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Aliases for C1orf109 Gene

Aliases for C1orf109 Gene

  • Chromosome 1 Open Reading Frame 109 2 3 5

External Ids for C1orf109 Gene

Previous GeneCards Identifiers for C1orf109 Gene

  • GC01M037817
  • GC01M037919
  • GC01M038147
  • GC01M036264

Summaries for C1orf109 Gene

GeneCards Summary for C1orf109 Gene

C1orf109 (Chromosome 1 Open Reading Frame 109) is a Protein Coding gene.

Additional gene information for C1orf109 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1orf109 Gene

Genomics for C1orf109 Gene

Regulatory Elements for C1orf109 Gene

Enhancers for C1orf109 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H037988 1.2 ENCODE 96.8 -297.5 -297452 2 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A ZFP41 SF3A3 C1orf109 INPP5B GNL2 FHL3 MYCBP FTH1P1 RSPO1 RRAGC YRDC
GH01H038008 1.7 Ensembl ENCODE dbSUPER 35.8 -320.6 -320574 9 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC MEF2D ZNF610 SF3A3 C1orf109 INPP5B SNIP1 RNU6-510P RSPO1 ENSG00000230955 MTF1 YRDC C1orf122
GH01H037552 1.1 ENCODE 51.4 +138.5 138463 2 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 CBX5 SNIP1 C1orf109 SF3A3 GNL2 FTH1P1 YRDC INPP5B CDCA8 ZC3H12A RSPO1
GH01H037688 1.2 ENCODE 31.4 +1.2 1214 4 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B EPHA10 C1orf109 SF3A3 GNL2 FTH1P1 RSPO1 YRDC DNALI1 GC01P037645
GH01H037930 1 ENCODE 28.6 -239.4 -239380 3 HDGF PKNOX1 ATF1 ZFP64 ARID4B SIN3A YY1 TCF12 GLIS2 ZNF143 SF3A3 SNIP1 C1orf109 GNL2 FHL3 UTP11 LOC105378651 RNU6-584P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C1orf109 on UCSC Golden Path with GeneCards custom track

Promoters for C1orf109 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000004880 -164 1801 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B

Genomic Location for C1orf109 Gene

Chromosome:
1
Start:
37,681,570 bp from pter
End:
37,692,336 bp from pter
Size:
10,767 bases
Orientation:
Minus strand

Genomic View for C1orf109 Gene

Genes around C1orf109 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1orf109 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1orf109 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1orf109 Gene

Proteins for C1orf109 Gene

  • Protein details for C1orf109 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NX04-CA109_HUMAN
    Recommended name:
    Uncharacterized protein C1orf109
    Protein Accession:
    Q9NX04
    Secondary Accessions:
    • D3DPT1
    • Q8WVD1

    Protein attributes for C1orf109 Gene

    Size:
    203 amino acids
    Molecular mass:
    23373 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C1orf109 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C1orf109 Gene

Post-translational modifications for C1orf109 Gene

  • Ubiquitination at Lys76
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for C1orf109 Gene

Domains & Families for C1orf109 Gene

Gene Families for C1orf109 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C1orf109 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C1orf109: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C1orf109 Gene

Function for C1orf109 Gene

Phenotypes From GWAS Catalog for C1orf109 Gene

Gene Ontology (GO) - Molecular Function for C1orf109 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with C1orf109: view
genes like me logo Genes that share phenotypes with C1orf109: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C1orf109 Gene

Localization for C1orf109 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C1orf109 gene
Compartment Confidence
nucleus 2
cytosol 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for C1orf109 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 22548824
GO:0005737 cytoplasm IDA 22548824
genes like me logo Genes that share ontologies with C1orf109: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for C1orf109 Gene

Pathways & Interactions for C1orf109 Gene

SuperPathways for C1orf109 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C1orf109 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C1orf109 Gene

Drugs & Compounds for C1orf109 Gene

No Compound Related Data Available

Transcripts for C1orf109 Gene

Unigene Clusters for C1orf109 Gene

Chromosome 1 open reading frame 109:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for C1orf109 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b · 7c ^ 8a · 8b ·
SP1: - - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - -
SP4: - - -
SP5: - - - - - - - - - - - -
SP6: - -
SP7: - - - - - - - -
SP8: - - - - - - - -
SP9: - - - - - - -
SP10: - - - - - - - - - -
SP11: - - - - - - - - - -
SP12: - - - - - -
SP13: - -
SP14: -
SP15:
SP16: - -
SP17: -

ExUns: 8c ^ 9a · 9b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for C1orf109 Gene

GeneLoc Exon Structure for
C1orf109
ECgene alternative splicing isoforms for
C1orf109

Expression for C1orf109 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C1orf109 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for C1orf109 Gene

This gene is overexpressed in Fetal ovary (24.5) and Plasma (18.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C1orf109 Gene



Protein tissue co-expression partners for C1orf109 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C1orf109 Gene:

C1orf109

SOURCE GeneReport for Unigene cluster for C1orf109 Gene:

Hs.272673

Evidence on tissue expression from TISSUES for C1orf109 Gene

  • Nervous system(3.3)
genes like me logo Genes that share expression patterns with C1orf109: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C1orf109 Gene

Orthologs for C1orf109 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C1orf109 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C1orf109 34
  • 99 (a)
OneToOne
C1H1orf109 33
  • 98.85 (n)
cow
(Bos Taurus)
Mammalia C3H1orf109 33
  • 87.85 (n)
MGC166151 34
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C15H1orf109 33
  • 83.42 (n)
C1orf109 34
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 9930104L06Rik 33 16
  • 80.95 (n)
rat
(Rattus norvegicus)
Mammalia RGD1560436 33
  • 80.62 (n)
oppossum
(Monodelphis domestica)
Mammalia C1orf109 34
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C1orf109 34
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves C1ORF109 33
  • 54.02 (n)
C1orf109 34
  • 37 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C1orf109 34
  • 43 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c1orf109 33
  • 55.72 (n)
zebrafish
(Danio rerio)
Actinopterygii c1orf109 33
  • 49.74 (n)
C19H1orf109 34
  • 37 (a)
OneToOne
Species where no ortholog for C1orf109 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C1orf109 Gene

ENSEMBL:
Gene Tree for C1orf109 (if available)
TreeFam:
Gene Tree for C1orf109 (if available)

Paralogs for C1orf109 Gene

No data available for Paralogs for C1orf109 Gene

Variants for C1orf109 Gene

Sequence variations from dbSNP and Humsavar for C1orf109 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000159373 -- 37,687,826(+) CCTTA(C/G)CCTCT intron-variant
rs1000316293 -- 37,688,188(+) TTTAG(C/T)TGGGA intron-variant
rs1000468782 -- 37,691,486(+) GCCGT(C/T)CAGTC intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000496392 -- 37,686,764(+) GGTAC(A/G)GGTGG intron-variant
rs1000823175 -- 37,691,036(+) GGGTT(C/G)TCATC intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for C1orf109 Gene

Variant ID Type Subtype PubMed ID
nsv819737 CNV loss 19587683
nsv834746 CNV loss 17160897

Variation tolerance for C1orf109 Gene

Residual Variation Intolerance Score: 59.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.99; 20.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C1orf109 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C1orf109

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1orf109 Gene

Disorders for C1orf109 Gene

Relevant External Links for C1orf109

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C1orf109

No disorders were found for C1orf109 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1orf109 Gene

Publications for C1orf109 Gene

  1. Identification and characterization of a novel gene, c1orf109, encoding a CK2 substrate that is involved in cancer cell proliferation. (PMID: 22548824) Liu SS … Li Y (Journal of biomedical science 2012) 2 3 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) Kırlı K … Görlich D (eLife 2015) 3 60

Products for C1orf109 Gene

Sources for C1orf109 Gene

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