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Aliases for FNBP1L Gene

Aliases for FNBP1L Gene

  • Formin Binding Protein 1-Like 2 3
  • C1orf39 3 4 6
  • TOCA1 3 4 6
  • Transducer Of Cdc42-Dependent Actin Assembly Protein 1 3 4
  • Toca-1 3 4
  • Transducer Of Cdc42-Dependent Actin Assembly 1 3
  • Chromosome 1 Open Reading Frame 39 2
  • Formin-Binding Protein 1-Like 3

External Ids for FNBP1L Gene

Previous Symbols for FNBP1L Gene

  • C1orf39

Summaries for FNBP1L Gene

Entrez Gene Summary for FNBP1L Gene

  • The protein encoded by this gene binds to both CDC42 and N-WASP. This protein promotes CDC42-induced actin polymerization by activating the N-WASP-WIP complex and, therefore, is involved in a pathway that links cell surface signals to the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for FNBP1L Gene

FNBP1L (Formin Binding Protein 1-Like) is a Protein Coding gene. Among its related pathways are Actin Nucleation by ARP-WASP Complex. GO annotations related to this gene include lipid binding. An important paralog of this gene is TRIP10.

UniProtKB/Swiss-Prot for FNBP1L Gene

  • Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens.

Gene Wiki entry for FNBP1L Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FNBP1L Gene

Genomics for FNBP1L Gene

Genomic Location for FNBP1L Gene

Start:
93,448,091 bp from pter
End:
93,554,661 bp from pter
Size:
106,571 bases
Orientation:
Plus strand

Genomic View for FNBP1L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FNBP1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FNBP1L Gene

Regulatory Elements for FNBP1L Gene

Proteins for FNBP1L Gene

  • Protein details for FNBP1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T0N5-FBP1L_HUMAN
    Recommended name:
    Formin-binding protein 1-like
    Protein Accession:
    Q5T0N5
    Secondary Accessions:
    • J3QSS4
    • Q5T0N6
    • Q6B097
    • Q6P653
    • Q6R4Q4
    • Q9NXG1

    Protein attributes for FNBP1L Gene

    Size:
    605 amino acids
    Molecular mass:
    70065 Da
    Quaternary structure:
    • Homodimerizes, the dimers can polymerize end-to-end to form filamentous structures (By similarity). Interacts with GTP-bound CDC42. Interacts with DAAM1, DIAPH1, DIAPH2, DNM1, DNM2 and WASL/N-WASP. Interacts with ATG3.
    SequenceCaution:
    • Sequence=BAA91051.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for FNBP1L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FNBP1L Gene

Proteomics data for FNBP1L Gene at MOPED

Post-translational modifications for FNBP1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FNBP1L Gene

No data available for DME Specific Peptides for FNBP1L Gene

Domains for FNBP1L Gene

Suggested Antigen Peptide Sequences for FNBP1L Gene

Graphical View of Domain Structure for InterPro Entry

Q5T0N5

UniProtKB/Swiss-Prot:

FBP1L_HUMAN
Domain:
  • The F-BAR domain binds the phospholipid membrane with its concave surface. The end-to-end polymerization of dimers of these domains provides a curved surface that fits best membranes with around 600 A diameter, and may drive tubulation (By similarity).:
    • Q5T0N5
  • Contains 1 F-BAR domain.:
    • Q5T0N5
  • Contains 1 SH3 domain.:
    • Q5T0N5
Family:
  • Belongs to the FNBP1 family.:
    • Q5T0N5
Similarity:
  • Contains 1 REM (Hr1) repeat.:
    • Q5T0N5
genes like me logo Genes that share domains with FNBP1L: view

No data available for Gene Families for FNBP1L Gene

Function for FNBP1L Gene

Molecular function for FNBP1L Gene

UniProtKB/Swiss-Prot Function: Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens.

Gene Ontology (GO) - Molecular Function for FNBP1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16630611
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with FNBP1L: view

Phenotypes for FNBP1L Gene

genes like me logo Genes that share phenotypes with FNBP1L: view

miRNA for FNBP1L Gene

miRTarBase miRNAs that target FNBP1L

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FNBP1L Gene

Localization for FNBP1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for FNBP1L Gene

Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Cytoplasmic vesicle. Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FNBP1L Gene COMPARTMENTS Subcellular localization image for FNBP1L gene
Compartment Confidence
plasma membrane 5
cytoskeleton 2
cytosol 2
nucleus 2
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FNBP1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 22684256
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IEA --
GO:0005938 cell cortex IEA --
GO:0016023 cytoplasmic membrane-bounded vesicle IDA 20730103
genes like me logo Genes that share ontologies with FNBP1L: view

Pathways for FNBP1L Gene

SuperPathways for FNBP1L Gene

Superpath Contained pathways
1 Actin Nucleation by ARP-WASP Complex
genes like me logo Genes that share pathways with FNBP1L: view

Pathways by source for FNBP1L Gene

1 Qiagen pathway for FNBP1L Gene

Gene Ontology (GO) - Biological Process for FNBP1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006900 membrane budding IDA 20730103
GO:0006914 autophagy IEA --
GO:0007165 signal transduction --
GO:0010324 membrane invagination IDA 20730103
GO:0016050 vesicle organization IDA 20730103
genes like me logo Genes that share ontologies with FNBP1L: view

Compounds for FNBP1L Gene

(125) HMDB Compounds for FNBP1L Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
PS(14:0/14:0)
  • Phosphatidylserine(14:0/14:0)
Not Available
PS(14:0/14:1(9Z))
  • Phosphatidylserine(14:0/14:1n5)
Not Available
PS(14:0/16:0)
  • 1-myristoyl-2-palmitoyl-sn-glycero-3-phosphoserine
Not Available
PS(14:0/16:1(9Z))
  • PS(14:0/16:1n7)
Not Available
genes like me logo Genes that share compounds with FNBP1L: view

Transcripts for FNBP1L Gene

Unigene Clusters for FNBP1L Gene

Formin binding protein 1-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FNBP1L Gene

No ASD Table

Relevant External Links for FNBP1L Gene

GeneLoc Exon Structure for
FNBP1L
ECgene alternative splicing isoforms for
FNBP1L

Expression for FNBP1L Gene

mRNA expression in normal human tissues for FNBP1L Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FNBP1L Gene

SOURCE GeneReport for Unigene cluster for FNBP1L Gene Hs.134060

genes like me logo Genes that share expressions with FNBP1L: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FNBP1L Gene

Orthologs for FNBP1L Gene

This gene was present in the common ancestor of animals.

Orthologs for FNBP1L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FNBP1L 35
  • 99.82 (n)
  • 99.82 (a)
FNBP1L 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FNBP1L 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FNBP1L 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fnbp1l 16
Fnbp1l 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FNBP1L 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FNBP1L 36
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves FNBP1L 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FNBP1L 36
  • 88 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.33887 35
tropical clawed frog
(Silurana tropicalis)
Amphibia fnbp1l 35
  • 77.39 (n)
  • 85.82 (a)
Str.20339 35
zebrafish
(Danio rerio)
Actinopterygii fnbp1l 35
  • 70.74 (n)
  • 77.37 (a)
fnbp1l 36
  • 76 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Cip4 36
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea toca-1 36
  • 25 (a)
ManyToMany
toca-2 36
  • 19 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
OneToMany
Species with no ortholog for FNBP1L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FNBP1L Gene

ENSEMBL:
Gene Tree for FNBP1L (if available)
TreeFam:
Gene Tree for FNBP1L (if available)

Paralogs for FNBP1L Gene

Paralogs for FNBP1L Gene

Selected SIMAP similar genes for FNBP1L Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FNBP1L: view

Variants for FNBP1L Gene

Sequence variations from dbSNP and Humsavar for FNBP1L Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs3595 -- 93,554,544(-) AAAAT(G/T)ACCAA utr-variant-3-prime
rs142933 -- 93,549,007(-) TCACT(C/G)GGTCT intron-variant
rs237424 -- 93,545,258(-) atgtt(C/T)ctcat intron-variant
rs237425 -- 93,546,730(-) AGTCA(C/T)ATCTT intron-variant
rs237426 -- 93,546,822(-) GAACC(A/C)CAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FNBP1L Gene

Variant ID Type Subtype PubMed ID
nsv871640 CNV Loss 21882294

Relevant External Links for FNBP1L Gene

HapMap Linkage Disequilibrium report
FNBP1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FNBP1L Gene

Disorders for FNBP1L Gene

Relevant External Links for FNBP1L

Genetic Association Database (GAD)
FNBP1L
Human Genome Epidemiology (HuGE) Navigator
FNBP1L
genes like me logo Genes that share disorders with FNBP1L: view

No data available for UniProtKB/Swiss-Prot for FNBP1L Gene

Publications for FNBP1L Gene

  1. A novel hybrid yeast-human network analysis reveals an essential role for FNBP1L in antibacterial autophagy. (PMID: 19342671) Huett A. … Xavier R.J. (J. Immunol. 2009) 3 4 23
  2. Identification and characterization of human FNBP1L gene in silico. (PMID: 14654988) Katoh M. … Katoh M. (Int. J. Mol. Med. 2004) 2 3 23
  3. Dynamin and the actin cytoskeleton cooperatively regulate plasma membrane invagination by BAR and F-BAR proteins. (PMID: 16326391) Itoh T. … De Camilli P. (Dev. Cell 2005) 3 4
  4. Coordination between the actin cytoskeleton and membrane deformation by a novel membrane tubulation domain of PCH proteins is involved in endocytosis. (PMID: 16418535) Tsujita K. … Takenawa T. (J. Cell Biol. 2006) 3 4
  5. The diaphanous-related formin DAAM1 collaborates with the Rho GTPases RhoA and Cdc42, CIP4 and Src in regulating cell morphogenesis and actin dynamics. (PMID: 16630611) Aspenstroem P. … Johansson A.-S. (Exp. Cell Res. 2006) 3 4

Products for FNBP1L Gene

Sources for FNBP1L Gene

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