Aliases for PPM1B Gene
External Ids for PPM1B Gene
Previous GeneCards Identifiers for PPM1B Gene
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences. [provided by RefSeq, Jul 2008]
GeneCards Summary for PPM1B Gene
PPM1B (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1B) is a Protein Coding gene. Diseases associated with PPM1B include 2p21 microdeletion syndrome and cystinuria. Among its related pathways are MAPK signaling pathway and MAPK signaling pathway. GO annotations related to this gene include magnesium ion binding and manganese ion binding. An important paralog of this gene is PPM1A.
UniProtKB/Swiss-Prot for PPM1B Gene
Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at Ser-172. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.