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Aliases for SLC41A3 Gene

Aliases for SLC41A3 Gene

  • Solute Carrier Family 41, Member 3 2 3
  • SLC41A1-Like 2 3
  • SLC41A1-L2 3

External Ids for SLC41A3 Gene

Previous GeneCards Identifiers for SLC41A3 Gene

  • GC03M127046
  • GC03M127207
  • GC03M125725
  • GC03M123105

Summaries for SLC41A3 Gene

GeneCards Summary for SLC41A3 Gene

SLC41A3 (Solute Carrier Family 41, Member 3) is a Protein Coding gene. GO annotations related to this gene include cation transmembrane transporter activity. An important paralog of this gene is SLC41A2.

Gene Wiki entry for SLC41A3 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC41A3 Gene

Genomics for SLC41A3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC41A3 Gene

Chromosome:
3
Start:
126,006,355 bp from pter
End:
126,101,561 bp from pter
Size:
95,207 bases
Orientation:
Minus strand

Genomic View for SLC41A3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC41A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC41A3 Gene

No data available for Regulatory Elements for SLC41A3 Gene

Proteins for SLC41A3 Gene

  • Protein details for SLC41A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96GZ6-S41A3_HUMAN
    Recommended name:
    Solute carrier family 41 member 3
    Protein Accession:
    Q96GZ6
    Secondary Accessions:
    • A6ND60
    • B3KSD9
    • B7Z4Y2
    • C9JE96
    • E7ENY4
    • Q8N342
    • Q8NB27
    • Q9H9I6
    • Q9HAB1
    • Q9NX30

    Protein attributes for SLC41A3 Gene

    Size:
    507 amino acids
    Molecular mass:
    54767 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC41A3 Gene

neXtProt entry for SLC41A3 Gene

Proteomics data for SLC41A3 Gene at MOPED

Post-translational modifications for SLC41A3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC41A3 Gene

Domains & Families for SLC41A3 Gene

Gene Families for SLC41A3 Gene

Protein Domains for SLC41A3 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q96GZ6

UniProtKB/Swiss-Prot:

S41A3_HUMAN :
  • Belongs to the SLC41A transporter family.
Family:
  • Belongs to the SLC41A transporter family.
genes like me logo Genes that share domains with SLC41A3: view

Function for SLC41A3 Gene

Gene Ontology (GO) - Molecular Function for SLC41A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008324 cation transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC41A3: view
genes like me logo Genes that share phenotypes with SLC41A3: view

Animal Model Products

CRISPR Products

miRNA for SLC41A3 Gene

miRTarBase miRNAs that target SLC41A3

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC41A3 Gene

Localization for SLC41A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC41A3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC41A3 Gene COMPARTMENTS Subcellular localization image for SLC41A3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for SLC41A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC41A3: view

Pathways & Interactions for SLC41A3 Gene

SuperPathways for SLC41A3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLC41A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006812 cation transport --
GO:0055085 transmembrane transport IBA --
GO:0098655 cation transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC41A3: view

No data available for Pathways by source and SIGNOR curated interactions for SLC41A3 Gene

Drugs & Compounds for SLC41A3 Gene

No Compound Related Data Available

Transcripts for SLC41A3 Gene

Unigene Clusters for SLC41A3 Gene

Solute carrier family 41, member 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC41A3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC41A3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ·
SP1: - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - -
SP4: - - - - - - - - - -
SP5: - - -
SP6: - - - - - - - - - - - - -
SP7: - - - -
SP8: - - - - - -
SP9: - - - - - - - - - - - -
SP10: - - - - - - -
SP11: - - - - - - - - - -
SP12: - - - - - - - - - - - - - - -
SP13: - - - -
SP14: - - - - - - -
SP15: - - - - -
SP16: - - - - - - - - - - -
SP17: - - - - - - - - - -
SP18: - - - - -
SP19: - - -
SP20: - - - - - - - - - - - - -

ExUns: 14c · 14d · 14e ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
SP1:
SP2: - - - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:

Relevant External Links for SLC41A3 Gene

GeneLoc Exon Structure for
SLC41A3
ECgene alternative splicing isoforms for
SLC41A3

Expression for SLC41A3 Gene

mRNA expression in normal human tissues for SLC41A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC41A3 Gene

This gene is overexpressed in Nasal epithelium (36.4) and Frontal cortex (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC41A3 Gene



SOURCE GeneReport for Unigene cluster for SLC41A3 Gene Hs.573007

genes like me logo Genes that share expression patterns with SLC41A3: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SLC41A3 Gene

Orthologs for SLC41A3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC41A3 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia SLC41A3 35
  • 85.24 (n)
  • 86.07 (a)
SLC41A3 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc41a3 35
  • 79.88 (n)
  • 75.98 (a)
Slc41a3 16
Slc41a3 36
  • 73 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC41A3 35
  • 99.52 (n)
  • 99.79 (a)
SLC41A3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC41A3 36
  • 61 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC41A3 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC41A3 36
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC41A3 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC41A3 36
  • 55 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii BX294434.1 36
  • 54 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG33181 36
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea K07H8.2 36
  • 39 (a)
ManyToMany
ZK1053.6 36
  • 26 (a)
ManyToMany
ZK185.2 36
  • 35 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToMany
Species with no ortholog for SLC41A3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLC41A3 Gene

ENSEMBL:
Gene Tree for SLC41A3 (if available)
TreeFam:
Gene Tree for SLC41A3 (if available)

Paralogs for SLC41A3 Gene

Paralogs for SLC41A3 Gene

genes like me logo Genes that share paralogs with SLC41A3: view

Variants for SLC41A3 Gene

Sequence variations from dbSNP and Humsavar for SLC41A3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs13133 -- 126,006,613(+) CTTGG(G/T)AACAG intron-variant, utr-variant-3-prime
rs868149 -- 126,032,014(-) CACCA(G/T)GTGTA intron-variant
rs879385 -- 126,025,230(-) TTGCC(A/G)CACGT intron-variant
rs879386 -- 126,025,304(-) TCTGC(A/G)ACACA intron-variant
rs883207 -- 126,014,238(+) TATTC(G/T)GCTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC41A3 Gene

Variant ID Type Subtype PubMed ID
nsv829716 CNV Gain+Loss 17160897
esv267856 CNV Insertion 20981092
nsv524971 CNV Loss 19592680
esv2725861 CNV Deletion 23290073
esv2725863 CNV Deletion 23290073
nsv877411 CNV Loss 21882294
nsv236467 CNV Insertion 16902084
nsv237531 CNV Insertion 16902084
nsv877412 CNV Loss 21882294
esv7912 OTHER Inversion 19470904

Variation tolerance for SLC41A3 Gene

Residual Variation Intolerance Score: 28.48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.28; 81.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC41A3 Gene

HapMap Linkage Disequilibrium report
SLC41A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC41A3 Gene

Disorders for SLC41A3 Gene

Relevant External Links for SLC41A3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC41A3
genes like me logo Genes that share disorders with SLC41A3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC41A3 Gene

Publications for SLC41A3 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 67
  4. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 67
  5. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 67

Products for SLC41A3 Gene

Sources for SLC41A3 Gene

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