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Aliases for CHTF8 Gene

Aliases for CHTF8 Gene

  • Chromosome Transmission Fidelity Factor 8 2 3 5
  • Decreased Expression In Renal And Prostate Cancer Protein 3 4
  • DERPC 3 4
  • CTF8 3 4
  • CTF8, Chromosome Transmission Fidelity Factor 8 Homolog (S. Cerevisiae) 2
  • CTF8, Chromosome Transmission Fidelity Factor 8 Homolog 3
  • HCTF8 4

External Ids for CHTF8 Gene

Previous GeneCards Identifiers for CHTF8 Gene

  • GC16M067714
  • GC16M055024

Summaries for CHTF8 Gene

Entrez Gene Summary for CHTF8 Gene

  • This gene encodes a short protein that forms part of the Ctf18 replication factor C (RFC) complex that occurs in both yeast and mammals. The heteroheptameric RFC complex plays a role in sister chromatid cohesion and may load the replication clamp PCNA (proliferating cell nuclear antigen) onto DNA during DNA replication and repair. This gene is ubiquitously expressed and has been shown to have reduced expression in renal and prostate tumors. Alternatively spliced transcript variants have been described. This gene has a pseudogene on chromosome X. [provided by RefSeq, Jan 2010]

GeneCards Summary for CHTF8 Gene

CHTF8 (Chromosome Transmission Fidelity Factor 8) is a Protein Coding gene. Among its related pathways are Gastric cancer network 2.

UniProtKB/Swiss-Prot for CHTF8 Gene

  • Potential tumor suppressor. Inhibits prostate tumor cell growth, when overexpressed.

  • Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated the presence of primed DNA, replication protein A (RPA) and proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. It also interacts with and stimulates POLH, which is suggestive of a protein network that coordinates DNA repair, recombination and chromosome cohesion reactions with replication fork progression.

Gene Wiki entry for CHTF8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHTF8 Gene

Genomics for CHTF8 Gene

Regulatory Elements for CHTF8 Gene

Promoters for CHTF8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CHTF8 on UCSC Golden Path with GeneCards custom track

Genomic Location for CHTF8 Gene

Chromosome:
16
Start:
69,118,009 bp from pter
End:
69,132,590 bp from pter
Size:
14,582 bases
Orientation:
Minus strand

Genomic View for CHTF8 Gene

Genes around CHTF8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHTF8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHTF8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHTF8 Gene

Proteins for CHTF8 Gene

  • Protein details for CHTF8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CG12-CTF8A_HUMAN
    Recommended name:
    Chromosome transmission fidelity protein 8 homolog isoform 2
    Protein Accession:
    P0CG12
    Secondary Accessions:
    • A8MYX8
    • Q71E72
    • Q8NDH8
    • Q8WV66
    • Q9NX73

    Protein attributes for CHTF8 Gene

    Size:
    524 amino acids
    Molecular mass:
    51391 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Found in a common chromosomal region of deletion in breast cancer.
    SequenceCaution:
    • Sequence=CAD38758.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for CHTF8 Gene

    UniProtKB/Swiss-Prot:
  • Protein details for CHTF8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CG13-CTF8_HUMAN
    Recommended name:
    Chromosome transmission fidelity protein 8 homolog
    Protein Accession:
    P0CG13
    Secondary Accessions:
    • A8MYX8
    • Q71E72
    • Q8NDH8
    • Q8WV66
    • Q9NX73

    Protein attributes for CHTF8 Gene

    Size:
    121 amino acids
    Molecular mass:
    13314 Da
    Quaternary structure:
    • Component of the CTF18-RFC complex, which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex does not interact with the Rad9/Rad1/Hus1 complex. The CTF18-RFC complex interacts with POLH. CTF18/CTF8/DCC1 associate with PCNA. CTF8 exists as a dimer with DCC1.
    SequenceCaution:
    • Sequence=AAQ08897.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=BAA91144.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=EAW83250.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for CHTF8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CHTF8 Gene

Proteomics data for CHTF8 Gene at MOPED

Post-translational modifications for CHTF8 Gene

No data available for DME Specific Peptides for CHTF8 Gene

Domains & Families for CHTF8 Gene

Protein Domains for CHTF8 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CHTF8 Gene

Graphical View of Domain Structure for InterPro Entry

P0CG12

UniProtKB/Swiss-Prot:

CTF8_HUMAN :
  • Belongs to the DERPC family.
Family:
  • Belongs to the DERPC family.
  • Belongs to the CTF8 family.
genes like me logo Genes that share domains with CHTF8: view

No data available for Gene Families for CHTF8 Gene

Function for CHTF8 Gene

Molecular function for CHTF8 Gene

UniProtKB/Swiss-Prot Function:
Potential tumor suppressor. Inhibits prostate tumor cell growth, when overexpressed.
UniProtKB/Swiss-Prot Function:
Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated the presence of primed DNA, replication protein A (RPA) and proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. It also interacts with and stimulates POLH, which is suggestive of a protein network that coordinates DNA repair, recombination and chromosome cohesion reactions with replication fork progression.

Phenotypes for CHTF8 Gene

GenomeRNAi human phenotypes for CHTF8:
genes like me logo Genes that share phenotypes with CHTF8: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CHTF8 Gene

Localization for CHTF8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHTF8 Gene

Nucleus.
Nucleus. Note=Associates with chromatin during S phase.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CHTF8 Gene COMPARTMENTS Subcellular localization image for CHTF8 gene
Compartment Confidence
extracellular 5
nucleus 4
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CHTF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031390 Ctf18 RFC-like complex IDA 12930902
genes like me logo Genes that share ontologies with CHTF8: view

Pathways & Interactions for CHTF8 Gene

SuperPathways for CHTF8 Gene

Superpath Contained pathways
1 Gastric cancer network 2
genes like me logo Genes that share pathways with CHTF8: view

Pathways by source for CHTF8 Gene

1 BioSystems pathway for CHTF8 Gene

Interacting Proteins for CHTF8 Gene

Gene Ontology (GO) - Biological Process for CHTF8 Gene

None

No data available for SIGNOR curated interactions for CHTF8 Gene

Drugs & Compounds for CHTF8 Gene

No Compound Related Data Available

Transcripts for CHTF8 Gene

mRNA/cDNA for CHTF8 Gene

(8) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CHTF8 Gene

CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CHTF8 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e · 5f
SP1: - - -
SP2: -
SP3: - -
SP4: - - - -
SP5: - - - -
SP6: - -
SP7: - - - - -

Relevant External Links for CHTF8 Gene

GeneLoc Exon Structure for
CHTF8
ECgene alternative splicing isoforms for
CHTF8

Expression for CHTF8 Gene

mRNA expression in normal human tissues for CHTF8 Gene

Protein differential expression in normal tissues from HIPED for CHTF8 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (16.0), CD8 Tcells (14.8), Testis (14.2), and NK cells (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CHTF8 Gene



SOURCE GeneReport for Unigene cluster for CHTF8 Gene Hs.85962

mRNA Expression by UniProt/SwissProt for CHTF8 Gene

P0CG12-CTF8A_HUMAN
Tissue specificity: Ubiquitously expressed, with abundant expression in kidney, skeletal muscle, testis, liver, ovary, and heart and moderate expression in prostate. Expression is significantly reduced in renal and prostate tumors. No differential expression in breast cancer cells, between lobular carcinoma and normal lobules.
genes like me logo Genes that share expression patterns with CHTF8: view

Protein tissue co-expression partners for CHTF8 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CHTF8 Gene

Orthologs for CHTF8 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHTF8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CHTF8 35
  • 94.77 (n)
  • 94.21 (a)
CHTF8 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CHTF8 35
  • 96.14 (n)
  • 94.21 (a)
mouse
(Mus musculus)
Mammalia Chtf8 35
  • 94.77 (n)
  • 91.74 (a)
Chtf8 16
Chtf8 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CHTF8 35
  • 99.72 (n)
  • 99.17 (a)
CHTF8 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Chtf8 35
  • 96.14 (n)
  • 94.21 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia CHTF8 36
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves CHTF8 35
  • 69.64 (n)
  • 75.89 (a)
CHTF8 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CHTF8 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia chtf8 35
  • 67.22 (n)
  • 66.67 (a)
Str.4395 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.10569 35
zebrafish
(Danio rerio)
Actinopterygii chtf8 35
  • 65.01 (n)
  • 67.77 (a)
Dr.24240 35
chtf8 36
  • 64 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2759 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012170 35
  • 54.01 (n)
  • 45.37 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG34001 35
  • 51.85 (n)
  • 47.01 (a)
CG34001 36
  • 33 (a)
OneToOne
Species with no ortholog for CHTF8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CHTF8 Gene

ENSEMBL:
Gene Tree for CHTF8 (if available)
TreeFam:
Gene Tree for CHTF8 (if available)

Paralogs for CHTF8 Gene

Pseudogenes.org Pseudogenes for CHTF8 Gene

genes like me logo Genes that share paralogs with CHTF8: view

No data available for Paralogs for CHTF8 Gene

Variants for CHTF8 Gene

Sequence variations from dbSNP and Humsavar for CHTF8 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs3743680 -- 69,119,705(+) CAGGC(C/T)ACTTG intron-variant, nc-transcript-variant, reference, missense, utr-variant-3-prime
rs6499219 -- 69,122,560(+) ttttg(A/G)gaggg intron-variant
rs6499220 -- 69,124,884(+) CACTT(C/T)GGGAA intron-variant
rs7197515 -- 69,129,240(+) cctgg(A/C)taaca intron-variant
rs7197537 -- 69,129,273(+) aaaat(A/T)caaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CHTF8 Gene

Variant ID Type Subtype PubMed ID
nsv906819 CNV Loss 21882294
nsv1850 CNV Loss 18451855

Variation tolerance for CHTF8 Gene

Residual Variation Intolerance Score: 46.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.60; 56.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CHTF8 Gene

HapMap Linkage Disequilibrium report
CHTF8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHTF8 Gene

Disorders for CHTF8 Gene

Relevant External Links for CHTF8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CHTF8

No disorders were found for CHTF8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CHTF8 Gene

Publications for CHTF8 Gene

  1. Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment. (PMID: 12766176) Merkle C.J. … Chen J. (J. Biol. Chem. 2003) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3

Products for CHTF8 Gene

Sources for CHTF8 Gene

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