2R3C complex. May play a role in the activation-induced cell death of B-cells.

Gene Ontology (GO) - Molecular Function for PPP2R3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PPP2R3C: view

Phenotypes for PPP2R3C Gene

genes like me logo Genes that share phenotypes with PPP2R3C: view

Animal Model Products

CRISPR Products

miRNA for PPP2R3C Gene

miRTarBase miRNAs that target PPP2R3C

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP2R3C Gene

Localization for PPP2R3C Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP2R3C Gene

Nucleus. Cytoplasm. Note=Excluded from the nucleoli. Localization is cell cycle-dependent. Localizes to the cytoplasm during cytokinesis. {ECO:0000269 PubMed:15820313}.

Subcellular locations from

Jensen Localization Image for PPP2R3C Gene COMPARTMENTS Subcellular localization image for PPP2R3C gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for PPP2R3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 21399614
GO:0005819 spindle IBA --
genes like me logo Genes that share ontologies with PPP2R3C: view

Pathways for PPP2R3C Gene

genes like me logo Genes that share pathways with PPP2R3C: view

Pathways by source for PPP2R3C Gene

Gene Ontology (GO) - Biological Process for PPP2R3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IBA --
GO:0001782 B cell homeostasis IBA --
GO:0002759 regulation of antimicrobial humoral response IEA --
GO:0030865 cortical cytoskeleton organization IBA --
GO:0032147 activation of protein kinase activity IEA --
genes like me logo Genes that share ontologies with PPP2R3C: view

Drugs for PPP2R3C Gene

(5) Tocris Compounds for PPP2R3C Gene

Compound Action Cas Number
Calyculin A Protein phosphatase 1 and 2A inhibitor [101932-71-2]
Cyclosporin A Calcineurin inhibitor [59865-13-3]
FK 506 Potent calcineurin inhibitor; immunosuppressant [104987-11-3]
Okadaic acid Protein phosphatase 1 and 2A inhibitor [78111-17-8]
Salubrinal Selective inhibitor of eIF2alpha dephosphorylation [405060-95-9]
genes like me logo Genes that share compounds with PPP2R3C: view

Transcripts for PPP2R3C Gene

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPP2R3C

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP2R3C Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b
SP1: - - - - - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: -
SP5: - -
SP6: - - - - - -
SP9: - - - -

Relevant External Links for PPP2R3C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPP2R3C Gene

mRNA expression in normal human tissues for PPP2R3C Gene

Protein differential expression in normal tissues for PPP2R3C Gene

This gene is overexpressed in Testis (30.3), Fetal heart (25.3), and CD8 Tcells (6.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPP2R3C Gene

SOURCE GeneReport for Unigene cluster for PPP2R3C Gene Hs.530712

mRNA Expression by UniProt/SwissProt for PPP2R3C Gene

Tissue specificity: Ubiquitously expressed in brain and other tissues.
genes like me logo Genes that share expressions with PPP2R3C: view

Expression partners for PPP2R3C Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PPP2R3C Gene

Orthologs for PPP2R3C Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP2R3C Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PPP2R3C 35
  • 93.52 (n)
  • 98.45 (a)
PPP2R3C 36
  • 98 (a)
(Canis familiaris)
Mammalia PPP2R3C 35
  • 93.75 (n)
  • 98.01 (a)
PPP2R3C 36
  • 98 (a)
(Mus musculus)
Mammalia Ppp2r3c 35
  • 90.29 (n)
  • 98.23 (a)
Ppp2r3c 16
Ppp2r3c 36
  • 98 (a)
(Pan troglodytes)
Mammalia PPP2R3C 35
  • 99.63 (n)
  • 100 (a)
PPP2R3C 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Ppp2r3c 35
  • 90.43 (n)
  • 97.79 (a)
(Monodelphis domestica)
Mammalia PPP2R3C 36
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia PPP2R3C 36
  • 95 (a)
(Gallus gallus)
Aves PPP2R3C 35
  • 82.15 (n)
  • 92 (a)
PPP2R3C 36
  • 89 (a)
(Anolis carolinensis)
Reptilia PPP2R3C 36
  • 89 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp2r3c 35
  • 76.19 (n)
  • 86.61 (a)
Str.17328 35
African clawed frog
(Xenopus laevis)
Amphibia MGC68494 35
(Danio rerio)
Actinopterygii ppp2r3c 35
  • 73.44 (n)
  • 86.61 (a)
zgc55473 35
ppp2r3c 36
  • 84 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons FASS 35
  • 50.23 (n)
  • 39.4 (a)
(Oryza sativa)
Liliopsida Os05g0149800 35
  • 52 (n)
  • 40.32 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1229 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 79 (a)
Species with no ortholog for PPP2R3C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PPP2R3C Gene

Gene Tree for PPP2R3C (if available)
Gene Tree for PPP2R3C (if available)

Paralogs for PPP2R3C Gene

Paralogs for PPP2R3C Gene

genes like me logo Genes that share paralogs with PPP2R3C: view

Variants for PPP2R3C Gene

Sequence variations from dbSNP and Humsavar for PPP2R3C Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs4982240 -- 35,114,130(+) AAGGA(A/G)AGTGT intron-variant
rs8019523 -- 35,119,140(+) tcaag(C/T)gattc intron-variant
rs8019700 -- 35,119,285(+) tgcct(A/G)cctcg intron-variant
rs12437439 -- 35,116,463(+) TTGCC(A/C)TGGCT intron-variant
rs12891382 -- 35,114,935(+) gtcgc(A/C)gtgag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPP2R3C Gene

Variant ID Type Subtype PubMed ID
nsv901602 CNV Loss 21882294
dgv1871n71 CNV Loss 21882294
nsv901612 CNV Gain+Loss 21882294
nsv901614 CNV Loss 21882294
nsv901615 CNV Loss 21882294

Relevant External Links for PPP2R3C Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP2R3C Gene

Disorders for PPP2R3C Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for PPP2R3C Gene in MalaCards »

(1) Disease for PPP2R3C Gene

Relevant External Links for PPP2R3C

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with PPP2R3C: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for PPP2R3C Gene

Publications for PPP2R3C Gene

  1. MCM3-binding GANP DNA-primase is associated with a novel phosphatase component G5PR. (PMID: 12167160) Kono Y. … Sakaguchi N. (Genes Cells 2002) 2 3 4
  2. Protein phosphatase complex PP5/PPP2R3C dephosphorylates P- glycoprotein/ABCB1 and down-regulates the expression and function. (PMID: 24333728) Katayama K. … Sugimoto Y. (Cancer Lett. 2014) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Defining a holoprosencephaly locus on human chromosome 14q13 and characterization of potential candidate genes. (PMID: 15820313) Kamnasaran D. … Cox D.W. (Genomics 2005) 3 4

Products for PPP2R3C Gene

Sources for PPP2R3C Gene

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