Aliases for FNBP1L Gene
External Ids for FNBP1L Gene
Previous Symbols for FNBP1L Gene
The protein encoded by this gene binds to both CDC42 and N-WASP. This protein promotes CDC42-induced actin polymerization by activating the N-WASP-WIP complex and, therefore, is involved in a pathway that links cell surface signals to the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
GeneCards Summary for FNBP1L Gene
FNBP1L (Formin Binding Protein 1-Like) is a Protein Coding gene. Among its related pathways are Actin Nucleation by ARP-WASP Complex. GO annotations related to this gene include lipid binding. An important paralog of this gene is TRIP10.
UniProtKB/Swiss-Prot for FNBP1L Gene
Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens.