Aliases for LIME1 Gene
External Ids for LIME1 Gene
Previous GeneCards Identifiers for LIME1 Gene
This gene encodes a transmembrane adaptor protein that links the T and B-cell receptor stimulation to downstream signaling pathways via its association with the Src family kinases Lck and Lyn, respectively. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Mar 2015]
GeneCards Summary for LIME1 Gene
LIME1 (Lck Interacting Transmembrane Adaptor 1) is a Protein Coding gene. Among its related pathways are B Cell Receptor Signaling Pathway (WikiPathways). GO annotations related to this gene include protein kinase binding. An important paralog of this gene is ENSG00000273047.
UniProtKB/Swiss-Prot for LIME1 Gene
Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T-cell signaling in T-cells. In absence of TCR signaling, may be involved in CD4-mediated inhibition of T-cell activation. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization or MAPK activation through the recruitment of PLCG2, GRB2, GRAP2, and other signaling molecules.