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Aliases for UBE2R2 Gene

Aliases for UBE2R2 Gene

  • Ubiquitin Conjugating Enzyme E2 R2 2 3
  • Ubiquitin-Conjugating Enzyme E2-CDC34B 3 4
  • Ubiquitin-Conjugating Enzyme E2R 2 2 3
  • Ubiquitin Conjugating Enzyme E2R 2 3 5
  • E2 Ubiquitin-Conjugating Enzyme R2 3 4
  • Ubiquitin Carrier Protein R2 3 4
  • Ubiquitin-Protein Ligase R2 3 4
  • CDC34B 3 4
  • UBC3B 3 4
  • Ubiquitin-Conjugating Enzyme UBC3B 3
  • EC 6.3.2.19 63
  • EC 2.3.2.23 4
  • E2-CDC34B 3

External Ids for UBE2R2 Gene

Previous GeneCards Identifiers for UBE2R2 Gene

  • GC09P033987
  • GC09P033807
  • GC09P033774

Summaries for UBE2R2 Gene

Entrez Gene Summary for UBE2R2 Gene

  • Protein kinase CK2 is a ubiquitous and pleiotropic Ser/Thr protein kinase involved in cell growth and transformation. This gene encodes a protein similar to the E2 ubiquitin conjugating enzyme UBC3/CDC34. Studies suggest that CK2-dependent phosphorylation of this ubiquitin-conjugating enzyme functions by regulating beta-TrCP substrate recognition and induces its interaction with beta-TrCP, enhancing beta-catenin degradation. [provided by RefSeq, Jul 2008]

GeneCards Summary for UBE2R2 Gene

UBE2R2 (Ubiquitin Conjugating Enzyme E2 R2) is a Protein Coding gene. Among its related pathways are Influenza A and Antigen processing- Ubiquitination and Proteasome degradation. GO annotations related to this gene include ligase activity and ubiquitin protein ligase binding. An important paralog of this gene is UBE2G1.

UniProtKB/Swiss-Prot for UBE2R2 Gene

  • Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes monoubiquitination and Lys-48-linked polyubiquitination. May be involved in degradation of katenin.

Gene Wiki entry for UBE2R2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2R2 Gene

Genomics for UBE2R2 Gene

Regulatory Elements for UBE2R2 Gene

Enhancers for UBE2R2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around UBE2R2 on UCSC Golden Path with GeneCards custom track

Promoters for UBE2R2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around UBE2R2 on UCSC Golden Path with GeneCards custom track

Genomic Location for UBE2R2 Gene

Chromosome:
9
Start:
33,817,164 bp from pter
End:
33,920,404 bp from pter
Size:
103,241 bases
Orientation:
Plus strand

Genomic View for UBE2R2 Gene

Genes around UBE2R2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBE2R2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBE2R2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2R2 Gene

Proteins for UBE2R2 Gene

  • Protein details for UBE2R2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q712K3-UB2R2_HUMAN
    Recommended name:
    Ubiquitin-conjugating enzyme E2 R2
    Protein Accession:
    Q712K3
    Secondary Accessions:
    • D3DRL5
    • Q9NX64

    Protein attributes for UBE2R2 Gene

    Size:
    238 amino acids
    Molecular mass:
    27166 Da
    Quaternary structure:
    • When phosphorylated, interacts with beta-TrCP (BTRC).

neXtProt entry for UBE2R2 Gene

Proteomics data for UBE2R2 Gene at MOPED

Post-translational modifications for UBE2R2 Gene

  • Ubiquitination at Lys 11 and Lys 63
  • Modification sites at PhosphoSitePlus

Other Protein References for UBE2R2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for UBE2R2 Gene

Gene Families for UBE2R2 Gene

Protein Domains for UBE2R2 Gene

Suggested Antigen Peptide Sequences for UBE2R2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q712K3

UniProtKB/Swiss-Prot:

UB2R2_HUMAN :
  • Belongs to the ubiquitin-conjugating enzyme family.
Family:
  • Belongs to the ubiquitin-conjugating enzyme family.
genes like me logo Genes that share domains with UBE2R2: view

Function for UBE2R2 Gene

Molecular function for UBE2R2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.
UniProtKB/Swiss-Prot Function:
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes monoubiquitination and Lys-48-linked polyubiquitination. May be involved in degradation of katenin.

Enzyme Numbers (IUBMB) for UBE2R2 Gene

Gene Ontology (GO) - Molecular Function for UBE2R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 20061386
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with UBE2R2: view
genes like me logo Genes that share phenotypes with UBE2R2: view

Animal Model Products

miRNA for UBE2R2 Gene

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBE2R2 Gene

Localization for UBE2R2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBE2R2 Gene COMPARTMENTS Subcellular localization image for UBE2R2 gene
Compartment Confidence
nucleus 2
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for UBE2R2 Gene

Pathways & Interactions for UBE2R2 Gene

genes like me logo Genes that share pathways with UBE2R2: view

Pathways by source for UBE2R2 Gene

UniProtKB/Swiss-Prot Q712K3-UB2R2_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for UBE2R2 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for UBE2R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA --
genes like me logo Genes that share ontologies with UBE2R2: view

Drugs & Compounds for UBE2R2 Gene

(3) Drugs for UBE2R2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Diphosphate Experimental Pharma 0

(1) Additional Compounds for UBE2R2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
genes like me logo Genes that share compounds with UBE2R2: view

Transcripts for UBE2R2 Gene

mRNA/cDNA for UBE2R2 Gene

Unigene Clusters for UBE2R2 Gene

Ubiquitin-conjugating enzyme E2R 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2R2 Gene

No ASD Table

Relevant External Links for UBE2R2 Gene

GeneLoc Exon Structure for
UBE2R2
ECgene alternative splicing isoforms for
UBE2R2

Expression for UBE2R2 Gene

mRNA expression in normal human tissues for UBE2R2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UBE2R2 Gene

This gene is overexpressed in Whole Blood (x5.2).

Protein differential expression in normal tissues from HIPED for UBE2R2 Gene

This gene is overexpressed in Heart (19.5) and Cervix (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBE2R2 Gene



SOURCE GeneReport for Unigene cluster for UBE2R2 Gene Hs.643648

genes like me logo Genes that share expression patterns with UBE2R2: view

Protein tissue co-expression partners for UBE2R2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for UBE2R2 Gene

Orthologs for UBE2R2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UBE2R2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UBE2R2 35
  • 95.8 (n)
  • 100 (a)
UBE2R2 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UBE2R2 35
  • 96.5 (n)
  • 100 (a)
UBE2R2 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ube2r2 35
  • 94.4 (n)
  • 100 (a)
Ube2r2 16
Ube2r2 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UBE2R2 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 100 (a)
OneToMany
UBE2R2 36
  • 100 (a)
OneToMany
UBE2R2 35
  • 99.63 (n)
  • 99.45 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia UBE2R2 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC689226 35
  • 94.12 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves LOC427134 35
  • 88.66 (n)
  • 99.16 (a)
-- 36
  • 95 (a)
OneToMany
UBE2R2 36
  • 99 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia UBE2R2 36
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ube2r2 35
  • 82.35 (n)
  • 99.58 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
ube2r2 35
  • 79.64 (n)
  • 94.09 (a)
ube2r2 36
  • 86 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008680 35
  • 68.71 (n)
  • 76.02 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7656 35
  • 68.25 (n)
  • 74.74 (a)
CG7656 36
  • 52 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ubc-3 36
  • 60 (a)
OneToMany
ubc-3 35
  • 62.12 (n)
  • 65.66 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL203C 35
  • 51.36 (n)
  • 42.77 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D09196g 35
  • 47.91 (n)
  • 39.89 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBC7 36
  • 44 (a)
OneToMany
CDC34 35
  • 50.45 (n)
  • 38.5 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01188 35
  • 50.2 (n)
  • 41.18 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 63 (a)
OneToMany
Species with no ortholog for UBE2R2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBE2R2 Gene

ENSEMBL:
Gene Tree for UBE2R2 (if available)
TreeFam:
Gene Tree for UBE2R2 (if available)

Paralogs for UBE2R2 Gene

Paralogs for UBE2R2 Gene

(6) SIMAP similar genes for UBE2R2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with UBE2R2: view

Variants for UBE2R2 Gene

Sequence variations from dbSNP and Humsavar for UBE2R2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs733384 -- 33,920,453(-) AATGA(C/G)ACCAC downstream-variant-500B
rs855719 -- 33,817,619(+) TGGTC(C/T)GGCCC utr-variant-5-prime
rs912732 -- 33,852,476(+) AGACT(C/T)CCACA intron-variant
rs1041099 -- 33,899,787(-) GGCGC(A/G)GTGTC intron-variant
rs1044452 -- 33,917,306(+) GGACC(C/T)GGCCA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for UBE2R2 Gene

Variant ID Type Subtype PubMed ID
nsv518977 CNV Gain 19592680
nsv893028 CNV Gain 21882294
dgv2311e1 CNV Complex 17122850
nsv520467 CNV Gain 19592680
esv23020 CNV Loss 19812545
nsv893029 CNV Gain 21882294
nsv831541 CNV Loss 17160897
nsv893030 CNV Gain 21882294
esv2656909 CNV Deletion 23128226

Variation tolerance for UBE2R2 Gene

Residual Variation Intolerance Score: 31.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.08; 1.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBE2R2 Gene

HapMap Linkage Disequilibrium report
UBE2R2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBE2R2 Gene

Disorders for UBE2R2 Gene

Relevant External Links for UBE2R2

Genetic Association Database (GAD)
UBE2R2
Human Genome Epidemiology (HuGE) Navigator
UBE2R2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBE2R2

No disorders were found for UBE2R2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBE2R2 Gene

Publications for UBE2R2 Gene

  1. CK2-dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TrCP and enhances beta-catenin degradation. (PMID: 12037680) Semplici F. … Oliviero S. (Oncogene 2002) 2 3 4 67
  2. BioID-based Identification of Skp Cullin F-box (SCF)I^-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E. … Raught B. (Mol. Cell Proteomics 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. A systems-wide screen identifies substrates of the SCFI^TrCP ubiquitin ligase. (PMID: 25515538) Low T.Y. … Heck A.J. (Sci Signal 2014) 3

Products for UBE2R2 Gene

Sources for UBE2R2 Gene

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