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Aliases for FNBP1L Gene

Aliases for FNBP1L Gene

  • Formin Binding Protein 1 Like 2 3 5
  • Transducer Of Cdc42-Dependent Actin Assembly Protein 1 3 4
  • C1orf39 3 4
  • Toca-1 3 4
  • TOCA1 3 4
  • Transducer Of Cdc42-Dependent Actin Assembly 1 3
  • Chromosome 1 Open Reading Frame 39 2
  • Formin Binding Protein 1-Like 2
  • Formin-Binding Protein 1-Like 3

External Ids for FNBP1L Gene

Previous HGNC Symbols for FNBP1L Gene

  • C1orf39

Previous GeneCards Identifiers for FNBP1L Gene

  • GC01P093626
  • GC01P093737
  • GC01P093913
  • GC01P092035

Summaries for FNBP1L Gene

Entrez Gene Summary for FNBP1L Gene

  • The protein encoded by this gene binds to both CDC42 and N-WASP. This protein promotes CDC42-induced actin polymerization by activating the N-WASP-WIP complex and, therefore, is involved in a pathway that links cell surface signals to the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for FNBP1L Gene

FNBP1L (Formin Binding Protein 1 Like) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and Clathrin-mediated endocytosis. GO annotations related to this gene include lipid binding. An important paralog of this gene is FNBP1.

UniProtKB/Swiss-Prot for FNBP1L Gene

  • Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens.

Gene Wiki entry for FNBP1L Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FNBP1L Gene

Genomics for FNBP1L Gene

Regulatory Elements for FNBP1L Gene

Enhancers for FNBP1L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G093446 1.6 FANTOM5 Ensembl ENCODE 9.1 +0.7 744 4.4 FOXA2 ARID4B SIN3A DMAP1 SLC30A9 ZNF766 ZNF143 ZNF263 SP3 MXD4 CCDC18 FNBP1L RNA5SP53 GC01M093489
GH01G093177 1.4 ENCODE dbSUPER 4.7 -268.1 -268053 4.7 CREB3L1 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF548 ZNF263 SP3 NFYC CCDC18-AS1 SNORA66 SNORD21 RPL5 DNTTIP2 DR1 CCDC18 ENSG00000230439 FNBP1L TMED5
GH01G093344 1.4 ENCODE dbSUPER 4.3 -100.5 -100533 5.9 MLX CREB3L1 ZFP64 DMAP1 FEZF1 YY1 ZNF143 ZNF263 SP3 NFYC CCDC18-AS1 DR1 SNORD21 SNORA66 CCDC18 EVI5 FNBP1L GC01M093359
GH01G093324 1.2 Ensembl ENCODE dbSUPER 4.6 -122.9 -122902 1.9 TBP JUN ZNF133 MAX FEZF1 ZBTB40 YY1 GATA3 RCOR1 FOS CCDC18-AS1 DR1 CCDC18 FAM69A FNBP1L GC01P093330 GC01P093285
GH01G093441 1 ENCODE 5.5 -5.6 -5584 1.3 ATF1 PKNOX1 MLX E2F7 SIN3A TCF12 ZNF121 SLC30A9 REST SMARCA4 CCDC18-AS1 SNORD21 SNORA66 DNTTIP2 DR1 CCDC18 FNBP1L ENSG00000207379
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FNBP1L on UCSC Golden Path with GeneCards custom track

Promoters for FNBP1L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000009932 424 2600 FOXA2 ARID4B SIN3A DMAP1 SLC30A9 ZNF766 ZNF143 ZNF263 SP3 MXD4

Genomic Location for FNBP1L Gene

Chromosome:
1
Start:
93,448,076 bp from pter
End:
93,570,905 bp from pter
Size:
122,830 bases
Orientation:
Plus strand

Genomic View for FNBP1L Gene

Genes around FNBP1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FNBP1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FNBP1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FNBP1L Gene

Proteins for FNBP1L Gene

  • Protein details for FNBP1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T0N5-FBP1L_HUMAN
    Recommended name:
    Formin-binding protein 1-like
    Protein Accession:
    Q5T0N5
    Secondary Accessions:
    • J3QSS4
    • Q5T0N6
    • Q6B097
    • Q6P653
    • Q6R4Q4
    • Q9NXG1

    Protein attributes for FNBP1L Gene

    Size:
    605 amino acids
    Molecular mass:
    70065 Da
    Quaternary structure:
    • Homodimerizes, the dimers can polymerize end-to-end to form filamentous structures (By similarity). Interacts with GTP-bound CDC42 (PubMed:15260990). Interacts with DAAM1, DIAPH1, DIAPH2, DNM1, DNM2 and WASL/N-WASP (PubMed:16326391, PubMed:16630611, PubMed:16418535). Interacts with ATG3 (PubMed:19342671). Interacts (via SH3 domain) with ABI1, WASF2, CDC42 and WIPF1 (PubMed:19798448).
    SequenceCaution:
    • Sequence=BAA91051.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for FNBP1L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FNBP1L Gene

Post-translational modifications for FNBP1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FNBP1L Gene

Domains & Families for FNBP1L Gene

Gene Families for FNBP1L Gene

Suggested Antigen Peptide Sequences for FNBP1L Gene

Graphical View of Domain Structure for InterPro Entry

Q5T0N5

UniProtKB/Swiss-Prot:

FBP1L_HUMAN :
  • The F-BAR domain binds the phospholipid membrane with its concave surface. The end-to-end polymerization of dimers of these domains provides a curved surface that fits best membranes with around 600 A diameter, and may drive tubulation (By similarity).
  • Belongs to the FNBP1 family.
Domain:
  • The F-BAR domain binds the phospholipid membrane with its concave surface. The end-to-end polymerization of dimers of these domains provides a curved surface that fits best membranes with around 600 A diameter, and may drive tubulation (By similarity).
Family:
  • Belongs to the FNBP1 family.
genes like me logo Genes that share domains with FNBP1L: view

Function for FNBP1L Gene

Molecular function for FNBP1L Gene

UniProtKB/Swiss-Prot Function:
Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens.

Gene Ontology (GO) - Molecular Function for FNBP1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16630611
GO:0008289 lipid binding IEA --
GO:0045296 cadherin binding IDA 25468996
GO:0051020 GTPase binding IPI 19798448
genes like me logo Genes that share ontologies with FNBP1L: view
genes like me logo Genes that share phenotypes with FNBP1L: view

Animal Model Products

CRISPR Products

miRNA for FNBP1L Gene

miRTarBase miRNAs that target FNBP1L

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FNBP1L Gene

Localization for FNBP1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for FNBP1L Gene

Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Cytoplasmic vesicle. Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FNBP1L gene
Compartment Confidence
extracellular 5
cytosol 5
plasma membrane 4
cytoskeleton 4
nucleus 2
mitochondrion 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for FNBP1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 22684256
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IEA --
GO:0005938 cell cortex IEA --
genes like me logo Genes that share ontologies with FNBP1L: view

Pathways & Interactions for FNBP1L Gene

genes like me logo Genes that share pathways with FNBP1L: view

Pathways by source for FNBP1L Gene

1 Qiagen pathway for FNBP1L Gene

Gene Ontology (GO) - Biological Process for FNBP1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006897 endocytosis IEA --
GO:0006900 membrane budding IDA 20730103
GO:0006914 autophagy IEA --
GO:0010324 membrane invagination IDA 20730103
GO:0016050 vesicle organization IDA 20730103
genes like me logo Genes that share ontologies with FNBP1L: view

No data available for SIGNOR curated interactions for FNBP1L Gene

Drugs & Compounds for FNBP1L Gene

(1) Drugs for FNBP1L Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(124) Additional Compounds for FNBP1L Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PS(14:0/14:0)
  • 1-Myristoyl-2-myristoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/14:0)
  • Phosphatidylserine(28:0)
  • PS(14:0/14:0)
  • PS(28:0)
PS(14:0/14:1(9Z))
  • 1-Myristoyl-2-myristoleoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/14:1)
  • Phosphatidylserine(14:0/14:1n5)
  • Phosphatidylserine(14:0/14:1w5)
  • Phosphatidylserine(28:1)
PS(14:0/16:0)
  • 1-Myristoyl-2-palmitoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/16:0)
  • Phosphatidylserine(30:0)
  • PS(14:0/16:0)
  • PS(30:0)
PS(14:0/16:1(9Z))
  • 1-Myristoyl-2-palmitoleoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/16:1)
  • Phosphatidylserine(14:0/16:1n7)
  • Phosphatidylserine(14:0/16:1w7)
  • Phosphatidylserine(30:1)
PS(14:0/18:0)
  • 1-Myristoyl-2-stearoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/18:0)
  • Phosphatidylserine(32:0)
  • PS(14:0/18:0)
  • PS(32:0)
genes like me logo Genes that share compounds with FNBP1L: view

Transcripts for FNBP1L Gene

Unigene Clusters for FNBP1L Gene

Formin binding protein 1-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FNBP1L Gene

No ASD Table

Relevant External Links for FNBP1L Gene

GeneLoc Exon Structure for
FNBP1L
ECgene alternative splicing isoforms for
FNBP1L

Expression for FNBP1L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FNBP1L Gene

Protein differential expression in normal tissues from HIPED for FNBP1L Gene

This gene is overexpressed in Fetal Brain (18.0), Peripheral blood mononuclear cells (8.7), Islet of Langerhans (7.2), and Platelet (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FNBP1L Gene



Protein tissue co-expression partners for FNBP1L Gene

NURSA nuclear receptor signaling pathways regulating expression of FNBP1L Gene:

FNBP1L

SOURCE GeneReport for Unigene cluster for FNBP1L Gene:

Hs.134060

Evidence on tissue expression from TISSUES for FNBP1L Gene

  • Nervous system(4.9)
  • Lung(4.3)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with FNBP1L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FNBP1L Gene

Orthologs for FNBP1L Gene

This gene was present in the common ancestor of animals.

Orthologs for FNBP1L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FNBP1L 34 35
  • 99.82 (n)
cow
(Bos Taurus)
Mammalia FNBP1L 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FNBP1L 35
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fnbp1l 35
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FNBP1L 35
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FNBP1L 35
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves FNBP1L 35
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FNBP1L 35
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fnbp1l 34
  • 77.39 (n)
Str.20339 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.33887 34
zebrafish
(Danio rerio)
Actinopterygii fnbp1l 34 35
  • 70.74 (n)
fruit fly
(Drosophila melanogaster)
Insecta Cip4 35
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea toca-1 35
  • 25 (a)
ManyToMany
toca-2 35
  • 19 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 37 (a)
OneToMany
Species where no ortholog for FNBP1L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FNBP1L Gene

ENSEMBL:
Gene Tree for FNBP1L (if available)
TreeFam:
Gene Tree for FNBP1L (if available)

Paralogs for FNBP1L Gene

Paralogs for FNBP1L Gene

(4) SIMAP similar genes for FNBP1L Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FNBP1L: view

Variants for FNBP1L Gene

Sequence variations from dbSNP and Humsavar for FNBP1L Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000002822 -- 93,478,874(+) ATTCG(C/G)ACTCA intron-variant
rs1000015502 -- 93,454,503(+) GAAGA(C/T)GAAAG intron-variant
rs1000024703 -- 93,496,577(+) TAAAT(G/T)TTTTT intron-variant
rs1000062433 -- 93,525,576(+) AAAAT(A/G)ACATA intron-variant
rs1000074122 -- 93,549,554(+) TTCTT(C/T)AGTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FNBP1L Gene

Variant ID Type Subtype PubMed ID
esv3403196 CNV insertion 20981092
nsv1011853 CNV loss 25217958
nsv946083 CNV duplication 23825009

Variation tolerance for FNBP1L Gene

Residual Variation Intolerance Score: 38.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.76; 16.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FNBP1L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FNBP1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FNBP1L Gene

Disorders for FNBP1L Gene

Relevant External Links for FNBP1L

Genetic Association Database (GAD)
FNBP1L
Human Genome Epidemiology (HuGE) Navigator
FNBP1L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FNBP1L

No disorders were found for FNBP1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FNBP1L Gene

Publications for FNBP1L Gene

  1. A novel hybrid yeast-human network analysis reveals an essential role for FNBP1L in antibacterial autophagy. (PMID: 19342671) Huett A. … Xavier R.J. (J. Immunol. 2009) 3 4 22 64
  2. Identification and characterization of human FNBP1L gene in silico. (PMID: 14654988) Katoh M. … Katoh M. (Int. J. Mol. Med. 2004) 2 3 22 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. The Toca-1-N-WASP complex links filopodial formation to endocytosis. (PMID: 19213734) Bu W. … Ahmed S. (J. Biol. Chem. 2009) 3 22 64
  5. Requirements for F-BAR proteins TOCA-1 and TOCA-2 in actin dynamics and membrane trafficking during Caenorhabditis elegans oocyte growth and embryonic epidermal morphogenesis. (PMID: 19798448) Giuliani C. … Scita G. (PLoS Genet. 2009) 3 4 64

Products for FNBP1L Gene

Sources for FNBP1L Gene

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