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Aliases for CHTF8 Gene

Aliases for CHTF8 Gene

  • CTF8, Chromosome Transmission Fidelity Factor 8 Homolog (S. Cerevisiae) 2 3
  • CTF8 3 4 6
  • Decreased Expression In Renal And Prostate Cancer Protein 3 4
  • DERPC 3 4
  • Chromosome Transmission Fidelity Protein 8 Homolog 3
  • HCTF8 4

External Ids for CHTF8 Gene

Summaries for CHTF8 Gene

Entrez Gene Summary for CHTF8 Gene

  • This gene encodes a short protein that forms part of the Ctf18 replication factor C (RFC) complex that occurs in both yeast and mammals. The heteroheptameric RFC complex plays a role in sister chromatid cohesion and may load the replication clamp PCNA (proliferating cell nuclear antigen) onto DNA during DNA replication and repair. This gene is ubiquitously expressed and has been shown to have reduced expression in renal and prostate tumors. Alternatively spliced transcript variants have been described. This gene has a pseudogene on chromosome X. [provided by RefSeq, Jan 2010]

GeneCards Summary for CHTF8 Gene

CHTF8 (CTF8, Chromosome Transmission Fidelity Factor 8 Homolog (S. Cerevisiae)) is a Protein Coding gene. Diseases associated with CHTF8 include prostate cancer. Among its related pathways are Gastric cancer network 2.

UniProtKB/Swiss-Prot for CHTF8 Gene

  • Potential tumor suppressor. Inhibits prostate tumor cell growth, when overexpressed.

  • Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated the presence of primed DNA, replication protein A (RPA) and proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. It also interacts with and stimulates POLH, which is suggestive of a protein network that coordinates DNA repair, recombination and chromosome cohesion reactions with replication fork progression.

Gene Wiki entry for CHTF8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHTF8 Gene

Genomics for CHTF8 Gene

Genomic Location for CHTF8 Gene

Start:
69,118,009 bp from pter
End:
69,132,590 bp from pter
Size:
14,582 bases
Orientation:
Minus strand

Genomic View for CHTF8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CHTF8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHTF8 Gene

Regulatory Elements for CHTF8 Gene

Proteins for CHTF8 Gene

  • Protein details for CHTF8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CG12-CTF8A_HUMAN
    Recommended name:
    Chromosome transmission fidelity protein 8 homolog isoform 2
    Protein Accession:
    P0CG12
    Secondary Accessions:
    • A8MYX8
    • Q71E72
    • Q8NDH8
    • Q8WV66
    • Q9NX73

    Protein attributes for CHTF8 Gene

    Size:
    524 amino acids
    Molecular mass:
    51391 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Found in a common chromosomal region of deletion in breast cancer
    SequenceCaution:
    • Sequence=CAD38758.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for CHTF8 Gene

    UniProtKB/Swiss-Prot:
  • Protein details for CHTF8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CG13-CTF8_HUMAN
    Recommended name:
    Chromosome transmission fidelity protein 8 homolog
    Protein Accession:
    P0CG13
    Secondary Accessions:
    • A8MYX8
    • Q71E72
    • Q8NDH8
    • Q8WV66
    • Q9NX73

    Protein attributes for CHTF8 Gene

    Size:
    121 amino acids
    Molecular mass:
    13314 Da
    Quaternary structure:
    • Component of the CTF18-RFC complex, which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex does not interact with the Rad9/Rad1/Hus1 complex. The CTF18-RFC complex interacts with POLH. CTF18/CTF8/DCC1 associate with PCNA. CTF8 exists as a dimer with DCC1.
    SequenceCaution:
    • Sequence=AAQ08897.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=BAA91144.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=EAW83250.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for CHTF8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CHTF8 Gene

Proteomics data for CHTF8 Gene at MOPED

Post-translational modifications for CHTF8 Gene

No data available for DME Specific Peptides for CHTF8 Gene

Domains for CHTF8 Gene

Protein Domains for CHTF8 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

CTF8_HUMAN
Family:
  • Belongs to the DERPC family.:
    • P0CG12
  • Belongs to the CTF8 family.:
    • P0CG13
genes like me logo Genes that share domains with CHTF8: view

No data available for Gene Families for CHTF8 Gene

Function for CHTF8 Gene

Molecular function for CHTF8 Gene

UniProtKB/Swiss-Prot Function: Potential tumor suppressor. Inhibits prostate tumor cell growth, when overexpressed.
UniProtKB/Swiss-Prot Function: Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated the presence of primed DNA, replication protein A (RPA) and proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. It also interacts with and stimulates POLH, which is suggestive of a protein network that coordinates DNA repair, recombination and chromosome cohesion reactions with replication fork progression.

Gene Ontology (GO) - Molecular Function for CHTF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with CHTF8: view

miRNA for CHTF8 Gene

miRTarBase miRNAs that target CHTF8

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CHTF8 Gene

Localization for CHTF8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHTF8 Gene

Nucleus.
Nucleus. Note=Associates with chromatin during S phase.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CHTF8 Gene COMPARTMENTS Subcellular localization image for CHTF8 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CHTF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with CHTF8: view

Pathways for CHTF8 Gene

SuperPathways for CHTF8 Gene

Superpath Contained pathways
1 Gastric cancer network 2
genes like me logo Genes that share pathways with CHTF8: view

Pathways by source for CHTF8 Gene

1 BioSystems pathway for CHTF8 Gene

Interacting Proteins for CHTF8 Gene

Gene Ontology (GO) - Biological Process for CHTF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006260 DNA replication IEA --
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with CHTF8: view

Transcripts for CHTF8 Gene

mRNA/cDNA for CHTF8 Gene

(8) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CHTF8 Gene

CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CHTF8 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e · 5f
SP1: - - -
SP2: -
SP3: - -
SP4: - - - -
SP5: - - - -
SP6: - -
SP7: - - - - -

Relevant External Links for CHTF8 Gene

GeneLoc Exon Structure for
CHTF8
ECgene alternative splicing isoforms for
CHTF8

Expression for CHTF8 Gene

mRNA expression in normal human tissues for CHTF8 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CHTF8 Gene

SOURCE GeneReport for Unigene cluster for CHTF8 Gene Hs.85962

mRNA Expression by UniProt/SwissProt for CHTF8 Gene

P0CG12-CTF8A_HUMAN
Tissue specificity: Ubiquitously expressed, with abundant expression in kidney, skeletal muscle, testis, liver, ovary, and heart and moderate expression in prostate. Expression is significantly reduced in renal and prostate tumors. No differential expression in breast cancer cells, between lobular carcinoma and normal lobules.
genes like me logo Genes that share expressions with CHTF8: view

Orthologs for CHTF8 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHTF8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHTF8 36
  • 99.72 (n)
  • 99.17 (a)
CHTF8 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CHTF8 36
  • 94.77 (n)
  • 94.21 (a)
CHTF8 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CHTF8 36
  • 96.14 (n)
  • 94.21 (a)
mouse
(Mus musculus)
Mammalia Chtf8 36
  • 94.77 (n)
  • 91.74 (a)
Chtf8 16
Chtf8 37
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CHTF8 37
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Chtf8 36
  • 96.14 (n)
  • 94.21 (a)
chicken
(Gallus gallus)
Aves CHTF8 36
  • 69.64 (n)
  • 75.89 (a)
CHTF8 37
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CHTF8 37
  • 68 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.10569 36
tropical clawed frog
(Silurana tropicalis)
Amphibia chtf8 36
  • 67.22 (n)
  • 66.67 (a)
Str.4395 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2759 36
zebrafish
(Danio rerio)
Actinopterygii chtf8 36
  • 65.01 (n)
  • 67.77 (a)
chtf8 37
  • 64 (a)
OneToOne
Dr.24240 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012170 36
  • 54.01 (n)
  • 45.37 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG34001 36
  • 51.85 (n)
  • 47.01 (a)
CG34001 37
  • 33 (a)
OneToOne
Species with no ortholog for CHTF8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CHTF8 Gene

ENSEMBL:
Gene Tree for CHTF8 (if available)
TreeFam:
Gene Tree for CHTF8 (if available)

Paralogs for CHTF8 Gene

Pseudogenes.org Pseudogenes for CHTF8 Gene

genes like me logo Genes that share paralogs with CHTF8: view

No data available for Paralogs for CHTF8 Gene

Variants for CHTF8 Gene

Sequence variations from dbSNP and Humsavar for CHTF8 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs3743680 -- 69,119,705(+) CAGGC(C/T)ACTTG utr-variant-3-prime, nc-transcript-variant
rs6499219 -- 69,122,560(+) ttttg(A/G)gaggg intron-variant
rs6499220 -- 69,124,884(+) CACTT(C/T)GGGAA intron-variant
rs7197515 -- 69,129,240(+) cctgg(A/C)taaca intron-variant
rs7197537 -- 69,129,273(+) aaaat(A/T)caaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CHTF8 Gene

Variant ID Type Subtype PubMed ID
nsv906819 CNV Loss 21882294
nsv1850 CNV Loss 18451855

Relevant External Links for CHTF8 Gene

HapMap Linkage Disequilibrium report
CHTF8

Disorders for CHTF8 Gene

(1) MalaCards Diseases for CHTF8 Gene

Search for CHTF8 Gene in MalaCards »
genes like me logo Genes that share disorders with CHTF8: view

No data available for UniProtKB/Swiss-Prot for CHTF8 Gene

Publications for CHTF8 Gene

  1. Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment. (PMID: 12766176) Merkle C.J. … Chen J. (J. Biol. Chem. 2003) 2 3 4
  2. The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA. (PMID: 12930902) Bermudez V.P. … Hurwitz J. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J. … Pennacchio L.A. (Nature 2004) 3 4

Products for CHTF8 Gene

Sources for CHTF8 Gene

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