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Aliases for ADPRHL2 Gene

Aliases for ADPRHL2 Gene

  • ADP-Ribosylhydrolase Like 2 2 3
  • [Protein ADP-Ribosylarginine] Hydrolase-Like Protein 2 3 4
  • ADP-Ribosylhydrolase 3 3 4
  • EC 3.2.1.143 4 63
  • ARH3 3 4
  • Protein ADP-Ribosylarginine Hydrolase-Like Protein 2 3

External Ids for ADPRHL2 Gene

Previous GeneCards Identifiers for ADPRHL2 Gene

  • GC01P035981
  • GC01P035982
  • GC01P036223
  • GC01P036327
  • GC01P036554
  • GC01P034671

Summaries for ADPRHL2 Gene

Entrez Gene Summary for ADPRHL2 Gene

  • This gene encodes a member of the ADP-ribosylglycohydrolase family. The encoded enzyme catalyzes the removal of ADP-ribose from ADP-ribosylated proteins. This enzyme localizes to the mitochondria, in addition to the nucleus and cytoplasm.[provided by RefSeq, Feb 2009]

GeneCards Summary for ADPRHL2 Gene

ADPRHL2 (ADP-Ribosylhydrolase Like 2) is a Protein Coding gene. GO annotations related to this gene include poly(ADP-ribose) glycohydrolase activity.

UniProtKB/Swiss-Prot for ADPRHL2 Gene

  • Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. Poly(ADP-ribose) metabolism may be required for maintenance of the normal function of neuronal cells. Generates ADP-ribose from poly-(ADP-ribose), but does not hydrolyze ADP-ribose-arginine, -cysteine, -diphthamide, or -asparagine bonds. Due to catalytic inactivity of PARG mitochondrial isoforms, ARH3 is the only PAR hydrolyzing enzyme in mitochondria.

Gene Wiki entry for ADPRHL2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADPRHL2 Gene

Genomics for ADPRHL2 Gene

Regulatory Elements for ADPRHL2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ADPRHL2 Gene

Chromosome:
1
Start:
36,088,852 bp from pter
End:
36,093,932 bp from pter
Size:
5,081 bases
Orientation:
Plus strand

Genomic View for ADPRHL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADPRHL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADPRHL2 Gene

Proteins for ADPRHL2 Gene

  • Protein details for ADPRHL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NX46-ARHL2_HUMAN
    Recommended name:
    Poly(ADP-ribose) glycohydrolase ARH3
    Protein Accession:
    Q9NX46
    Secondary Accessions:
    • Q53G94
    • Q6IAB8
    • Q9BY47

    Protein attributes for ADPRHL2 Gene

    Size:
    363 amino acids
    Molecular mass:
    38947 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 2 magnesium ions per subunit.;
    Quaternary structure:
    • Monomer.
    SequenceCaution:
    • Sequence=AAK14922.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ADPRHL2 Gene

neXtProt entry for ADPRHL2 Gene

Proteomics data for ADPRHL2 Gene at MOPED

Selected DME Specific Peptides for ADPRHL2 Gene

Post-translational modifications for ADPRHL2 Gene

  • Ubiquitination at Lys 146
  • Modification sites at PhosphoSitePlus

Other Protein References for ADPRHL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for ADPRHL2 Gene

Protein Domains for ADPRHL2 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9NX46

UniProtKB/Swiss-Prot:

ARHL2_HUMAN :
  • Belongs to the ADP-ribosylglycohydrolase family.
Family:
  • Belongs to the ADP-ribosylglycohydrolase family.
genes like me logo Genes that share domains with ADPRHL2: view

No data available for Gene Families for ADPRHL2 Gene

Function for ADPRHL2 Gene

Molecular function for ADPRHL2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolyzes poly(ADP-D-ribose) at glycosidic (1-2) linkage of ribose-ribose bond to produce free ADP-D-ribose.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activity is enhanced by magnesium.
UniProtKB/Swiss-Prot Function:
Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. Poly(ADP-ribose) metabolism may be required for maintenance of the normal function of neuronal cells. Generates ADP-ribose from poly-(ADP-ribose), but does not hydrolyze ADP-ribose-arginine, -cysteine, -diphthamide, or -asparagine bonds. Due to catalytic inactivity of PARG mitochondrial isoforms, ARH3 is the only PAR hydrolyzing enzyme in mitochondria.

Enzyme Numbers (IUBMB) for ADPRHL2 Gene

Gene Ontology (GO) - Molecular Function for ADPRHL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004649 poly(ADP-ribose) glycohydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ADPRHL2: view
genes like me logo Genes that share phenotypes with ADPRHL2: view

Animal Model Products

CRISPR Products

miRNA for ADPRHL2 Gene

miRTarBase miRNAs that target ADPRHL2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADPRHL2

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for ADPRHL2 Gene

Localization for ADPRHL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADPRHL2 Gene

Cytoplasm. Mitochondrion matrix. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADPRHL2 Gene COMPARTMENTS Subcellular localization image for ADPRHL2 gene
Compartment Confidence
mitochondrion 5
nucleus 5

Gene Ontology (GO) - Cellular Components for ADPRHL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm --
GO:0005739 mitochondrion --
GO:0005759 mitochondrial matrix IEA --
genes like me logo Genes that share ontologies with ADPRHL2: view

Pathways & Interactions for ADPRHL2 Gene

SuperPathways for ADPRHL2 Gene

No Data Available

Interacting Proteins for ADPRHL2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000362273%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: Q9NX46-ARHL2_HUMAN ENSP00000362273 for ADPRHL2 Gene via I2D MINT STRING

Gene Ontology (GO) - Biological Process for ADPRHL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
GO:0071451 cellular response to superoxide IEA --
genes like me logo Genes that share ontologies with ADPRHL2: view

No data available for Pathways by source and SIGNOR curated interactions for ADPRHL2 Gene

Drugs & Compounds for ADPRHL2 Gene

(1) Drugs for ADPRHL2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Nutra 0

(1) Additional Compounds for ADPRHL2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with ADPRHL2: view

Transcripts for ADPRHL2 Gene

mRNA/cDNA for ADPRHL2 Gene

Unigene Clusters for ADPRHL2 Gene

ADP-ribosylhydrolase like 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADPRHL2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADPRHL2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b
SP1: -
SP2: - -
SP3: - -
SP4:

Relevant External Links for ADPRHL2 Gene

GeneLoc Exon Structure for
ADPRHL2
ECgene alternative splicing isoforms for
ADPRHL2

Expression for ADPRHL2 Gene

mRNA expression in normal human tissues for ADPRHL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ADPRHL2 Gene

This gene is overexpressed in Testis (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ADPRHL2 Gene



SOURCE GeneReport for Unigene cluster for ADPRHL2 Gene Hs.18021

mRNA Expression by UniProt/SwissProt for ADPRHL2 Gene

Q9NX46-ARHL2_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with ADPRHL2: view

Protein tissue co-expression partners for ADPRHL2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ADPRHL2 Gene

Orthologs for ADPRHL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADPRHL2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ADPRHL2 35
  • 90.66 (n)
  • 93.64 (a)
ADPRHL2 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADPRHL2 35
  • 89.79 (n)
  • 94.51 (a)
ADPRHL2 36
  • 65 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adprhl2 35
  • 87.76 (n)
  • 92.49 (a)
Adprhl2 16
Adprhl2 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ADPRHL2 35
  • 99.45 (n)
  • 99.72 (a)
ADPRHL2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adprhl2 35
  • 87.19 (n)
  • 92.49 (a)
oppossum
(Monodelphis domestica)
Mammalia ADPRHL2 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADPRHL2 36
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADPRHL2 35
  • 70.29 (n)
  • 70 (a)
ADPRHL2 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADPRHL2 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adprhl2 35
  • 60.71 (n)
  • 57.14 (a)
Str.3494 35
zebrafish
(Danio rerio)
Actinopterygii adprhl2 35
  • 57.94 (n)
  • 55.95 (a)
wufj36e06 35
adprhl2 36
  • 51 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002530 35
  • 49.95 (n)
  • 40.79 (a)
Species with no ortholog for ADPRHL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADPRHL2 Gene

ENSEMBL:
Gene Tree for ADPRHL2 (if available)
TreeFam:
Gene Tree for ADPRHL2 (if available)

Paralogs for ADPRHL2 Gene

No data available for Paralogs for ADPRHL2 Gene

Variants for ADPRHL2 Gene

Sequence variations from dbSNP and Humsavar for ADPRHL2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs274747 -- 36,093,952(+) TTCTC(C/T)TGCCC downstream-variant-500B
rs274748 -- 36,094,020(+) GCACT(A/G)TCATA downstream-variant-500B
rs373514 -- 36,089,773(+) CCTTG(A/G)CCTTG intron-variant
rs767999 -- 36,091,156(+) AGAGC(G/T)AGACT intron-variant
rs768000 -- 36,091,266(+) GATGA(C/T)ACAGC reference, synonymous-codon, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADPRHL2 Gene

Variant ID Type Subtype PubMed ID
nsv871396 CNV Gain 21882294
nsv834691 CNV Loss 17160897
nsv871804 CNV Loss 21882294

Variation tolerance for ADPRHL2 Gene

Residual Variation Intolerance Score: 22.32% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.19; 75.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADPRHL2 Gene

HapMap Linkage Disequilibrium report
ADPRHL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADPRHL2 Gene

Disorders for ADPRHL2 Gene

Relevant External Links for ADPRHL2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADPRHL2
genes like me logo Genes that share disorders with ADPRHL2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADPRHL2 Gene

Publications for ADPRHL2 Gene

  1. Identification and characterization of a mammalian 39-kDa poly(ADP- ribose) glycohydrolase. (PMID: 16278211) Oka S. … Moss J. (J. Biol. Chem. 2006) 2 23 67
  2. The structure of human ADP-ribosylhydrolase 3 (ARH3) provides insights into the reversibility of protein ADP-ribosylation. (PMID: 17015823) Mueller-Dieckmann C. … Koch-Nolte F. (Proc. Natl. Acad. Sci. U.S.A. 2006) 23 67
  3. The family of toxin-related ecto-ADP-ribosyltransferases in humans and the mouse. (PMID: 12070318) Glowacki G. … Koch-Nolte F. (Protein Sci. 2002) 2 67
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67

Products for ADPRHL2 Gene

Sources for ADPRHL2 Gene

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