Aliases for ACPP Gene
Aliases for ACPP Gene
External Ids for ACPP Gene
- HGNC: 125
- Entrez Gene: 55
- Ensembl: ENSG00000014257
- OMIM: 171790
- UniProtKB: P15309
Previous GeneCards Identifiers for ACPP Gene
- GC03P128977
- GC03P132781
- GC03P133317
- GC03P133357
- GC03P133518
- GC03P132036
- GC03P129415
Summaries for ACPP Gene
-
This gene encodes an enzyme that catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is synthesized under androgen regulation and is secreted by the epithelial cells of the prostate gland. An alternatively spliced transcript variant encoding a longer isoform has been found for this gene. This isoform contains a transmembrane domain and is localized in the plasma membrane-endosomal-lysosomal pathway. [provided by RefSeq, Sep 2008]
GeneCards Summary for ACPP Gene
ACPP (Acid Phosphatase, Prostate) is a Protein Coding gene. Diseases associated with ACPP include Prostate Cancer and Nephrogenic Adenoma Of The Urethra. Among its related pathways are Innate Immune System and Pyrimidine metabolism (KEGG). Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and phosphatase activity. An important paralog of this gene is ACP2.
UniProtKB/Swiss-Prot for ACPP Gene
-
A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma.
-
Isoform 2: the cellular form also has ecto-5-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor. Acts as a tumor suppressor of prostate cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACPP Gene
Genomics for ACPP Gene
GeneHancer (GH) Regulatory Elements for ACPP Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH03I132316 | Promoter/Enhancer | 1.8 | EPDnew Ensembl ENCODE | 550.8 | +0.4 | 354 | 2.7 | PKNOX1 NFIB NEUROD1 MZF1 SIN3A FEZF1 ZNF2 ZNF335 FOS REST | ACPP ENSG00000261167 CPNE4 GC03P132328 | |
GH03I132290 | Enhancer | 0.7 | Ensembl ENCODE | 16.2 | -26.5 | -26466 | 0.6 | ZFHX2 POLR2A MAX CEBPB MYC | ACPP CPNE4 | |
GH03I132342 | Enhancer | 0.6 | Ensembl | 13.1 | +25.7 | 25710 | 0.6 | CTCF ZNF654 TRIM22 CEBPB REST RAD21 RFX5 ZNF316 SMC3 ZNF143 | ACPP GC03P132328 LOC100130550 | |
GH03I132282 | Enhancer | 0.9 | Ensembl ENCODE | 4.5 | -32.6 | -32634 | 3.5 | CTCF USF1 MAX POLR2A HNF4G STAT1 RXRA ZNF740 CEBPB USF2 | CPNE4 ACPP RPL7P16 | |
GH03I132346 | Enhancer | 0.8 | Ensembl ENCODE | 4.6 | +29.7 | 29739 | 1.1 | SOX5 SOX13 FOXA2 RFX1 DPF2 FOXA1 CTBP1 GATA3 FOXP1 | ACPP GC03P132328 LOC100130550 |
Regulatory Element Products
Genomic Locations for ACPP Gene
- chr3:132,317,367-132,368,302
- (GRCh38/hg38)
- Size:
- 50,936 bases
- Orientation:
- Plus strand
- chr3:132,036,211-132,087,146
- (GRCh37/hg19)
Genomic View for ACPP Gene
- Cytogenetic band:
-
- 3q22.1 by Ensembl
- 3q22.1 by Entrez Gene
- 3q22.1 by HGNC


RefSeq DNA sequence for ACPP Gene
Proteins for ACPP Gene
-
Protein details for ACPP Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P15309-PPAP_HUMAN
- Recommended name:
- Prostatic acid phosphatase
- Protein Accession:
- P15309
- D3DNC6
- Q5FBY0
- Q96KY0
- Q96QK9
- Q96QM0
Protein attributes for ACPP Gene
- Size:
- 386 amino acids
- Molecular mass:
- 44566 Da
- Quaternary structure:
-
- Homodimer; dimer formation is required for phosphatase activity.
- Miscellaneous:
-
- Used as a diagnostic tool for staging metastatic prostatic cancer.
Three dimensional structures from OCA and Proteopedia for ACPP Gene
Protein Expression for ACPP Gene
Selected DME Specific Peptides for ACPP Gene
- P15309:
-
- WPQGFGQLT
- DRTLMSA
- DTTVSGLQMAL
- WQPIPVHT
- RLQGGVL
Post-translational modifications for ACPP Gene
- N-glycosylated. High mannose content, partially sialylated and fucosylated biantennary complex. Also fucosylated with partially sialylated triantennary complex oligosaccharides.
- Proteolytically cleaved in seminal fluid to produce several peptides. Peptide PAPf39, the most prominent, forms amyloid beta-sheet fibrils, SEVI (semen-derived enhancer of viral infection) which entrap HIV virions, attach them to target cells and enhance infection. SEVI amyloid fibrils are degraded by polyphenol epigallocatechin-3-gallate (EGCG), a constituent of green tea. Target cell attachment and enhancement of HIV infection is inhibited by surfen. Also similarly boosts XMRV (xenotropic murine leukemia virus-related virus) infection.
- Glycosylation at Asn94, posLast=220220, and posLast=333333
Other Protein References for ACPP Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for ACPP (Prostatic Acid Phosphatase/ACPP)
- Cell Signaling Technology (CST) Antibodies for ACPP (ACPP)
-
Custom Antibody ServicesOriGene Antibodies for ACPP
- Novus Biologicals Antibodies for ACPP
-
Abcam antibodies for ACPP
-
Cloud-Clone Corp. Antibodies for ACPP
- Invitrogen Antibodies for ACPP
- GeneTex ACPP antibody for ACPP
-
Santa Cruz Biotechnology (SCBT) Antibodies for ACPP
- Sino Biological Antibodies for ACPP
Protein Products
- R&D Systems Proteins and Enzymes for ACPP (Prostatic Acid Phosphatase/ACPP)
-
OriGene Purified Proteins for ACPP
- Search Origene for MassSpec and Protein Over-expression Lysates for ACPP
- Origene Custom Protein Services for ACPP
- Sino Biological Cell Lysates for ACPP
- Sino Biological Recombinant Proteins for ACPP
- ProSpec Recombinant Proteins for ACPP
-
Cloud-Clone Corp. Proteins for ACPP
- Search GeneTex for Proteins for ACPP
-
ProSci Proteins for ACPP
-
Abcam proteins for ACPP
Assay Products
- R&D Systems ELISAs and other biochemical assays for ACPP (Prostatic Acid Phosphatase/ACPP)
-
Cloud-Clone Corp. Assay Kits for ACPP
- antibodies-online: Search results for 22 available CD73 Elisa Kits ranked by validation data
- Compare Top CD73 Elisa Kits
-
Quality Products:
- ABIN414946
- ABIN1565898
- ABIN1565899
- ABIN1565900
- ABIN1565901
- ABIN626641
- ABIN1049796
- ABIN777999
- ABIN988497
- ABIN627472
- ABIN626641
- ABIN1565901
- ABIN1565900
- ABIN1565899
- ABIN1565898
- ABIN414946
- ABIN1049796
- ABIN777999
- ABIN988497
- ABIN627472
- ABIN626641
- ABIN1565901
- ABIN1565900
- ABIN1565899
- ABIN1565898
- ABIN414946
- ABIN1049796
- ABIN777999
- ABIN988497
- ABIN627472
- Sino Biological Assays for ACPP
Domains & Families for ACPP Gene
Gene Families for ACPP Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for ACPP Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ACPP Gene
Graphical View of Domain Structure for InterPro Entry
P15309- Family:
-
- Belongs to the histidine acid phosphatase family.
Function for ACPP Gene
Molecular function for ACPP Gene
- GENATLAS Biochemistry:
- phosphatase acid,prostate
- UniProtKB/Swiss-Prot CatalyticActivity:
- A phosphate monoester + H(2)O = an alcohol + phosphate.
- UniProtKB/Swiss-Prot CatalyticActivity:
- A 5-ribonucleotide + H(2)O = a ribonucleoside + phosphate.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Phosphatase activity inhibited by L(+)-tartrate, and by its derivative, alpha-benzylaminobenzylphosphonic acid.
- UniProtKB/Swiss-Prot Function:
- A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma.
- UniProtKB/Swiss-Prot Function:
- Isoform 2: the cellular form also has ecto-5-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor. Acts as a tumor suppressor of prostate cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling.
Enzyme Numbers (IUBMB) for ACPP Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003993 | acid phosphatase activity | IMP | 8132635 |
GO:0005515 | protein binding | IPI | 9705354 |
GO:0008253 | 5-nucleotidase activity | IDA,IEA | 18940592 |
GO:0016787 | hydrolase activity | IEA | -- |
GO:0016791 | phosphatase activity | IMP | 18940592 |
Phenotypes for ACPP Gene
- MGI mutant phenotypes for ACPP:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ACPP:
Animal Models for ACPP Gene
- MGI Knock Outs for ACPP:
-
- Acpp tm1Pivi
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ACPP
-
-
ViGene Biosciences lentiviral particle packaged cDNA for ACPP gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ACPP gene
- Search ViGene Biosciences for ACPP
CRISPR Products
-
OriGene CRISPR knockouts for ACPP
- genomics-online: gRNA clones - Search results for 163 available ACP3 gene related products
- Overview of 163 available ACP3 gene related products
- Applied Biological Materials CRISPR for ACPP
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ACPP
- GenScript: Design CRISPR guide RNA sequences for ACPP
miRNA for ACPP Gene
- miRTarBase miRNAs that target ACPP
-
- hsa-let-7b-5p (MIRT032233)
- hsa-mir-539-5p (MIRT441291)
- hsa-mir-6803-5p (MIRT443462)
- hsa-mir-6751-5p (MIRT443463)
- hsa-mir-548s (MIRT443464)
- hsa-mir-6881-5p (MIRT443465)
- hsa-mir-7110-5p (MIRT443466)
- hsa-mir-6752-5p (MIRT443467)
- hsa-mir-6842-5p (MIRT443468)
- hsa-mir-6835-5p (MIRT443469)
- hsa-mir-4731-5p (MIRT443470)
- hsa-mir-3926 (MIRT443471)
- hsa-mir-637 (MIRT443472)
- hsa-mir-3973 (MIRT443473)
- hsa-mir-5197-5p (MIRT443474)
- hsa-mir-320e (MIRT443475)
- hsa-mir-548l (MIRT443476)
- hsa-mir-4429 (MIRT443477)
- hsa-mir-320d (MIRT443478)
- hsa-mir-320c (MIRT443479)
- hsa-mir-320b (MIRT443480)
- hsa-mir-320a (MIRT443481)
- hsa-mir-3672 (MIRT785110)
- hsa-mir-4461 (MIRT785938)
- hsa-mir-4524a-3p (MIRT786098)
- hsa-mir-4524b-3p (MIRT786146)
- hsa-mir-6864-3p (MIRT789115)
miRNA Products
- Search ViGene Biosciences for ACPP
Inhibitory RNA Products
- Origene RNAi and shrna products in human, mouse, rat for ACPP
- Browse OriGene Inhibitory RNA Products For ACPP
- genomics-online: shRNA clones - Search results for 163 available ACP3 gene related products
- Overview of 163 available ACP3 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for ACPP gene
Clone Products
- Sino Biological Human cDNA Clone for ACPP
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ACPP
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ACPP
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for ACPP
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for ACPP
-
ViGene Biosciences adenoviral particle packaged cDNA for ACPP gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ACPP gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ACPP gene
No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ACPP Gene
Localization for ACPP Gene
Subcellular locations from UniProtKB/Swiss-Prot for ACPP Gene
- Isoform 1: Secreted.
- Isoform 2: Cell membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=Appears to shuttle between the cell membrane and intracellular vesicles. Colocalizes with FLOT1 at cell membrane and in intracellular vesicles (PubMed:17638863). Colocalizes with LAMP2 on the lysosome membrane (PubMed:17897319). {ECO:0000269 PubMed:17638863, ECO:0000269 PubMed:17897319}.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO:0005615 | extracellular space | IMP | 22389722 |
GO:0005622 | intracellular | IDA | 17658863 |
GO:0005634 | nucleus | IDA,HDA | 21630459 |
GO:0005764 | lysosome | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for ACPP Gene
Pathways & Interactions for ACPP Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Innate Immune System |
.61
|
|
2 | Pyrimidine metabolism (KEGG) |
Pathways by source for ACPP Gene
3 Reactome pathways for ACPP Gene
1 GeneGo (Thomson Reuters) pathway for ACPP Gene
Interacting Proteins for ACPP Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006144 | purine nucleobase metabolic process | IEA | -- |
GO:0006772 | thiamine metabolic process | ISS,IEA | -- |
GO:0009117 | nucleotide metabolic process | IEA | -- |
GO:0016311 | dephosphorylation | IMP | 8132635 |
GO:0043312 | neutrophil degranulation | TAS | -- |
No data available for SIGNOR curated interactions for ACPP Gene
Drugs & Compounds for ACPP Gene
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Sipuleucel-T | Approved, Investigational | Pharma | Target, antagonist, inhibitory immune response | 0 | ||
Phosphoric acid | Approved | Pharma | 0 | |||
Water | Approved | Pharma | 0 | |||
Riboflavin | Approved, Investigational, Vet_approved | Nutra | 188 | |||
Alpha-Benzyl-Aminobenzyl-Phosphonic Acid | Experimental | Pharma | Target | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
Phosphate |
|
14265-44-2 |
|
Transcripts for ACPP Gene
mRNA/cDNA for ACPP Gene
- (5) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (449) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ACPP Gene
CRISPR Products
-
OriGene CRISPR knockouts for ACPP
- genomics-online: gRNA clones - Search results for 163 available ACP3 gene related products
- Overview of 163 available ACP3 gene related products
- Applied Biological Materials CRISPR for ACPP
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ACPP
- GenScript: Design CRISPR guide RNA sequences for ACPP
miRNA Products
- Search ViGene Biosciences for ACPP
Inhibitory RNA Products
- Origene RNAi and shrna products in human, mouse, rat for ACPP
- Browse OriGene Inhibitory RNA Products For ACPP
- genomics-online: shRNA clones - Search results for 163 available ACP3 gene related products
- Overview of 163 available ACP3 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for ACPP gene
Clone Products
- Sino Biological Human cDNA Clone for ACPP
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ACPP
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ACPP
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for ACPP
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | · | 10c | ^ | 11 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | |||||||||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||||||||||
SP3: | - | - | - | ||||||||||||||||||||||||||||||||
SP4: | |||||||||||||||||||||||||||||||||||
SP5: | - | - | - | ||||||||||||||||||||||||||||||||
SP6: |
Expression for ACPP Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Epithelial Cells
- Dental Placode Cells Dental Placode
- Podocytes Podocyte Layer
- Inner Cell Mass (Early Embryonic Tissues)
-
Tooth (Integumentary System)
- Dental Placode Cells Dental Placode
-
Limb (Muscoskeletal System)
- Apical Ectodermal Ridge Cells Limb Ectoderm
-
Ectoderm (Gastrulation Derivatives)
- Apical Ectodermal Ridge Cells Limb Ectoderm
-
Kidney (Urinary System)
- Podocytes Podocyte Layer
mRNA differential expression in normal tissues according to GTEx for ACPP Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ACPP Gene
NURSA nuclear receptor signaling pathways regulating expression of ACPP Gene:
ACPPSOURCE GeneReport for Unigene cluster for ACPP Gene:
Hs.433060mRNA Expression by UniProt/SwissProt for ACPP Gene:
P15309-PPAP_HUMANEvidence on tissue expression from TISSUES for ACPP Gene
- Kidney(2.2)
- Blood(2.1)
Primer Products
-
OriGene qPCR primer pairs for ACPP
-
OriGene qPCR primer pairs and template standards for ACPP
- genomics-online: primer clones - Search results for 163 available ACP3 gene related products
- Overview of 163 available ACP3 gene related products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ACPP Gene
Orthologs for ACPP Gene
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | ACPP 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | ACPP 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | ACPP 33 34 |
|
||
mouse (Mus musculus) |
Mammalia | Acpp 33 16 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Acpp 33 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | ACPP 34 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | ACPP 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | ACPP 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | ACPP 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | acpp 33 |
|
||
fruit fly (Drosophila melanogaster) |
Insecta | Acph-1 35 34 |
|
||
CG9449 35 34 |
|
||||
CG9452 35 34 |
|
||||
CG9451 35 34 |
|
||||
CG6656 35 34 |
|
||||
worm (Caenorhabditis elegans) |
Secernentea | pho-6 33 |
|
||
F52E1.8 35 |
|
|
|||
T13B5.3 35 |
|
|
|||
pho-1 35 34 |
|
||||
T21B6.2 35 |
|
|
|||
pho-14 34 |
|
ManyToMany | |||
R13H4.3 35 |
|
|
|||
pho-5 34 |
|
ManyToMany | |||
pho-10 34 |
|
ManyToMany | |||
pho-12 34 |
|
ManyToMany | |||
F26C11.1 34 |
|
ManyToMany | |||
C27A2.12 34 |
|
ManyToMany | |||
pho-11 34 |
|
ManyToMany | |||
pho-13 34 |
|
ManyToMany | |||
pho-4 34 |
|
ManyToMany | |||
acp-1 34 |
|
ManyToMany | |||
acp-3 34 |
|
ManyToMany | |||
acp-5 34 |
|
ManyToMany | |||
acp-2 34 |
|
ManyToMany | |||
acp-4 34 |
|
ManyToMany | |||
sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany | |
sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.11668 33 |
|
- Species where no ortholog for ACPP was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- zebrafish (Danio rerio)
Paralogs for ACPP Gene
(2) SIMAP similar genes for ACPP Gene using alignment to 5 proteins:
Variants for ACPP Gene
SNP ID | Clin | Chr 03 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs864309497 | uncertain-significance, Acute megakaryoblastic leukemia, Mediastinal germ cell tumor | 132,349,986(+) | TCATCAT/TCAT | coding_sequence_variant, inframe_deletion | |
rs1000006397 | -- | 132,348,241(+) | G/T | intron_variant | |
rs1000084793 | -- | 132,347,190(+) | C/T | intron_variant | |
rs1000124506 | -- | 132,361,432(+) | G/A | genic_downstream_transcript_variant, intron_variant | |
rs1000144114 | -- | 132,357,053(+) | C/T | 3_prime_UTR_variant, intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2762346 | CNV | loss | 21179565 |
esv3597825 | CNV | loss | 21293372 |
nsv478509 | CNV | novel sequence insertion | 20440878 |
nsv508245 | CNV | deletion | 20534489 |
nsv829728 | CNV | gain | 17160897 |
Additional Variant Information for ACPP Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ACPP
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACPP Gene
Disorders for ACPP Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
prostate cancer |
|
|
nephrogenic adenoma of the urethra |
|
|
phosphatase, acid, of tissues |
|
|
bladder neck obstruction |
|
|
Additional Disease Information for ACPP
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for ACPP Gene
Publications for ACPP Gene
- Structural origins of L(+)-tartrate inhibition of human prostatic acid phosphatase. (PMID: 9804805) LaCount MW … Lebioda L (The Journal of biological chemistry 1998) 3 4 22 58
- Structure of human prostatic acid phosphatase gene. (PMID: 1375464) Sharief FS … Li SS (Biochemical and biophysical research communications 1992) 2 3 4 58
- Molecular cloning and sequence analysis of cDNA encoding human prostatic acid phosphatase. (PMID: 2842184) Vihko P … Huhtala ML (FEBS letters 1988) 2 3 4 58
- Prostatic acid phosphatase expression in human tissues. (PMID: 21487525) Graddis TJ … Trager JB (International journal of clinical and experimental pathology 2011) 3 4 58
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
Products for ACPP Gene
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- antibodies-online: Search results for 24 available CD73 Proteins ranked by validation data
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- GeneTex ACPP antibody for ACPP
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- genomics-online: cdna clones - Search results for 163 available CD73 gene related products
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- Overview of 163 available CD73 gene related products
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- Overview of 163 available CD73 gene related products
Sources for ACPP Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
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- (14) ProtoNet
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- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
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- (84) Vector BioLabs
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