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Aliases for PPM1A Gene

Aliases for PPM1A Gene

  • Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A 2 3
  • Protein Phosphatase 1A (Formerly 2C), Magnesium-Dependent, Alpha Isoform 2 3
  • EC 3.1.3.16 4 63
  • PP2C-ALPHA 3 4
  • Protein Phosphatase 2C Isoform Alpha 4
  • Protein Phosphatase 2C 2
  • Protein Phosphatase IA 4
  • Phosphatase 2C Alpha 2
  • Alpha Isoform 2
  • PP2Calpha 3
  • PPPM1A 4
  • PP2CA 3

External Ids for PPM1A Gene

Previous GeneCards Identifiers for PPM1A Gene

  • GC14P058042
  • GC14P054506
  • GC14P058702
  • GC14P059782
  • GC14P060712
  • GC14P040876

Summaries for PPM1A Gene

Entrez Gene Summary for PPM1A Gene

  • The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPM1A Gene

PPM1A (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A) is a Protein Coding gene. Among its related pathways are MAPK signaling pathway and Signaling by GPCR. GO annotations related to this gene include signal transducer activity and protein C-terminus binding. An important paralog of this gene is PPM1B.

UniProtKB/Swiss-Prot for PPM1A Gene

  • Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.

Gene Wiki entry for PPM1A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPM1A Gene

Genomics for PPM1A Gene

Regulatory Elements for PPM1A Gene

Transcription factor binding sites by QIAGEN in the PPM1A gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PPM1A Gene

Chromosome:
14
Start:
60,245,752 bp from pter
End:
60,299,087 bp from pter
Size:
53,336 bases
Orientation:
Plus strand

Genomic View for PPM1A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPM1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPM1A Gene

Proteins for PPM1A Gene

  • Protein details for PPM1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35813-PPM1A_HUMAN
    Recommended name:
    Protein phosphatase 1A
    Protein Accession:
    P35813
    Secondary Accessions:
    • B5BU11
    • J3KNM0
    • O75551

    Protein attributes for PPM1A Gene

    Size:
    382 amino acids
    Molecular mass:
    42448 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Binds 2 magnesium or manganese ions per subunit.;
    Quaternary structure:
    • Monomer. Interacts with SMAD2; the interaction dephosphorylates SMAD2 in its C-terminal SXS motif resulting in disruption of the SMAD2/SMAD4 complex, SMAD2 nuclear export and termination of the TGF-beta-mediated signaling. Interacts with SMAD2; the interaction dephosphorylates SMAD2 in its C-terminal SXS motif resulting in disruption of the SMAD2/SMAD4 complex, SMAD2 nuclear export and termination of the TGF-beta-mediated signaling. Interacts with the phosphorylated form of IKBKB/IKKB.

    Three dimensional structures from OCA and Proteopedia for PPM1A Gene

    Alternative splice isoforms for PPM1A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPM1A Gene

Proteomics data for PPM1A Gene at MOPED

Post-translational modifications for PPM1A Gene

  • N-myristoylation is essential for the recognition of its substrates for dephosphorylation.
  • Ubiquitination at Lys 278
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for PPM1A (PP2C alpha/PPM1A)
  • Cell Signaling Technology (CST) Antibodies for PPM1A (PPPM1A)

Domains & Families for PPM1A Gene

Gene Families for PPM1A Gene

Protein Domains for PPM1A Gene

Suggested Antigen Peptide Sequences for PPM1A Gene

Graphical View of Domain Structure for InterPro Entry

P35813

UniProtKB/Swiss-Prot:

PPM1A_HUMAN :
  • Contains 1 PPM-type phosphatase domain.
  • Belongs to the PP2C family.
Domain:
  • Contains 1 PPM-type phosphatase domain.
Family:
  • Belongs to the PP2C family.
genes like me logo Genes that share domains with PPM1A: view

Function for PPM1A Gene

Molecular function for PPM1A Gene

UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
UniProtKB/Swiss-Prot Function:
Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.

Enzyme Numbers (IUBMB) for PPM1A Gene

Gene Ontology (GO) - Molecular Function for PPM1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0003824 catalytic activity --
GO:0004721 phosphoprotein phosphatase activity --
GO:0004722 protein serine/threonine phosphatase activity TAS --
GO:0004871 signal transducer activity IMP 12761501
genes like me logo Genes that share ontologies with PPM1A: view
genes like me logo Genes that share phenotypes with PPM1A: view

Animal Models for PPM1A Gene

MGI Knock Outs for PPM1A:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPM1A

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for PPM1A Gene

Localization for PPM1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPM1A Gene

Nucleus. Cytoplasm, cytosol. Membrane. Note=Weakly associates at the membrane and N-myristoylation mediates the membrane localization. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPM1A Gene COMPARTMENTS Subcellular localization image for PPM1A gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 2

Gene Ontology (GO) - Cellular Components for PPM1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 16751101
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
GO:0005891 voltage-gated calcium channel complex IEA --
GO:0016020 membrane ISS --
genes like me logo Genes that share ontologies with PPM1A: view

Pathways & Interactions for PPM1A Gene

genes like me logo Genes that share pathways with PPM1A: view

Pathways by source for PPM1A Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

SIGNOR curated interactions for PPM1A Gene

Inactivates:
Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for PPM1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS --
GO:0006351 transcription, DNA-templated TAS --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0006470 protein dephosphorylation IMP 18930133
GO:0006499 N-terminal protein myristoylation ISS --
genes like me logo Genes that share ontologies with PPM1A: view

Drugs & Compounds for PPM1A Gene

(5) Drugs for PPM1A Gene - From: HMDB and NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Manganese Pharma 30
Calcium Nutra 0
Magnesium Nutra 0
serine Nutra 420
threonine Nutra 16

(3) Additional Compounds for PPM1A Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with PPM1A: view

Transcripts for PPM1A Gene

Unigene Clusters for PPM1A Gene

Protein phosphatase, Mg2+/Mn2+ dependent, 1A:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPM1A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPM1A Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12 ^ 13
SP1: - - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - -
SP4:
SP5: -
SP6: - - - -

Relevant External Links for PPM1A Gene

GeneLoc Exon Structure for
PPM1A
ECgene alternative splicing isoforms for
PPM1A

Expression for PPM1A Gene

mRNA expression in normal human tissues for PPM1A Gene

Protein differential expression in normal tissues from HIPED for PPM1A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.3) and Platelet (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPM1A Gene



SOURCE GeneReport for Unigene cluster for PPM1A Gene Hs.130036

genes like me logo Genes that share expression patterns with PPM1A: view

Protein tissue co-expression partners for PPM1A Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PPM1A Gene

Orthologs for PPM1A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PPM1A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PPM1A 35
  • 96.42 (n)
  • 98.95 (a)
-- 36
  • 96 (a)
OneToMany
PPM1A 36
  • 99 (a)
OneToMany
dog
(Canis familiaris)
Mammalia PPM1A 35
  • 94.29 (n)
  • 92.97 (a)
PPM1A 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppm1a 35
  • 93.54 (n)
  • 98.17 (a)
Ppm1a 16
Ppm1a 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PPM1A 35
  • 99.78 (n)
  • 100 (a)
PPM1A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppm1a 35
  • 93.63 (n)
  • 98.95 (a)
oppossum
(Monodelphis domestica)
Mammalia PPM1A 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPM1A 36
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPM1A 35
  • 88.13 (n)
  • 93.98 (a)
PPM1A 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPM1A 36
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppm1a 35
  • 83.77 (n)
  • 91.36 (a)
Str.7047 35
African clawed frog
(Xenopus laevis)
Amphibia ppm1a-prov 35
zebrafish
(Danio rerio)
Actinopterygii Dr.11472 35
ppm1aa 35
  • 73.33 (n)
  • 86.22 (a)
ppm1aa 36
  • 84 (a)
OneToMany
ppm1ab 36
  • 73 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG12169 37
  • 41 (a)
CG17746 37
  • 40 (a)
CG1906 37
  • 52 (a)
CG6036 37
  • 50 (a)
alph 36
  • 52 (a)
ManyToMany
CG6036 36
  • 49 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea F25D1.1 37
  • 48 (a)
T23F11.1 37
  • 43 (a)
ppm-1 36
  • 35 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PTC2 36
  • 23 (a)
ManyToMany
PTC3 36
  • 23 (a)
ManyToMany
PTC2 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 55 (a)
OneToMany
Species with no ortholog for PPM1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPM1A Gene

ENSEMBL:
Gene Tree for PPM1A (if available)
TreeFam:
Gene Tree for PPM1A (if available)

Paralogs for PPM1A Gene

Paralogs for PPM1A Gene

(2) SIMAP similar genes for PPM1A Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for PPM1A Gene

genes like me logo Genes that share paralogs with PPM1A: view

Variants for PPM1A Gene

Sequence variations from dbSNP and Humsavar for PPM1A Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs116204366 -- 60,279,645(+) CTCCT(A/G)TCGGC intron-variant
rs139136195 -- 60,262,298(+) CTACA(A/G)GACTG intron-variant
rs139240653 -- 60,258,505(+) ATGGG(A/G)GTGTG intron-variant
rs139245947 -- 60,273,509(+) GCCAT(A/G)TTAAG intron-variant
rs139317639 -- 60,274,995(+) TTACA(A/G)TTAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPM1A Gene

Variant ID Type Subtype PubMed ID
nsv832812 CNV Loss 17160897
esv2748750 CNV Deletion 23290073
esv2256431 CNV Deletion 18987734
esv2453133 CNV Insertion 19546169
esv274146 CNV Insertion 20981092
esv268412 CNV Insertion 20981092

Variation tolerance for PPM1A Gene

Residual Variation Intolerance Score: 21.17% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.56; 12.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPM1A Gene

HapMap Linkage Disequilibrium report
PPM1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPM1A Gene

Disorders for PPM1A Gene

Relevant External Links for PPM1A

Genetic Association Database (GAD)
PPM1A
Human Genome Epidemiology (HuGE) Navigator
PPM1A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPM1A
genes like me logo Genes that share disorders with PPM1A: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPM1A Gene

Publications for PPM1A Gene

  1. Mammalian protein serine/threonine phosphatase 2C: cDNA cloning and comparative analysis of amino acid sequences. (PMID: 1311954) Mann D.J. … Cohen P.T.W. (Biochim. Biophys. Acta 1992) 2 23 67
  2. Sanguinarine as a potent and specific inhibitor of protein phosphatase 2C in vitro and induces apoptosis via phosphorylation of p38 in HL60 cells. (PMID: 20208361) Aburai N. … Kimura K. (Biosci. Biotechnol. Biochem. 2010) 23 67
  3. Protein phosphatase magnesium-dependent 1A-mediated inhibition of BMP signaling is independent of Smad dephosphorylation. (PMID: 19594322) Kokabu S. … Katagiri T. (J. Bone Miner. Res. 2010) 23 67
  4. Protein phosphatase 1A (PPM1A) is involved in human cytotrophoblast cell invasion and migration. (PMID: 19404668) Zhang B. … Wang H. (Histochem. Cell Biol. 2009) 23 67
  5. AZD5438, a potent oral inhibitor of cyclin-dependent kinases 1, 2, and 9, leads to pharmacodynamic changes and potent antitumor effects in human tumor xenografts. (PMID: 19509270) Byth K.F. … Wilkinson R.W. (Mol. Cancer Ther. 2009) 23 67

Products for PPM1A Gene

Sources for PPM1A Gene

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