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Aliases for BCAS3 Gene

Aliases for BCAS3 Gene

  • Breast Carcinoma Amplified Sequence 3 2 3
  • GAOB1 3 4
  • Breast Carcinoma Amplified Sequence 4/3 Fusion Protein 3
  • Metastasis Associated Antigen Of Breast Cancer 3
  • Breast Carcinoma-Amplified Sequence 3 3
  • BCAS4/BCAS3 Fusion 3
  • Protein Maab1 3
  • MAAB 3

External Ids for BCAS3 Gene

Previous GeneCards Identifiers for BCAS3 Gene

  • GC17P058649
  • GC17P061310
  • GC17P059097
  • GC17P059229
  • GC17P056109
  • GC17P058755
  • GC17P054125

Summaries for BCAS3 Gene

GeneCards Summary for BCAS3 Gene

BCAS3 (Breast Carcinoma Amplified Sequence 3) is a Protein Coding gene. Diseases associated with BCAS3 include breast cancer.

UniProtKB/Swiss-Prot for BCAS3 Gene

  • Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation (By similarity). Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor-responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin.

Gene Wiki entry for BCAS3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCAS3 Gene

Genomics for BCAS3 Gene

Regulatory Elements for BCAS3 Gene

Genomic Location for BCAS3 Gene

Start:
60,677,453 bp from pter
End:
61,392,838 bp from pter
Size:
715,386 bases
Orientation:
Plus strand

Genomic View for BCAS3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BCAS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BCAS3 Gene

Proteins for BCAS3 Gene

  • Protein details for BCAS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H6U6-BCAS3_HUMAN
    Recommended name:
    Breast carcinoma-amplified sequence 3
    Protein Accession:
    Q9H6U6
    Secondary Accessions:
    • Q17RM0
    • Q6KF21
    • Q8IXI6
    • Q8NDR8
    • Q8TDL9
    • Q8TDM1
    • Q8WY55
    • Q9BVF0
    • Q9H957
    • Q9H9Y9
    • Q9NXP4

    Protein attributes for BCAS3 Gene

    Size:
    928 amino acids
    Molecular mass:
    101237 Da
    Quaternary structure:
    • Interacts with histone H3, ESR1, KAT2B and PELP1; the interactions occur in a estrogen-dependent manner. Interacts with beta-tubulin and VIM.
    SequenceCaution:
    • Sequence=AAF70324.1; Type=Frameshift; Positions=693; Evidence={ECO:0000305}; Sequence=AAL99634.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA90966.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14078.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for BCAS3 Gene

neXtProt entry for BCAS3 Gene

Proteomics data for BCAS3 Gene at MOPED

Post-translational modifications for BCAS3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for BCAS3 Gene

Domains for BCAS3 Gene

Gene Families for BCAS3 Gene

HGNC:
  • WDR :WD repeat domain containing

Protein Domains for BCAS3 Gene

Suggested Antigen Peptide Sequences for BCAS3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H6U6

UniProtKB/Swiss-Prot:

BCAS3_HUMAN :
  • Q9H6U6
Family:
  • Belongs to the WD repeat BCAS3 family.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with BCAS3: view

Function for BCAS3 Gene

Molecular function for BCAS3 Gene

UniProtKB/Swiss-Prot Function: Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation (By similarity). Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor-responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin.
UniProtKB/Swiss-Prot Induction: By estrogen.

Gene Ontology (GO) - Molecular Function for BCAS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IDA 17505058
GO:0005515 protein binding IPI 22300583
GO:0008134 transcription factor binding IPI 17505058
GO:0010698 acetyltransferase activator activity IDA 17505058
GO:0035035 histone acetyltransferase binding IPI 17505058
genes like me logo Genes that share ontologies with BCAS3: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for BCAS3 Gene

Localization for BCAS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BCAS3 Gene

Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Note=Localizes in the cytoplasm in stationary cells. Translocates from the cytoplasm to the leading edge in motile cells. Colocalizes with microtubules and intermediate filaments in both stationary and motile cells (By similarity). Associates with chromatin. Recruited to estrogen receptor-induced promoters in a PELP1-dependent manner. {ECO:0000250 UniProtKB:Q8CCN5, ECO:0000269 PubMed:17505058}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BCAS3 Gene COMPARTMENTS Subcellular localization image for BCAS3 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for BCAS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 17505058
GO:0005737 cytoplasm IDA 17505058
GO:0005881 cytoplasmic microtubule ISS --
GO:0031252 cell leading edge ISS --
GO:0035327 transcriptionally active chromatin IDA 17505058
genes like me logo Genes that share ontologies with BCAS3: view

Pathways for BCAS3 Gene

SuperPathways for BCAS3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for BCAS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0007030 Golgi organization ISS --
GO:0010595 positive regulation of endothelial cell migration ISS --
GO:0016192 vesicle-mediated transport IBA --
genes like me logo Genes that share ontologies with BCAS3: view

No data available for Pathways by source for BCAS3 Gene

Transcripts for BCAS3 Gene

Unigene Clusters for BCAS3 Gene

Breast carcinoma amplified sequence 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BCAS3 Gene

No ASD Table

Relevant External Links for BCAS3 Gene

GeneLoc Exon Structure for
BCAS3
ECgene alternative splicing isoforms for
BCAS3

Expression for BCAS3 Gene

mRNA expression in normal human tissues for BCAS3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BCAS3 Gene

SOURCE GeneReport for Unigene cluster for BCAS3 Gene Hs.655028

mRNA Expression by UniProt/SwissProt for BCAS3 Gene

Q9H6U6-BCAS3_HUMAN
Tissue specificity: Expressed in stomach, liver, lung, kidney, prostate, testis, thyroid gland, adrenal gland, brain, heart, skeletal muscle, colon, spleen, small intestine, placenta, blood leukocyte and mammary epithelial cells. Expressed in undifferentiated ES cells. Expressed in blood islands and nascent blood vessels derived from differentiated ES cells into embryoid bodies (BD). Expressed in endothelial cells. Not detected in brain. Expressed in brain tumors (at protein level). Expressed in brain. Highly expressed in breast cancers and in glioma cell lines.
genes like me logo Genes that share expressions with BCAS3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for BCAS3 Gene

Orthologs for BCAS3 Gene

This gene was present in the common ancestor of animals.

Orthologs for BCAS3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BCAS3 35
  • 98.37 (n)
  • 98.37 (a)
BCAS3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BCAS3 35
  • 92.57 (n)
  • 98.32 (a)
BCAS3 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BCAS3 35
  • 93.58 (n)
  • 98.92 (a)
BCAS3 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bcas3 35
  • 89.08 (n)
  • 96.87 (a)
Bcas3 16
Bcas3 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BCAS3 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BCAS3 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bcas3 35
  • 89.55 (n)
  • 97.84 (a)
chicken
(Gallus gallus)
Aves BCAS3 35
  • 82.72 (n)
  • 94.16 (a)
BCAS3 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 89 (a)
OneToMany
-- 36
  • 85 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia bcas3 35
  • 77.5 (n)
  • 88.44 (a)
zebrafish
(Danio rerio)
Actinopterygii bcas3 35
  • 75.21 (n)
  • 85.26 (a)
bcas3 36
  • 85 (a)
OneToOne
zgc63764 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001090 35
  • 47.96 (n)
  • 43.25 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG43154 35
  • 47.04 (n)
  • 42.24 (a)
CG43154 36
  • 15 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F56C9.10 36
  • 16 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
OneToOne
Species with no ortholog for BCAS3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BCAS3 Gene

ENSEMBL:
Gene Tree for BCAS3 (if available)
TreeFam:
Gene Tree for BCAS3 (if available)

Paralogs for BCAS3 Gene

No data available for Paralogs for BCAS3 Gene

Variants for BCAS3 Gene

Sequence variations from dbSNP and Humsavar for BCAS3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs721968 -- 61,168,560(+) CCCTA(G/T)TAATT intron-variant
rs722681 -- 60,990,260(-) CAAGA(C/T)AACAG intron-variant
rs723835 -- 61,205,147(+) ACCTA(C/T)GAAAA intron-variant
rs725004 -- 60,877,249(-) CAATG(C/T)GACTT intron-variant
rs729948 -- 61,289,287(-) AGAGA(C/T)CCCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BCAS3 Gene

Variant ID Type Subtype PubMed ID
esv2663813 CNV Deletion 23128226
esv33904 CNV Loss 17666407
nsv908659 CNV Loss 21882294
esv2669101 CNV Deletion 23128226
nsv908660 CNV Loss 21882294
esv2581647 CNV Insertion 19546169
nsv908661 CNV Loss 21882294
esv2665893 CNV Deletion 23128226
nsv428349 CNV Loss 18775914
esv2660744 CNV Deletion 23128226
esv2676217 CNV Deletion 23128226
esv27670 CNV Loss 19812545
nsv908662 CNV Loss 21882294
nsv2111 CNV Loss 18451855
esv2669962 CNV Deletion 23128226
dgv43n68 CNV Loss 17160897
esv2664239 CNV Deletion 23128226
esv2668879 CNV Deletion 23128226
esv991598 OTHER Inversion 20482838
nsv2112 CNV Insertion 18451855
nsv518130 CNV Gain 19592680
nsv908663 CNV Loss 21882294
dgv3241n71 CNV Loss 21882294

Relevant External Links for BCAS3 Gene

HapMap Linkage Disequilibrium report
BCAS3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BCAS3 Gene

Disorders for BCAS3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for BCAS3 Gene including...

Search for BCAS3 Gene in MalaCards »

UniProtKB/Swiss-Prot

BCAS3_HUMAN
  • Note=A chromosomal aberration involving BCAS3 has been found in some breast carcinoma cell lines. Translocation t(17;20)(q23;q13) with BCAS4.

(1) University of Copenhagen DISEASES for BCAS3 Gene

(3) Novoseek inferred disease relationships for BCAS3 Gene

Disease -log(P) Hits PubMed IDs
breast cancer 61.9 10
cancer 26.5 2
tumors 25.3 5

Relevant External Links for BCAS3

Genetic Association Database (GAD)
BCAS3
Human Genome Epidemiology (HuGE) Navigator
BCAS3
genes like me logo Genes that share disorders with BCAS3: view

Publications for BCAS3 Gene

  1. Cloning of BCAS3 (17q23) and BCAS4 (20q13) genes that undergo amplification, overexpression, and fusion in breast cancer. (PMID: 12378525) Baerlund M. … Kallioniemi A. (Genes Chromosomes Cancer 2002) 2 3 4 23
  2. Estrogen induces expression of BCAS3, a novel estrogen receptor-alpha coactivator, through proline-, glutamic acid-, and leucine-rich protein-1 (PELP1). (PMID: 17505058) Gururaj A.E. … Kumar R. (Mol. Endocrinol. 2007) 3 4
  3. Human BCAS3 expression in embryonic stem cells and vascular precursors suggests a role in human embryogenesis and tumor angiogenesis. (PMID: 18030336) Siva K. … Inamdar M.S. (PLoS ONE 2007) 3 4
  4. Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson D.F. … Stefansson K. (Nat. Genet. 2008) 3 48
  5. New loci associated with kidney function and chronic kidney disease. (PMID: 20383146) KAPttgen A. … Fox C.S. (Nat. Genet. 2010) 3 48

Products for BCAS3 Gene

Sources for BCAS3 Gene

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