Aliases for UBE2R2 Gene
External Ids for UBE2R2 Gene
Previous GeneCards Identifiers for UBE2R2 Gene
Protein kinase CK2 is a ubiquitous and pleiotropic Ser/Thr protein kinase involved in cell growth and transformation. This gene encodes a protein similar to the E2 ubiquitin conjugating enzyme UBC3/CDC34. Studies suggest that CK2-dependent phosphorylation of this ubiquitin-conjugating enzyme functions by regulating beta-TrCP substrate recognition and induces its interaction with beta-TrCP, enhancing beta-catenin degradation. [provided by RefSeq, Jul 2008]
GeneCards Summary for UBE2R2 Gene
UBE2R2 (Ubiquitin Conjugating Enzyme E2 R2) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ligase activity and ubiquitin protein ligase binding. An important paralog of this gene is CDC34.
UniProtKB/Swiss-Prot for UBE2R2 Gene
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes monoubiquitination and Lys-48-linked polyubiquitination. May be involved in degradation of katenin.