Aliases for TRPM7 Gene
External Ids for TRPM7 Gene
Previous GeneCards Identifiers for TRPM7 Gene
The protein encoded by this gene is both an ion channel and a serine/threonine protein kinase. The kinase activity is essential for the ion channel function, which serves to increase intracellular calcium levels and to help regulate magnesium ion homeostasis. Defects in this gene are a cause of amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2014]
GeneCards Summary for TRPM7 Gene
TRPM7 (Transient Receptor Potential Cation Channel, Subfamily M, Member 7) is a Protein Coding gene. Diseases associated with TRPM7 include amyotrophic lateral sclerosis-parkinsonism/dementia complex and ophthalmomyiasis. Among its related pathways are CREB Pathway and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and actin binding. An important paralog of this gene is TRPM1.
UniProtKB/Swiss-Prot for TRPM7 Gene
Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF-induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1).