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Aliases for ACPP Gene

Aliases for ACPP Gene

  • Acid Phosphatase, Prostate 2 3
  • Thiamine Monophosphatase 3 4
  • Ecto-5-Nucleotidase 3 4
  • 5-Nucleotidase 3 4
  • EC 3.1.3.2 4 63
  • TMPase 3 4
  • 5-NT 3 4
  • Prostatic Acid Phosphatase 3
  • Prostatic Acid Phosphotase 3
  • EC 3.1.3.5 4
  • ACP-3 3
  • ACP3 3
  • PAP 4

External Ids for ACPP Gene

Summaries for ACPP Gene

Entrez Gene Summary for ACPP Gene

  • This gene encodes an enzyme that catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is synthesized under androgen regulation and is secreted by the epithelial cells of the prostate gland. An alternatively spliced transcript variant encoding a longer isoform has been found for this gene. This isoform contains a transmembrane domain and is localized in the plasma membrane-endosomal-lysosomal pathway. [provided by RefSeq, Sep 2008]

GeneCards Summary for ACPP Gene

ACPP (Acid Phosphatase, Prostate) is a Protein Coding gene. Diseases associated with ACPP include prostatic adenoma and nephrogenic adenoma of the urethra. Among its related pathways are Riboflavin metabolism and Purine metabolism (KEGG). GO annotations related to this gene include protein homodimerization activity and acid phosphatase activity. An important paralog of this gene is ACPT.

UniProtKB/Swiss-Prot for ACPP Gene

  • A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma

  • Isoform 2: the cellular form also has ecto-5-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor. Acts as a tumor suppressor of prostate cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling

Gene Wiki entry for ACPP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACPP Gene

Genomics for ACPP Gene

Genomic Location for ACPP Gene

Start:
132,317,367 bp from pter
End:
132,368,302 bp from pter
Size:
50,936 bases
Orientation:
Plus strand

Genomic View for ACPP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ACPP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACPP Gene

Regulatory Elements for ACPP Gene

Proteins for ACPP Gene

  • Protein details for ACPP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15309-PPAP_HUMAN
    Recommended name:
    Prostatic acid phosphatase
    Protein Accession:
    P15309
    Secondary Accessions:
    • D3DNC6
    • Q5FBY0
    • Q96KY0
    • Q96QK9
    • Q96QM0

    Protein attributes for ACPP Gene

    Size:
    386 amino acids
    Molecular mass:
    44566 Da
    Quaternary structure:
    • Homodimer; dimer formation is required for phosphatase activity.
    Miscellaneous:
    • Used as a diagnostic tool for staging metastatic prostatic cancer

    Three dimensional structures from OCA and Proteopedia for ACPP Gene

    Alternative splice isoforms for ACPP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ACPP Gene

Proteomics data for ACPP Gene at MOPED

Selected DME Specific Peptides for ACPP Gene

Post-translational modifications for ACPP Gene

  • N-glycosylated. High mannose content, partially sialylated and fucosylated biantennary complex. Also fucosylated with partially sialylated triantennary complex oligosaccharides.
  • Proteolytically cleaved in seminal fluid to produce several peptides. Peptide PAPf39, the most prominent, forms amyloid beta-sheet fibrils, SEVI (semen-derived enhancer of viral infection) which entrap HIV virions, attach them to target cells and enhance infection. SEVI amyloid fibrils are degraded by polyphenol epigallocatechin-3-gallate (EGCG), a constituent of green tea. Target cell attachment and enhancement of HIV infection is inhibited by surfen. Also similarly boosts XMRV (xenotropic murine leukemia virus-related virus) infection.
  • Glycosylation at Asn94, Asn220, and Asn333

Other Protein References for ACPP Gene

Domains for ACPP Gene

Protein Domains for ACPP Gene

Graphical View of Domain Structure for InterPro Entry

P15309

UniProtKB/Swiss-Prot:

PPAP_HUMAN
Family:
  • Belongs to the histidine acid phosphatase family.:
    • P15309
genes like me logo Genes that share domains with ACPP: view

No data available for Gene Families for ACPP Gene

Function for ACPP Gene

Molecular function for ACPP Gene

GENATLAS Biochemistry: phosphatase acid,prostate
UniProtKB/Swiss-Prot CatalyticActivity: A phosphate monoester + H(2)O = an alcohol + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity: A 5-ribonucleotide + H(2)O = a ribonucleoside + phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation: Phosphatase activity inhibited by L(+)-tartrate, and by its derivative, alpha-benzylaminobenzylphosphonic acid.
UniProtKB/Swiss-Prot Function: A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma
UniProtKB/Swiss-Prot Function: Isoform 2: the cellular form also has ecto-5-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor. Acts as a tumor suppressor of prostate cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling

Enzyme Numbers (IUBMB) for ACPP Gene

Gene Ontology (GO) - Molecular Function for ACPP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003993 acid phosphatase activity IMP 8132635
GO:0008253 5-nucleotidase activity IDA 18940592
GO:0016791 phosphatase activity IMP 18940592
GO:0033265 choline binding IEA --
GO:0042131 thiamine phosphate phosphatase activity ISS --
genes like me logo Genes that share ontologies with ACPP: view

Phenotypes for ACPP Gene

genes like me logo Genes that share phenotypes with ACPP: view

miRNA for ACPP Gene

miRTarBase miRNAs that target ACPP

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ACPP Gene

Localization for ACPP Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACPP Gene

Isoform 1: Secreted.
Isoform 2: Cell membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=Appears to shuttle between the cell membrane and intracellular vesicles. Colocalizes with FLOT1 at cell membrane and in intracellular vesicles. Colocalizes with LAMP2 on the lysosome membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACPP Gene COMPARTMENTS Subcellular localization image for ACPP gene
Compartment Confidence
extracellular 5
lysosome 5
plasma membrane 5
vacuole 5
endoplasmic reticulum 3
golgi apparatus 3
mitochondrion 3
nucleus 3
cytoskeleton 2
cytosol 2
endosome 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for ACPP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IMP 22389722
GO:0005622 intracellular IDA 17658863
GO:0005634 nucleus IDA 21630459
GO:0005765 lysosomal membrane IDA 17897319
GO:0005771 multivesicular body IEA --
genes like me logo Genes that share ontologies with ACPP: view

Pathways for ACPP Gene

genes like me logo Genes that share pathways with ACPP: view

Pathways by source for ACPP Gene

1 GeneGo (Thomson Reuters) pathway for ACPP Gene
1 KEGG pathway for ACPP Gene

Gene Ontology (GO) - Biological Process for ACPP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006144 purine nucleobase metabolic process IEA --
GO:0006772 thiamine metabolic process ISS --
GO:0009117 nucleotide metabolic process IEA --
GO:0016311 dephosphorylation IMP 8132635
GO:0046085 adenosine metabolic process IDA 18940592
genes like me logo Genes that share ontologies with ACPP: view

Compounds for ACPP Gene

(6) HMDB Compounds for ACPP Gene

Compound Synonyms Cas Number PubMed IDs
4-Nitrophenol
  • 1-Hydroxy-4-nitrobenzene
100-02-7
Flavin Mononucleotide
  • FMN
146-17-8
Phosphate
  • NFB Orthophosphate
14265-44-2
Riboflavin
  • (-)-Riboflavin
83-88-5
Tartaric acid
  • (+)-(2R,3R)-Tartaric acid
87-69-4

(3) Drugbank Compounds for ACPP Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Alpha-Benzyl-Aminobenzyl-Phosphonic Acid
target
Alpha-D-Mannose
3458-28-4 target
N-Propyl-Tartramic Acid
target

(65) Novoseek inferred chemical compound relationships for ACPP Gene

Compound -log(P) Hits PubMed IDs
provenge 91.2 12
estracyt 68.3 2
nilutamide 65.5 4
testosterone 64 63
dihydrotestosterone 62.2 14
genes like me logo Genes that share compounds with ACPP: view

Transcripts for ACPP Gene

Unigene Clusters for ACPP Gene

Acid phosphatase, prostate:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ACPP Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11
SP1: - - - -
SP2: - -
SP3: - - -
SP4:
SP5: - - -
SP6:

Relevant External Links for ACPP Gene

GeneLoc Exon Structure for
ACPP
ECgene alternative splicing isoforms for
ACPP

Expression for ACPP Gene

mRNA expression in normal human tissues for ACPP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ACPP Gene

This gene is overexpressed in Prostate (47.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ACPP Gene

SOURCE GeneReport for Unigene cluster for ACPP Gene Hs.433060

mRNA Expression by UniProt/SwissProt for ACPP Gene

P15309-PPAP_HUMAN
Tissue specificity: Highly expressed in the prostate, restricted to glandular and ductal epithelial cells. Also expressed in bladder, kidney, pancreas, lung, cervix, testis and ovary. Weak expression in a subset of pancreatic islet cells, squamous epithelia, the pilosebaceous unit, colonic neuroendocrine cells and skin adnexal structures. Isoform 2 also expressed in the sarcolemma of skeletal muscle. Levels of this cellular isoform decreased in prostate cancer.
genes like me logo Genes that share expressions with ACPP: view

Orthologs for ACPP Gene

This gene was present in the common ancestor of animals.

Orthologs for ACPP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACPP 35
  • 99.44 (n)
  • 99.04 (a)
ACPP 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ACPP 35
  • 85.07 (n)
  • 79.95 (a)
ACPP 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ACPP 35
  • 84.61 (n)
  • 80.62 (a)
ACPP 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Acpp 35
  • 82.86 (n)
  • 80.62 (a)
Acpp 16
Acpp 36
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ACPP 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ACPP 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Acpp 35
  • 82 (n)
  • 80.1 (a)
chicken
(Gallus gallus)
Aves ACPP 35
  • 61.21 (n)
  • 55.06 (a)
ACPP 36
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ACPP 36
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia acpp 35
  • 58.03 (n)
  • 52.07 (a)
fruit fly
(Drosophila melanogaster)
Insecta Acph-1 36
  • 32 (a)
ManyToMany
CG6656 36
  • 26 (a)
ManyToMany
CG9449 36
  • 30 (a)
ManyToMany
CG9451 36
  • 29 (a)
ManyToMany
CG9452 36
  • 27 (a)
ManyToMany
CG9449 37
  • 36 (a)
CG6656 37
  • 29 (a)
CG9452 37
  • 33 (a)
CG9451 37
  • 32 (a)
Acph-1 37
  • 37 (a)
worm
(Caenorhabditis elegans)
Secernentea acp-1 36
  • 21 (a)
ManyToMany
acp-2 36
  • 20 (a)
ManyToMany
acp-3 36
  • 21 (a)
ManyToMany
acp-4 36
  • 18 (a)
ManyToMany
acp-5 36
  • 21 (a)
ManyToMany
C27A2.12 36
  • 23 (a)
ManyToMany
F26C11.1 36
  • 24 (a)
ManyToMany
pho-1 36
  • 24 (a)
ManyToMany
pho-10 36
  • 25 (a)
ManyToMany
pho-11 36
  • 23 (a)
ManyToMany
pho-12 36
  • 25 (a)
ManyToMany
pho-13 36
  • 22 (a)
ManyToMany
pho-14 36
  • 30 (a)
ManyToMany
pho-4 36
  • 22 (a)
ManyToMany
pho-5 36
  • 28 (a)
ManyToMany
pho-6 35
  • 43.24 (n)
  • 33.13 (a)
T13B5.3 37
  • 32 (a)
pho-1 37
  • 31 (a)
R13H4.3 37
  • 29 (a)
T21B6.2 37
  • 31 (a)
F52E1.8 37
  • 32 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11668 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToMany
Species with no ortholog for ACPP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ACPP Gene

ENSEMBL:
Gene Tree for ACPP (if available)
TreeFam:
Gene Tree for ACPP (if available)

Paralogs for ACPP Gene

Paralogs for ACPP Gene

Selected SIMAP similar genes for ACPP Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ACPP: view

Variants for ACPP Gene

Sequence variations from dbSNP and Humsavar for ACPP Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs10115 -- 132,358,285(+) TAATT(A/G)TGTTC utr-variant-3-prime, intron-variant
rs12817 -- 132,358,477(+) TGGCA(G/T)ATCTA utr-variant-3-prime, intron-variant
rs13131 -- 132,358,448(+) AGAAG(A/G)AATCA utr-variant-3-prime, intron-variant
rs14192 -- 132,357,707(+) TTCTC(C/T)AGAAG utr-variant-3-prime, intron-variant
rs15096 -- 132,358,726(+) TGTAA(A/G)ATAGT utr-variant-3-prime, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACPP Gene

Variant ID Type Subtype PubMed ID
nsv508245 CNV Loss 20534489
nsv829728 CNV Gain 17160897

Relevant External Links for ACPP Gene

HapMap Linkage Disequilibrium report
ACPP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACPP Gene

Disorders for ACPP Gene

(66) Novoseek inferred disease relationships for ACPP Gene

Disease -log(P) Hits PubMed IDs
prostate carcinoma 89 73
prostate cancer 87 151
prostatic adenocarcinoma 83.5 26
benign prostatic hyperplasia 77.9 26
lysosomal acid phosphatase 75.4 1

Relevant External Links for ACPP

Genetic Association Database (GAD)
ACPP
Human Genome Epidemiology (HuGE) Navigator
ACPP
genes like me logo Genes that share disorders with ACPP: view

No data available for UniProtKB/Swiss-Prot for ACPP Gene

Publications for ACPP Gene

  1. Structural origins of L(+)-tartrate inhibition of human prostatic acid phosphatase. (PMID: 9804805) Lacount M.W. … Lebioda L. (J. Biol. Chem. 1998) 3 4 23
  2. Prostatic acid phosphatase degrades lysophosphatidic acid in seminal plasma. (PMID: 15280042) Tanaka M. … Arai H. (FEBS Lett. 2004) 3 4 23
  3. Fibrils of prostatic acid phosphatase fragments boost infections with XMRV (xenotropic murine leukemia virus-related virus), a human retrovirus associated with prostate cancer. (PMID: 19403677) Hong S. … Silverman R.H. (J. Virol. 2009) 3 4 23
  4. Prostatic acid phosphatase in breast cyst fluid. (PMID: 19108401) Erbas H. … Irfanoglu M.E. (Malays J Pathol 2007) 3 23
  5. Tyrosine phosphorylation of c-ErbB-2 is regulated by the cellular form of prostatic acid phosphatase in human prostate cancer cells. (PMID: 9705354) Meng T.C. … Lin M.F. (J. Biol. Chem. 1998) 3 23

Products for ACPP Gene

Sources for ACPP Gene

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