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Aliases for TRPM7 Gene

Aliases for TRPM7 Gene

  • Transient Receptor Potential Cation Channel, Subfamily M, Member 7 2 3
  • LTRPC7 3 4 6
  • Long Transient Receptor Potential Channel 7 3 4
  • Channel-Kinase 1 3 4
  • EC 2.7.11.1 4 63
  • LTrpC-7 3 4
  • ALSPDC 3 6
  • CHAK1 3 4
  • CHAK 3 6
  • Transient Receptor Potential Cation Channel Subfamily M Member 7 3
  • Transient Receptor Potential-Phospholipase C-Interacting Kinase 3
  • LTRPC Ion Channel Family Member 7 3
  • TRP-PLIK 3

External Ids for TRPM7 Gene

Previous GeneCards Identifiers for TRPM7 Gene

  • GC15M046409
  • GC15M043898
  • GC15M048431
  • GC15M048568
  • GC15M048639
  • GC15M050852
  • GC15M027680

Summaries for TRPM7 Gene

Entrez Gene Summary for TRPM7 Gene

  • The protein encoded by this gene is both an ion channel and a serine/threonine protein kinase. The kinase activity is essential for the ion channel function, which serves to increase intracellular calcium levels and to help regulate magnesium ion homeostasis. Defects in this gene are a cause of amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for TRPM7 Gene

TRPM7 (Transient Receptor Potential Cation Channel, Subfamily M, Member 7) is a Protein Coding gene. Diseases associated with TRPM7 include amyotrophic lateral sclerosis-parkinsonism/dementia complex and dementia. Among its related pathways are CREB Pathway and Ion channel transport. GO annotations related to this gene include protein serine/threonine kinase activity and calcium channel activity. An important paralog of this gene is TRPM1.

UniProtKB/Swiss-Prot for TRPM7 Gene

  • Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF-induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1).

Gene Wiki entry for TRPM7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRPM7 Gene

Genomics for TRPM7 Gene

Regulatory Elements for TRPM7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TRPM7 Gene

Start:
50,552,473 bp from pter
End:
50,686,815 bp from pter
Size:
134,343 bases
Orientation:
Minus strand

Genomic View for TRPM7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRPM7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRPM7 Gene

Proteins for TRPM7 Gene

  • Protein details for TRPM7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96QT4-TRPM7_HUMAN
    Recommended name:
    Transient receptor potential cation channel subfamily M member 7
    Protein Accession:
    Q96QT4
    Secondary Accessions:
    • Q6ZMF5
    • Q86VJ4
    • Q8NBW2
    • Q9BXB2
    • Q9NXQ2

    Protein attributes for TRPM7 Gene

    Size:
    1865 amino acids
    Molecular mass:
    212697 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    • Homodimer. Interacts with PLCB1 (By similarity). Forms heterodimers with TRPM6.
    SequenceCaution:
    • Sequence=BAC11462.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD18773.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TRPM7 Gene

Proteomics data for TRPM7 Gene at MOPED

Post-translational modifications for TRPM7 Gene

Other Protein References for TRPM7 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for TRPM7 Gene

Gene Families for TRPM7 Gene

HGNC:
  • TRP :Voltage-gated ion channels / Transient receptor potential cation channels
IUPHAR :

Protein Domains for TRPM7 Gene

Suggested Antigen Peptide Sequences for TRPM7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96QT4

UniProtKB/Swiss-Prot:

TRPM7_HUMAN :
  • Q96QT4
Domain:
  • Contains 1 alpha-type protein kinase domain.
Family:
  • In the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.
  • In the N-terminal section; belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM7 sub-subfamily.
genes like me logo Genes that share domains with TRPM7: view

Function for TRPM7 Gene

Molecular function for TRPM7 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot Function: Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF-induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1).

Enzyme Numbers (IUBMB) for TRPM7 Gene

Gene Ontology (GO) - Molecular Function for TRPM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0005216 ion channel activity --
GO:0005262 calcium channel activity IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with TRPM7: view
genes like me logo Genes that share phenotypes with TRPM7: view

Animal Models for TRPM7 Gene

MGI Knock Outs for TRPM7:

Animal Model Products

CRISPR Products

miRNA for TRPM7 Gene

miRTarBase miRNAs that target TRPM7

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRPM7

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for TRPM7 Gene

Localization for TRPM7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRPM7 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRPM7 Gene COMPARTMENTS Subcellular localization image for TRPM7 gene
Compartment Confidence
plasma membrane 3
extracellular 2
cytoskeleton 1
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TRPM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TRPM7: view

Pathways for TRPM7 Gene

genes like me logo Genes that share pathways with TRPM7: view

Pathways by source for TRPM7 Gene

1 KEGG pathway for TRPM7 Gene

Gene Ontology (GO) - Biological Process for TRPM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation --
GO:0006811 ion transport --
GO:0006812 cation transport --
GO:0006816 calcium ion transport --
GO:0010961 cellular magnesium ion homeostasis IEA --
genes like me logo Genes that share ontologies with TRPM7: view

Compounds for TRPM7 Gene

(4) HMDB Compounds for TRPM7 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Calcium
  • Ca
7440-70-2
Magnesium
  • Magnesium
7439-95-4

(3) Drugbank Compounds for TRPM7 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
1,4-Dithiothreitol
target
Adenosine-5'-Diphosphate
20398-34-9 target
Phosphoaminophosphonic Acid-Adenylate Ester
target

(8) IUPHAR Ligand for TRPM7 Gene

Ligand Type Action Affinity Pubmed IDs
H+ (extracellular) Activator None 5.4
spermine Channel blocker None 4.43
cAMP Activator None
carvacrol Activator None
ATP Activator None
La3+ Channel blocker None
2-APB Channel blocker None
Mg2+ Antagonist Antagonist

(3) Novoseek inferred chemical compound relationships for TRPM7 Gene

Compound -log(P) Hits PubMed IDs
magnesium 57.8 18
threonine 20.2 2
serine 4.6 2
genes like me logo Genes that share compounds with TRPM7: view

Transcripts for TRPM7 Gene

Unigene Clusters for TRPM7 Gene

Transient receptor potential cation channel, subfamily M, member 7:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRPM7

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TRPM7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRPM7 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
SP1:
SP2:
SP3:
SP4: -
SP5:
SP6:

ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31a · 31b ^ 32 ^ 33 ^ 34 ^ 35 ^ 36a · 36b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for TRPM7 Gene

GeneLoc Exon Structure for
TRPM7
ECgene alternative splicing isoforms for
TRPM7

Expression for TRPM7 Gene

mRNA expression in normal human tissues for TRPM7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRPM7 Gene

SOURCE GeneReport for Unigene cluster for TRPM7 Gene Hs.512894

genes like me logo Genes that share expressions with TRPM7: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TRPM7 Gene

Orthologs for TRPM7 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRPM7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRPM7 35
  • 99.7 (n)
  • 99.89 (a)
TRPM7 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRPM7 35
  • 94.62 (n)
  • 96.25 (a)
TRPM7 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRPM7 35
  • 94.51 (n)
  • 96.67 (a)
TRPM7 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trpm7 35
  • 90.83 (n)
  • 94.36 (a)
Trpm7 16
Trpm7 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRPM7 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 91 (a)
OneToMany
-- 36
  • 89 (a)
OneToMany
-- 36
  • 84 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Trpm7 35
  • 90.6 (n)
  • 94.09 (a)
chicken
(Gallus gallus)
Aves gga-mir-6596 36
  • 86 (a)
OneToOne
TRPM7 35
  • 82.3 (n)
  • 87.9 (a)
lizard
(Anolis carolinensis)
Reptilia TRPM7 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trpm7 35
  • 75.15 (n)
  • 79.98 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
trpm7 35
  • 66.12 (n)
  • 76.09 (a)
trpm7 36
  • 68 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG30078 37
  • 43 (a)
CG30079 37
  • 43 (a)
Species with no ortholog for TRPM7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRPM7 Gene

ENSEMBL:
Gene Tree for TRPM7 (if available)
TreeFam:
Gene Tree for TRPM7 (if available)

Paralogs for TRPM7 Gene

Paralogs for TRPM7 Gene

Selected SIMAP similar genes for TRPM7 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TRPM7: view

Variants for TRPM7 Gene

Sequence variations from dbSNP and Humsavar for TRPM7 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs2630 -- 50,557,202(+) TTGAT(C/T)GTCTA utr-variant-3-prime
rs473357 -- 50,574,885(+) TCTTT(A/G)TAAAT reference, synonymous-codon
rs476733 -- 50,595,433(-) ATGTT(A/G)TATTG intron-variant
rs480280 -- 50,594,002(+) CCTCC(C/G)CTATC intron-variant
rs480328 -- 50,595,063(-) ATCAC(A/G)CCTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRPM7 Gene

Variant ID Type Subtype PubMed ID
nsv524613 CNV Loss 19592680
nsv471242 CNV Gain 18288195
dgv317n27 CNV Gain 19166990
esv1392000 CNV Insertion 17803354
nsv904211 CNV Loss 21882294
esv2674857 CNV Deletion 23128226
esv2749686 CNV Deletion 23290073
nsv1532 CNV Insertion 18451855
nsv524596 CNV Loss 19592680
esv2664477 CNV Deletion 23128226
esv2749687 CNV Deletion 23290073

Relevant External Links for TRPM7 Gene

HapMap Linkage Disequilibrium report
TRPM7
Human Gene Mutation Database (HGMD)
TRPM7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRPM7 Gene

Disorders for TRPM7 Gene

(1) OMIM Diseases for TRPM7 Gene (605692)

UniProtKB/Swiss-Prot

TRPM7_HUMAN
  • Amyotrophic lateral sclerosis-parkinsonism/dementia complex 1 (ALS-PDC1) [MIM:105500]: A neurodegenerative disorder characterized by chronic, progressive and uniformly fatal amyotrophic lateral sclerosis and parkinsonism-dementia. Both diseases are known to occur in the same kindred, the same sibship and even the same individual. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for TRPM7

Genetic Association Database (GAD)
TRPM7
Human Genome Epidemiology (HuGE) Navigator
TRPM7
genes like me logo Genes that share disorders with TRPM7: view

Publications for TRPM7 Gene

  1. LTRPC7 is a Mg.ATP-regulated divalent cation channel required for cell viability. (PMID: 11385574) Nadler M.J.S. … Fleig A. (Nature 2001) 2 3 4 23
  2. Regulation of vertebrate cellular Mg2+ homeostasis by TRPM7. (PMID: 12887921) Schmitz C. … Scharenberg A.M. (Cell 2003) 3 4 23
  3. A TRPM7 variant shows altered sensitivity to magnesium that may contribute to the pathogenesis of two Guamanian neurodegenerative disorders. (PMID: 16051700) Hermosura M.C. … Garruto R.M. (Proc. Natl. Acad. Sci. U.S.A. 2005) 3 4 23
  4. TRPM7 is not associated with amyotrophic lateral sclerosis-parkinsonism dementia complex in the Kii peninsula of Japan. (PMID: 19405049) Hara K. … Tsuji S. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 23 48
  5. Silencing TRPM7 promotes growth/proliferation and nitric oxide production of vascular endothelial cells via the ERK pathway. (PMID: 19454490) Inoue K. … Xiong Z.G. (Cardiovasc. Res. 2009) 3 23

Products for TRPM7 Gene

Sources for TRPM7 Gene

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