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Aliases for PPM1A Gene

Aliases for PPM1A Gene

  • Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A 2 3
  • Protein Phosphatase 1A (Formerly 2C), Magnesium-Dependent, Alpha Isoform 2 3
  • EC 3.1.3.16 4 64
  • PP2C-ALPHA 3 4
  • Protein Phosphatase 2C Isoform Alpha 4
  • Protein Phosphatase 2C 2
  • Protein Phosphatase 1A 3
  • Protein Phosphatase IA 4
  • Phosphatase 2C Alpha 2
  • Alpha Isoform 2
  • PP2Calpha 3
  • PPPM1A 4
  • PP2CA 3

External Ids for PPM1A Gene

Summaries for PPM1A Gene

Entrez Gene Summary for PPM1A Gene

  • The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPM1A Gene

PPM1A (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A) is a Protein Coding gene. Among its related pathways are MAPK signaling pathway and Signaling by GPCR. GO annotations related to this gene include signal transducer activity and protein C-terminus binding. An important paralog of this gene is PPM1B.

UniProtKB/Swiss-Prot for PPM1A Gene

  • Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.

Gene Wiki entry for PPM1A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPM1A Gene

Genomics for PPM1A Gene

Genomic Location for PPM1A Gene

Start:
60,245,752 bp from pter
End:
60,299,087 bp from pter
Size:
53,336 bases
Orientation:
Plus strand

Genomic View for PPM1A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPM1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPM1A Gene

Regulatory Elements for PPM1A Gene

Transcription factor binding sites by QIAGEN in the PPM1A gene promoter:

Proteins for PPM1A Gene

  • Protein details for PPM1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35813-PPM1A_HUMAN
    Recommended name:
    Protein phosphatase 1A
    Protein Accession:
    P35813
    Secondary Accessions:
    • B5BU11
    • J3KNM0
    • O75551

    Protein attributes for PPM1A Gene

    Size:
    382 amino acids
    Molecular mass:
    42448 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Binds 2 magnesium or manganese ions per subunit.;
    Quaternary structure:
    • Monomer. Interacts with SMAD2; the interaction dephosphorylates SMAD2 in its C-terminal SXS motif resulting in disruption of the SMAD2/SMAD4 complex, SMAD2 nuclear export and termination of the TGF-beta-mediated signaling. Interacts with SMAD2; the interaction dephosphorylates SMAD2 in its C-terminal SXS motif resulting in disruption of the SMAD2/SMAD4 complex, SMAD2 nuclear export and termination of the TGF-beta-mediated signaling. Interacts with the phosphorylated form of IKBKB/IKKB.

    Three dimensional structures from OCA and Proteopedia for PPM1A Gene

    Alternative splice isoforms for PPM1A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPM1A Gene

Proteomics data for PPM1A Gene at MOPED

Post-translational modifications for PPM1A Gene

  • N-myristoylation is essential for the recognition of its substrates for dephosphorylation.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys278

Other Protein References for PPM1A Gene

Domains for PPM1A Gene

Gene Families for PPM1A Gene

HGNC:
  • PPM :Serine/threonine phosphatases / Protein phosphatases, Mg2+/Mn2+ dependent

Protein Domains for PPM1A Gene

UniProtKB/Swiss-Prot:

PPM1A_HUMAN
Domain:
  • Contains 1 PPM-type phosphatase domain.:
    • P35813
Family:
  • Belongs to the PP2C family.:
    • P35813
genes like me logo Genes that share domains with PPM1A: view

Function for PPM1A Gene

Molecular function for PPM1A Gene

UniProtKB/Swiss-Prot CatalyticActivity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
UniProtKB/Swiss-Prot Function: Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.

Enzyme Numbers (IUBMB) for PPM1A Gene

Gene Ontology (GO) - Molecular Function for PPM1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0003824 catalytic activity --
GO:0004721 phosphoprotein phosphatase activity --
GO:0004722 protein serine/threonine phosphatase activity TAS --
GO:0004871 signal transducer activity IMP 12761501
genes like me logo Genes that share ontologies with PPM1A: view

Phenotypes for PPM1A Gene

MGI mutant phenotypes for PPM1A:
inferred from 2 alleles
GenomeRNAi human phenotypes for PPM1A:
genes like me logo Genes that share phenotypes with PPM1A: view

Animal Models for PPM1A Gene

MGI Knock Outs for PPM1A:

miRNA for PPM1A Gene

No data available for Transcription Factor Targeting and HOMER Transcription for PPM1A Gene

Localization for PPM1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPM1A Gene

Nucleus. Cytoplasm, cytosol. Membrane. Note=Weakly associates at the membrane and N-myristoylation mediates the membrane localization. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPM1A Gene COMPARTMENTS Subcellular localization image for PPM1A gene
Compartment Confidence
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for PPM1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 16751101
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
GO:0005891 voltage-gated calcium channel complex IEA --
GO:0016020 membrane ISS --
genes like me logo Genes that share ontologies with PPM1A: view

Pathways for PPM1A Gene

genes like me logo Genes that share pathways with PPM1A: view

Pathways by source for PPM1A Gene

Gene Ontology (GO) - Biological Process for PPM1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS --
GO:0006351 transcription, DNA-templated TAS --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0006470 protein dephosphorylation IMP 18930133
GO:0006499 N-terminal protein myristoylation ISS --
genes like me logo Genes that share ontologies with PPM1A: view

Compounds for PPM1A Gene

(5) HMDB Compounds for PPM1A Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Magnesium
  • Magnesium
7439-95-4
Manganese
  • manganese
7439-96-5
Phosphate
  • NFB Orthophosphate
14265-44-2
Water
  • Dihydrogen oxide
7732-18-5

(3) Novoseek inferred chemical compound relationships for PPM1A Gene

Compound -log(P) Hits PubMed IDs
threonine 52 1
manganese 48.2 1
serine 39.1 1
genes like me logo Genes that share compounds with PPM1A: view

Transcripts for PPM1A Gene

Unigene Clusters for PPM1A Gene

Protein phosphatase, Mg2+/Mn2+ dependent, 1A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPM1A Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12 ^ 13
SP1: - - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - -
SP4:
SP5: -
SP6: - - - -

Relevant External Links for PPM1A Gene

GeneLoc Exon Structure for
PPM1A
ECgene alternative splicing isoforms for
PPM1A

Expression for PPM1A Gene

mRNA expression in normal human tissues for PPM1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPM1A Gene

SOURCE GeneReport for Unigene cluster for PPM1A Gene Hs.130036

genes like me logo Genes that share expressions with PPM1A: view

Orthologs for PPM1A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PPM1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPM1A 36
  • 99.78 (n)
  • 100 (a)
PPM1A 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 96 (a)
OneToMany
PPM1A 36
  • 96.42 (n)
  • 98.95 (a)
PPM1A 37
  • 99 (a)
OneToMany
dog
(Canis familiaris)
Mammalia PPM1A 36
  • 94.29 (n)
  • 92.97 (a)
PPM1A 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppm1a 36
  • 93.54 (n)
  • 98.17 (a)
Ppm1a 16
Ppm1a 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPM1A 37
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPM1A 37
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppm1a 36
  • 93.63 (n)
  • 98.95 (a)
chicken
(Gallus gallus)
Aves PPM1A 36
  • 88.13 (n)
  • 93.98 (a)
PPM1A 37
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPM1A 37
  • 91 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia ppm1a-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia ppm1a 36
  • 83.77 (n)
  • 91.36 (a)
Str.7047 36
zebrafish
(Danio rerio)
Actinopterygii Dr.11472 36
ppm1aa 36
  • 73.33 (n)
  • 86.22 (a)
ppm1aa 37
  • 84 (a)
OneToMany
ppm1ab 37
  • 73 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta alph 37
  • 52 (a)
ManyToMany
CG6036 37
  • 49 (a)
ManyToMany
CG12169 38
  • 41 (a)
CG6036 38
  • 50 (a)
CG17746 38
  • 40 (a)
CG1906 38
  • 52 (a)
worm
(Caenorhabditis elegans)
Secernentea ppm-1 37
  • 35 (a)
OneToMany
F25D1.1 38
  • 48 (a)
T23F11.1 38
  • 43 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PTC2 37
  • 23 (a)
ManyToMany
PTC2 39
PTC3 37
  • 23 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 55 (a)
OneToMany
Species with no ortholog for PPM1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPM1A Gene

ENSEMBL:
Gene Tree for PPM1A (if available)
TreeFam:
Gene Tree for PPM1A (if available)

Paralogs for PPM1A Gene

Paralogs for PPM1A Gene

Selected SIMAP similar genes for PPM1A Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for PPM1A Gene

genes like me logo Genes that share paralogs with PPM1A: view

Variants for PPM1A Gene

Sequence variations from dbSNP and Humsavar for PPM1A Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs721445 -- 60,259,135(+) CTACA(C/T)ACACA intron-variant
rs1018639 -- 60,264,322(-) AATTA(C/T)ATACA intron-variant
rs1048318 -- 60,293,009(+) GGAGT(C/T)ATTGA utr-variant-3-prime
rs1048359 -- 60,293,311(+) ATATT(C/T)TGAAT utr-variant-3-prime
rs1111368 -- 60,275,839(-) GGCTA(A/C)TCTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPM1A Gene

Variant ID Type Subtype PubMed ID
nsv832812 CNV Loss 17160897
esv2748750 CNV Deletion 23290073
esv2256431 CNV Deletion 18987734
esv2453133 CNV Insertion 19546169
esv274146 CNV Insertion 20981092
esv268412 CNV Insertion 20981092

Relevant External Links for PPM1A Gene

HapMap Linkage Disequilibrium report
PPM1A

Disorders for PPM1A Gene

(1) Novoseek inferred disease relationships for PPM1A Gene

Disease -log(P) Hits PubMed IDs
cancer 0 1

Relevant External Links for PPM1A

Genetic Association Database (GAD)
PPM1A
Human Genome Epidemiology (HuGE) Navigator
PPM1A
genes like me logo Genes that share disorders with PPM1A: view

No data available for UniProtKB/Swiss-Prot for PPM1A Gene

Publications for PPM1A Gene

  1. Mammalian protein serine/threonine phosphatase 2C: cDNA cloning and comparative analysis of amino acid sequences. (PMID: 1311954) Mann D.J. … Cohen P.T.W. (Biochim. Biophys. Acta 1992) 2 3 4 23
  2. Dephosphorylation of PKCdelta by protein phosphatase 2Ac and its inhibition by nucleotides. (PMID: 11959144) Srivastava J. … Parker P.J. (FEBS Lett. 2002) 3 23
  3. Cell cycle regulation and p53 activation by protein phosphatase 2C alpha. (PMID: 12514180) Ofek P. … Lavi S. (J. Biol. Chem. 2003) 3 23
  4. Protein phosphatase-2C alpha as a positive regulator of insulin sensitivity through direct activation of phosphatidylinositol 3-kinase in 3T3-L1 adipocytes. (PMID: 15016818) Yoshizaki T. … Kashiwagi A. (J. Biol. Chem. 2004) 3 23
  5. Crystal structure of the protein serine/threonine phosphatase 2C at 2.0-A resolution. (PMID: 9003755) Das A.K. … Barford D. (EMBO J. 1996) 3 4

Products for PPM1A Gene

Sources for PPM1A Gene

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