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Aliases for ACPP Gene

Aliases for ACPP Gene

  • Acid Phosphatase, Prostate 2 3
  • Thiamine Monophosphatase 3 4
  • Ecto-5-Nucleotidase 3 4
  • 5-Nucleotidase 3 4
  • EC 3.1.3.2 4 63
  • TMPase 3 4
  • 5-NT 3 4
  • Prostatic Acid Phosphatase 2
  • Prostatic Acid Phosphotase 3
  • EC 3.1.3.5 4
  • ACP-3 3
  • ACP3 3
  • PAP 4

External Ids for ACPP Gene

Previous GeneCards Identifiers for ACPP Gene

  • GC03P128977
  • GC03P132781
  • GC03P133317
  • GC03P133357
  • GC03P133518
  • GC03P132036
  • GC03P129415

Summaries for ACPP Gene

Entrez Gene Summary for ACPP Gene

  • This gene encodes an enzyme that catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is synthesized under androgen regulation and is secreted by the epithelial cells of the prostate gland. An alternatively spliced transcript variant encoding a longer isoform has been found for this gene. This isoform contains a transmembrane domain and is localized in the plasma membrane-endosomal-lysosomal pathway. [provided by RefSeq, Sep 2008]

GeneCards Summary for ACPP Gene

ACPP (Acid Phosphatase, Prostate) is a Protein Coding gene. Diseases associated with ACPP include nephrogenic adenoma of the urethra and lysosomal acid phosphatase deficiency. Among its related pathways are Pyrimidine metabolism (KEGG). GO annotations related to this gene include protein homodimerization activity and phosphatase activity. An important paralog of this gene is ACPT.

UniProtKB/Swiss-Prot for ACPP Gene

  • A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma

  • Isoform 2: the cellular form also has ecto-5-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor. Acts as a tumor suppressor of prostate cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling

Gene Wiki entry for ACPP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACPP Gene

Genomics for ACPP Gene

Regulatory Elements for ACPP Gene

Genomic Location for ACPP Gene

Chromosome:
3
Start:
132,317,367 bp from pter
End:
132,368,302 bp from pter
Size:
50,936 bases
Orientation:
Plus strand

Genomic View for ACPP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ACPP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACPP Gene

Proteins for ACPP Gene

  • Protein details for ACPP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15309-PPAP_HUMAN
    Recommended name:
    Prostatic acid phosphatase
    Protein Accession:
    P15309
    Secondary Accessions:
    • D3DNC6
    • Q5FBY0
    • Q96KY0
    • Q96QK9
    • Q96QM0

    Protein attributes for ACPP Gene

    Size:
    386 amino acids
    Molecular mass:
    44566 Da
    Quaternary structure:
    • Homodimer; dimer formation is required for phosphatase activity.
    Miscellaneous:
    • Used as a diagnostic tool for staging metastatic prostatic cancer

    Three dimensional structures from OCA and Proteopedia for ACPP Gene

    Alternative splice isoforms for ACPP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ACPP Gene

Proteomics data for ACPP Gene at MOPED

Selected DME Specific Peptides for ACPP Gene

Post-translational modifications for ACPP Gene

  • N-glycosylated. High mannose content, partially sialylated and fucosylated biantennary complex. Also fucosylated with partially sialylated triantennary complex oligosaccharides.
  • Proteolytically cleaved in seminal fluid to produce several peptides. Peptide PAPf39, the most prominent, forms amyloid beta-sheet fibrils, SEVI (semen-derived enhancer of viral infection) which entrap HIV virions, attach them to target cells and enhance infection. SEVI amyloid fibrils are degraded by polyphenol epigallocatechin-3-gallate (EGCG), a constituent of green tea. Target cell attachment and enhancement of HIV infection is inhibited by surfen. Also similarly boosts XMRV (xenotropic murine leukemia virus-related virus) infection.
  • Glycosylation at Asn 94, Asn 220, and Asn 333
  • Modification sites at PhosphoSitePlus

Other Protein References for ACPP Gene

Antibody Products

  • R&D Systems Antibodies for ACPP (Prostatic Acid Phosphatase/ACPP)
  • Cell Signaling Technology (CST) Antibodies for ACPP (ACPP)

Protein Products

Domains & Families for ACPP Gene

Gene Families for ACPP Gene

Protein Domains for ACPP Gene

Graphical View of Domain Structure for InterPro Entry

P15309

UniProtKB/Swiss-Prot:

PPAP_HUMAN :
  • Belongs to the histidine acid phosphatase family.
Family:
  • Belongs to the histidine acid phosphatase family.
genes like me logo Genes that share domains with ACPP: view

Function for ACPP Gene

Molecular function for ACPP Gene

GENATLAS Biochemistry:
phosphatase acid,prostate
UniProtKB/Swiss-Prot CatalyticActivity:
A phosphate monoester + H(2)O = an alcohol + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
A 5-ribonucleotide + H(2)O = a ribonucleoside + phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Phosphatase activity inhibited by L(+)-tartrate, and by its derivative, alpha-benzylaminobenzylphosphonic acid.
UniProtKB/Swiss-Prot Function:
A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma
UniProtKB/Swiss-Prot Function:
Isoform 2: the cellular form also has ecto-5-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor. Acts as a tumor suppressor of prostate cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling

Enzyme Numbers (IUBMB) for ACPP Gene

Gene Ontology (GO) - Molecular Function for ACPP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003993 acid phosphatase activity IMP 8132635
GO:0008253 5-nucleotidase activity IDA 18940592
GO:0016791 phosphatase activity IMP 18940592
GO:0042131 thiamine phosphate phosphatase activity ISS --
GO:0042802 identical protein binding IPI 18083097
genes like me logo Genes that share ontologies with ACPP: view
genes like me logo Genes that share phenotypes with ACPP: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ACPP

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for ACPP Gene

Localization for ACPP Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACPP Gene

Isoform 1: Secreted.
Isoform 2: Cell membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=Appears to shuttle between the cell membrane and intracellular vesicles. Colocalizes with FLOT1 at cell membrane and in intracellular vesicles. Colocalizes with LAMP2 on the lysosome membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACPP Gene COMPARTMENTS Subcellular localization image for ACPP gene
Compartment Confidence
extracellular 5
lysosome 5
nucleus 5
plasma membrane 5
vacuole 5
cytoskeleton 1
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ACPP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IMP 22389722
GO:0005622 intracellular IDA 17658863
GO:0005634 nucleus IDA 21630459
GO:0005765 lysosomal membrane IDA 17897319
GO:0005886 plasma membrane IDA 17658863
genes like me logo Genes that share ontologies with ACPP: view

Pathways & Interactions for ACPP Gene

SuperPathways for ACPP Gene

Superpath Contained pathways
1 Pyrimidine metabolism (KEGG)
genes like me logo Genes that share pathways with ACPP: view

Pathways by source for ACPP Gene

1 GeneGo (Thomson Reuters) pathway for ACPP Gene

Gene Ontology (GO) - Biological Process for ACPP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006144 purine nucleobase metabolic process IEA --
GO:0006470 protein dephosphorylation --
GO:0006772 thiamine metabolic process ISS --
GO:0009117 nucleotide metabolic process IEA --
GO:0016311 dephosphorylation IMP 8132635
genes like me logo Genes that share ontologies with ACPP: view

No data available for SIGNOR curated interactions for ACPP Gene

Drugs & Compounds for ACPP Gene

(41) Drugs for ACPP Gene - From: NovoSeek, DGIdb, HMDB, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Riboflavin Approved Nutra 138
Bicalutamide Approved Pharma Androgen receptor antagonist, Non-steroidal androgen receptor antagonist 158
Buserelin Approved Pharma Full agonist, Agonist 30
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Platinum, Potent pro-apoptotic anticancer agent; activates caspase-3 2437
Diethylstilbestrol Approved Pharma Antagonist 5

(35) Additional Compounds for ACPP Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
D-Mannose
  • (+)-mannose
  • (+-)-mannose
  • Carubinose
  • D(+)-Mannose
  • D-Mannopyranose
3458-28-4
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Tartaric acid
  • (+)-(2R,3R)-Tartaric acid
  • (+)-tartarate
  • (+)-tartaric acid
  • (1R,2R)-1,2-Dihydroxyethane-1,2-dicarboxylic acid
  • (2R,3R)-2,3-dihydroxybutanedioate
87-69-4
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with ACPP: view

Transcripts for ACPP Gene

Unigene Clusters for ACPP Gene

Acid phosphatase, prostate:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ACPP

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACPP Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11
SP1: - - - -
SP2: - -
SP3: - - -
SP4:
SP5: - - -
SP6:

Relevant External Links for ACPP Gene

GeneLoc Exon Structure for
ACPP
ECgene alternative splicing isoforms for
ACPP

Expression for ACPP Gene

mRNA expression in normal human tissues for ACPP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ACPP Gene

This gene is overexpressed in Prostate (x47.6).

Protein differential expression in normal tissues from HIPED for ACPP Gene

This gene is overexpressed in Urine (28.4), Prostate (20.6), and Seminal vesicle (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ACPP Gene



SOURCE GeneReport for Unigene cluster for ACPP Gene Hs.433060

mRNA Expression by UniProt/SwissProt for ACPP Gene

P15309-PPAP_HUMAN
Tissue specificity: Highly expressed in the prostate, restricted to glandular and ductal epithelial cells. Also expressed in bladder, kidney, pancreas, lung, cervix, testis and ovary. Weak expression in a subset of pancreatic islet cells, squamous epithelia, the pilosebaceous unit, colonic neuroendocrine cells and skin adnexal structures. Isoform 2 also expressed in the sarcolemma of skeletal muscle. Levels of this cellular isoform decreased in prostate cancer.
genes like me logo Genes that share expression patterns with ACPP: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for ACPP Gene

Orthologs for ACPP Gene

This gene was present in the common ancestor of animals.

Orthologs for ACPP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ACPP 35
  • 85.07 (n)
  • 79.95 (a)
ACPP 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ACPP 35
  • 84.61 (n)
  • 80.62 (a)
ACPP 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Acpp 35
  • 82.86 (n)
  • 80.62 (a)
Acpp 16
Acpp 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ACPP 35
  • 99.44 (n)
  • 99.04 (a)
ACPP 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Acpp 35
  • 82 (n)
  • 80.1 (a)
oppossum
(Monodelphis domestica)
Mammalia ACPP 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ACPP 36
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves ACPP 35
  • 61.21 (n)
  • 55.06 (a)
ACPP 36
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ACPP 36
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia acpp 35
  • 58.03 (n)
  • 52.07 (a)
fruit fly
(Drosophila melanogaster)
Insecta Acph-1 37
  • 37 (a)
CG6656 37
  • 29 (a)
CG9449 37
  • 36 (a)
CG9451 37
  • 32 (a)
CG9452 37
  • 33 (a)
Acph-1 36
  • 32 (a)
ManyToMany
CG6656 36
  • 26 (a)
ManyToMany
CG9449 36
  • 30 (a)
ManyToMany
CG9451 36
  • 29 (a)
ManyToMany
CG9452 36
  • 27 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea F52E1.8 37
  • 32 (a)
pho-1 37
  • 31 (a)
R13H4.3 37
  • 29 (a)
T13B5.3 37
  • 32 (a)
T21B6.2 37
  • 31 (a)
pho-6 35
  • 43.24 (n)
  • 33.13 (a)
acp-1 36
  • 21 (a)
ManyToMany
acp-2 36
  • 20 (a)
ManyToMany
acp-3 36
  • 21 (a)
ManyToMany
acp-4 36
  • 18 (a)
ManyToMany
acp-5 36
  • 21 (a)
ManyToMany
C27A2.12 36
  • 23 (a)
ManyToMany
F26C11.1 36
  • 24 (a)
ManyToMany
pho-1 36
  • 24 (a)
ManyToMany
pho-10 36
  • 25 (a)
ManyToMany
pho-11 36
  • 23 (a)
ManyToMany
pho-12 36
  • 25 (a)
ManyToMany
pho-13 36
  • 22 (a)
ManyToMany
pho-14 36
  • 30 (a)
ManyToMany
pho-4 36
  • 22 (a)
ManyToMany
pho-5 36
  • 28 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11668 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToMany
Species with no ortholog for ACPP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ACPP Gene

ENSEMBL:
Gene Tree for ACPP (if available)
TreeFam:
Gene Tree for ACPP (if available)

Paralogs for ACPP Gene

Paralogs for ACPP Gene

(2) SIMAP similar genes for ACPP Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ACPP: view

Variants for ACPP Gene

Sequence variations from dbSNP and Humsavar for ACPP Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs10115 -- 132,358,285(+) TAATT(A/G)TGTTC utr-variant-3-prime, intron-variant
rs12817 -- 132,358,477(+) TGGCA(G/T)ATCTA utr-variant-3-prime, intron-variant
rs13131 -- 132,358,448(+) AGAAG(A/G)AATCA utr-variant-3-prime, intron-variant
rs14192 -- 132,357,707(+) TTCTC(C/T)AGAAG utr-variant-3-prime, intron-variant
rs15096 -- 132,358,726(+) TGTAA(A/G)ATAGT utr-variant-3-prime, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACPP Gene

Variant ID Type Subtype PubMed ID
nsv508245 CNV Loss 20534489
nsv829728 CNV Gain 17160897

Variation tolerance for ACPP Gene

Residual Variation Intolerance Score: 21.35% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.68; 32.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ACPP Gene

HapMap Linkage Disequilibrium report
ACPP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACPP Gene

Disorders for ACPP Gene

MalaCards: The human disease database

(4) MalaCards diseases for ACPP Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
nephrogenic adenoma of the urethra
  • nephrogenic adenoma of urethra
lysosomal acid phosphatase deficiency
  • lysosomal acid phosphatase
bladder neck obstruction
  • obstruction of bladder neck
prostate cancer
  • prostate cancer, hereditary, 5
- elite association
Search ACPP in MalaCards View complete list of genes associated with diseases

Relevant External Links for ACPP

Genetic Association Database (GAD)
ACPP
Human Genome Epidemiology (HuGE) Navigator
ACPP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ACPP
genes like me logo Genes that share disorders with ACPP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ACPP Gene

Publications for ACPP Gene

  1. Analysis of the molecular networks in androgen dependent and independent prostate cancer revealed fragile and robust subsystems. (PMID: 20126616) Tasseff R. … Varner J.D. (PLoS ONE 2010) 23 67
  2. Glycomic characterization of prostate-specific antigen and prostatic acid phosphatase in prostate cancer and benign disease seminal plasma fluids. (PMID: 19128049) White K.Y. … Drake R.R. (J. Proteome Res. 2009) 23 67
  3. Safety and immunological efficacy of a DNA vaccine encoding prostatic acid phosphatase in patients with stage D0 prostate cancer. (PMID: 19636017) McNeel D.G. … Wilding G. (J. Clin. Oncol. 2009) 23 67
  4. Does female ejaculation serve an antimicrobial purpose? (PMID: 19766406) Moalem S. … Reidenberg J.S. (Med. Hypotheses 2009) 23 67
  5. Gene expression profiles of lysophosphatidic acid-related molecules in the prostate: relevance to prostate cancer and benign hyperplasia. (PMID: 19025891) Zeng Y. … Wu X.X. (Prostate 2009) 23 67

Products for ACPP Gene

Sources for ACPP Gene

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