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Aliases for PPM1B Gene

Aliases for PPM1B Gene

  • Protein Phosphatase, Mg2+/Mn2+ Dependent, 1B 2 3
  • Protein Phosphatase 1B (Formerly 2C), Magnesium-Dependent, Beta Isoform 2 3
  • EC 3.1.3.16 4 63
  • PP2C-Beta 3 4
  • PP2CB 3 4
  • Ser/Thr Protein Phosphatase Type 2C Beta 2 Isoform 3
  • Protein Phosphatase 2C-Like Protein 3
  • Protein Phosphatase 2C Isoform Beta 4
  • Protein Phosphatase 2C 2
  • Protein Phosphatase 1B 3
  • Beta Isoform 2
  • PP2C-Beta-X 3
  • PPC2BETAX 3
  • PP2CBETA 3

External Ids for PPM1B Gene

Previous GeneCards Identifiers for PPM1B Gene

  • GC02P044394
  • GC02P044564
  • GC02P044370
  • GC02P044307
  • GC02P044395

Summaries for PPM1B Gene

Entrez Gene Summary for PPM1B Gene

  • The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPM1B Gene

PPM1B (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1B) is a Protein Coding gene. Diseases associated with PPM1B include 2p21 microdeletion syndrome and cystinuria. Among its related pathways are MAPK signaling pathway and MAPK signaling pathway. GO annotations related to this gene include magnesium ion binding and manganese ion binding. An important paralog of this gene is PPM1A.

UniProtKB/Swiss-Prot for PPM1B Gene

  • Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at Ser-172. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.

Gene Wiki entry for PPM1B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPM1B Gene

Genomics for PPM1B Gene

Regulatory Elements for PPM1B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PPM1B Gene

Start:
44,167,969 bp from pter
End:
44,244,384 bp from pter
Size:
76,416 bases
Orientation:
Plus strand

Genomic View for PPM1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPM1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPM1B Gene

Proteins for PPM1B Gene

  • Protein details for PPM1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75688-PPM1B_HUMAN
    Recommended name:
    Protein phosphatase 1B
    Protein Accession:
    O75688
    Secondary Accessions:
    • Q461Q2
    • Q4J6C1
    • Q4J6C2
    • Q658R4
    • Q96ER6
    • Q9HAY8

    Protein attributes for PPM1B Gene

    Size:
    479 amino acids
    Molecular mass:
    52643 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Binds 2 magnesium or manganese ions per subunit.;
    Quaternary structure:
    • Monomer (By similarity). Interacts with PAK6. Interacts with the phosphorylated form of IKBKB/IKKB.

    Three dimensional structures from OCA and Proteopedia for PPM1B Gene

    Alternative splice isoforms for PPM1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPM1B Gene

Proteomics data for PPM1B Gene at MOPED

Post-translational modifications for PPM1B Gene

  • Isgylation negatively regulates its activity.
  • N-myristoylation is essential for the recognition of its substrates for dephosphorylation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPM1B Gene

Antibody Products

  • R&D Systems Antibodies for PPM1B (PP2C beta/PPM1B)

Domains for PPM1B Gene

Gene Families for PPM1B Gene

HGNC:
  • PPM :Serine/threonine phosphatases / Protein phosphatases, Mg2+/Mn2+ dependent

Protein Domains for PPM1B Gene

Suggested Antigen Peptide Sequences for PPM1B Gene

Graphical View of Domain Structure for InterPro Entry

O75688

UniProtKB/Swiss-Prot:

PPM1B_HUMAN :
  • O75688
Domain:
  • Contains 1 PPM-type phosphatase domain.
Family:
  • Belongs to the PP2C family.
genes like me logo Genes that share domains with PPM1B: view

Function for PPM1B Gene

Molecular function for PPM1B Gene

UniProtKB/Swiss-Prot CatalyticActivity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
UniProtKB/Swiss-Prot Function: Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at Ser-172. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.

Enzyme Numbers (IUBMB) for PPM1B Gene

Gene Ontology (GO) - Molecular Function for PPM1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0003824 catalytic activity --
GO:0004721 phosphoprotein phosphatase activity --
GO:0004722 protein serine/threonine phosphatase activity IDA 20801214
GO:0005515 protein binding IPI 16872604
genes like me logo Genes that share ontologies with PPM1B: view
genes like me logo Genes that share phenotypes with PPM1B: view

Animal Models for PPM1B Gene

MGI Knock Outs for PPM1B:

Animal Model Products

CRISPR Products

miRNA for PPM1B Gene

miRTarBase miRNAs that target PPM1B

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPM1B

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for PPM1B Gene

Localization for PPM1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPM1B Gene

Cytoplasm, cytosol. Membrane. Note=Weakly associates at the membrane and N-myristoylation mediates the membrane localization. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPM1B Gene COMPARTMENTS Subcellular localization image for PPM1B gene
Compartment Confidence
cytosol 4
nucleus 2

Gene Ontology (GO) - Cellular Components for PPM1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0016020 membrane ISS --
genes like me logo Genes that share ontologies with PPM1B: view

Pathways for PPM1B Gene

genes like me logo Genes that share pathways with PPM1B: view

Pathways by source for PPM1B Gene

1 KEGG pathway for PPM1B Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for PPM1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IMP 18930133
GO:0006499 N-terminal protein myristoylation ISS --
GO:0019221 cytokine-mediated signaling pathway TAS --
GO:0032688 negative regulation of interferon-beta production IMP 22750291
GO:0035970 peptidyl-threonine dephosphorylation IDA 20801214
genes like me logo Genes that share ontologies with PPM1B: view

Compounds for PPM1B Gene

(5) HMDB Compounds for PPM1B Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Magnesium
  • Magnesium
7439-95-4
Manganese
  • manganese
7439-96-5
Phosphate
  • NFB Orthophosphate
14265-44-2
Water
  • Dihydrogen oxide
7732-18-5

(2) Novoseek inferred chemical compound relationships for PPM1B Gene

Compound -log(P) Hits PubMed IDs
threonine 54.7 1
serine 36 1
genes like me logo Genes that share compounds with PPM1B: view

Transcripts for PPM1B Gene

Unigene Clusters for PPM1B Gene

Protein phosphatase, Mg2+/Mn2+ dependent, 1B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPM1B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPM1B Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b
SP1: -
SP2: - -
SP3: - - - - -
SP4: - - - -
SP5: - - - - -
SP6: - - -
SP7:

Relevant External Links for PPM1B Gene

GeneLoc Exon Structure for
PPM1B
ECgene alternative splicing isoforms for
PPM1B

Expression for PPM1B Gene

mRNA expression in normal human tissues for PPM1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PPM1B Gene

This gene is overexpressed in Muscle - Skeletal (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPM1B Gene

SOURCE GeneReport for Unigene cluster for PPM1B Gene Hs.416769

mRNA Expression by UniProt/SwissProt for PPM1B Gene

O75688-PPM1B_HUMAN
Tissue specificity: Highly expressed in heart and skeletal muscle
genes like me logo Genes that share expressions with PPM1B: view

In Situ Assay Products

Orthologs for PPM1B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PPM1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPM1B 35
  • 99.93 (n)
  • 100 (a)
PPM1B 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PPM1B 35
  • 94.81 (n)
  • 96.36 (a)
PPM1B 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPM1B 35
  • 96.73 (n)
  • 97.29 (a)
PPM1B 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppm1b 35
  • 90.01 (n)
  • 91.82 (a)
Ppm1b 16
Ppm1b 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPM1B 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPM1B 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppm1b 35
  • 91.07 (n)
  • 93.74 (a)
chicken
(Gallus gallus)
Aves PPM1B 35
  • 88.05 (n)
  • 94.29 (a)
PPM1B 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPM1B 36
  • 93 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.10032 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ppm1b 35
  • 79.65 (n)
  • 88.05 (a)
Str.3223 35
zebrafish
(Danio rerio)
Actinopterygii ppm1ba 35
  • 72.31 (n)
  • 77.34 (a)
ppm1ba 36
  • 76 (a)
OneToMany
ppm1bb 36
  • 83 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008149 35
  • 55.84 (n)
  • 59.1 (a)
fruit fly
(Drosophila melanogaster)
Insecta alph 35
  • 54.3 (n)
  • 54.95 (a)
alph 36
  • 52 (a)
ManyToMany
CG17746 36
  • 35 (a)
ManyToMany
CG6036 36
  • 49 (a)
ManyToMany
Ppm1 36
  • 38 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ppm-1 35
  • 57.66 (n)
  • 56.08 (a)
ppm-1 36
  • 38 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PTC2 36
  • 25 (a)
ManyToMany
PTC3 36
  • 26 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3033 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 53 (a)
OneToMany
Species with no ortholog for PPM1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPM1B Gene

ENSEMBL:
Gene Tree for PPM1B (if available)
TreeFam:
Gene Tree for PPM1B (if available)

Paralogs for PPM1B Gene

Paralogs for PPM1B Gene

Selected SIMAP similar genes for PPM1B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PPM1B: view

Variants for PPM1B Gene

Sequence variations from dbSNP and Humsavar for PPM1B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs920519 -- 44,225,205(+) CTTCC(C/T)TAGAT intron-variant
rs920520 -- 44,225,251(+) TTACT(C/T)TAAAA intron-variant
rs1139306 -- 44,223,581(+) gaggc(A/G)ggagg intron-variant
rs1551315 -- 44,180,479(-) ATTTA(C/T)TAAGT intron-variant
rs2053456 -- 44,221,493(+) TCGCC(A/G)GGAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPM1B Gene

Variant ID Type Subtype PubMed ID
esv2751893 CNV Loss 17911159
nsv833936 CNV Loss 17160897

Relevant External Links for PPM1B Gene

HapMap Linkage Disequilibrium report
PPM1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPM1B Gene

Disorders for PPM1B Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for PPM1B Gene including...

Search for PPM1B Gene in MalaCards »

(1) University of Copenhagen DISEASES for PPM1B Gene

Relevant External Links for PPM1B

Genetic Association Database (GAD)
PPM1B
Human Genome Epidemiology (HuGE) Navigator
PPM1B
genes like me logo Genes that share disorders with PPM1B: view

No data available for UniProtKB/Swiss-Prot for PPM1B Gene

Publications for PPM1B Gene

  1. The cloning expression and tissue distribution of human PP2Cbeta. (PMID: 9684878) Marely A.E. … Beri R.K. (FEBS Lett. 1998) 2 3 4 23
  2. Dephosphorylation of human cyclin-dependent kinases by protein phosphatase type 2Calpha and beta2 isoforms. (PMID: 10934208) Cheng A. … Solomon M.J. (J. Biol. Chem. 2000) 3 4 23
  3. Negative regulation of protein phosphatase 2Cbeta by ISG15 conjugation. (PMID: 16872604) Takeuchi T. … Yokosawa H. (FEBS Lett. 2006) 3 4 23
  4. Proteomic analysis of GTP cyclohydrolase 1 multiprotein complexes in cultured normal adult human astrocytes under both basal and cytokine-activated conditions. (PMID: 19294699) Chiarini A. … Dal Pra I. (Proteomics 2009) 3 23
  5. A recessive contiguous gene deletion of chromosome 2p16 associated with cystinuria and a mitochondrial disease. (PMID: 11524703) Parvari R. … Hershkovitz E. (Am. J. Hum. Genet. 2001) 3 23

Products for PPM1B Gene

Sources for PPM1B Gene

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