Aliases for SEMA4C Gene
External Ids for SEMA4C Gene
Previous HGNC Symbols for SEMA4C Gene
Previous GeneCards Identifiers for SEMA4C Gene
GeneCards Summary for SEMA4C Gene
SEMA4C (Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) And Short Cytoplasmic Domain, (Semaphorin) 4C) is a Protein Coding gene. Diseases associated with SEMA4C include esophageal cancer. Among its related pathways are Axon guidance. GO annotations related to this gene include receptor activity. An important paralog of this gene is SEMA4G.
UniProtKB/Swiss-Prot for SEMA4C Gene
Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at Tyr-1248. Required for normal brain development, axon guidance and cell migration (By similarity). Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade.